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Inorganic phosphate transportsome and human disease

Research Project

Project/Area Number 17081013
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokushima

Principal Investigator

MIYAMOTO Kenichi  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (70174208)

Co-Investigator(Kenkyū-buntansha) TAKETANI Yutaka  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)
TATSUMI Sawako  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80420545)
SEGAWA Hiroko  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (70325257)
ITOH Mikiko  兵庫県立大学, 環境人間学部, 准教授 (50314852)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥60,600,000 (Direct Cost: ¥60,600,000)
Fiscal Year 2009: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2007: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2006: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2005: ¥6,900,000 (Direct Cost: ¥6,900,000)
Keywords無機リン酸 / 腎臓 / ナトリウム依存性 / 輸送体 / リン利尿因子Inorganic phosphate / Kidney / Sodium-dependent / transporter / phosphaturic factor / 膜輸送 / 分子認識 / 賢臓 / リン酸 / fibroblast growth factor 23 / マイクロドメイン / リン / 腎尿細管 / トランスポーター / エンドサイトーシス / 脂質マイクロドメイン / PTH / Ezrin
Research Abstract

The maintenance of constant circulating levels of Pi depends on the activity of the kidney. Two types of Na/Pi co-transporters (Npt2a, Npt2c) have been identified in the kidney. The abundance of Npt2a and Npt2c in the apical membrane of the renal epithelial cells is a major determinant for Pi homeostasis. Npt2a knockout (KO) mice exhibit increased urinary Pi excretion, a 50% to 70% decrease in renal BBM vesicle Na/Pi cotransport, and hypophosphatemia. Npt2a KO mice also overexpress Npt2c, which may support residual renal Pi reabsorption function. Laboratory and bone abnormalities are more profound in Npt2a^<-/->Npt2c^<-/->double knockout (DKO) mice than in animals with ablation of only one transporter (Npt2a or Npt2c), indicating that both molecules have similar non-redundant roles in Pi homeostasis in rodents and humans. In addition, we found that the mutations of human Npt2c cause hereditary hypophosphatemie rickets with hypercalciuria (ITHRH)
After correct targeting and insertion into the plasma membrane of epithelial cells, specific protein-protein interactions may be required to stabilize the final localization of membrane proteins. Classical yeast two-hybrid screens performed against the C-terminus of NaPi-ll (Npt2a and Npt2c) revealed interactions of this cotransporter with several PDZ domain containing proteins that may contribute to the stabilization of NaPi-ll at the apical membrane. NaPi-He (Npt2c) was shown to interact with NHERF1 and NHERF4. The consequences of these interactions for apical positioning and regulation of NaPi-llc remain to be clarified. In this study, we discovered new aspect of the regulation of the Pi transportsome in the kidney.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (175 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (94 results) (of which Peer Reviewed: 50 results) Presentation (61 results) Book (20 results)

  • [Journal Article] An apical expression signal of the renal type II Na+-dependent phosphate cotransporter in renal prithelial cells.2010

    • Author(s)
      Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, Sugino S, Uehata Y, Kamahara A, Sakata Tatsumi S, Kuwahata M, Taketani Y, Segawa H, Miyamoto K.
    • Journal Title

      Am J Physiol Renal Physiol.

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.2010

    • Author(s)
      Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami H, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto K.
    • Journal Title

      Am J Physicl Renal Physiol. 298(6)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent.2010

    • Author(s)
      Ishiguro M, Yamamoto H, Masuda M, Kozai NI, Takei Y, Tanaka S, Sato T, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E.
    • Journal Title

      Biochem J. 427(1)

      Pages: 161-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 摂取過剰で老化が進む?解明進むリン代謝系2010

    • Author(s)
      宮本賢一
    • Journal Title

      日経メディカル 8

      Pages: 34-35

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 骨と腸管の臓器相関2010

    • Author(s)
      宮本賢一
    • Journal Title

      腎と骨代謝 23(2)

      Pages: 85-90

    • Related Report
      2009 Annual Research Report
  • [Journal Article] リン代謝と腸管2010

    • Author(s)
      辰巳佐和子
    • Journal Title

      腎と骨代謝 23(2)

      Pages: 99-104

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Not2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.2009

    • Author(s)
      Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K.
    • Journal Title

      Am J Physiol Renal Physiol. 297(3)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.2009

    • Author(s)
      Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander JW, Wilson P, Miyazaki-Anzai S, Sutherl, E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M.
    • Journal Title

      Am J Physiol Renal Physiol. 297(2)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of Na/Pi-II transporters in phosphate metabolism.2009

    • Author(s)
      Segawa H, Aranami H, Kaneko I, Tomoe Y, Miyamoto K.
    • Journal Title

      Bone. Vol.45

      Pages: 52-57

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Type llc sodium- dependent phosphate transporter regulates calcium metabolism.2009

