• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Ca^<2+> channelplexes : assembly in the membrane and physiological significance

Research Project

Project/Area Number 17081011
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

MORI Yasuo  Kyoto University, 大学院・工学研究科, 教授 (80212265)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Toyoshi  名古屋大学, 大学院・医学系研究科, 教授 (50115929)
WAKAMORI Minoru  東北大学, 大学院・歯学研究科, 教授 (50222401)
HARA Yuji  アイオワ大学, 医学部, ポスドク (60362456)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥76,500,000 (Direct Cost: ¥76,500,000)
Fiscal Year 2009: ¥17,100,000 (Direct Cost: ¥17,100,000)
Fiscal Year 2008: ¥17,100,000 (Direct Cost: ¥17,100,000)
Fiscal Year 2007: ¥17,100,000 (Direct Cost: ¥17,100,000)
Fiscal Year 2006: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2005: ¥7,200,000 (Direct Cost: ¥7,200,000)
KeywordsCa^<2+>チャネル / 分子複合体 / 膜分子集積 / シグナル伝達 / バイオセンサー / カルシウムチャネル
Research Abstract

Ca^<2+> as a second messenger controls a wide variety of biological responses and contributes to formation of tissues such as bones, thereby playing a central role in regulating "homeostasis" at whole body, tissue, and cell levels. In my research, I have focused on voltage-dependent Ca^<2+> channels (VDCCs) and transient receptor potential (TRP) channels to aim at understanding mechanisms, that underlie formation and assembly at the biomembrane of Ca^<2+> channel protein complexes (Ca^<2+> channelplexes), and their physiological significance. Firstly, I have unveiled several unique activation mechanisms, that regulate cellular signal transduction for TRP Ca^<2+>-permeable caion channels. Secondly, I have demonstrated that channel proteins act not only as Ca^<2+>-permeating apparatus but also as assembly centers for receptors, signal-regulating proteins, and scaffolding proteins. Thirdly, important roles of Ca^<2+> channel protein complexes via formation of feedback regulation pathways in signal transduction have been demonstrated. Finally, I have also shown physiological significance of Ca^<2+> channelplexes at tissue levels. TRPC3 channelplexes in B lymphocyte activation and P/Q type VDCCplexes in presynaptic vesicle fusion are examples of the outcome of this study. Thus, my study clarifies how individual Ca^<2+> channels play roles in unique cellular responses.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (70 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (69 results) (of which Peer Reviewed: 54 results) Remarks (1 results)

  • [Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.2010

    • Author(s)
      Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 107

      Pages: 332-337

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Ca^<2+> Channel Synprint Site in Synaptic Vesicle Endocytosis.2010

    • Author(s)
      Watanabe H, Yamashita T, Saitoh N, Kiyonaka S, Iwamatsu A, Campbell KP, Mori Y, Takahashi T.
    • Journal Title

      J. Neurosci. 30

      Pages: 655-660

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An in vivo fluorescent sensor reveals intracellular Ins(1, 3, 4, 5)P(4) dynamics in single cells.2010

    • Author(s)
      Sakaguchi R, Tainaka K, Shimada N, Nakano S, Inoue M, Kiyonaka S, Mori Y, Morii T.
    • Journal Title

      Angew. Chem. Int. Ed. 17

      Pages: 7381-7386

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An in vivo fluorescent sensor reveals intracellular Ins(1, 3, 4, 5)P(4) dynamics in single cells.2010

    • Author(s)
      Sakaguchi R, Tainaka K, Shimad a N, Nakano S, Inoue M, Kiyonaka S, Mori Y, Morii T
    • Journal Title

      Angew. Chem. Int. Ed. 17

      Pages: 7381-7386

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement o fCa^<2+> Channel Synprint Site in Synaptic Vesicle Endocytosis.2010

    • Author(s)
      Watanabe H, Yamashita T, Saitoh N, Kiyonaka S, Iwamatsu A, Campbell KP, Mori Y, Takahashi T.
    • Journal Title

      J.Neurosci.30, 655-660 30

      Pages: 655-660

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade2010

    • Author(s)
      Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T
    • Journal Title

      Proc. Natl. Acad. Sci. USA 107, 332-337 107

      Pages: 332-337

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+> influx and protein scaffolding via TRPC3 sustain PKC and ERK activation in B cells.2010

    • Author(s)
      Numaga T, Nishida M, Kiyonaka S, Kato K, Katano K, Mori E, Kurosaki T, Inoue R, Hikida T, Putney Jr JW, Mori Y
    • Journal Title

