| Project/Area Number |
17081008
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HATA Yutaka Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80313237)
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| Co-Investigator(Kenkyū-buntansha) |
池田 光伸 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00451930)
中川 健太郎 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (70451929)
平林 享 東京医科歯科大学, 大学院医歯学総合研究科, 助手 (80376730)
飯田 純子 東京医科歯科大学, 大学院医歯学総合研究科, 助手 (80376805)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWA Kentaro 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (70451929)
IKEDA Misunobu 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00451930)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥67,800,000 (Direct Cost: ¥67,800,000)
Fiscal Year 2009: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2007: ¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2006: ¥22,000,000 (Direct Cost: ¥22,000,000)
Fiscal Year 2005: ¥6,700,000 (Direct Cost: ¥6,700,000)
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| Keywords | トランスポーター / チャネル / 細胞接着 / 細胞極性 / 細胞死 / シグナル伝達 / scaffold / Scaffold / 細胞骨格 / PDZ / エンドサイトーシス / 受容体 |
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| Research Abstract |
Cell junctions are important not only for cell adhesion but also for signal transduction. Thereby, we focused on S-SCAM(MAGI2), MAGI1, and LNX1, all of which are localized at cell junctions. We revealed the roles of S-SCAM at excitatory and inhibitory synapses, of MAGI1 at kidney diaphragm, and of LNX1 in the endocytosis of a cell adhesion molecule named JAM4 during the epithelial and mesenchymal transition. We also identified RASSF6 as a new MAGI1-binding partner, which mediates apoptosis. A protein kinase named MST2 functions as a scaffold to assemble a complex including RASSF6 and blocks RASSF6-induced apoptosis. Once MST2 is activated, RASSF6 is released from the complex. This finding implies that MST2 is a dynamic scaffold to directly regulate protein interactions.
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