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Physiological role of the blood-brain barrier transportsome

Research Project

Project/Area Number 17081002
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

TERASAKI Tetsuya  Tohoku University, 大学院・薬学研究科, 教授 (60155463)

Co-Investigator(Kenkyū-buntansha) OHTSUKI Sumio  東北大学, 大学院・薬学研究科, 准教授 (60323036)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥58,200,000 (Direct Cost: ¥58,200,000)
Fiscal Year 2009: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2008: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2007: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2006: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2005: ¥6,200,000 (Direct Cost: ¥6,200,000)
Keywords血液脳関門 / 血液脳脊髄液関門 / トランスポートソーム / 膜輸送複合体 / P-糖蛋白質 / LXR / P-gp / Mct1 / oatp2 / siRNA / ABCG2 / LRP-1 / GLUT1 / OAT / 脂質代謝 / コレステロール / 24-S-水酸化コレステロール / リポタンパク質 / ApoE
Research Abstract

The quantification method of transporter proteins was established by means of mass spectrometer. The protein expression amounts and transport activities of transporters were determined in brain capillary endothelial cells, which form the blood-brain barrier. As a result, the function of glucose transporter 1 and multidrug resistant protein 1a (mdr1a) was able to be re-constructed in normal conditions, while the function of mdr1a in inflammation conditions was not. It was also suggested that the transportsome was involved in a part of physiological function of the blood-brain barrier.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (134 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (53 results) (of which Peer Reviewed: 42 results) Presentation (77 results) Book (4 results)

  • [Journal Article] Involvement of multidrug resistance- associated protein 4 in efflux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins.2010

    • Author(s)
      S. Akanuma, K. Hosoya, S. Ito, M. Tachikawa, T. Terasaki, S. Ohtsuki
    • Journal Title

      J. Pharmacol. Exp. Ther 99

      Pages: 912-919

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect.2010

    • Author(s)
      Nakazawa Y, Okura T, Shimomura K, Terasaki T, Deguchi Y
    • Journal Title

      J. Pharm. Sci 99

      Pages: 467-474

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of multidrug resistance-associated protein 4 in of flux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins2010

    • Author(s)
      Akanuma SI, T.Terasaki
    • Journal Title

      J Pharmacol Exp Ther. E-PUB

      Pages: 912-919

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect2010

    • Author(s)
      Nakazawa Y, T.Terasaki
    • Journal Title

      J Pharm Sci. 99

      Pages: 467-474

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters.2009

    • Author(s)
      achikawa M, Kasai Y, Yokoyama R, Fujinawa J, Ganapathy V, Terasaki T, Hosoya K
    • Journal Title

      J. Neurochem 111

      Pages: 499-509

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of inner blood-retinal barrier organic anion transporter 3 in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercapto- purine.2009

    • Author(s)
      Hosoya K, Makihara A, Tsujikawa Y, Yoneyama D, Mori S, Terasaki T, Akanuma S, Tomi M, Tachikawa M
    • Journal Title

      J Pharmacol Exp Ther 329

      Pages: 87-93

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted Absolute Proteomicsを用いたトランスポーターの新しい研究展開2009

    • Author(s)
      大槻純男、上家潤一、寺崎哲也
    • Journal Title

      遺伝子医学MOOK12

      Pages: 48-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中枢への薬物分布におけるトランスポーターの機能と役割2009

    • Author(s)
      大槻純男
    • Journal Title

      日本薬理学雑誌 134

      Pages: 83-86

    • NAID

      10025741265

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats : involvement of creatine and taurine transporters2009

    • Author(s)
      Tachikawa M, T.Terasaki
    • Journal Title

      J Neurochem 111

      Pages: 499-509

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of inner blood-retinal barrier organic anion transporter 3(OAT3)in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercaptopurine2009

    • Author(s)
      KI.Hosoya, T.Terasaki
    • Journal Title

      J Pharmacol Exp Ther. 329

      Pages: 87-93

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted Absolute Proteomics を用いたトランスポーターの新しい研究展開2009