      J.Cell Sci. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dofferemtoa; redpx regi;atopm pf PRAO Cjammels : a mechanism to tune cellular calcium responses2010

    • Author(s)
      Bogeski I, Kummerow C, Al-Ansary D, Koehler R, Schwarz EC, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem B, Mori Y, Hoth M, Niemeyer BA
    • Journal Title

      Science Signaling (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pathogenic C-terminus-truncated Polycistin-2 mutant enhances receptor-activated Ca^<2+> entry via association with TRPC3 and TRPC7.2009

    • Author(s)
      Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 34400-34412

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.2009

    • Author(s)
      Sun H-S, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, MacDonald JF, Tymianski M.
    • Journal Title

      Nature Neurosci. 12

      Pages: 1300-1307

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targetted disruption of the voltage-dependent Ca^<2+> channelα-2/δ-1 subunit.2009

    • Author(s)
      Fuller-Bicer GA, Varadi G, Koch SE, Ishii M, Bodi I, Kadeer N, Muth JN, Mikala G, Petrashevskaya NN, Jordan MA, Zhang SP, Qin N, Flores CM, Isaacsohn I, Varadi M, Mori Y, Jones WK, Schwartz A.
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol. 297

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via PLC/diacylglycerol and PLA-2/£s-hydroxylase/20-HETE pathways.2009

    • Author(s)
      Inoue R, Jensen LJ, JianZ, Shi J, Hai L, Lurie AI, Henriksen FH, Salmonsson M, Morita H, Kawarabayashi Y, Mori M, Mori Y, Ito Y.
    • Journal Title

      Circ Res. 104

      Pages: 1399-1409

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] STIM protein coupling in the activation of Orai channels.2009

    • Author(s)
      Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, Ritchie MF, Tang XD, Baba Y, Kurosaki T, Mori Y, Soboloff J, Gill DL.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 7391-7396

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2 functions as lysosomal Ca^<2+> release channel in β-cells.2009

    • Author(s)
      Lange I, Yamamoto Y, Partida-Sanchez S, Mori Y, Fleig A, Penner R.
    • Journal Title

      Science Signaling 2

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tetrameric Orail is a teardrop-shaped molecule with a long, tapered cytoplasmic domain.2009

    • Author(s)
      Maruyama Y, Ogura T, Mio K, Kato K, Kaneko T, Kiyonaka S, Mori Y, Sato C.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 13676-13685

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.2009

    • Author(s)
      Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, Mori Y
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 5400-5405

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in temperature preferences and energy homeostasis in dystroglycan mutants.2009

    • Author(s)
      Takeuchi K, Nakano Y, Kato U, Kaneda M, Aizu M, Awano W, Yonemura S, Kiyonaka S, Mori Y, Yamamoto D, Umeda M.
    • Journal Title

      Science 323

      Pages: 1740-1743

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>-dependent induction of TRPM2 currents in hippocampal neurons.2009

    • Author(s)
      Olah ME, Jackson MF, Li H, Perez Y, Sun HS, Kiyonaka S, Mori Y, TymianskiM, Macdonald JF.
    • Journal Title

      J. Physiol. 587

      Pages: 965-979

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>-dependent induction of TRPM2 currents in hippocampal neurons.2009

    • Author(s)
      Olah ME, Jackson MF, LiH, Perez Y, Sun HS, Kiyonaka S, Mori Y, TymianskiM, Macdonald JF
    • Journal Title

      J.Physiol. 587

      Pages: 965-979

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in temperature preferences and energy homeostasis in dystroglycan mutants.2009

    • Author(s)
      Takeuc K, Nakan Y, Kato U, Kaneda M, Aizu M, Awano W, Yonemura S, Kiyonaka S, MoriY, Yamamoto D, Umeda M
    • Journal Title

      Science 323

      Pages: 1740-1743

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.2009

    • Author(s)
      Kiyonaka S, Kato K, (他19名), Mori Y
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106, 5400-5405 106

      Pages: 5400-5405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tetrameric Orail is a teardrop-shaped molecule with a long, tapered cytoplasmic domain.2009

    • Author(s)
      Maruyama Y, Ogura T, Mio K, Kato K, Kaneko T, Kiyonaka S, Mori Y, SatoC.
    • Journal Title

