| Budget Amount *help |
¥111,670,000 (Direct Cost: ¥85,900,000、Indirect Cost: ¥25,770,000)
Fiscal Year 2009: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2008: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2007: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2006: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2005: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
|
|---|
| Research Abstract |
Guanosine triphosphatases (GTPases) of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphorylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted its association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation.
|