    • Author(s)
      大槻純男、寺崎哲也
    • Journal Title

      遺伝子医学 12

      Pages: 48-54

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 中枢への薬物分布におけるトランスポーターの機能と役割2009

    • Author(s)
      大槻純男、寺崎哲也
    • Journal Title

      日本薬理学雑誌 134

      Pages: 83-86

    • NAID

      10025741265

    • Related Report
      2009 Annual Research Report
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.2008

    • Author(s)
      Ohtsuki S, Yamaguchi H, Katsukura Y, Asashima T, Terasaki T
    • Journal Title

      J. Neurochem 104

      Pages: 147-154

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier.2008

    • Author(s)
      Akanuma S, Hori S, Ohtsuki S, Fujiyoshi M, Terasaki T
    • Journal Title

      Neurochem. Int 52

      Pages: 669-674

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria.2008

    • Author(s)
      Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine Y, Uchida Y, Ito S, Terasaki T
    • Journal Title

      Pharm. Res 25

      Pages: 1469-1483

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血液脳関門におけるモノアミン関連トランスポーターの役割2008

    • Author(s)
      大槻純男
    • Journal Title

      Clinical Neuroscience 26

      Pages: 1077-1080

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting2008

    • Author(s)
      S. Ohtsuki
    • Journal Title

      J. Neurochem 104

      Pages: 147-154

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter Al at rat blood-brain barrier2008

    • Author(s)
      S. Akanuma
    • Journal Title

      Neurochem. Int 52

      Pages: 669-674

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative atlas of membrane transporter proteins : Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria2008

    • Author(s)
      J. Kamiie
    • Journal Title

      Pharm. Res 25

      Pages: 1469-1483

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.2008

    • Author(s)
      S. Ohtsuki
    • Journal Title

      J. Neurochem. 104

      Pages: 147-154

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria.2008

    • Author(s)
      J. Kamiie
    • Journal Title

      Pharm. Res. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血液脳関門機能と薬物の分布2008

    • Author(s)
      寺崎哲也
    • Journal Title

      薬剤学 68(2)

      Pages: 88-96

    • NAID

      10025719948

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro.2007

    • Author(s)
      M. Belanger, T. Asashima, S. Ohtsuki, H. Yamaguchi, S. Ito, T. Terasaki
    • Journal Title

      Neurochem. Int 50

      Pages: 95-101

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 24S-Hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression.2007

    • Author(s)
      Fujiyoshi M, Ohtsuki S, Hori S, Tachikawa M, Terasaki T
    • Journal Title

      J. Neurochem 100

      Pages: 968-978

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells.2007

    • Author(s)
      Ohtsuki S, Yamaguchi H, Asashima T, Terasaki T
    • Journal Title

      Pharm. Res 24

      Pages: 688-694

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.2007

    • Author(s)
      Ohtsuki S, Kamoi M, Watanabe Y, Suzuki H, Hori S, Terasaki T
    • Journal Title

      Biol. Pharm. Bull 30

      Pages: 1144-1146

    • NAID

      110006278407

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-to-blood elimination of 24S-hydroxy- cholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier.2007

    • Author(s)
      Ohtsuki S, Ito S, Matsuda A, Hori S, Abe T, Terasaki T
    • Journal Title

      J. Neurochem 103

      Pages: 1430-1438

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multichannel Liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter.2007

    • Author(s)
      Uchida Y, Kamiie J, Ohtsuki S, Terasaki T
    • Journal Title

      Pharm. Res 24

      Pages: 2281-2296

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 24S-Hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical-and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression.2007

    • Author(s)
      M. Fujiyoshi
    • Journal Title

      J. Neurochem. 100

      Pages: 968-978

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      Pharm. Res. 24

      Pages: 688-694

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      Biol. Pharm. Bull. 30

      Pages: 1144-1146

    • NAID

      110006278407

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      J. Neurochem. 103

      Pages: 1430-1438

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro.2007

    • Author(s)
      M. Belanger
    • Journal Title

      Neurochem. Int 50

      Pages: 95-101

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier.2007

    • Author(s)
      S. Akanuma
    • Journal Title

      Neurochem. Int. 52

      Pages: 669-674

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multichannel Liquid Chromatography-Tandem Mass Spectrometry Cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter.2007

    • Author(s)
      Y. Uchida
    • Journal Title

      Pharm. Res. 24

      Pages: 2281-2296

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discoverv and development.2007

    • Author(s)
      S. Ohtsuki
    • Journal Title

      Pharm. Res. 24

      Pages: 1745-1757

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 尿毒症物質の血液脳関門と腎輸送2007

    • Author(s)
      内田康雄
    • Journal Title

      腎と透析 62

      Pages: 327-333

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 薬物の薬効、毒性標的への分布:血液脳関門の透過性の評価2007

    • Author(s)
      寺崎哲也
    • Journal Title

      遺伝子医学Mook 8

      Pages: 170-177

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ABCタンパク質と個体維持機構:脳関門におけるABCトランスポーターの働きと疾患治療2007

    • Author(s)
      寺崎哲也
    • Journal Title

      最新医学 62(11)

      Pages: 2461-2466

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier.2006

    • Author(s)
      Deguchi T, Isozaki K, Yousuke K, Terasaki T, Otagiri M
    • Journal Title

      J Neurochem 96(4)

      Pages: 1051-1059

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo delivery of small interfering RNA targeting brain capillary endothelial cells.2006

    • Author(s)
      Hino T, Yokota T, Ito S, Nishina K, Kang YS, Mori S., Hori S, Kanda T, Terasaki T, Mizusawa H
    • Journal Title

      Biochem Biophys Res Commun 340(1)

      Pages: 263-267

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells.2006

    • Author(s)
      Asashima T, Hori S, Ohtsuki S, Tachikawa M, Watanabe M, Mukai C, Kitagaki S, Miyakoshi N, Terasaki T
    • Journal Title

      Pharm Res 23

      Pages: 1235-1242

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Major involvement of low-density lipoprotein receptor- related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver.2006

    • Author(s)
      Tamaki C., Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T
    • Journal Title

      Pharm Res 23

      Pages: 1407-1416

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice.2006

    • Author(s)
      Ohtsuki S, Kikkawa T, Hori S, Terasaki T
    • Journal Title

      Biol. Pharm. Bull 29

      Pages: 1587-1591

    • NAID

      110005663994

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳関門輸送の分子機構と脳へのDDS2006

    • Author(s)
      大槻純男
    • Journal Title

      DDS学会誌 21

      Pages: 102-110

    • NAID

      10018118754

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier.2006

    • Author(s)
      T.Deguchi
    • Journal Title

      J Neurochem. 96(4)

      Pages: 1051-1059

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In vivo delivery of small interfering RNA targeting brain capillary endothelial cells.2006

    • Author(s)
      T.Hino
    • Journal Title

      Biochem Biophys Res Commun. 340(1)

      Pages: 263-267

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells.2006

    • Author(s)
      T.Asashima
    • Journal Title

      Pharm Res. 23

      Pages: 1235-1242

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver.2006

    • Author(s)
      C.Tamaki
    • Journal Title

      Pharm Res. 23

      Pages: 1407-1416

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice.2006

    • Author(s)
      S.Ohtsuki
    • Journal Title

      Biol. Pharm. Bull. 29

      Pages: 1587-1591

    • NAID

      110005663994

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Increased JNK Phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells.2005

    • Author(s)
      Zhou J, Deo BK, Hosoya K, Terasaki T, Obrosova IG, Brosius III FC, Kumagai AK
    • Journal Title

      Invest Ophthalmol Vis Sci 46

      Pages: 3403-3410

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain.2005

    • Author(s)
      Tachikawa M, Watanabe M, Hori S, Fukaya M, Ohtsuki S, Asashima T, Terasaki T
    • Journal Title

      J Neurochem 95

      Pages: 294-304

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.2005

    • Author(s)
      Okabe M, Unno M, Harigae H, Kaku M, Okitsu Y, Sasaki T, Mizuno T, Shiiba K, Takanaga H, Terasaki T, Matsuno S, Sasaki I, Ito S, Abe T
    • Journal Title

