| Budget Amount *help |
¥112,710,000 (Direct Cost: ¥86,700,000、Indirect Cost: ¥26,010,000)
Fiscal Year 2009: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2007: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2006: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2005: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
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| Research Abstract |
The neural plate, or the embryonic neural primordium, is the first somatic tissue to develop in vertebrate embryos. Although its development is marked by Sox2 gene activation regardless of the tissue domain, the Sox2 gene itself is regulated by different enhancers of distinct domain specificities. Investigation of this domain-specific regulation indicated that the anterior, medial and posterior portions of the neural plate are individually derived from the epiblast through distinct regulatory mechanisms. Of particular note is that the posterior neural plate arises from a common precursor shared by the paraxial mesoderm, which is a derivative of the posterior epiblast. This fact rules out a classical model that describes the neural primordium as being induced from the ectoderm after its separation from the mesoderm. Further results indicated that SOX2 interacts with POU factors to regulate many genes involved in promoting neural plate development.
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