      J.Biol. Chem.284, 13676-13685 284

      Pages: 13676-13685

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2 functions as lysosomal Ca^<2+> release channel in β-cells.2009

    • Author(s)
      Lange I, Yamamoto Y, Partida-Sanchez S, Mori Y, Fleig A, Penner R
    • Journal Title

      Science Signaling 2

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] STIM protein coupling in the activation of Orai channels2009

    • Author(s)
      Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, Ritchie MF, Tang XD, Baba Y, Kurosaki T, Mori Y, Soboloff J, Gill DL
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106, 7391-7396 106

      Pages: 7391-7396

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via PLC/diacylglycerol and PLA_2/£s-hydroxylase/20-HETE pathways.2009

    • Author(s)
      Inoue R, Jensen LJ, JianZ, Shi J, Hai L, Lurie AI, Henriksen FH, Salmonsson M, Morita H, Kawarabayashi Y, Mori M, Mori Y, Ito Y.
    • Journal Title

      Circ Res.104, 1399-1409 104

      Pages: 1399-1409

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targetted disruption of the voltage-dependent Ca^<2+> channel α_2/δ-1 subunit.2009

    • Author(s)
      Fuller-Bicer GA, Varadi G Koch SE, Ishii M, Bodi I, Kadeer N, Muth JN, Mikala G, Petrashevskaya NN, Jordan MA, Zhang SP, Qin N, Flores CM, Isaacsohn I, Varadi M, Mori Y, Jones WK. Schwartz A
    • Journal Title

      Am. J.Physiol. Heart Circ. Physiol. 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia2009

    • Author(s)
      Sun H-S, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, MacDonald JF, Tvmianski M.
    • Journal Title

      Nature Neurosci. 12

      Pages: 1300-1307

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pathogenic C-terminus-truncated Polycistin-2 mutant enhances receptor-a ctivated Ca^<2+> entry via association with TRPC3 and TRPC7.2009

    • Author(s)
      Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.
    • Journal Title

      J.Biol. Chem.284, 34400-34412 284

      Pages: 34400-34412

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators.2008

    • Author(s)
      Takahashi N, Mizuno Y, Kozai D, Yamamoto S, Kiyonaka S, Shibata T, Uchida K, Mori Y.
    • Journal Title

      Channels 2

      Pages: 287-298

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2-mediated Ca^<2+> influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration2008

    • Author(s)
      Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y.
    • Journal Title

      Nature Med. 14

      Pages: 738-747

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2-mediated Ca^<2+> influx induces chemokine production in monocytes that aggravates inflammatory neutronhil infiltration2008

    • Author(s)
      Yamamto S, (他15名), Mori Y.
    • Journal Title

      Nature Med. 14

      Pages: 738-747

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>-dependent induction of TRPM2 currents in hippocampal neurons2008

    • Author(s)
      Olah ME, (他5名), MoriY, Tymianski M & MacDonald JF.
    • Journal Title

      J. Phys io

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pvrazole compound2008

    • Author(s)
      Kiyonaka S, (他19名), Mori Y.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The TRPM2 channel is a swelled, bell-shaped molecule with a protrusion on the cytoplasmic end.2007

    • Author(s)
      Maruyama Y, Ogura T, Mio K, Kiyonaka S, Kato K, Mori Y, Sato C
    • Journal Title

      J. Biol. Chem. 282

      Pages: 36961-36970

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM7 a possible extracellular divalent cati on sensor in hippocampal neurons.2007

    • Author(s)
      Wei W-L, Olah ME, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong Z-G, Jackson MF, Tymianski M, MacDonald JF
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 16323-16328

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca^<2+> channels.2007

    • Author(s)
      Miki T, Kiyonaka S, Uriu Y, De Waard M, Wakamori M, Beedle AM, Campbell KP, Mori Y
    • Journal Title

      Channels 1

      Pages: 144-147

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gα_<12/13>-mediated upregulation of TPPC6 negatively regulates endothelin-induced cardiac myofibroblast formation and collagen synthesis through NFAT activation.2007

    • Author(s)
      Nishida M, Onohara N, Sato Y, Suda R, Ogushi M, Tanabe S, Inoue R, Mori Y, Kurose H
    • Journal Title

      J. Biol. Chem. 282

      Pages: 23117-23128

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca^<2+> channels.2007

    • Author(s)
      Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, Beedle AM, Mori E, Hara Y, De Waard M, Kanagawa M, Itakura M, Takahashi M, Campbell KP, Mori Y
    • Journal Title