      Biochem Biophys Res Commun 333

      Pages: 754-762

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Pharmacoproteomics:タンパク質の高感度絶対定量法を用いた創薬研究の新地平2009

    • Author(s)
      寺崎哲也
    • Organizer
      医薬基盤研究所セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 質量分析装置を用いたトランスポータータンパク質の絶対定量と in vivo 機能の再構築2009

    • Author(s)
      寺崎哲也
    • Organizer
      第82回生化学会大会 シンポジウム「トランスポーター研究のパラダイムシフト:ヒトシステムの理解を目指して」
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pharmacoproteomics (PPx): Quantitative Targeted Absolute Proteomics (QTAP) based Pharmacokinetics as a New Path for the Drug Discovery and Development2009

    • Author(s)
      T. Terasaki
    • Organizer
      Asian Federation for Pharmacutical Sciences 2009
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2009-10-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative Targeted Absolute Proteomics(QTAP)based Pharmacokinetics as a New Path for the Drug Discovery and Development2009

    • Author(s)
      寺崎哲也
    • Organizer
      Asian Federation for Pharmacutical Sciences 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新薬開発のボトルネック解消を目指した解収束型プロテオミクスの新展開:高感度多検体同時普遍的タンパク質絶対定量法を用いたファーマコプロテオミクス、S2タンパク質研究から医薬品開発への道2009

    • Author(s)
      寺崎哲也
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 創薬研究の新地平:血液脳関門ファーマコプロテオミクス2009

    • Author(s)
      寺崎哲也
    • Organizer
      東北大学バイオフォーラム(産学官連携の展開を図るため)、脳科学の革新的発展を目指して、東京ステーションカンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Quantitative Targeted Absolute Proteomics(QTAP)を用いたトランスポーター研究のPK-PDへの応用、Transporter Symposium トランスポーター研究の新たな展開2009

    • Author(s)
      寺崎哲也
    • Organizer
      トランスポーターを標的とした創薬への動向、トランスポーター研究会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] New approach to drug design by quantitative membrane proteomics2009

    • Author(s)
      S. Ohtsuki
    • Organizer
      Special lecture in Seoul National University
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-05-20
    • Related Report
      2009 Final Research Report
  • [Presentation] New approach to drug design by quantitative membrane proteomics2009

    • Author(s)
      大槻純男, 寺崎哲也
    • Organizer
      Special lecture in Seoul Netional University
    • Place of Presentation
      Seoul
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pharmacoproteomics as a novel method for the prediction of drug delivery to the brain2009

    • Author(s)
      T. Terasaki, Y. Uchida, H. Kawakami, Y. Katsukura, J. Kamiie, S. Ohtsuki
    • Organizer
      7th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2009-05-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Pharmacoproteomics as a novel method for the prediction of drug delivery to the brain2009

    • Author(s)
      寺崎哲也
    • Organizer
      7th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Florida(USA)
    • Year and Date
      2009-05-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prediction of In Vivo ADME Based on the Transporter Protein Quantification.2009

    • Author(s)
      T. Terasaki
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angels, CA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 22th Biennal Meeting of the International Society for Neurochemistry (ISN)2009

    • Author(s)
      T. Terasaki
    • Organizer
      American Society Neurochemistry Joint Meeting
    • Place of Presentation
      Busan, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] Transporter protein quantification for the future of transporter science. Advanced Technologies for the Future of Transporter Sciences2009

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative transporter protein analysis of human brain capillary endothelial2009

    • Author(s)
      T. Terasaki
    • Organizer
      8the Cerebral Vascular Biology International Conference (CVB2009)
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] In vitro-to-in vivo re-construction of blood-brain barrier penetration integrating P-glycoprotein absolute expression, its in vitro activity, and free fractions in plasma and brain2009

    • Author(s)
      内田康雄, 寺崎哲也
    • Organizer
      8th Cerebral Vascular International Conference
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Quantitative transporter protein analysis of human brain capillary endothelial2009

