|Budget Amount *help
¥58,200,000 (Direct Cost: ¥58,200,000)
Fiscal Year 2009: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2008: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2007: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2006: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2005: ¥6,200,000 (Direct Cost: ¥6,200,000)
The quantification method of transporter proteins was established by means of mass spectrometer. The protein expression amounts and transport activities of transporters were determined in brain capillary endothelial cells, which form the blood-brain barrier. As a result, the function of glucose transporter 1 and multidrug resistant protein 1a (mdr1a) was able to be re-constructed in normal conditions, while the function of mdr1a in inflammation conditions was not. It was also suggested that the transportsome was involved in a part of physiological function of the blood-brain barrier.