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The mechanism of somite segmentation with periodic patterning

Research Project

Project/Area Number 17082010
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute of Genetics

Principal Investigator

SAGA Yumiko  National Institute of Genetics, 系統生物研究センター, 教授 (50221271)

Co-Investigator(Kenkyū-buntansha) KOKUBO Hiroki  国立遺伝学研究所, 系統生物研究センター, 助教 (10270480)
MISTUI Kaoru  鹿児島大学, 大学院・医歯学総合研究科, 講師 (40324975)
TAKAHASHI Yu  国立医薬品食品衛生研究所, 毒性部, 主任研究官 (60321858)
Co-Investigator(Renkei-kenkyūsha) KANNO Jun  国立医薬品食品衛生研究所, 毒性部, 部長 (90186172)
YASUHIKO Yukuto  国立医薬品食品衛生研究所, 毒性部, 主任研究官 (40370944)
KITAJIMA Satoshi  国立医薬品食品衛生研究所, 毒性部, 主任研究官 (30270622)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥134,900,000 (Direct Cost: ¥134,900,000)
Fiscal Year 2009: ¥24,800,000 (Direct Cost: ¥24,800,000)
Fiscal Year 2008: ¥28,800,000 (Direct Cost: ¥28,800,000)
Fiscal Year 2007: ¥30,900,000 (Direct Cost: ¥30,900,000)
Fiscal Year 2006: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 2005: ¥25,200,000 (Direct Cost: ¥25,200,000)
Keywords体節形成 / Notchシグナ / 脊椎骨 / 体節時計 / Mesp2 / Tbx6 / 未分節中胚葉 / L-fng / Hes7 / 分節境界 / Notchシグナル / D111 / キメラ解析 / Pofut1 / Lunatic Fring / Lunatic Fringe / Dll1 / Notch-YFP
Research Abstract

Somites provide bases of segmental structure such as vertebra and rimb of our body. Somites are generated periodically every 2 hours in mouse embryos. The periodicity is known to be regulated by so-called molecular clock which is regulated by an oscillation of transcriptional repressor, Hes7. However, the mechanism to translate the clock information into the special pattern of each somite remained elusive. We have revealed that a transcription factor Mesp2 is a key regulator required for this process. We demonstrated that the expression of Mesp2 is positively regulated by Tbx6 and Notch signal oscillation and repressive function of Mesp2 on Tbx6 and Notch signaling is critically important to generate segmental border formation and establishing rostro-caudal patterning of somites.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (91 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (31 results) (of which Peer Reviewed: 12 results) Presentation (60 results)

  • [Journal Article] Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite.2010

    • Author(s)
      Takahashi J, Ohbayashi A, Oginuma M, Saito D, Mochizuki A, Saga Y, Takada S
    • Journal Title

      Dev Biol.

    • Related Report
      2009 Final Research Report
  • [Journal Article] The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.2010

    • Author(s)
      Oginuma M, Takahashi Y, Kitajima S, Kiso M, Kanno J, Kimura A, Saga Y
    • Journal Title

      Development.

    • Related Report
      2009 Final Research Report
  • [Journal Article] The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite2010

    • Author(s)
      Oginuma M, et al
    • Journal Title

      Development 137

      Pages: 1515-1522

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite2010

    • Author(s)
      Takahashi J, et al
    • Journal Title

      Developmental Biology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional gene targeting in mouse high endothelial venules2009

    • Author(s)
      Kawashima H., et al
    • Journal Title

      J Immunology 182

      Pages: 5461-5468

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord2009

    • Author(s)
      Ukita K., et al
    • Journal Title

      Mechanism of Development 126

      Pages: 791-803

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm (PSM) specific enhancer of Mesp.2008

    • Author(s)
      Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, Saga Y
    • Journal Title

      Development 135

      Pages: 3511-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Notch signaling is required for the maintenance of enteric neural crest progenitors.2008

    • Author(s)
      Okamura Y, Saga Y
    • Journal Title

      Development 135

      Pages: 3555-65

    • Related Report
      2009 Final Research Report
  • [Journal Article] Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis.2008

    • Author(s)
      Oginuma M, Niwa Y, Chapman DL, Saga Y
    • Journal Title

      Development 135

      Pages: 2555-62

    • Related Report
      2009 Final Research Report
  • [Journal Article] Pofut1 is required for the proper localization of the Notch receptor during mouse development.2008