    • Author(s)
      Segawa H, Onitsuka A, Kuwahata M, Hanabusa E, Furutani J, Kaneko I, Tomoe Y, Aranami H, Matsumoto M, Li M, Amizuka N, Miyamoto K.
    • Journal Title

      J Am Nephrol 20(1)

      Pages: 104-113

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutant FGF23 Prevents the Progression Chronic Kidney Disease but Aggravates Renal Osteodystrophy in Uremic Rats2009

    • Author(s)
      Kusano K.
    • Journal Title

      J Nutr Sci Vitaminol. 55

      Pages: 99-105

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development2009

    • Author(s)
      Segawa H.
    • Journal Title

      Am J Physiol Renal Physiol. 297(3)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of Na/Pi II transporters in phosphate metabolism2009

    • Author(s)
      Segawa H.
    • Journal Title

      Bone. 45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progress in the identification of intestinal Pi transport inhibitors2009

    • Author(s)
      Miyamoto K.
    • Journal Title

      Clin Calcium. 19(2)

      Pages: 242-247

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of phosphate in chronic kidney disease-Regulation of posphate homeostasis2009

    • Author(s)
      Segawa H.
    • Journal Title

      Clin Calcium. 19(2)

      Pages: 159-165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リン低下薬の今後の行方2009

    • Author(s)
      宮本賢一
    • Journal Title

      Nephrology Frontier 12

      Pages: 33-38

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 腸管トランスポーターを分子標的とした腎疾患治療法の確立を目指して2009

    • Author(s)
      菊池浩子
    • Journal Title

      四国医誌 65

      Pages: 173-176

    • Related Report
      2009 Annual Research Report
  • [Journal Article] カルシウム/リン代謝調節機序の最近の進歩2009

    • Author(s)
      宮本賢一
    • Journal Title

      臨床透析 26(1)

      Pages: 9-16

    • Related Report
      2009 Annual Research Report
  • [Journal Article] リン低下薬の今後の行方2009

    • Author(s)
      宮本賢一
    • Journal Title

      Nephrology Frontier 8(4)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Type 11c Sodium-Dependent Phosphate Transporter Regulates Calcium Metabolism2009

    • Author(s)
      Segawa H.
    • Journal Title

      J Am Soc Nephrol 20(1)

      Pages: 104-113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute effect of elevation of serum phosphorus on endothelial function2009

    • Author(s)
      Shuto E.
    • Journal Title

      J Am Soc Nephrol 54(In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kkithoとカルシウム/リン代謝の最前線2009

    • Author(s)
      宮本賢一
    • Journal Title

      腎と骨代謝 22(2)

      Pages: 101-103

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Klothoとリン代謝2009

    • Author(s)
      瀬川博子
    • Journal Title

      腎と骨代謝 22(2)

      Pages: 145-152

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Role of Low Protein and Low Phosphorus Diet in the progression of Chronic Kidney Disease Uremic Rats2008

    • Author(s)
      Kusano K.
    • Journal Title

      J Nutr Sci Vitaminol 54

      Pages: 237-243

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polypyrimidine tract-binding protein is involved in regulation of albumin synthesis in response to food intake2008

    • Author(s)
      Kuwahata M.
    • Journal Title

      J Nutr Sci Vitaminol 54(2)

      Pages: 142-147

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stanniocalcin 2 is positively and negatively controlled by 1, 25(OH)(2) D(3) and PTH in renal proximal tubular cells2008

    • Author(s)
      Takei Y.
    • Journal Title

      J Mol Endoclinol 42

      Pages: 261-268

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨細胞とリン代謝2008

    • Author(s)
      辰巳佐和子
    • Journal Title

      腎と骨代謝 21(3)

      Pages: 211-217

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体におけるリン代謝とその異常2008

    • Author(s)
      宮本賢一
    • Journal Title

      化学と生物 46(7)

      Pages: 496-500

    • NAID

      10024334077

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ナトリウム依存性リン輸送体の構造と機能調節2008

    • Author(s)
      伊藤美紀子
    • Journal Title

      THE BONE 22(6)

      Pages: 713-717

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 生体内バランス調節機構2008

    • Author(s)
      瀬川博子
    • Journal Title

      CLINICAL CALCIUM 19(2)

      Pages: 159-165

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 新しいリン調節薬2008

    • Author(s)
      宮本賢一
    • Journal Title

      CLINICAL CALCIUM 19(2)

      Pages: 242-247

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リントランスポーター疾患2008

    • Author(s)
      宮本賢一
    • Journal Title

      遺伝子医学MOOK 12

      Pages: 243-260

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 栄養管理の重要性2008

    • Author(s)
      宮本賢一
    • Journal Title

      地域リハビリテーション 3(8)

      Pages: 698-704

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polypyrimidine tract-binding protein is involved in regulation of albumin synthesis in response to food intake.2008