    • Author(s)
      寺崎哲也
    • Organizer
      8th Cerebral Vascular International Conference
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] The comparison of absolute expression profiles of membrane proteins between immortalized human cerebral microvascular endothelial cells(hCMEC/D3)and isolated human brain capillaries2009

    • Author(s)
      C.Ikeda, T.Terasaki
    • Organizer
      8th Cerebral Vascular International Conference
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Quantitative protein expression profiles of membrane transporters at isolated human brain capillaries2009

    • Author(s)
      内田康雄, 寺崎哲也
    • Organizer
      8th Cerebral Vascular International Conference
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transporter protein qunatification for the future of thransporter science2009

    • Author(s)
      寺崎哲也
    • Organizer
      Advanced Technologies for the Future of Transporter Sciences, The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Conditionally immortalized cell line of rat choroid plexus epithelial cell(TR-CSFB)as an useful in vitro model for the blood-cerebrospinal fluid barrier2009

    • Author(s)
      寺崎哲也
    • Organizer
      22th Biennal Meeting of the International Society for Neurochemistry(ISN), American Society Neurochemistry Joint Meeting
    • Place of Presentation
      Busan(韓国)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ファーマコプロテオミクスを基盤とする新しい薬物動態研究2009

    • Author(s)
      大槻純男
    • Organizer
      第13回薬物動態談話会セミナー
    • Place of Presentation
      つくば
    • Related Report
      2009 Annual Research Report
  • [Presentation] ファーマコプロテオミクス解析によるガン薬剤耐性機構の解明2009

    • Author(s)
      大槻純男
    • Organizer
      日本医療薬学会
    • Place of Presentation
      長崎
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prediction of In Vivo ADME Based on the Transporter Protein Quantification2009

    • Author(s)
      寺崎哲也
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angels(USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alteration of protein expression profile of transporters and the in vitro-to-in vivo re-construction of P-gp function at the blood-brain barrier in mouse model of epilepsy2009

    • Author(s)
      内田康雄, 寺崎哲也
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angels(USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression profile of membrane transporter proteins at isolated human brain capillaries by targeted absolute proteomics2009

    • Author(s)
      内田康雄, 寺崎哲也
    • Organizer
      2009 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Los Angels(USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] PHARMACOPROTEOMICS(PPX): QUANTITATIVE TARGETED ABSOLUTE PROTEOMICS(QTAP)BASED PHARMACO KINETICS, PHARMACODYNAMICS AND TOXICOKINETICS2009

    • Author(s)
      寺崎哲也
    • Organizer
      日本薬物動態学会第24回年会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] QUANTITATIVE TARGETED ABSOLUTE PROTEOMICS(QTAP)FOR MEMBRANE TRANSPORTERS AT HUMAN BLOOD-BRAIN BARRIERS2009

    • Author(s)
      内田康雄、寺崎哲也
    • Organizer
      日本薬物動態学会第24回年会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vitro-to-in vivo re-construction of brain distribution for P-glycoprotein substrates in mouse and monkey based on its absolute expression, intrinsic transport activity, and unbound fraction in plasma and brain2009

    • Author(s)
      内田康雄、寺崎哲也
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Quantitative targeted absolute proteomics(QTAP)for the tumor drug resistance2009

    • Author(s)
      寺崎哲也
    • Organizer
      Global COE Network Medicine The 1st International Symposium-Challenge to Medical Innovation-
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protein expression profile of membrane transporters in the capillaries of normal human brain by lc-ms/ms based quantification2009

    • Author(s)
      Y.Katsukura, T.Terasaki
    • Organizer
      Global COE Network Medicine The 1st International Symposium-Challenge to Medical Innovation-
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alteration of transporter protein expressions and in vitro-to-in vivo re-construction of p-glycoprotein function at the blood-brain barrier in mouse model of epilepsy and phenytoin therapy2009

    • Author(s)
      内田康雄, 寺崎哲也
    • Organizer
      Global COE Network Medicine The 1st International Symposium-Challenge to Medical Innovation-
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Blood-Brain Barrier Pharmacoproteomics (PPx): Targeted absolute proteomics-based pharmacokinetics as a new path for the blood-brain barrier research2008

    • Author(s)
      T. Terasaki, Y. Uchida, J. Kamiie, S. Ohtsuki
    • Organizer
      BLOOD-BRAIN BARRIER CONSORTIUM CLUB Symposium: 'The impact of efflux transports on CNS drug distribution'
    • Place of Presentation
      Gordon Museum, Hodgkin Building, King's College Guy's Campus, London, United Kingdom
    • Year and Date
      2008-11-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Blood-Brain Barrier Pharmacoproteomics (PPx) : Targeted absolute proteomics-based pharmacokinetics as a new path for the blood-brain barrier research2008

    • Author(s)
      T. Terasaki
    • Organizer
      BLOOD-BRAIN BARRIER CONSORTIUM CLUB Symposium : The impact of efflux transports on CNS drug distribution
    • Place of Presentation
      London, United Kingdo
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 標的プロテオミクスによる膜タンパク質研究の新たな展開2008

    • Author(s)
      大槻純男
    • Organizer
      BMA2008、若手シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-08-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pharmacoproteomics : Targeted Absolute Proteomicsに基づく薬剤学の新展開2008

    • Author(s)
      寺崎哲也
    • Organizer
      Frontier's Nanomedicine-Summer Workshop 2008-、(主催 : 日本薬学会北海道支部会、共催 : 日本生化学会北海道支部、北海道分子生物学研究会)
    • Place of Presentation
      札幌、北海道大学大学院薬学研究院
    • Year and Date
      2008-08-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 動的インターフェースとしての血液脳関門の分子機構2008

    • Author(s)
      寺崎哲也
    • Organizer
      第23回新潟腎シンポジウム
    • Place of Presentation
      新潟市・有壬記念館
    • Year and Date
      2008-08-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pharmacoproteomics : Targeted Absolute Proteomlcsに基づく薬剤学の新展開2008

    • Author(s)
      寺崎哲也
    • Organizer
      成20年度国公私立大学病院薬剤部職員研修会、(文部科学省後援)
    • Place of Presentation
      東京大学医学部附属病院中央診療棟
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantitative Targeted Proteomicsによる膜タンパク質の網羅的定量技術の開発と応用2008

    • Author(s)
      大槻純男
    • Organizer
      第5回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 定量的Targeted proteomicsによるマウス肝臓トランスポータータンパク質の細胞膜局在評価法の開発2008

    • Author(s)
      勝倉由樹
    • Organizer
      第5回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted Absolute Proteomics as A New Path to the Pharmaceutical and Biomedical Sciences both for Academia and Industry2008

    • Author(s)
      T. Terasaki
    • Organizer
      Special Seminar at the University Paris 5, Faculty of Pharmaceutical Sciences
    • Place of Presentation
      Paris, France 14.
    • Year and Date
      2008-04-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Targeted Absolute Proteomics as A New Path to the Pharmaceutical and Biomedical Sciences both for Academia and Industry2008

    • Author(s)
      T. Terasaki
    • Organizer
      Special Seminar at the University Paris 5, Faculty of Pharmaceutical Sciences
    • Place of Presentation
      Paris, France
    • Year and Date
      2008-04-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted Absolute Proteomics as A New Path to the Biomedical Sciences2008

    • Author(s)
      T. Terasaki
    • Organizer
      Leibniz-Institut of Molekulare Pharmakologie (FMP)
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2008-04-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Targeted Absolute Proteomics as A New Path to the Biomedi cal Sciences2008

    • Author(s)
      T. Terasaki
    • Organizer
      Leibniz-Institut of Molekulare Pharmakolo gie (FMP)
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2008-04-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted Absolute Proteomicsに基づく創薬科学の新展開2008

    • Author(s)
      寺崎哲也
    • Organizer
      ヒューマンサイエンス振興財団情報委員会、(主催 : ヒューマンサイエンス振興財団)
    • Place of Presentation
      東京
    • Year and Date
      2008-04-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted absolute proteomics as a new path to the drug discovery and development2008

