| Budget Amount *help |
¥71,100,000 (Direct Cost: ¥71,100,000)
Fiscal Year 2009: ¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2008: ¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2007: ¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 2006: ¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 2005: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Research Abstract |
The aim of this study was to identify functionally important proteincomplexes regulating AQP water channels, CLC chloride channels and Na-Cl cotransporter(NCC), by focusing on the naturally occurring mutations of these genes. We found that thebinding of tropomyosin 5b to phosphorylated AQP2 was necessary for AQP2's apical sortingby vasopressin. We also found a novel phosphorylation cascade (WNK-OSR1/SPAK-NCC)in the kidney that is important for blood pressure regulation.
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