    • Author(s)
      Kuwahata M.
    • Journal Title

      J Nutr Svi Vitaminol. 54(2) (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カルシウム・リン代謝の基本と最近の話題2008

    • Author(s)
      宮本賢一
    • Journal Title

      medicina 45(3)

      Pages: 413-416

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function.2007

    • Author(s)
      Yamamoto T, Michigami T, Aranami F, Segawa H, Yoh K, Nakajima S, Miyamoto K, Ozono K.
    • Journal Title

      J Bone Miner Metab. 25(6)

      Pages: 407-13

    • NAID

      10024125535

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter.2007

    • Author(s)
      Miyamoto K, Ito M, Tatsumi S, Kuwahata Segawa H.
    • Journal Title

      Am J Nephrol 27(5)

      Pages: 503-15

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cavelin-1 in extracellular matrix vesicles secreted from osteoblasts.2007

    • Author(s)
      Sawada N, Taketani Y, Amizuka N, Ichikawa M, Ogawa C, Nomoto K, Nashiki K, Sato T, Arai H, Isshiki M, Segawa H, Yamamoto H, Miyamoto K, Takeda E.
    • Journal Title

      Bone 41(1)

      Pages: 52-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter.2007

    • Author(s)
      Segawa H, Yamanaka S, Onitsuka A, Tomoe Y, Kuwahata M, Ito M, Taketani Y, Miyamoto K.
    • Journal Title

      Am J Physiol Renal Physiol. 292(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between hyperphosphatemia and type II Na/Pi cotransporter activity in klotho mice.2007

    • Author(s)
      Segawa H, Yamanaka S, Ohno Y, Onitsuka A, Shiozawa K, Aranami F, Furutani J, Tomoe Y, Ito M, Kuwahata M, Tatsumi S, Imura A, Nabeshima Y, Miyamoto K.
    • Journal Title

      Am J Physiol Renal Physiol. 292(2)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells.2007

    • Author(s)
      Ito M, Haito S, Furumoto M, Uehata Y, Sakurai A, Segawa H, Tatsumi S, Kuwahata Miyamoto K.
    • Journal Title

      Am J Physiol Cell Physiol 292(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.2007

    • Author(s)
      Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K.
    • Journal Title

      Cell Metab. 5(6)

      Pages: 464-75

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between hyperphosphatemia and type II Na/Pi cotransporter activity in klotho mice.2007

    • Author(s)
      Segawa H.
    • Journal Title

      Am J Physiol Renal Physiol. 292(2)

      Pages: 769-779

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure.2007

    • Author(s)
      Kuwahata M.
    • Journal Title

      Biochim Biophys Acta. 1772(1)

      Pages: 60-65

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotran sporter.2007

    • Author(s)
      Segawa H.
    • Journal Title

      Am J Physiol Renal Physiol. 292(1)

      Pages: 395-403

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells.2007

    • Author(s)
      Ito M.
    • Journal Title

      Am J Physiol Cell Physiol. 292(1)

      Pages: 526-534

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anxiolytix effect of music depends on ovarian steroid in female mice.2007

    • Author(s)
      Chikahisa S.
    • Journal Title

      Behav Brain Res. 179(1)

      Pages: 50-59

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice.2007

    • Author(s)
      Kitaoka K.
    • Journal Title

      Brain Res. May 30(1150)

      Pages: 121-130

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts.2007

    • Author(s)
      Sawada N.
    • Journal Title

      Bone. 41(1)

      Pages: 52-58

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of phosphate appetite in young rats.2007

    • Author(s)
      Ohnishi R.
    • Journal Title

      J Med Invest. 53(3-4)

      Pages: 366-369

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of poly pyrimidine-tract-binding protein is involved in the regulation of albumin synthesis by branched-chain amino acids in HepG2 cells.2007

    • Author(s)
      Kuwahata M.
    • Journal Title

      J Nutr Biochem. Aug 16

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporer.2007

    • Author(s)
      Miyamoto K.
    • Journal Title

      Am J Nephrol. 27(5)

      Pages: 503-515

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Life-long caloric restriction reveals biphasic and dimorphic effects on bone metabolism in rodents.2007

    • Author(s)
      Tatsumi S.
    • Journal Title

      Endocrinology. Nov 8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted ablation of osteocytes induces osteoporosis with defective mecha notransduction.2007

    • Author(s)
      Tatsumi S.
    • Journal Title

      Cell Metab. 5(6)

      Pages: 464-475

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca/Mg輸送調節の新展開ー基礎と臨床2007

    • Author(s)
      宮本賢一
    • Journal Title

      腎と骨代謝 20(1)

      Pages: 7-11

    • Related Report
      2007 Annual Research Report
  • [Journal Article] リン輸送異常とKlotho/FGF232007

    • Author(s)
      瀬川 博子
    • Journal Title

      腎と骨代謝 20(1)