    • Author(s)
      kamura Y, Saga Y
    • Journal Title

      Mech Dev. 125

      Pages: 663-73

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-null mouse using BAC-based rescue technology.2008

    • Author(s)
      Oginuma M, Hirata T, Saga Y
    • Journal Title

      Mech Dev. 125(5-6)

      Pages: 432-40

    • Related Report
      2009 Final Research Report
  • [Journal Article] Mutations in the MESP2 gene cause spondylothoracic dysostosis / Jarcho-Levin syndrome2008

    • Author(s)
      Cornier AS, et.al
    • Journal Title

      Am J Hum Genet. 82

      Pages: 1334-1341

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pofutl is required for the proper localization of the Notch receptor during mouse development2008

    • Author(s)
      Okamura Y, et.al
    • Journal Title

      Mechanism of Development 125

      Pages: 663-675

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling is required for the maintenance of enteric neural crest progenitors2008

    • Author(s)
      Okamura Y, et.al
    • Journal Title

      Development 135

      Pages: 3555-3565

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm (PSM) specific enhancer of Mesp2008

    • Author(s)
      Yasuhiko Y, et.al
    • Journal Title

      Development 135

      Pages: 3511-3519

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis2008

    • Author(s)
      Oginuma M, et.al
    • Journal Title

      Development 135

      Pages: 2555-2562

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of presomitic mesoderm(PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-nullmouseusing BAC-based rescue technology2008

    • Author(s)
      Oginuma M
    • Journal Title

      Mechanism of Development 125

      Pages: 432-440

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation.2007

    • Author(s)
      Takahashi Y, Takagi A, Hiraoka S, Koseki H, Kanno J, Rawls A, Saga Y
    • Journal Title

      Dev Dyn 236

      Pages: 1484-94

    • Related Report
      2009 Final Research Report
  • [Journal Article] Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of notch activity.2007

    • Author(s)
      Saga Y
    • Journal Title

      Dev Dyn. 236

      Pages: 1450-5

    • Related Report
      2009 Final Research Report
  • [Journal Article] The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite.2007

    • Author(s)
      Morimoto M, Sasaki N, Oginuma M, Kiso M, Igarashi K, Aizaki K, Kanno J, Saga Y
    • Journal Title

      Development 134

      Pages: 1561-9

    • Related Report
      2009 Final Research Report 2006 Annual Research Report
  • [Journal Article] Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.2007

    • Author(s)
      Takahashi Y, Yasuhiko Y, Kitajima S, Kannno, J, Saga Y
    • Journal Title

      Dev. Biol. 304

      Pages: 593-603

    • Related Report
      2009 Final Research Report 2006 Annual Research Report
  • [Journal Article] Transcription factors Mesp2 and Paraxishave critical roles in axial musculoskeletal formation.2007

    • Author(s)
      Takahashi Y
    • Journal Title

      Developmental Dynamics 236

      Pages: 1484-1494

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of notch activity.2007

    • Author(s)
      Saga Y
    • Journal Title

      Developmental Dynamics 236

      Pages: 1450-1455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis.2006

    • Author(s)
      Morimoto M, Kiso M, Sasaki N. Saga Y
    • Journal Title

      Dev. Biol. 300

      Pages: 687-698

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of EphA4 enhancer required for segmental expression and the regulation by Mesp2.2006

    • Author(s)
      Nakajima Y, Morimoto, Takahashi Y, Koseki K, Saga Y.
    • Journal Title

      Development 133

      Pages: 2517-25

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression.2006

    • Author(s)
      Yasuhiko Y., Haraguchi S., Kitajima S., Takahashi Y, Kanno J. Saga, Y.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 3651-3656

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of EphA4 enhancer required for segmental expression and the regulation by Mesp2.2006

    • Author(s)
      Nakajima Y., Morimoto M., Takahashi Y., Koseki K., Saga Y.
    • Journal Title

      Development 133

      Pages: 2517-2525

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis.2006

    • Author(s)
      Morimoto M, Kiso M, Sasaki N, Saga Y
    • Journal Title

      Dev. Biol. 300

      Pages: 687-698

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression.2006

    • Author(s)
      Yasuhiko Y, Haraguchi S., Kitajima S., Takahashi Y., Jun Kanno J., Saga Y.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103

      Pages: 3651-3656

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The transcription factor Mesp2 establishes segmental borders by suppressing Notch activity.2005

