Molecular mechanism of brain layer formation regulated by Reelin
Project/Area Number |
17082007
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Nagoya City University |
Principal Investigator |
HATTORI Mitsuharu Nagoya City University, 大学院・薬学研究科, 教授 (60272481)
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Project Period (FY) |
2005 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥70,900,000 (Direct Cost: ¥70,900,000)
Fiscal Year 2009: ¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2008: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2007: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2006: ¥16,700,000 (Direct Cost: ¥16,700,000)
Fiscal Year 2005: ¥11,200,000 (Direct Cost: ¥11,200,000)
|
Keywords | 脳 / タンパク質 / 遺伝子 / プロテアーゼ / 神経細胞 / 精神神経疾患 / 発生 / 細胞移動 / リーリン / 変異マウス |
Research Abstract |
Reelin is essential for brain layer formation, but its exact function and underlying mechanism are nor well understood. We found that the C-terminal region of Reelin plays important roles in the interaction between this protein and neuronal cell membrane. We identified the protease in charge of specific proteolysis of Reelin. We also investigated when and where Reelin is received in the developing brain and found that Reelin acts on pre/early migratory neurons,
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Report
(6 results)
Research Products
(97 results)
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[Journal Article] Mechanism and significance of specific proteolytic cleavage of Reelin.2009
Author(s)
Kohno, S., Kohno, T., Nakano, Y., Suzuki, K., Ishii, M., Tagami, H., Baba, A., Hattori, M
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Journal Title
Biochem. Biophys. Res. Commun 380
Pages: 93-97
Related Report
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[Journal Article] Fyn tyrosine kinase regulates the surface expression of GPI-linked ephrin via the modulation of sphingomyelin metabolism.2009
Author(s)
Baba, A., Akagi, K., Takayanagi, M., Flanagan, J., Kobayashi, T., Hattori, M.
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Journal Title
J. Biol. Chem. 284
Pages: 9206-9214
Related Report
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[Journal Article] C-terminal region-dependent change of antibody-binding to the eighth Reelin repeat reflects the signaling activity of Reelin.2009
Author(s)
Kohno, T., Nakano, Y., Kitoh, N., Yagi, H., Kato, K., Baba, A., Hattori, M.
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Journal Title
J. Neurosci. Res. 87
Pages: 3043-3053
Related Report
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[Journal Article] Downregulation of functional Reelin receptors in projection neurons implys that primary Reelin action occurs at early/pre-migratory stages.2009
Author(s)
Uchida, T., Baba, A., Perez-Martinez, F.J., Hibi, T., Miyata, T., Luque, J.M., Nakajima, K., Hattori, M.
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Journal Title
J. Neurosci 29
Pages: 10653-10662
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[Journal Article] Novel affinity tag system using structurally defined antibody-tag interaction: application to single-step protein purification.2008
Author(s)
Nogi, T., Sangawa, T., Tabata, S., Nagae, M., Tamura-Kawakami, K., Beppu, A., Hattori, M., Yasui, N., Takagi, J.
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Journal Title
Protein Sci. 17
Pages: 2120-2126
Related Report
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[Journal Article] Structure of a receptor-binding fragment of Reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.2007
Author(s)
Yasui, N., Nogi, T., Kitao, T., Nakano, Y., Hattori, M., Takagi, J.
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Journal Title
Proc. Natl. Acad. Sci. U.S.A. 104
Pages: 9988-9993
Related Report
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[Journal Article] The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signaling.2007
Author(s)
Nakano, Y., Kohno, T., Hibi, T., Kohno, S., Baba, A., Mikoshiba, K., Nakajima, K., Hattori, M.
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Journal Title
J. Biol. Chem. 282
Pages: 20544-20552
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