Development of new bone method for evaluating pathological or regenerated hard tissues and bone design for biomedical application

• Project/Area Number: 17101005
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Osaka University
• Principal Investigator: UMAKOSHI Yukichi Osaka University, 名誉教授 (00029216)
• Co-Investigator(Kenkyū-buntansha): NAKANO Takayoshi 大阪大学, 大学院・工学研究科, 教授 (30243182) ; YASUDA Hideyuki 大阪大学, 大学院・工学研究科, 教授 (60239762) ; HASHIMOTO JYUN 大阪大学, 大学院・医学系研究科, 准教授 (40237938) ; YOSHIKAWA Hideki 大阪大学, 大学院・医学系研究科, 教授 (60191558)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥101,660,000 (Direct Cost: ¥78,200,000、Indirect Cost: ¥23,460,000); Fiscal Year 2008: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2006: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000); Fiscal Year 2005: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
• Keywords: 骨再生・骨疾患 / アパタイト / 結晶配向 / 骨質 / 外場 / 足場材料 / 骨配向性 / 骨再生モデル / 外場印加 / 微小領域X線回折法 / 骨再生デザイン / 透過型光学系 / 骨診断 / op / opマウス / 骨再生 / 疾患骨 / 骨粗鬆症 / 骨系細胞 / 生体環境 / 大理石骨病 / X線回折 / 材料工学的アプローチ / 骨疾患 / 骨量 / 硬組織

Research Abstract

超高齢化社会の到来に際し、骨疾患への新たな治療法の開発や再生された骨組織の機能を評価するための新たな評価・診断法の開発が求められている。本研究では、材料工学的手法を駆使し、骨の主要成分である生体アパタイトに注目し、その骨中の密度のみでなく、配向性に代表される結晶学的特徴に注目して、骨機能および再生過程を評価するとともに、各種硬組織健全化のための骨デザインを行なった

