• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Interactions of transportsome and cytoskeleton

Research Project

Project/Area Number 17081014
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKumamoto University

Principal Investigator

NAKANISHI Hiroyuki  Kumamoto University, 大学院・生命科学研究部, 教授 (80314318)

Co-Investigator(Kenkyū-buntansha) 上江洲 章吉  熊本大学, 大学院・医学薬学研究部, 助教 (70363520)
Co-Investigator(Renkei-kenkyūsha) UEZU Akiyoshi  熊本大学, 大学院・生命科学研究部, 助教 (70363520)
FUJITA Naoyuki  熊本大学, 大学院・生命科学研究部, 准教授 (50403192)
UMEDA Kazuaki  熊本大学, 大学院・生命科学研究部, 助教 (80444876)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥60,500,000 (Direct Cost: ¥60,500,000)
Fiscal Year 2009: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2008: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2007: ¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2006: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2005: ¥6,400,000 (Direct Cost: ¥6,400,000)
Keywords微小管 / 細胞膜 / クラスリン / エンドサイトーシス / 上皮性ナトリウムチャンネル / 中心体 / リポソーム / ユビキチン / ユビキチン化酵素E3 / リン脂質 / インテグリン / ユビキンチン化酵素E3 / 線毛 / ソーティング / 微小管結合蛋白質 / 初期エンドソーム / チュブリン / 微小管結合タンパク質 / 細胞膜変形 / 一次線毛
Research Abstract

We have identified SGIP1・ and its homologous molecules, FCHO1 and FCHO2, as novel microtubule-binding proteins. They bound not only to microtubules but also to membrane phospholipids and deformed membranes to tubules. SGIP1・ and FCHO2 were involved in clathrin-dependent endocytosis. FCHO2 regulated the ubiquitination and endocytosis of epithelial sodium channel (ENaC). In addition, FCHO2, which was also localized in centrosomes, regulated the organization of microtubules.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2008 2007 2006 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Identification and characterization of the novel centrosomal protein centlein. Biochem.2008

    • Author(s)
      Makino, K., Umeda, K., Uezu, A., Hiragami, Y., Sakamoto, T., Ihn, H., Nakanishi, H.
    • Journal Title

      Biophys. Res. Commun. 366

      Pages: 958-962

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mass spectrometric analysis of microtubule-cosedimented proteins from rat brain.2008

    • Author(s)
      Sakamoto, T., Uezu, A., Kawauchi, S., Kuramoto, T., Makino, K., Umeda, K., Araki, N., Baba, H., Nakanishi, H.
    • Journal Title

      Genes Cells 13

      Pages: 295-312

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frabin and its related Cdc42-specific guanine nucleotide exchange factors couple the actin cytoskeleton with the plasma membrane.2008

    • Author(s)
      Nakanishi, H., Takai, Y.
    • Journal Title

      J. Cell. Mol. Med 12

      Pages: 1160-1176

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frabin and its related Cdc42-specific guanine nucleotide exchange factors couple the actin cytoskeleton with the plasma membrane2008

    • Author(s)
      H. Nakanishi and Y. Takai
    • Journal Title

      J.Cell.Mol.Med 12

      Pages: 1119-1176

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of the novel centrosomal protein centlein2008

    • Author(s)
      K. Makino, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 366

      Pages: 958-962

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mass spectrometric analysis of microtubule-cosedimented proteins from rat brain2008

    • Author(s)
      T. Sakamoto, et. al.
    • Journal Title

      Genes to Cells 13

      Pages: 295-312

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SGIP1・is an endocytic protein that directly interacts with phospholipids and Eps15.2007

    • Author(s)
      Uezu, A., Horiuchi, A., Kanda, K., Kikuchi, N., Umeda, K., Tsujita, K., Suetsugu, S., Araki, N., Yamamoto, H., Takenawa, H., Nakanishi, H.
    • Journal Title

      J. Biol. Chem 282

      Pages: 26481-26489

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SGIP1α is an endocytic protein that directly interacts with phospholipids and Eps152007

    • Author(s)
      A. Uezu, et. al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 26481-26489

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新しいリン脂質結合タンパク質SGIP1αによる初期エンドソームでのEGF受容体のソーティング機構2008

    • Author(s)
      上江洲章吉
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新しいリン脂質結合タンパク質SGIP1・による初期エンドソームでのEGF受容体のソーティング機構2008

    • Author(s)
      上江洲章吉
    • Organizer
      BMB2008
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Final Research Report
  • [Presentation] SGIP1・is an endocytic protein that directly interacts with phospholipids and Eps152007

    • Author(s)
      上江洲章吉
    • Organizer
      BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] SGIP1α is an endocytic protein that directly interacts with phospholipids and Eps152007

    • Author(s)
      上江州章吉
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新しい中心体蛋白質の同定と機能解析2007

    • Author(s)
      牧野公治
    • Organizer
      BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経突起の形成に関わる新しい微小管結合蛋白質2007

    • Author(s)
      菊池直也、Brelin
    • Organizer
      BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しい中心体蛋白質の同定と機能解析2007

    • Author(s)
      牧野公治
    • Organizer
      日本研究皮膚化学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] SGIP1・による膜輸送の制御2006

    • Author(s)
      堀内綾香
    • Organizer
      第59回日本薬理学学会西南部会
    • Place of Presentation
      沖縄(メルパルク沖縄)
    • Year and Date
      2006-11-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しい微小管結合タンパク質による中心体の機能制御2006

    • Author(s)
      坂本達彦
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://srv02.medic.kumamoto-u.ac.jp/dept/pharma1/pharma1.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi