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Imaging Study of Dynamic Cellular Signaling

Research Project

Project/Area Number 17109003
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

IINO Masamitsu  東大, 医学(系)研究科(研究院), 教授 (50133939)

Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥117,650,000 (Direct Cost: ¥90,500,000、Indirect Cost: ¥27,150,000)
Fiscal Year 2009: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2008: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2007: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2006: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2005: ¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Keywords細胞内情報伝達 / ニューロン・シナプス機能 / シグナル伝達 / 生体分子 / 脳・神経 / 薬理学 / 生理学
Research Abstract

Ca^<2+> makes bones strong but is also a "switch" for cellular functions. We studied the switching mechanism of Ca^<2+> in the brain and other tissues making use of imaging methods to visualize the switching events. We found new Ca^<2+> switch-dependent mechanisms in the following functions. To keep using neural circuit is required for its maintenance. Glial cells support neuron to extend their processes. Thus, the present study shed new light on the functions of the brain.

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (95 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (35 results) (of which Peer Reviewed: 25 results) Presentation (59 results) Remarks (1 results)

  • [Journal Article] Imaging extrasynaptic glutamate dynamics in the brain2010

    • Author(s)
      Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Iinuma, S., Yamasaki, M., Watanabe, M., Hirose, K., Iino, M.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 107

      Pages: 6526-6531

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal switching and cell-to-cell variability in Ca^<2+> release activity in mammalian cells2009

    • Author(s)
      Nakamura, N., Yamazawa, T., Okubo, Y., Iino, M.
    • Journal Title

      Mol.Syst.Biol. 5 : 247

      Pages: 1-10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal switching and cel-to-cell variability in Ca^<2+> release activity in mammalian cells.2009

    • Author(s)
      Nakamura, N.
    • Journal Title

      Mol. Syst. Biol. 5, 247

      Pages: 1-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions2008

    • Author(s)
      Kakizawa, S., Moriguchi, S., Ikeda, A., Iino M., Takeshima, H.
    • Journal Title

      Cerebellum 7

      Pages: 385-391

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of new functions of Ca^<2+> release from intracellular stores in central nervous system2008

    • Author(s)
      Iino, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 369

      Pages: 220-224

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional crosstaIk between cell-surface and intracellular channels mediated by junotophilins essential for neuronal functions.2008

    • Author(s)
      Kakizawa, S.
    • Journal Title

      Cerebellum 7

      Pages: 385-391

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of new functions of Ca^<2+> release from intrace‖ular stores in central nervous system2008

    • Author(s)
      Iino, M
    • Journal Title

      Biochem. Biophys. Res. Commun. 369

      Pages: 220-224

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer2008

    • Author(s)
      Yogo, T.
    • Journal Title

      Proc.NatAcad.Sci.U.S.A 105

      Pages: 28-32

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of neurite growth by spontaneous Ca^<2+> oscillations in astrocytes2007

    • Author(s)
      Kanemaru, K, Okubo, Y, Hirose, K., Iino M.
    • Journal Title

      J.Neurosci. 27

      Pages: 8957-8966

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells2007

    • Author(s)
      Fujiwara, A., Kakizawa, S., Iino, M.
    • Journal Title

      Neuropharmacology 52

      Pages: 1663-1670

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical glutamate sensor for spatiotemporal analysis of synaptic transmission2007

    • Author(s)
      Namiki, S., Sakamoto, H., Iinuma, S., Iino, M., Hirose, K.
    • Journal Title

      Eur.J.Neurosci. 25

      Pages: 2249-2259

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity2007

    • Author(s)
      Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A, Kondo, H, Kano, M, Watanabe, M, Iino, M., Takeshima, H.
    • Journal Title

      EMBO J. 26

      Pages: 1924-1933

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of longr-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells2007

    • Author(s)
      Uemura, T.
    • Journal Title

      J.Neurosci 27

      Pages: 12096-12108

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells2007

    • Author(s)
      Kamikubo, Y.
    • Journal Title

      J.Physiol 585

      Pages: 549-563

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins2007

    • Author(s)
      Ikeda, A.
    • Journal Title

      Biochem.Biophys.Res.Commun 363

      Pages: 835-839

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression2007

    • Author(s)
      Kina, S.
    • Journal Title

      Neurosci 26

      Pages: 2269-2278

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of neurite growth by spontaneous Ca^<2+>oscillations in astrocytes2007

    • Author(s)
      Kanemaru, K.
    • Journal Title

      J.Neurosci 27

      Pages: 8957-8966

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells2007

    • Author(s)
      Fujiwara, A.
    • Journal Title

      Neuropharmacology 52

      Pages: 1663-1670

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical glutamate sensor for spatiotemporal analysis of synaptic transmission2007

    • Author(s)
      Namiki, S.
    • Journal Title

      Eur.J.Neurosci 25

      Pages: 2249-2259

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity2007

    • Author(s)
      Kakizawa, S.
    • Journal Title

      EMBO J 26

      Pages: 1924-1933

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.2007

    • Author(s)
      Kakizawa, S.
    • Journal Title

      EMBO J. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells.2007

    • Author(s)
      Fujiwara, A.
    • Journal Title

      Neuropharmacology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ca^<2+> lightning conveys cell-cell contact information inside the cells2006

    • Author(s)
      Hashido, M., Hayashi, K., Hirose, K., Iino, M.
    • Journal Title

      EMBO Rep. 7

      Pages: 1117-1123

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postsynaptic inositol 1, 4, 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF2006

    • Author(s)
      Furutani, K., Okubo, