Basement membrane regulation in C.elegans organogenesis
| Project/Area Number |
17082011
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kwansei Gakuin University (2008-2009)
The Institute of Physical and Chemical Research (2005-2007) |
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Principal Investigator |
NISHIWAKI Kiyoji Kwansei Gakuin University, 理工学部, 教授 (30342827)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Yukihiko 関西学院大学, 理工学部, 研究員 (70333325)
OHKURA Kiyotaka 独立行政法人理化学研究所, 細胞移動研究チーム, 研究員 (30415103)
IHARA Shinji 独立行政法人理化学研究所, 細胞移動研究チーム, 研究員 (70373272)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥47,000,000 (Direct Cost: ¥47,000,000)
Fiscal Year 2009: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2008: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2007: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
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| Keywords | 線虫 / ADAMTS family / MIG-17 / 抑圧遺伝子 / fibulin / nidogen / type IV collagen / ADAM family / 基底膜 |
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| Research Abstract |
An ADAMTS family protease MIG-17 is recruited to the gonadal basement membrane in a prodomain-dependent manner, where it is activated to control gonadal leader cell migration in Caenorhabditis elegans. We found that fibulin-1 and type IV collagen act downstream of MIG-17 to recruit nidogen and that type IV collagen also activates a nidogen-independent pathway for directional control of leader cell migration.
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Report
(6 results)
Research Products
(85 results)
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[Journal Article] C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV.2009
Author(s)
Kawano, T., Zheng, H., Merz, D.C., Kohara, Y., Tamai, K.K., Nishiwaki, K., Culotti, J.G.
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Journal Title
Development 136
Pages: 1433-1442
Related Report
Peer Reviewed
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[Journal Article] MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in C. elegans.2007
Author(s)
Takasaki, T., Liu, Z., Habara, Y., Nishiwaki, K., Nakayama, J., Inoue, K., Sakamoto, H., Strome, S.
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Journal Title
Development 134
Pages: 757-767
Related Report
Peer Reviewed
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[Journal Article] Behavioral genetics of Caenorhabditis elegans unc-103-encoded erg-like K(+) channel.2006
Author(s)
Reiner, D.J., Weinshenker, D., Tian, H., Thomas, J.H., Nishiwaki, K., Miwa, J., Gruninger, T., Leboeuf, B., Garcia, L.R.
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Journal Title
J. Neurogenet 20
Pages: 41-66
Related Report
Peer Reviewed
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[Journal Article] Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.2006
Author(s)
Rottiers, V., Motola, D.L., Gerisch, B., Cummins, C.L., Nishiwaki, K., Mangelsdorf, D.J., Antebi A.
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Related Report
Peer Reviewed
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[Journal Article] SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.2005
Author(s)
Itoh, B., Hirose, T., Takata, N., Nishiwaki, K., Koga, M., Ohshima, Y., Okada, M.
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Journal Title
Development 132
Pages: 5161-5172
Related Report
Peer Reviewed
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[Presentation] MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.2008
Author(s)
Kubota, Y., Ohkura, K., Nagata, K., Tamai, K.K., Nishiwaki, K.
Organizer
American Society for Matrix Biology
Place of Presentation
San Diego, USA
Year and Date
2008-12-07
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