Roles of Notch localization to adherens junctions in Notch signaling
Project/Area Number |
17082009
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Tokyo University of Science |
Principal Investigator |
MATSUNO Kenji Tokyo University of Science, 基礎工学部, 教授 (60318227)
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Co-Investigator(Renkei-kenkyūsha) |
前田 礼男 東京理科大学, 基礎工学部, 助教 (40453831)
奥村 高志 東京理科大学, 基礎工学部, ポストドクトラル研究員 (20449234)
|
Project Period (FY) |
2005 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥78,300,000 (Direct Cost: ¥78,300,000)
Fiscal Year 2009: ¥17,400,000 (Direct Cost: ¥17,400,000)
Fiscal Year 2008: ¥17,400,000 (Direct Cost: ¥17,400,000)
Fiscal Year 2007: ¥17,400,000 (Direct Cost: ¥17,400,000)
Fiscal Year 2006: ¥17,400,000 (Direct Cost: ¥17,400,000)
Fiscal Year 2005: ¥8,700,000 (Direct Cost: ¥8,700,000)
|
Keywords | Notch / adherens junctions / エンドサイトーシス / エキソサイトーシス / 上皮細胞 / 細胞極性 / O-フコシル化 / ショウジョウバエ / エキソサイトーシ / adherens junction / 0-フコシル化 / subapical complex |
Research Abstract |
Notch (N) signaling regulates cell-specifications through cell-cell interactions. N andits ligands localize to the adherence junctions (AJs) in epithelial cells. We identifiedgenes required for the localization of N to AJs.
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Report
(6 results)
Research Products
(179 results)
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[Journal Article] Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila.2010
Author(s)
Okumura, T., Fujiwara, H., Taniguchi, K., Kuroda, J., Nakazawa, N., Nakamura, N., Hatori, R., Ishio, A., Maeda, R., Matsuno, K.
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Related Report
Peer Reviewed
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[Journal Article] Two pathways for importing GDP-fucose into the ER lumen function redundantly in the O-fucosylation of Notch in Drosophila.2010
Author(s)
Ishikawa, H., Ayukawa, T., Nakayama, N., Higashi, S., Kamiyama, S., Nishihara, S., Aoki, K., Ishida, N., Sanai, Y., Matsuno, K
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Journal Title
J. Biol. Chem. 285
Pages: 4122-4129
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Peer Reviewed
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[Journal Article] The development and evolution of left-right asymmetry in invertebrates: lessons from Drosophila and snails.2008
Author(s)
Okumura, T., Utsuno, H., Kuroda, J., Gittenberger, E., Asami, T., Matsuno, K.
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Journal Title
Dev. Dyn 237
Pages: 3497-3515
Related Report
Peer Reviewed
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[Journal Article] The head region of unconventional Myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila.2008
Author(s)
Hozumi, S., Maeda, R., Taniguchi-Kanai, M., Okumura, T., Taniguchi, K., Kawakatsu, Y., Nakazawa, N., Hatori, R., Matsuno, K
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Journal Title
Dev. Dyn. 237
Pages: 3528-3537
Related Report
Peer Reviewed
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[Journal Article] Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of Notch in the endosomal trafficking pathway.2008
Author(s)
Wilkin, M.B., Tongngok, P., Gensch, N., Clemence, S., Motoki, M., Yamada, K., Hori, K., Taniguchi-Kanai, M., Franklin, E., Matsuno, K., Baron, M
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Journal Title
Dev. Cell 15
Pages: 762-772
Related Report
Peer Reviewed
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[Journal Article] Distinct activation patterns of EGF receptor signaling in the homoplastic evolution of eggshell morphology in genus Drosophila.2008
Author(s)
Kagesawa, T., Nakamura, Y., Nishikawa, M., Akiyama, Y., Kajiwara, M., Matsuno, K.
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Journal Title
Mech. Dev 125
Pages: 1020-1032
Related Report
Peer Reviewed
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[Journal Article] The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila.2007
Author(s)
Sasamura, T., Ishikawa, H.O., Sasaki, N., Higashi, S., Kanai, M., Nakao, S., Ayukawa, T., Aigaki, T., Noda, K., Miyoshi, E., Taniguchi, N., Matsuno, K.
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Journal Title
Development 134
Pages: 1347-1356
Related Report
Peer Reviewed
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[Journal Article] Soma-dependent modulations contribute to divergence of rhomboid expression during evolution of Drosophila eggshell morphology.2007
Author(s)
Nakamura, Y., Kagesawa, T., Nishikawa, M., Hayashi, Y., Kobayashi, S., Niimi, T., Matsuno, K.