Research Products

• [Journal Article] The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis (2009)
  • Author(s): A. Shiraishi, S. Miyabe, T. Nakano, Y. Umakoshi, M. Ito and M. Mihara
  • Journal Title: BMC Musculoskeletal Disorders (in press)
• [Journal Article] Regenerative behavior of biomineral/agarose composite gels as bone grafting materials in rat cranial defects, Journal of Biomedical Materials Research (2009)
  • Author(s): Y. Suzawa, T. Funaki, J. Watanabe, S. Iwai, Y. Yura, T. Nakano, Y. Umakoshi, M. Akashi
  • Journal Title: PartA (in press)
• [Journal Article] Changes in Bone Microstructure and Toughness during Healing Process of Long Bone (2009)
  • Author(s): T. Ishimoto, T. Nakano, et al.
  • Journal Title: Journal of Physics ; conference series (in press)
  • Peer Reviewed
• [Journal Article] Preferential Orientation of Biological Apatite in Normal and Osteoporotic Human Vertebral Trabeculae (2009)
  • Author(s): S. Miyabe T. Nakano, et al.
  • Journal Title: Journal of Physics ; conference series (in press)
  • Peer Reviewed
• [Journal Article] Alendronate treatment promotes bone formation with a less anistropic microstructure during intramembranous ossification in rats (2008)
  • Author(s): M. Kashii, J. Hashimoto, T. Nakano, Y. Umakoshi and H. Yoshikawa
  • Journal Title: Journal of Bone and Mineral Metabolism 26 Pages: 24-33
• [Journal Article] Peculiar elastic behavior of Ti-Nb-Ta-Zr single crystals (2008)
  • Author(s): M. Tane, S. Akita, T Nakano, K. Hagihara, Y. Umakoshi, M. Niinomi, and H. Nakajima
  • Journal Title: Acta Materialia Vol.56 Pages: 2856-2863
• [Journal Article] 透過型光学系を有する微小領域X線回折法によるヒト海綿骨内生体アパタイト配向性の2次元定量解析 (2008)
  • Author(s): 宮部さやか, 中野貴由, 石本卓也, 高野直樹, 安達泰治, 岩城啓好, 小林章郎, 高岡邦夫, 馬越佑吉
  • Journal Title: 日本金属学会誌 72[1] Pages: 57-62
  • NAID: 10020087972
• [Journal Article] New Technique for Evaluation of Preferential Alignment of Biological Apatite (BAp) Crystallites in Bone using Transmission X-ray Diffractometry (2008)
  • Author(s): T. Ishimoto, T. Nakano, et al.
  • Journal Title: Materials Transactions 49 Pages: 2129-2135
  • NAID: 10024272303
  • Peer Reviewed
• [Journal Article] 透過型光学系を有する微小領域X線回折法によるヒト海綿骨内生体アパタイト配向性の2次元定量解析 (2008)
  • Author(s): 宮部さやか、中野貴由、馬越佑吉, ら
  • Journal Title: 日本金属学会誌 72 Pages: 57-62
  • NAID: 10020087972
  • Peer Reviewed
• [Journal Article] Change in material and structural parameters of bone mechanical function during long-bone regenerations (2007)
  • Author(s): T. Ishimoto, T. Nakano, Y. Umakoshi. et.al.
  • Journal Title: Materials Science Forum 118 Pages: 313-315
  • Peer Reviewed
• [Journal Article] Areal distribution of preferential alignment of biological apatite (BAp) crystallite on cross-section of center of femoral diaphysis in osteopetrotic (op/op) mouse (2007)
  • Author(s): Jee-Wook Lee, T.Nakano, Y.Umakoshi
  • Journal Title: Materials Transactions 48[3] Pages: 337-342
  • NAID: 10018734352
• [Journal Article] Role of osteoclast in preferential alignment of biological apatite (BAp) in long bones (2006)
  • Author(s): J.-W.Lee, T.Nakano, S, Toyosawa, N.Ijuhin, Y.Tabata, M, Yamamoto, Y.Umakoshi
  • Journal Title: Materials Science Forum 512 Pages: 265-268
• [Journal Article] Role of stress distribution on healing process of preferential alignment of biological apatite in long bones (2006)
  • Author(s): T.Ishimoto, T.Nakano, Y.Umakoshi, M.Yamamoto, Y.Tabata
  • Journal Title: Materials Science Forum 512 Pages: 261-264
• [Journal Article] Crystallographic approach to regenerated and pathological hard tissue (2006)
  • Author(s): T.Nakano, T.Ishimoto, J.-W.Lee, Y.Umakoshi et al.
  • Journal Title: Materials Science Forum 512 Pages: 255-260
• [Journal Article] Changes of bone quality of cortical bone formed under alendronate treatment were detected by microbeam X-ray diffraction analysis (2006)
  • Author(s): M.Kashii, J.Hashimoto, T.Nakano, Y.Umakoshi, H.Yoshikawa
  • Journal Title: Bone 38[3] Pages: 12-13
