| Budget Amount *help |
¥76,500,000 (Direct Cost: ¥76,500,000)
Fiscal Year 2009: ¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2008: ¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2007: ¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2006: ¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2005: ¥15,300,000 (Direct Cost: ¥15,300,000)
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| Research Abstract |
In this research program, we tried to gain a better understanding of the molecular mechanisms underlying the establishment and maintenance of higher-order chromatin structure, heterochromatin. We successfully identified ARC and Eri1 as novel regulatory factors of heterochromatin assembly in fission yeast. We also demonstrated that the HP1 function is regulated by dosage balance and posttranslational modifications. Furthermore, using budding yeast, we defined the molecular mechanisms to form heterochromatin boundaries.
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