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Journal Title
Development 134
Pages: 1529-1537
Related Report
Peer Reviewed
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[Journal Article] D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut.2007
Author(s)
Taniguchi, K., Hozumi, S., Maeda, R., Ooike, M., Sasamura, T., Aigaki, T., Matsuno, K
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Journal Title
Dev. Biol. 311
Pages: 251-263
Related Report
Peer Reviewed
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[Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.2007
Author(s)
Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Oguro, H., Iwama, A., Matsuno, K., Sakamoto, R., Sato M., Yoshida, N., Kitagawa, M.
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Journal Title
Proc. Natl. Acad. Sci. USA 104
Pages: 9764-9769
Related Report
Peer Reviewed
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[Journal Article] The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.2007
Author(s)
Araki, Y., Kawano, T., Taru, H., Saito, Y., Wada, S., Miyamoto, K., Kobayashi, H., Ishikawa, H.O., Ohsugi, Y., Yamamoto, T., Matsuno, K., Kinjo, M. Suzuki, T
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Journal Title
EMBO J 26
Pages: 1475-1486
Related Report
Peer Reviewed
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[Journal Article] Roles of single-minded in the left-right asymmetric development and tissue specifications of the Drosophila embryonic gut.2007
Author(s)
Maeda, R., Hozumi, S., Taniguchi, K., Sasamura, T., Murakami, R., Matsuno, K
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Journal Title
Mech. Dev. 124
Pages: 204-217
Related Report
Peer Reviewed
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[Journal Article] Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells.2007
Author(s)
Sasaki N., Sasamura, T., Ishikawa, H.O., Kanai, M., Ueda, R., Saigo, K., Aigaki, T., Matsuno K. Polarized
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Journal Title
Genes to Cells 12
Pages: 89-103
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Peer Reviewed
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[Journal Article] A Drosophila unconventional myosin reverses the default handedness in visceral organs.2006
Author(s)
Hozumi, S., Maeda, R., Taniguchi, K., Sasamura, T., Speder, P., Noselli, S., Aigaki, T., Murakami, R., Matsuno, K
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Journal Title
Nature 440
Pages: 798-802
Related Report
Peer Reviewed
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[Journal Article] The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila.2006
Author(s)
Fuwa, T.J., Hori, K., Sasamura, T., Higgs, J., Baron, M., Matsuno, K
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Journal Title
Mol. Genet. and Genom 275
Pages: 251-263
Related Report
Peer Reviewed
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[Journal Article] Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc.2005
Author(s)
Ishikawa, H.O., Higashi, S., Ayukawa, T., Sasamura, T., Aoki, K., Ishida N., Sanai, Y., Matsuno, K
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Journal Title
Proc. Natl. Acad. Sci. USA 102
Pages: 18532-18537
Related Report
Peer Reviewed
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[Presentation] ショウジョウバエ生体内におけるRNAiを用いたNotchの小胞輸送因子の遺伝学的探索2009
Author(s)
Naoki Aoyama, Hiroyuki Okubo, Mki Ohhri, Ikuo Tamura, Eriko Iida, Ryu Ueda, Yuki Yamaguchi-Takei, Akira Watanabe, Yusuke Kitada, Kenji Matsuno
Organizer
42st Annual Meeting of JSDB
Place of Presentation
新潟
Year and Date
2009-05-30
Related Report
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[Presentation] A novel role of Notch monosaccharide O-fucose modification is required for Delta-Notch but not Serrate-Notch signaling in Drosophila.2009
Author(s)
Tomonori Ayukawa, Hiroyuki Ishikawa, Minoru Nakayama, Shunsuke Higashi, Shin Kamiyama, Shoko Nishihara, Tetsuya Okajima, Kazuhisa Aoki, Nobuhiro Ishida, Yutaka Sanai, Kenji Matsuno
Organizer
42st Annual Meeting of JSDB
Place of Presentation
新潟
Year and Date
2009-05-29
Related Report
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[Presentation] A genome-wide RNAi screen to indetify the genes regulating vesicular trafficking of Notch in Drosophila melanogaster2008
Author(s)
Naoki Aoyama, Hiroyuki Okubo, Maki Ohhori, Ikuo Tamura, Eriko Iida, Ryu Ueda, Yuki Yamaguchi-Takei, Akira Watanabe, Yusuke Kitada, Tetsuya Tabata, Kenji Matsuno
Organizer
第81回日本生化学会大会合同大会
Place of Presentation
神戸
Year and Date
2008-12-11
Related Report
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[Presentation] A novel role of Notch monosaccharide O-fucose modification is required for Delta-Notch but not Serrate-Notch signaling in Drosophila2008
Author(s)
Tomonori Ayukawa, Hiroyui Ishikawa, Minoru Nakayama, Shunsuke Higashi, Shin Kamiyama, Shoko Nishihara, Tetsuya Okajima, Nobuhiro Ishida, Kazuhisa Aoki, Yutaka Sanai, Kenji Matsuno
Organizer
第81回日本生化学会大会合同大会
Place of Presentation
神戸
Year and Date
2008-12-11
Related Report
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