• [Journal Article] Evaluation of Bone Quality near Metallic Implants with and without Lotus-Type Pores for Optimal Biomaterial Design (2006)
  • Author(s): T.Nakano, T.Kan, T.Ishimoto, W.Fujitani, Y.Umakoshi et al.
  • Journal Title: Materials Transactions 47[9] Pages: 2233-2239
  • NAID: 10018248776
• [Journal Article] Crystallographic approach to regenerated,pathological hard tissues (2006)
  • Author(s): T.Nakano, T.Ishimoto, J.-W.Lee, Y.Umakoshi et al.
  • Journal Title: Materials Science Forum 512 Pages: 255-260
• [Journal Article] Role of stress distribution on healing_process of preferential alignment of biological apatite in long bones (2006)
  • Author(s): T.Ishimoto, T.Nakano, Y.Umakoshi, M.Yamamoto, Y.Tabata
  • Journal Title: Materials Science Forum 512 Pages: 261-264
• [Journal Article] Role of osteoclast in preferential alignment of biological apatite (BAp) in long bones (2006)
  • Author(s): J.W.Lee, T.Nakano, S.Toyosawa, N.Ijuhin, Y.Tabata, M.Yamamoto, Y.Umakoshi
  • Journal Title: Materials Science Forum 512 Pages: 265-268
• [Journal Article] Effects of extended pore direction and stress shielding on biological apatite texture as bone quality after insertion of metallic implants with and without pores (2006)
  • Author(s): T.Nakano, T.Ishimoto, Y.Ohashi Y.Umakoshi, H.Nakajima et al.
  • Journal Title: Proceedings of MetFoam 2005 (in press)
• [Journal Article] Texture of Biological Apatite Crystallites and the Related Mechanical Function in Regenerated and Pathological Hard Tissues (2005)
  • Author(s): T.Nakano, T.Ishimoto, Y.Umakoshi, Y.Tabata
  • Journal Title: Journal of Hard Tissue Biology 14・2 Pages: 253-254
  • NAID: 110005853549
• [Journal Article] Texture,Bone Reinforcement (2005)
  • Author(s): T.Nakano, Y.Tabata, Y.Umakoshi
  • Journal Title: Encyclopedia of Materials, Science,Technology Updates, (Elsevier, Oxford) Ms2061 Pages: 1-8
• [Presentation] 細胞遊走のための溝構造を有する骨インプラントの骨再生挙動 (2009)
  • Author(s): 川田健太郎, 石本卓也, 中野貴由, 坂井孝司, 吉川秀樹
  • Organizer: 日本金属学会2009年春期講演大会
• [Presentation] Changes in Bone Microstructure and Toughness during Healing Process of Long Bone (2008)
  • Author(s): T. Ishimoto, T. Nakano, Y. Umakoshi, et al.
  • Organizer: International conference of Advanced Structural and Functional Materials Design
  • Place of Presentation: Osaka
  • Year and Date: 2008-11-12
• [Presentation] 生体用β型Ti-Nb-Ta-Zr合金単結晶における疲労変形誘起ω相の形成 (2008)
  • Author(s): 萩原幸司, 中野貴由, 馬越佑吉, 園浦章弘, 新家光雄
  • Organizer: 日本金属学会2008年秋期講演大会
• [Presentation] 一方向性孔導入によるTi3Al単結晶の塑性挙動制御 (2008)
  • Author(s): 佐々木啓太, 中野貴由, 萩原幸司, 馬越佑吉
  • Organizer: 日本金属学会2008年秋期講演大会
• [Presentation] TiAl-PST結晶への異方性孔導入による塑性挙動制御 (2008)
  • Author(s): 橘孝洋, 中野貴由, 萩原幸司, 馬越佑吉
  • Organizer: 日本金属学会2008年秋期講演大会
• [Presentation] ナノテクと材料研究の接点〜転位の振る舞いから骨再生まで〜 (2007)
  • Author(s): 馬越佑吉
  • Organizer: 日本金属学会(村上記念賞受賞講演)
  • Place of Presentation: 岐阜大学
  • Year and Date: 2007-09-19
• [Book] ますます重要になる細胞周辺環境の科学技術-細胞の存在、増殖、機能のコントロールから再生医療まで- (2009)
  • Author(s): 中野貴由, 石本卓也
  • Publisher: (株)メディカル ドゥ(in press)
• [Book] 「変革する大学」シリーズ,(大阪大学工学部工学研究科) (2006)
  • Author(s): 中野貴由
  • Total Pages: 191
  • Publisher: 航空宇宙材料の技術を骨の微細構造研究に応用
• [Book] 材料開発のための顕微鏡法と応用写真集〜海綿骨におけるアパタイト結晶の優先配向 (2006)
  • Author(s): 中野貴由, 石本卓也, 土田裕基, 藤谷渉, 黒越佑吉, 山本敏男
  • Total Pages: 300
  • Publisher: (社)日本金属学会
• [Book] Texture and Bone Reinforcement. In : Encyclopedia of Materials (2005)
  • Author(s): T. Nakano, Y. Tabata, and Y. Umakoshi
  • Publisher: Science and Technology Updates, Elsevier, Oxford
• [Remarks] 馬越佑吉 : 日本金属学会功労賞他、本研究に関連する受賞11件
• [Remarks]
  • URL: http://www.mat.eng.osaka-u.ac.jp/msp6/MSP6-HomeJ.htm
• [Remarks]
  • URL: http://www.mat.eng.osaka-u.ac.jp/mse3/Umakoshi/main-J-F2.htm
• [Patent(Industrial Property Rights)] 硬組織の評価方法 (2007)
  • Inventor(s): 馬越佑吉, ら
  • Industrial Property Rights Holder: 大阪大学総長
  • Acquisition Date: 2007-04-13
• [Patent(Industrial Property Rights)] 配向性の制御装置 (2006)
  • Inventor(s): 馬越佑吉, 中野貴由
  • Industrial Property Number: 2006-180675
  • Filing Date: 2006-06-30