    • Author(s)
      Morimoto M, Takahashi Y, Endo M. Saga Y.
    • Journal Title

      Nature 435

      Pages: 354-359

    • Related Report
      2009 Final Research Report
  • [Journal Article] The transcription factor Mesp2 establishes segmental borders by suppressing Notch activity.2005

    • Author(s)
      Morimoto M, Takahashi Y, Endo M, Saga Y.
    • Journal Title

      Nature 435

      Pages: 354-359

    • Related Report
      2005 Annual Research Report
  • [Presentation] マウスの生殖細胞の性分化制御機構2009

    • Author(s)
      相賀裕美子
    • Organizer
      第82回日本生化学会大会シンポジウム
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Repression of the Notch signaling activity via Mesp2 is essential for somitogenesis.2009

    • Author(s)
      Sasaki, N, et al., Saga Y
    • Organizer
      16th International Society of Developmental Biologists Congress
    • Place of Presentation
      Edinburgh
    • Related Report
      2009 Final Research Report
  • [Presentation] The coupling mechanism to generate synchronized oscillation in mouse somitogenesis.2009

    • Author(s)
      Okubo Y, Saga Y.
    • Organizer
      第42回発生生物学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Presentation] translation mechanism of the segmentation clock for periodic somite formation.2009

    • Author(s)
      相賀裕美子., 荻沼政之
    • Organizer
      32回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional analays of the degradation mechanism of Mastermind via Mesp2 to repress the activation of the Notch signaling pathway.2009

    • Author(s)
      佐々木伸雄、相賀裕美子
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] epression of the Notch signaling activity via Mesp2 is essential for somitogenesis2009

    • Author(s)
      佐々木伸雄
    • Organizer
      16th International Society of Developmental Biologists Congress 2009
    • Place of Presentation
      Edinburgh
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mastermind-1/Mastermind-2 are essential components of Notch signaling pathway2009

    • Author(s)
      小山敏尚
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Segmentation and rostro-caudal patterning of somites is not essential for vertebral body segmentation2009

    • Author(s)
      高橋雄
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ripply genes are required for the proper rostro-caudal patterning through degradation of Tbx6 protein during somitogenesis2009

    • Author(s)
      高橋潤
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional analays of the degradation mechanism of Mastermind via Mesp2 to repress the activation of the Notch signaling pathway2009

    • Author(s)
      佐々木伸雄
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] The function of Ripply and Ripply2 in the somite formation2009

    • Author(s)
      高橋潤
    • Organizer
      第42回 発生生物学会
    • Place of Presentation
      新潟市
    • Related Report
      2009 Annual Research Report
  • [Presentation] The coupling mechanism to generate synchronized oscillation in mouse somitogenesis2009

    • Author(s)
      Yusuke Okubo
    • Organizer
      第42回 発生生物学会
    • Place of Presentation
      新潟市
    • Related Report
      2009 Annual Research Report
  • [Presentation] A translation singnaling and the control of segmentation clock for periodic somite formation2009

    • Author(s)
      相賀裕美子
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mesp2 and Tbx6 cooperatively create periodic patterns during mouse somitogenesis.2008

    • Author(s)
      Saga Y.
    • Organizer
      Joint meeting of French and Japan Societies for Developmental Biology
    • Place of Presentation
      France
    • Related Report
      2009 Final Research Report
  • [Presentation] The stable and cyclic expression of L-fng, which is required for somitogenesis.2008

    • Author(s)
      Oginuma, M., Saga Y.
    • Organizer
      Joint meeting of French and Japan Societies for Developmental Biology
    • Place of Presentation
      France
    • Related Report
      2009 Final Research Report
  • [Presentation] マウス体節形成にはMesp2によるNotch情報伝達系の抑制が必要である。2008

    • Author(s)
      佐々木伸雄, 木曽誠, 相賀裕美子
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Delta-like3(Dll3) does not substitute for Delta-like1(Dll1) in somitogenesis in vivo but modulates Dll1/Notch signaling in the posterior PSM.2008

    • Author(s)
      Takahasi Y., et al, Saga Y
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      Tokushima
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional importance and evolutional conservation of Tbx6 binding sites in presomitic mesoderm(PSM)specific enhancer of Mesp2.2008

    • Author(s)
      Yasuhiko Y., et al., Saga Y
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      Tokushima
    • Related Report
      2009 Final Research Report
  • [Presentation] Mesp2 and Tbx6 cooperatively create periodic patterns, coupled with the clock machinery during mouse somitogenesis.2008

    • Author(s)
      Oginuma M, et al., Saga Y
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      Tokushima
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic evidence for the Mesp2 function as the suppressor of Notch signaling.2008

    • Author(s)
      Sasaki N., Saga Y.
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      Tokushima
    • Related Report
      2009 Final Research Report
  • [Presentation] Mesp2 and Tbx6 cooperatively create periodic patterns during mouse somitogenesis2008

    • Author(s)
      Yumiko Saga
    • Organizer
      Joint meeting of French and Japan Societies for Developmental Biology
    • Place of Presentation
      Giens, France
    • Related Report
      2008 Annual Research Report
  • [Presentation] The stable and cyclic expression of L-fng, which is required for somitogenesis2008

    • Author(s)
      Masayuki Oginuma
    • Organizer
      Joint meeting of French and Japan Societies for Developmental Biology
    • Place of Presentation
      Giens, France
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス体節形成にはMesp2によるNotch情報伝達系の抑制が必要である2008

    • Author(s)
      佐々木伸雄
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスRipply1は体節の前後極性の確立に重要である2008

    • Author(s)
      高橋潤
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hesr2 disrupted mice develop stenosis and regurgitation as a result of sclerotic degeneration of the aortic valve with advancing age2008

    • Author(s)
      Hiroki, Kokubo
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel mouse Delta-like 1 (Dll1) alleles yield insights into involvement of Notch signal in segmentation of vertebrae2008

    • Author(s)
      Yu, Takahashi
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional importance and evolutional conservation of Tbx6 binding sites in presomitic mesoderm (PSM) specific enhancer of Mesp22008

    • Author(s)
      Yhkhtb, Yasuhiko
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mesp2 and Tbx6 cooperatively create periodic patterns, coupled with the clock machinery during mouse somitogenesis2008

    • Author(s)
      Masayuki, Oginuma.
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      徳島
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic evidence for the Mesp2 function as the suppressor of Notch signaling2008

    • Author(s)
      Nobuo, Sasaki
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      徳島
    • Related Report
      2008 Annual Research Report
  • [Presentation] Delta-like3 (Dll3) does not substitute for Delta-like1 (Dll1) in somitogenesis in vivo but modulates Dll1 / Notch signaling in the posterior PSM2008

    • Author(s)
      Yu, Takahasi
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      徳島
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional importance and evolutional conservation of Tbx6 binding sites in presomitic mesoderm (PSM) specific enhancer of Mesp22008

    • Author(s)
      Yukuto, Yasuhiko
    • Organizer
      41st Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      徳島
    • Related Report
      2008 Annual Research Report
  • [Presentation] 体節形成過程で機能する転写因子Mesp2の時空的制御機構2007

    • Author(s)
      相賀 裕美子
    • Organizer
      分子・細胞・組織操作を目指したシステム細胞工学
    • Place of Presentation
      東京
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] The spatio-temporal regulation of the periodic Mesp2 expression2007

    • Author(s)
      Yumiko Saga
    • Organizer
      Pan-American SDB Congress
    • Place of Presentation
      Cancun
    • Year and Date
      2007-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] The spatio-temporal regulation of somitogenesis2007

    • Author(s)
      Saga Y.
    • Organizer
      The Notch Meeting
    • Place of Presentation
      Athens
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] The Mesp2 transcription factor establishes segmental borders by suppressing2007

    • Author(s)
      Saga Y
    • Organizer
      Notch activity, KORNBERG symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Final Research Report
  • [Presentation] The spatio-temporal regulation of somitogenesis2007

    • Author(s)
      Saga Y
    • Organizer
      Pan-American SDB Congress
    • Place of Presentation
      Cancun
    • Related Report
      2009 Final Research Report
  • [Presentation] The spatio-temporal regulation of somitogenesis.2007

    • Author(s)
      Saga Y
    • Organizer
      IMGC2007(第21回国際哺乳類ゲノム会議)
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Translation of the temporal Information provided by the Segmentation Clock.2007

    • Author(s)
      Saga Y
    • Organizer
      THE TERATOLOGY SOCIETY. 47th Annual Meeting
    • Place of Presentation
      Pittsburgh
    • Related Report
      2009 Final Research Report
  • [Presentation] The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity2007

    • Author(s)
      Yumiko Saga
    • Organizer
      KORNBERG symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2007 Annual Research Report
  • [Presentation] THE SPATIO-TEMPORAL REGULATION OF SOMITOGENESIS2007

