| Project/Area Number |
17081003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KINOSHITA Kengo The University of Tokyo, 大学院・情報科学研究科, 教授 (60332293)
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| Co-Investigator(Kenkyū-buntansha) |
中村 春木 大阪大学, たんぱく質研究所, 教授 (80134485)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Haruki 大阪大学, 蛋白質研究所, 教授 (80134485)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥53,100,000 (Direct Cost: ¥53,100,000)
Fiscal Year 2009: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2008: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2007: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2006: ¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2005: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | 膜輸送複合体 / トランスポートソーム / DNAマイクロアレイ / 遺伝子共発現 / タンパク質立体構造 / タンパク質間相互作用 / 膜分子輸送複合体 / 共発現 / 蛋白質立体構造 / タンパク質問相互作用 / トランスポートゾーム / バイオインフォマティクス / 蛋白質 / 分子間相互作用 / トランスポーター / シグナル伝達 / 立体構造 / 分子表面 / リガンド結合部位 / 静電ポテンシャル / ドッキングシュミレーション |
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| Research Abstract |
Construction of interaction network of protein is a first step toward the understanding of complex biological systems. Usually, the network is made from nodes and edges representing proteins and interactions, respectively. However, the abstract representation prevents us from analyzing the biological systems in molecular levels. Therefore, in this project, we have developed a method to construct the interaction networks based on gene coexpression, and also develop a method to predict the protein complex structures.
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