      Pages: 39-44

    • Related Report
      2007 Annual Research Report
  • [Journal Article] α Klothoとりン代謝2007

    • Author(s)
      宮本賢一
    • Journal Title

      CLINICAL CALCIUM 17(5)

      Pages: 54-59

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 腎臓とミネラル代謝ホルモン2007

    • Author(s)
      宮本賢一
    • Journal Title

      日本腎臓学会誌 49(4)

      Pages: 406-411

    • NAID

      10019731902

    • Related Report
      2007 Annual Research Report
  • [Journal Article] リン酸の新しい代謝調節作用2007

    • Author(s)
      宮本賢一
    • Journal Title

      CLINICAL CALCIUM 17(10)

      Pages: 13-20

    • Related Report
      2007 Annual Research Report
  • [Journal Article] リン摂取量と食品に含まれるリン2007

    • Author(s)
      桑波田雅士
    • Journal Title

      腎と骨代謝 20(4)

      Pages: 305-312

    • Related Report
      2007 Annual Research Report
  • [Journal Article] リン代謝とその異常2007

    • Author(s)
      宮本賢一
    • Journal Title

      日本医事新報 4364

      Pages: 67-71

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Pの役割とその異常2007

    • Author(s)
      宮本賢一
    • Journal Title

      腎と透析 63

      Pages: 96-100

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 栄養不良の定義2007

    • Author(s)
      伊藤美紀子
    • Journal Title

      臨牀透析 24(4)

      Pages: 127-133

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Molecular mechanism in biological transport in the kidney : Sodium-dependent glucose, phosphate, amino acid transporters.2007

    • Author(s)
      Miyamoto K.
    • Journal Title

      Nippon Rinsho 64(2)

      Pages: 145-149

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells.2007

    • Author(s)
      Ito M.
    • Journal Title

      Am J Physiol Cell Physiol 292(1)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phosphate restriction in diet therapy.2007

    • Author(s)
      Takeda E.
    • Journal Title

      Contrib Nephrol. 155

      Pages: 113-124

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure.2007

    • Author(s)
      Kuwahata M.
    • Journal Title

      Biochim Biophys 1772(1)

      Pages: 60-65

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter.2007

    • Author(s)
      Segawa H.
    • Journal Title

      Am J Physiol Renal Physiol. 292(1)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Anxiolytic effect of music depends on ovarian steroid in female mice.2007

    • Author(s)
      Chikahisa S.
    • Journal Title

      Behav Brain Res. 179

      Pages: 50-59

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts.2007

    • Author(s)
      Sawada N.
    • Journal Title

      Bone (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of prolonged high phosphorus diet on phosphorus and calcium balance in rats.2007

    • Author(s)
      Tani Y.
    • Journal Title

      J Clin Biochem Nutr. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hereditary hypophosphatemic rickets with hypercalciuria : A study for the phosphate transporter gene type II c and osteoblastic function.2007

    • Author(s)
      Yamamoto T.
    • Journal Title

      Bone (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice.2007

    • Author(s)
      Kitaoka K.
    • Journal Title

      Brain Res. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Correlation between hyperphosphatemia and type II Na/Pi cotransporter activity in klotho mice.2006

    • Author(s)
      Segawa H.
    • Journal Title

      Am J Physiol Renal Physiol.

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men.2006

    • Author(s)
      Nishida Y.
    • Journal Title

      Kidney Int. 70(12)

      Pages: 2141-2147

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel function of phosphate-mediated intracellular signal transduction pathways.2006

    • Author(s)
      Takeda E.
    • Journal Title

      Adv Enzyme Regul. 46

      Pages: 154-161

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Immobilization decreases duodenal calcium absorption through a 1,25-dihydroxyvitamin D-dependent pathway.2006

    • Author(s)
      Sato T.
    • Journal Title

      J Bone Miner Metab. 24(4)

      Pages: 291-299

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibitory effect of JTP-59557, a new triazole derivative, on intestinal phosphate transport in vitro and in vivo.2005

    • Author(s)
      Matsuo A, Negoro T, Seo T, Kitao Y, Shindo M, Segawa H, Miyamoto K.
    • Journal Title

      Eur J Pharmacol 517(1-2)

      Pages: 111-119

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the vitamin D receptor in FGF23 action on phosphate metabolism.2005

    • Author(s)
      Inoue Y, Segawa H, Kaneko I, Yamanaka S, Kusano K, Kawakami E, Furutani J, Ito M, Kuwahata M, Saito H, Fukushima N, Kato S, Kanayama HO, Miyamoto K.
    • Journal Title

      Biochem J. 390

      Pages: 325-31

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin D and phosphate regulate fibroblast groeth factor-23 in K-562 cells.2005