      Nature Neurosci. 10

      Pages: 691-701

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RIMI confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.2007

    • Author(s)
      Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, Beedle AM, Mori E, Hara Y, De Waard M, Kanagawa M, Itakura M, Takahashi M, Campbell KP & Mori Y
    • Journal Title

      Nature Neurosci. 10

      Pages: 691-701

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas.2007

    • Author(s)
      Mio K, Ogura T, Kiyonaka S, Hiroaki Y, Tanimura Y, Fujiyoshi Y, Mori Y & Sato C
    • Journal Title

      J. Mol. Biol. 367

      Pages: 373-383

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] G・12/13-mediated upregulation of TPPC6 negatively regulates endothelin-induced cardiac myofibroblast formation and collagen synthesis through NFAT activation.2007

    • Author(s)
      Nishida M, Onohara N, Sato Y, Suda R, Ogushi M, Tanabe S, Inoue R, Mori Y & Kurose H
    • Journal Title

      J. Biol. Chem. 282

      Pages: 23117-23128

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations.2007

    • Author(s)
      Wei W-L, Sun H-S, Olah ME, Sun XiuJun, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong Z-G, Jackson MF, Tymianski M & MacDonald JF
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 16323-16328

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels.2007

    • Author(s)
      Miki T, Kiyonaka S, Uriu Y, De Waard M, Wakamori M, Beedle AM, Campbell KP & Mori Y
    • Journal Title

      Channels 1

      Pages: 144-147

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy.2006

    • Author(s)
      Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T, Kurose H
    • Journal Title

      EMBO J. 25

      Pages: 5305-5316

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coupling of STIM1 to store-operated Ca^<2+> entry through its constitutive and inducible movement in the endoplasmic reticulum.2006

    • Author(s)
      Baba Y, Hayashi K, Fujii Y, Mizushima A, Watarai H, Wakamori M, Numaga T, Mori Y, Iino M, Hikida M, Kurosaki T
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 16704-16709

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide activates TRP channels by cysteine S-nitrosylation.2006

    • Author(s)
      Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, Mori Y
    • Journal Title

      Nature Chem. Biol. 2

      Pages: 596-607

    • NAID

      130007038569

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism.2006

    • Author(s)
      Vazquez G, Bird GSJ, Mori Y, Putney JW
    • Journal Title

      J. Biol. Chem. 281

      Pages: 25250-25258

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclosporin and Timothy syndrome increase mode 2 gating of Ca_V1.2 calcium channels through aberrant phosphorylation of S6 helices.2006

    • Author(s)
      Erxleben C, Liao Y, Gentile S, Chin D, Gomez-Alegria C, Mori Y, Birnbaumer L, Armstrong DL.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 103

      Pages: 3932-3937

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.2006

    • Author(s)
      Togashi K, Hara Y, Higashi T, Konishi Y, Tominaga T, Mori Y, Tominaga M
    • Journal Title

      EMBO J. 25

      Pages: 1804-1815

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional AMPA receptor-calcium channel complex in the postsynaptic membrane.2006

    • Author(s)
      Kang, MG, Chen CC, Wakamori M, Hara Y, Mori Y, Campbell KP
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 5561-5566

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>/calmodulin dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK cells.2006

    • Author(s)
      Shimizu S, Yoshida T, Wakamori M, Ishii M, Okada T, Takahashi M, Seto M, Sakurada K, Kiuchi Y, Mori Y
    • Journal Title

      J. Physiol. 570

      Pages: 219-235

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca2+/calmodulin dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK cells.2006

    • Author(s)
      Shimizu S, Yoshida T, Wakamori M.K, Kiuchi Y, Mori Y
    • Journal Title

      J.Physiol. 570

      Pages: 219-235

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A functional AMPA receptor-calcium channel complex in the postsynaptic membrane.2006

    • Author(s)
      Kang, MG, Chen CC, Wakamori M, Hara Y, Mori Y, Campbell KP
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103

      Pages: 5561-5566

    • Related Report
      2006 Annual Research Report
  • [Journal Article] TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.2006

    • Author(s)
      Togashi K, Hara Y, Mori Y, Tominaga M
    • Journal Title

      EMBO J. 25

      Pages: 1804-1815

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nitric oxide activates TRP channels by cysteine Snitrosylation.2006

    • Author(s)
      Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Mori Y
    • Journal Title