    • Author(s)
      Yumiko Saga
    • Organizer
      IMGC2007(第21回国際哺乳類ゲノム会議)
    • Place of Presentation
      Kyoto
    • Related Report
      2007 Annual Research Report
  • [Presentation] Translation of the Temporal Information Provided by the Segmentation Clock2007

    • Author(s)
      Yumiko Saga
    • Organizer
      THE TERATOLOGY SOCIETY 47th Annual Meeting
    • Place of Presentation
      Pittsburgh
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pofut1 ノックアウトマウスを用いたNotch シグナルの機能解析2007

    • Author(s)
      岡村佳明
    • Organizer
      第30回日本分子生物学会、第80回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心房と心室の境界領域形成におけるHesrの役割2007

    • Author(s)
      小久保博樹
    • Organizer
      第30回日本分子生物学会、第80回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mesp2の負の制御因子Ripply2による体節の前後極性決定機構の解析2007

    • Author(s)
      佐々木伸雄
    • Organizer
      第40回 日本発生生物学会、第59回 日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] A negative feedback regulation of Tbx6 by Mesp2 is critical to reset the spatial information and is required for the periodic somitogenesis2007

    • Author(s)
      荻沼政之
    • Organizer
      第40回 日本発生生物学会、第59回 日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Transcription factors Mesp2 and Mesp2 and Paraxis have critical roles in axial musculoskeletal formation2007

    • Author(s)
      高橋雄
    • Organizer
      第40回 日本発生生物学会、第59回 日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tbx6 controls Mesp2 expression in forming somites2007

    • Author(s)
      安彦行人
    • Organizer
      第40回 日本発生生物学会、第59回 日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス体節形成時における転写因子Mesp2の分子機能の解析2007

    • Author(s)
      佐々木伸雄
    • Organizer
      第30回 日本分子生物学会、第80回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of different enhancers for Mesp1 and Mesp2 expression in the presomitic mesoderm.2006

    • Author(s)
      Oginuma, M., Saga Y.
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] Analyses toward understanding the function of Protein O-fucosyltransferase1on Notch signaling.2006

    • Author(s)
      Okamura, Y, Saga Y
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] 体節形成に関わる転写因子Mesp2の発現制御における転写因子Tbx6の役割2006

    • Author(s)
      安彦行人, 原口清輝, 北嶋聡, 高橋雄, 菅野純, 相賀裕美子
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] Mesp2の負の制御因子Ripply2による体節の前後極性決定機構の解析2006

    • Author(s)
      佐々木伸雄、森本充、荻沼政之、相賀裕美子
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] A mechanism of somite segmentation.2005

    • Author(s)
      Saga Y.
    • Organizer
      UK-Japan Developmental Biology Meeting.
    • Place of Presentation
      London
    • Related Report
      2009 Final Research Report
  • [Presentation] Mesp2, the function and regulation2005

    • Author(s)
      Saga Y.
    • Organizer
      egmentation meeting
    • Place of Presentation
      France
    • Related Report
      2009 Final Research Report
  • [Presentation] BACトランスジェニックマウスを用いたbHLH型転写因子Mesp1とMesp2の発現制御機構の解析2005

    • Author(s)
      荻沼政之, 渡辺裕介, 相賀裕美子
    • Organizer
      日本発生生物学会第38回大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Mesp2タンパク質の機能ドメインの固体レベルでの解析2005

    • Author(s)
      森本充, 木曽誠, 相賀裕美子
    • Organizer
      日本発生生物学会第38回大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] NotchシグナルはTbx6の依存的にMesp2発現を活性化する.2005

    • Author(s)
      安彦行人, 原口清輝, 高橋雄, 菅野純, 相賀裕美子
    • Organizer
      第28回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 体節形成におけるストライプパターンの形成には未分節中胚葉前方におけるNotchシグナルのネガティブフィードバックが本質的に重要である.2005

    • Author(s)
      高橋雄, 北嶋聡, 菅野純, 相賀裕美子
    • Organizer
      日本発生生物学会第38回大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Mesp2はL-fringeを誘導し、Notch-signalingを抑制する事で分節境界を確率する.2005

    • Author(s)
      森本充, 相賀裕美子
    • Organizer
      日本発生生物学会第38回大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] NotchシグナルおよびTbx6によるMesp2発現制御機構の解析2005

    • Author(s)
      安彦行人, 原口清輝, 菅野純, 相賀裕美子
    • Organizer
      日本発生生物学会第38回大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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