    • Author(s)
      Ito M, Sakai Y, Furumoto M, Segawa H, Haiso S, Yamanaka S, Nakamura R, Kuwahata Miyamoto K.
    • Journal Title

      Am J Physiol Endocrinol Metab 288(6)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of inorganic phosphate transport in osteoclast like cells.2005

    • Author(s)
      Ito M, Matsuka N, Izuka M, Haito S, Sakai Y, Nakamura R, Segawall, Kuwahata M, Yamamoto H, Wesley J. Pike, Miyamoto K.
    • Journal Title

      Am J Physiol. 288(4)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Internalization of renal type IIc Na-Pi cotransporter in response to a high-phosphate diet.2005

    • Author(s)
      Segawa H, Yamanaka S, Ito M, Kuwahata M, Shono ht Yamamoto T, Miyamoto K.
    • Journal Title

      Am J Physiol Renal Physiol. 288(3)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating FGF-23 is regulated by lalpha, 25-dihydroxyvitamiq D3 and phosphorus in vivo.2005

    • Author(s)
      Saito H, Maeda A, Ohtomo S, Hirata M, Kusano K, Kato S, Ogata E, Segawa H, Miyamoto K, Fukushima N.
    • Journal Title

      J Biol Chem. 280(4)

      Pages: 2543-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells.2005

    • Author(s)
      Nashiki K, Taketani Y, Takeichi T, Sawada N, Yamamoto H, Ichikawa M, Arai H, Miyamoto K, Takeda E.
    • Journal Title

      Kidney Int. 68(3)

      Pages: 1137-47

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibion of intestinal sodium-dependent inorganic phosphate transport by fibroblast growth factor 23.2005

    • Author(s)
      Miyamoto K.
    • Journal Title

      Therapeutic Apheresis and Dialysis 9(4)

      Pages: 331-335

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibitory effect of JTP-59557, a new triazole derivative, on mtestinal phosphate transport in vitro and in vivo.2005

    • Author(s)
      Matsuo A.
    • Journal Title

      Eur J Pharmacol, 517

      Pages: 111-119

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Internalization of renal type IIc Na/Pi cotransporter in response to a high phosphate diet.2005

    • Author(s)
      Segawa H
    • Journal Title

      Am J Physiol.Renal Physiol. 288

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo.2005

    • Author(s)
      Saito H
    • Journal Title

      J Biol Chem. 280(4)

      Pages: 2543-2549

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of inorganic phosphate transport in osteoclast like cells.2005

    • Author(s)
      Ito M
    • Journal Title

      Am J Physiol. 288

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vitamin D and phosphate regulate fibroblast groeth factor-23 in K-562 cells.2005

    • Author(s)
      Ito M
    • Journal Title

      Am J Physiol Endocrinol Metab. 288

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of the vitamin D receptor in FGF23 action on phosphate metabolism.2005

    • Author(s)
      Miyamoto K.
    • Journal Title

      Biochem J. 390

      Pages: 325-331

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene.2005

    • Author(s)
      Yamamoto H.
    • Journal Title

      Kidney Int. 68(3)

      Pages: 1137-1147

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells.2005

    • Author(s)
      Nashiki K.
    • Journal Title

      Biochim Biophys Acta. 1732

      Pages: 43-52

    • Related Report
      2005 Annual Research Report
  • [Journal Article] fect of calcitonin on the transport of Ca,Mg and PO4 across the small intestine.2005

    • Author(s)
      Miyamoto K.
    • Journal Title

      Nippon Rinsho. 63(10)

      Pages: 202-206

    • Related Report
      2005 Annual Research Report
  • [Presentation] 慢性腎臓病時におけるリン管理の重要性Management of hyperp hosbhatemia in patients with chronic kidney disease2010

    • Author(s)
      宮本賢一
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 寿命調節因子Klothoによるリン代謝調節調節2010

    • Author(s)
      大井彰子
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腸管トランスポーターを分子標的とした腎疾患治療法の確立をめざして2010

    • Author(s)
      山本浩範
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] シナカルセト塩酸塩によるリン管理,第13回日本病態栄養学会年次学術集会2010

    • Author(s)
      菊井聡子
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病性骨症の発症機序の解析;ユビキチン化分解経路に及ぼすメイラード反応後期生成物(AGEs)の影響2010

    • Author(s)
      木戸慎介
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 敗血症のミネラル代謝の解析~リポ多糖のリン代謝に及ぼす影響について~2010

    • Author(s)
      池田翔子
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] リン酸代謝研究の新しい展開2009

    • Author(s)
      宮本賢一
    • Organizer
      第15回日本腹膜透析研究会総会・学術集会
    • Place of Presentation
      静岡市
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vitamin D receptor(VDR)欠損が引き起こすリン代謝異常の解明2009

    • Author(s)
      金子一郎
    • Organizer
      第9回徳島Bone Forum
    • Place of Presentation
      徳島市
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] CLCA6 (Chloride channel calcium activated 6)のリン代謝への関与2009

    • Author(s)
      斎藤友紀子
    • Organizer
      第42回日本栄養・食糧学会中国四国支部大会
    • Place of Presentation
      鳥取市
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病性骨症の発症機序の解析:ユビキチン化分解経路に及ぼすメイラード反応後期生成物(AGEs)の影響2009

    • Author(s)
      中川航司
    • Organizer
      第42回日本栄養・食糧学会中国四国支部大会
    • Place of Presentation
      鳥取市
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inorganic Phosphate Homeostasis in the Type 1 Na/Pi-transporter (NPT1) Null Mice2009

    • Author(s)
      Segawa H.
    • Organizer
      American Society of Nephrology(ASN)
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] klotho Modulates the Activity of Type llc Na+-Dependent Phosphate Cotransporter(NaPi-llc)in Renal Epithelial Cells2009

    • Author(s)
      Nishiyama T.
    • Organizer
      American Society of Nephrology(ASN)
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of Phosphate Metabolism in the NaPi-llb Hetero Knockout Mice. The American Society of Nephrology2009

    • Author(s)
      Hanabusa E.
    • Organizer
      American Society of Nephrology(ASN)
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Deficiency of Vitamin D Receptor Prevents the Development of Renal Pi Reabsorption2009

    • Author(s)
      Kaneko I.
    • Organizer
      American Society of Nephrology(ASN)
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小腸ペプチドトランスポーター(PRPT1)発現調節は、タンパク質中のリンに依存する2009

    • Author(s)
      古谷順也
    • Organizer
      第3回日本アミノ酸学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2009-09-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] リン代謝調節解明の進歩2009

    • Author(s)
      宮本賢一
    • Organizer
      第54回(社)日本透析医学会学術集会・総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] FGF23/klothoとカルシウム・リンバランス調節機構2009

    • Author(s)
      瀬川博子
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] リン代謝研究の新しい展開2009

    • Author(s)
      宮本賢一
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト腎モデル動物を用いたPTH-リン調節機構の解明2009

    • Author(s)
      富永理恵子
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝臓切除後の低リン血症を誘導するリン利尿因子の探索2009

    • Author(s)
      辰巳佐和子
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 無機リン酸代謝異常症の解明;糖鎖によるNpt2c cotransporterの機能調節2009

    • Author(s)
      大井彰子
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2つのリン酸輸送体分子による生体内リン代謝調節機構の解明2009

    • Author(s)
      伊藤美紀子
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 老化関連因子klothoによるリン代謝調節機構の解明2009

    • Author(s)
      西山俊
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝臓切除による低リン血症発症メカニズムの解明2009

    • Author(s)
      野村憲吾
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢に伴う骨形成低下のメカニズム:酸化ストレスの関与2009

    • Author(s)
      木戸慎介
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 長寿命食であるカロリー制限食は骨粗鬆症を軽減出来るのか2009

    • Author(s)
      辰巳佐和子
    • Organizer
      日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2009-01-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝臓切除における低リン血症発症メカニズムの解明2008

    • Author(s)
      八杉昌憲
    • Organizer
      第41回日本栄養・食糧学会中国四国支部大会
    • Place of Presentation
      香川
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナトリウム依存性リン酸トランスポーターtype I(Npt1)のリン代謝機構への関与の検討2008

    • Author(s)
      澤居由紀子
    • Organizer
      第41回日本栄養・食糧学会中国四国支部大会
    • Place of Presentation
      香川
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Fibroblast Growth Factor (FGF) 23 on Npt2a, Npt2c Double-Knockout (WKO) Mice2008

    • Author(s)
      Tomoe Y.
    • Organizer
      The American Society Nephrology (ASN)
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mutation of Type IIc Na^<+-> Dependent Phosphate Cotransporte (NaPi-IIc)and Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH)2008

    • Author(s)
      Ito M.
    • Organizer
      The American Society Nephrology (ASN)
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1.25 (OH)2 Vitamin D3 Modulates The Expression of the Human Type IIc Sodium-Dependent Phophate Cotransporter (NaPi-IIc)Gene in Renal Osteoblast Cells2008

    • Author(s)
      Tatsumi S.
    • Organizer
      The American Society Nephrology (ASN)
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝子性低リン血症性くる病(HHRH)原因遺伝子IIc型Na依存性リン酸トランスポーター(NaPi IIc)の解析2008

    • Author(s)
      寒川奈津美
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Synergistic Role Npt2a and Npt2c in Inorganic Phoshate Metabolism of Mice2008

    • Author(s)
      Segawa H.
    • Organizer
      The American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Montreal (Canada)
    • Year and Date
      2008-09-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高Ca尿を伴う遺伝子低リン血症性くる病発症機構の解明2008