      Nature Chem.Biol. (Article) 2

      Pages: 596-607

    • NAID

      130007038569

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.2006

    • Author(s)
      Baba Y, Hayashi K, Wakamori M, Numaga T, Mori Y, Kurosaki T
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103

      Pages: 16704-16709

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ca^<2+>/calmodulin dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK cells.2006

    • Author(s)
      Shimizu S, Yoshida T, Wakamori M, Ishii M, Okada T, Takahashi M, Seto M, Sakurada K, Kiuchi Y, Mori Y
    • Journal Title

      J.Physiol. 570

      Pages: 219-235

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of canonical transient receptor potential 7 (TRPC7) in B-cell receptor-activated channels.2005

    • Author(s)
      Lievremont J-P, Numaga T, Vazquez G, Lemonnier L, Hara Y, Mori E, Trebak M, Moss SE, Bird GS, Mori Y, Putney Jr JW
    • Journal Title

      J. Biol. Chem. 280

      Pages: 35346-35351

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] FPL-64176 modification of Ca_V1.2 L-type calcium channels : dissociation of effects on ionic current and gating current.2005

    • Author(s)
      McDonough SI, Mori Y, Bean BP
    • Journal Title

      Biophys.J. 81

      Pages: 211-223

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes2005

    • Author(s)
      Okamura Y, Murata Y, Nakajo K, Iwasaki I, Ohtsuka Y, Tanaka-Kunishima M, Takahashi N, Hara Y, Yoshida T, Nishida M, Okado H, Watari H, Meinertzhagen IA, Nishino A, Satoh N, Takahashi K, Satou Y, Okada Y, Mori Y
    • Journal Title

      Physiological Genomics 222

      Pages: 269-282

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The non-selective cation permeating channel TRPC3 is a tetrahedron with a cap in the large cytoplasmic end2005

    • Author(s)
      Mio K, Ogura T, Hara Y, Mori Y, Sato C
    • Journal Title

      Biochem.Biophys.Res.Comm. 333

      Pages: 768-777

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of canonical transient receptor potential 7(TRPC7) in B-cell receptor-activated channels.2005

    • Author(s)
      Lievremont J-P, Numaga T, Vazquez G, Lemonnier L, Hara Y, Mori E, Trebak M, Trebak M, Moss SE, Bird GS, Mori Y, Putney Jr JW
    • Journal Title

      J.Biol.Chem. 280

      Pages: 35346-35351

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differential redox regulation of ORAI channels : a mechanism to tune cellular calcium responses.

    • Author(s)
      Bogeski I, Kummerow C, Al-Ansary D, Koehler R, Schwarz EC, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem B, Mori Y, Hoth M, Niemeyer BA
    • Journal Title

      Science Signaling (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+> influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells.

    • Author(s)
      Numaga T, Nishida M, Kiyonaka S, Kato K, Katano K, Mori E, Kurosaki T, Inoue R, Hikida T, Putney Jr JW, Mori Y
    • Journal Title

      J. Cell Sci. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

    • Author(s)
      Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Campbell KP, Mori Y
    • Journal Title

      Nature Neurosci.(Article) (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phoneutria nigriventer ωPhonetoxin IIA : A new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome.

    • Author(s)
      Martin-Moutot N, Haro LD, Santos RG, Mori Y, Seagar M
    • Journal Title

      Neurobiol.Dis. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Intracellular-produced hydroxyl radical mediates H_2O_2-induced TRPM2 channel activation and cell death in rat β-cell line RIN-5F.

    • Author(s)
      Ishii M, shimizu S, Hara Y, Hagiwara T, Miyazaki A, Mori Y, Kiuchi Y
    • Journal Title

      Cell Calcium (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A functional AMPA receptor-calcium channel complex in the postsynaptic membrane.

    • Author(s)
      Kang, MG, Chen CC, Wakamori M, Hara Y, Mori Y, Campbell KP
    • Journal Title

      Proc.Natl.Acad.Sci.USA (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A critical role of TRPM2 in neuronal cell death by hydrogen peroxide

    • Author(s)
      Kaneko S, Kawakami S, Hara Y Itoh E, Minami T, Takada Y, Kume T, Katsuki H, Mori Y, Akaike A
    • Journal Title

      J Pharmacol.Sci. (in press)

    • NAID

      10018237407

    • Related Report
      2005 Annual Research Report
  • [Remarks]

    • URL

      http://www.sbchem.kyoto-u.ac.jp/mori-lab/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi