The role of the extracellular matrix in focal localization of signal molecules
| Project/Area Number |
17082008
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Juntendo University |
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Principal Investigator |
HIRASAWA Eri Juntendo University, 大学院・医学研究科, 准教授 (50245718)
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| Co-Investigator(Kenkyū-buntansha) |
IWABUCHI Kazuhisa 順天堂大学, 教授 (10184897)
YANAGIDA Mituaki 順天堂大学, 大学院, 准教授 (80365569)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥65,400,000 (Direct Cost: ¥65,400,000)
Fiscal Year 2009: ¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2008: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2007: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2006: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2005: ¥6,700,000 (Direct Cost: ¥6,700,000)
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| Keywords | 細胞外マトリックス / シグナル分子 / ヘパラン硫酸プロテオグリカン / 神経 / 筋 / シグナル / ラミニン / パールカン / 神経細胞 / 筋細胞 / 超分子複合体 / 神経突起伸長 / メカニカルストレス / GM1ガングリオシド / NGF受容体 / 細胞内シグナル |
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| Research Abstract |
The extracellular matrix (ECM) plays an important role in cell behavior and fate through the formation of supramolecular complexes and regulation of signal pathways. This research project aimed to analyze the molecular mechanism of the supramolecular complex formation and to define the initial step of cell signal pathways induced by ECM. We have used cell processes of neurite outgrowth and muscle contraction as a model system for the project. In collaboration with Dr. Frederic Mercier of University of Hawaii, we have identified the specialized structure fractone in the adult neurogenic zone that consists of basement membrane components such as laminins and perlecan. Our results revealed that the basement membrane structure provides not only physical support for tissues, but also acts as a signal regulator in the proliferation and differentiation of neural progenitor cells (Krevier et al 2007). We also found that extracellular environments play a role in regulating mechanosensitive channels of synovial cells, which are implicated in the maintenance of joint homeostasis (Sakamoto et al.2010). We reported that perlecan, which surrounds skeletal muscle, is critical for homeostasis of skeletal muscle, and is a regulator for maintaining muscle fiber types in response to mechanical stress (Xu et al 2010). Our study regarding the role of ECM in maintenance and proliferation of neural stem cells is being prepared for publication.
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Report
(6 results)
Research Products
(56 results)
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[Journal Article] Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-d-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells.2010
Author(s)
Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E, Mochizuki H, Kohsaka S, Uchino S*
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Journal Title
Neuroscience. 167(2)(Epub ahead of print)
Pages: 372-383
Related Report
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[Journal Article] Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia2010
Author(s)
Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ichikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T*
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Journal Title
Neuropsychopharmaeology 35(5)(Epub ahead of print)
Pages: 1155-1164
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[Journal Article] Binding of laminin-1 to GM1 ganglioside in lipid rafts is critical for neurite outgrowth.2009
Author(s)
Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi T, Sasaki T, Hattori N, Mizuno Y, Hozumi K, Yamada Y, Arikawa-Hirasawa E*.
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Journal Title
J Cell Sei. 122
Pages: 289-299
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[Journal Article] Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation.2006
Author(s)
Sher, I., Zisman-Rozen, S., Eliahu L, Whitelock JM, Maas-Szabowski N, Yamada Y, Breitkreutz D, Fusenig NE, Arikawa-Hirasawa E, Iozzo RV, Bergman R, * Ron D.
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Journal Title
J. Biol. Chem. Vol.281,(8)
Pages: 5178-5187
Related Report
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[Journal Article] Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation.2006
Author(s)
Sher, I., Zisman-Rozen, S., Eliahu L, Whitelock JM, Maas-Szabowski N, Yamada Y, Breitkreutz D, FusenigNE, Arikawa-Hirasawa E, Iozzo RV, Bergman R, *Ron D
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Journal Title
J. Biol. Chem. Vol. 281(8)
Pages: 5178-5187
Related Report
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[Journal Article] Induction of human neutrophil chemotaxis by Candida albicans-derived-1,6 long glycoside side chains-branched -glucan.2006
Author(s)
Sato T, Iwabuchil K, Nagaoka I, Adachi Y, Ohno N, Tamura H, Seyama K, Fukuchi F, Nakayama H, Yoshizaki F, Takamori K, Ogawa H
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Journal Title
J Leuk. Biol. 80
Pages: 204-211
Related Report
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[Journal Article] Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermis formation.2006
Author(s)
Sher, I., Zisman-Rozen, S., Eliahu L, Whitelock JM, Maas-Szabowski N, Yamada Y, Breitkreutz D, Fusenig NE, Arikawa-Hirasawa E, Iozzo RV, Bergman R, Ron D
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Journal Title
J.Biol.Chem. 281(8)
Pages: 5178-5187
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[Journal Article] Identification of neurite outgrowth active sites on the laminin alpha4 chain G domain.2005
Author(s)
Ichikawa N, Kasai S, Suzuki N, Nishi N, Oishi S, Fujii N, Kadoya Y, Hatori, K, Mizuno Y, Nomizu M, Arikawa-Hirasawa E
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Journal Title
Biochemistry 44(15)
Pages: 5755-5762
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[Journal Article] Autophagic Vacuoles with Sarcolemmal Features Delineate Danon Disease and Related Myopathies.: 20052005
Author(s)
Sugie K, Noguchi S, Kozuka Y, Arikawa-Hirasawa E, Tanaka M, Yan C, Saftig P, von Figura K, Hirano M, Ueno S, Nonaka I, Nishino I
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Journal Title
Neuropathol Exp Neurol J 64,(6)
Pages: 513-522
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[Presentation]2009
Author(s)
Douet, V., Saint Georges Chaumet, M., Kerever, A., Arikawa-Hirasawa, E., Mercier
Organizer
8th Pan-Pacific Connective Tissue Societies Fractones: specialized extracellular matrix structures governing the stem cell niches.
Place of Presentation
Shounan-villedge Kanagawa
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