    • Author(s)
      瀬川博子
    • Organizer
      第51回日本腎臓学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腎臓と骨を結ぶリン代謝系の探索 : NaPi-IIcの遺伝子制御機構の解明2008

    • Author(s)
      福島有佳子
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] コレステロール・胆汁酸代謝に及ぼす食餌性リンの影響2008

    • Author(s)
      田中更沙
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] タンパク質低栄養状態で誘発される脂肪肝へのHNF-4αの関与2008

    • Author(s)
      桑波田雅志
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝性低リン血症性くる病原因遺伝子ヒトNaPi IIc変異体の解析2008

    • Author(s)
      寒川奈津美
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 無機リン酸代謝異常症の解明 : リントランスポートソームの構成タンパク質膜移行シグナル2008

    • Author(s)
      大井彰子
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 分子複合体を介したリン酸トランスポーターの活性調節機構2008

    • Author(s)
      竹谷豊
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長寿命のカロリー制限食は、骨に良いのか悪いのか2008

    • Author(s)
      辰巳佐和子
    • Organizer
      第62回日本栄養・食糧学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] リン再吸収障害とクル病/骨軟化症の病態生理 : カドミウム代謝との関係2008

    • Author(s)
      宮本賢一
    • Organizer
      第78回日本衛生学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体内リン代謝調節機構の解明〜リン酸トランスポーターの調節機構を中心として〜2008

    • Author(s)
      上畑陽子
    • Organizer
      第11回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 慢性腎不全における腸管ペプチド吸収機構と甲状腺ホルモンの関与2008

    • Author(s)
      古谷順也
    • Organizer
      第11回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 栄養素による代謝調節機構:ミネラル代謝の基礎と臨床2008

    • Author(s)
      宮本賢一
    • Organizer
      弗11回日本病態栄養学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] 慢性腎不全時における 腸管ペプチド及び、アミノ酸輸送機構の解析2007

    • Author(s)
      古谷順也
    • Organizer
      第1回日本アミノ酸学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 遺伝性低リン血症性くる病(HHRH)原因遺伝子の生理機能解明2007

    • Author(s)
      上畑陽子
    • Organizer
      第40回日本栄養・食糧学会中四国支部大会
    • Place of Presentation
      広島
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腎臓と骨を結ぶリン代謝系の探索:NaPi-IIC遺伝子プロモーターの検討2007

    • Author(s)
      島村仁子
    • Organizer
      第40回日本栄養・食糧学会中四国支部大会
    • Place of Presentation
      広島
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of EZrin in the Regulation of Membrane Localization of Type IIa Sodium-Dependent Phosphate Transporter (NaPi-IIa)2007

    • Author(s)
      Taketani Y.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Localization of Sodium-Phosphate Cotransporters NaPi-IIa and -IIc in Human Renal Proximal and Distal Tubules.2007

    • Author(s)
      Ohkido I.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Molecular Mechanisms for the Alteration of PepT1 Expression in 3/4 Nephrectomized Rats.2007

    • Author(s)
      Furutani J.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Npt2a and Npt2c in Mice Play Distince and Synergistic Roles in Inorganic Phosphate Metabolism and Skeletal Development.2007

    • Author(s)
      Segawa H.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 食品に含まれる抗うつ成分評価系の開発2007

    • Author(s)
      宮本賢一
    • Organizer
      第54回日本栄養改善学会
    • Place of Presentation
      長崎
    • Year and Date
      2007-09-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of the type IIc sodium-dependent phosphate transporter (Npt2c) which is involved in hereditary hypophosphatemic rickets with hypercalciuria (HHRH)2007

    • Author(s)
      Segawa H.
    • Organizer
      The American Society for Bone and Mineral Research.
    • Place of Presentation
      San Honolulu, USA
    • Year and Date
      2007-09-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of Npt2c in renal Pi reabsorption in Npt2a KO mice.2007

    • Author(s)
      Tomoe Y.
    • Organizer
      The American Society for Bone and Mineral REsearch.
    • Place of Presentation
      San Honolulu, USA
    • Year and Date
      2007-09-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新しいリン代謝調節因子の理解に向けて2007

    • Author(s)
      瀬川博子
    • Organizer
      第52回日本透析医学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] リン代謝調節機構におけるNpt2aとNpt2cの役割2007

    • Author(s)
      瀬川博子
    • Organizer
      第50回日本腎臓学会
    • Place of Presentation
      静岡
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 無機リン酸代謝異常症の解析;リントランスポートソームの構成蛋白の膜移行シグナル2007

    • Author(s)
      櫻井文
    • Organizer
      第61回日本栄養・食糧学会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 遺伝性低リン血症性くる病に関与するリントランスポーターNpt2cスプライシングバリアントの同定と機能解析2007