    • Author(s)
      T. Terasaki
    • Organizer
      Winter Symposium of Research Triangle Park -Drug Metabolizing Discussion Group (RTP-DMDG)
    • Place of Presentation
      Chapel Hill, North Carolina, USA
    • Year and Date
      2008-03-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Targeted proteomics analysis of tight junction proteins expressed at the blood-brain barrier2008

    • Author(s)
      S. Ohtsuki, S. Murata, Y. Katsukura, J. Kamiie, P.O. Couraud, T. Terasaki
    • Organizer
      The 11th international symposium on "Signal transduction in the Blood-Brain Barriers"
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Targeted proteomics of the BBB tight junction2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      Gordon Research conference "Barriers of the CNS"
    • Place of Presentation
      Tilton, NH. USA
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Award Lecture for New Investigator Award2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2nd ISSX Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative targeted proteomics as a new strategy for the blood-brain barrier research2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2008 the Pharmaceutical Society of Korea Metting
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Award Lecture for New Investigator Award2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      2nd ISSX Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai, Chaina
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted Absolute Proteomicsを用いた創薬科学と薬物治療学への新たな挑戦2008

    • Author(s)
      寺崎哲也
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血液脳関門トランスポートソームの生理的役割2008

    • Author(s)
      寺崎哲也
    • Organizer
      特定領域研究「生体膜トランスポートソームの分子機構と生理機能』平成20年度第1回班会議
    • Place of Presentation
      淡路島
    • Related Report
      2008 Annual Research Report
  • [Presentation] 定量的プロテオミクスを用いたマウス肝臓におけるトランスポーターの定量的局在解析2008

    • Author(s)
      勝倉由樹
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 定量的プロテオミクス法を用いたin vitro輸送系からの血液脳関門P-glycoprotein輸送機能の再構築2008

    • Author(s)
      内田康雄
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] バイオインフォマティクス及びプロテオミクスを利用した新規トランスポーターの候補分子の探索2008

    • Author(s)
      相澤三四郎
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 不死化ヒト脳毛細血管内皮細胞株を用いた網羅的トランスポーター発現解析によるヒト血液脳関門輸送系の解明2008

    • Author(s)
      池田千絵美
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted proteomicsによる血液脳関門のtight junction構成タンパク質の網羅的な同定2008

    • Author(s)
      村田将
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted proteomics based comprehensive identification of tight junction proteins at the blood brain barrier2008

    • Author(s)
      村田将
    • Organizer
      日本薬物動態学会第23年会
    • Place of Presentation
      熊本
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantitative expression profile of 29 membrane transporters in Caco-2 cells based on quantitative targeted proteomics by LC-MS/MS2008

    • Author(s)
      Y. Uchida
    • Organizer
      2nd Asian Pacific Regional Meeting
    • Place of Presentation
      Shanghai, China
    • Related Report
      2008 Annual Research Report
  • [Presentation] Reconstruction of in vivo BBB P-glycoprotein function based on its absolute expression amount and in vitro transport activity2008

    • Author(s)
      Y. Uchida
    • Organizer
      Gordon Research conference "Barriers of the CNS"
    • Place of Presentation
      Tilton, NH. USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] ABCA1 deficiency does not affect the amyloid-beta elimination across the blood-brain barrier2008

    • Author(s)
      S. Ohtsuki
    • Organizer
      Gordon Research conference "Barriers of the CNS"
    • Place of Presentation
      Tilton, NH. USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantitative protein expression profile of transporters and receptors in immortalized human brain capillary endothelial cells by targeted absolute proteomics2008

    • Author(s)
      C. Ikeda
    • Organizer
      The 11th international symposium on "Sign al transduction in the Blood-Brain Barriers"
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2008 Annual Research Report
  • [Presentation] Reconstruction of P-glycoprotein function at blood-brain barrier based on its absolute expression amount and in vitro trans port activity2008

    • Author(s)
      Y. Uchida
    • Organizer
      2008 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, GA, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of human candidate proteins for transporters from human protein database by informatics and targeted proteomics approach2008

    • Author(s)
      S. Aizawa
    • Organizer
      2008 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, GA, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 定量的プロテオミクスによるトランスポーターの肝臓における定量的局在解析2008

    • Author(s)
      勝倉由樹
    • Organizer
      特定領域研究「生体膜トランスポートソームの分子機構と生理機能」平成20年度第1回班会議
    • Place of Presentation
      淡路島
    • Related Report
      2008 Annual Research Report
  • [Presentation] 定量的プロテオミクスによるin vitro輸送系からの血液脳関門P-glycoprotein輸送機能の再構築2008

    • Author(s)
      内田康雄
    • Organizer
      特定領域研究「生体膜トランスポートソームの分子機構と生理機能」平成20年度第1回班会議
    • Place of Presentation
      淡路島
    • Related Report
      2008 Annual Research Report
  • [Presentation] 標的プロテオミクスによる血液脳関門の密着結合構成膜タンパク質の網羅的な同定解析2008

    • Author(s)
      村田将
    • Organizer
      特定領域研究「生体膜トランスポートソームの分子機構と生理機能」平成20年度第1回班会議
    • Place of Presentation
      淡路島
    • Related Report
      2008 Annual Research Report
  • [Presentation] 不死化ヒト脳毛細血管内皮細胞株を用いたヒト脳関門トランスポートソームを構成する輸送担体発現プロファイルの同定2008

    • Author(s)
      池田千絵美
    • Organizer
      特定領域研究「生体膜トランスポートソームの分子機構と生理機能」平成20年度第1回班会議
    • Place of Presentation
      淡路島
    • Related Report
      2008 Annual Research Report
  • [Presentation] 標的プロテオミクスによるヒト新規トランスポーター候補分子の月刊蔵細胞膜における発現解析2008

    • Author(s)
      相澤三四郎
    • Organizer
      特定領域研究「生体膜トランスポートソームの分子機構と生理機能」平成20年度第1回班会議
    • Place of Presentation
      淡路島
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantitative proteomics as a path to new blood-brain barrier research2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      Tenth Symposium Signal Transduction in the Blood-Brain Barriers
    • Place of Presentation
      Potsdam, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional expression of transporters for organic anion at the blood-brain barrier2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      7th Cerebral Vascular Biology International Conference
    • Place of Presentation
      Ottawa, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] ain barrier transport protein for the brain drug delivery2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      6th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2009 Final Research Report
  • [Presentation] Special Lecture: Quantitative proteomics in transporter biology as a new strategy of the drug delivery research2007

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      International Workshop and Symposium on Transport, Metabolism and Disposition
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative and Simultaneous LC-MS/MS Analysis for Membrane Proteins: Its Application for the Blood-Brain Barrier Biology2006

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      Invited lecture at Seminar of Institut Cochin
    • Place of Presentation
      Paris, France
    • Year and Date
      2006-12-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative proteomics for membrane proteins as a new strategy for the blood-brain barrier biology2006

    • Author(s)
      T. Terasaki, J. Kamiie, S. Ohtsuki
    • Organizer
      Invited lecture at Seminar of Universite d'Atrois
    • Place of Presentation
      Lens, France
    • Year and Date
      2006-12-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Brain-to-blood efflux transporters at the blood brain barrier as a CNS detoxifying system2005

    • Author(s)
      T. Terasaki, S. Ohtsuki
    • Organizer
      1th Indo-Japanese Conference on Advances in Pharmaceutical Research and Technology - with special emphasis on Drug Discovery and Drug Delivery
    • Place of Presentation
      Mumbai, India
    • Related Report
      2009 Final Research Report
  • [Book] トランスポーター科学最前線2008

    • Author(s)
      寺崎哲也
    • Total Pages
      23
    • Publisher
      京都廣川書店
    • Related Report
      2007 Annual Research Report
  • [Book] A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, Creatine biosynthesis, and its use for brain and retinal energy homeostasis2007

    • Author(s)
      M. Tachikawa, K. Hosoya, S. Ohtsuki, T. Terasaki
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] 生物薬剤学2007

    • Author(s)
      寺崎哲也
    • Total Pages
      6
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report
  • [Book] Creatine and Creatine Kinase in Health and Disease2007

    • Author(s)
      M. Tachikawa
    • Publisher
      Springer(In press)
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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