    • Author(s)
      本田尚子
    • Organizer
      第61回日本栄養・食糧学会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Thyroid Hormones Regulate the Phosphate Homeostasis through the Tran scriptional Control of teh Renal Type IIa Sodium-Dependent Phosphate Cotransporter (NaPi-IIa) Gene.2007

    • Author(s)
      Yamamoto H.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト肝癌細胞におけるmTOR依存症アルブミン合成調節機構2007

    • Author(s)
      桑波田雅士
    • Organizer
      第61回日本栄養・食糧学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Book] CKD-MBDハンドブック2009

    • Author(s)
      木戸慎介
    • Total Pages
      220
    • Publisher
      日本メディカルセンター
    • Related Report
      2009 Annual Research Report
  • [Book] 最新トランスポーター研究〜リントランスポーターと疾患〜2008

    • Author(s)
      宮本賢一
    • Total Pages
      365
    • Publisher
      メディカルドウ社
    • Related Report
      2008 Annual Research Report
  • [Book] トランスポーター化学最前線2008

    • Author(s)
      宮本賢一
    • Total Pages
      374
    • Publisher
      廣川書店
    • Related Report
      2008 Annual Research Report
  • [Book] AnnualReview腎臓20082008

    • Author(s)
      宮本賢一
    • Publisher
      FGF23/klothoシグナルによるリン代謝調節
    • Related Report
      2007 Annual Research Report
  • [Book] からだの科学2008

    • Author(s)
      伊藤美紀子
    • Publisher
      分子栄養学的アプローチによるテーラーメイド予防
    • Related Report
      2007 Annual Research Report
  • [Book] 日本医師会雑誌特別号2007

    • Author(s)
      宮本賢一
    • Publisher
      Caの異常[成人]
    • Related Report
      2007 Annual Research Report
  • [Book] 日本医師会雑誌特別号2007

    • Author(s)
      宮本賢一
    • Publisher
      Pの異常[成人]
    • Related Report
      2007 Annual Research Report
  • [Book] Ca/P/Mg輸送調節の新展開-基礎と臨床2007

    • Author(s)
      宮本賢一
    • Total Pages
      5
    • Publisher
      腎と骨代謝
    • Related Report
      2006 Annual Research Report
  • [Book] リン輸送異常とKlotho/FGF232007

    • Author(s)
      瀬川博子
    • Total Pages
      6
    • Publisher
      腎と骨代謝
    • Related Report
      2006 Annual Research Report
  • [Book] 無機リン酸の生体内代謝2007

    • Author(s)
      宮本賢一
    • Total Pages
      10
    • Publisher
      生化学
    • Related Report
      2006 Annual Research Report
  • [Book] FGF232006

    • Author(s)
      宮本賢一
    • Total Pages
      2
    • Publisher
      医学のあゆみ
    • Related Report
      2006 Annual Research Report
  • [Book] 生体内におけるリンの役割 -光と影-2006

    • Author(s)
      瀬川博子
    • Total Pages
      6
    • Publisher
      腎と透析
    • Related Report
      2006 Annual Research Report
  • [Book] ナトリウム依存症リントランスポータ-の調節機構2006

    • Author(s)
      宮本賢一
    • Total Pages
      5
    • Publisher
      Annual Review 腎臓
    • Related Report
      2006 Annual Research Report
  • [Book] 栄養素の構造と機能・遺伝子発現と栄養2006

    • Author(s)
      宮本賢一
    • Total Pages
      26
    • Publisher
      新ガイドライン準拠 エキスパート 管理栄養士養成シリーズ 基礎栄養学[第2版]
    • Related Report
      2006 Annual Research Report
  • [Book] リン代謝と疾患~遺伝性低リン血症くる病の病因解析2006

    • Author(s)
      宮本賢一
    • Total Pages
      5
    • Publisher
      医学のあゆみ
    • Related Report
      2006 Annual Research Report
  • [Book] Neutral endopeptidase family of protein2006

    • Author(s)
      宮本賢一
    • Total Pages
      3
    • Publisher
      腎と透析
    • Related Report
      2006 Annual Research Report
  • [Book] リン酸トランスポーターをめぐる最近の話題2006

    • Author(s)
      瀬川博子
    • Total Pages
      6
    • Publisher
      腎と透析
    • Related Report
      2006 Annual Research Report
  • [Book] リン制限は糖代謝を制御して寿命を延長させる2006

    • Author(s)
      伊藤美紀子
    • Total Pages
      8
    • Publisher
      食品工業
    • Related Report
      2006 Annual Research Report
  • [Book] リンとビタミンDの相互作用2006

    • Author(s)
      宮本賢一
    • Total Pages
      6
    • Publisher
      整形・災害外科
    • Related Report
      2006 Annual Research Report
  • [Book] 栄養素の代謝と生理機能2006

    • Author(s)
      宮本賢一
    • Total Pages
      6
    • Publisher
      病態栄養専門師のための病態栄養ガイドブック
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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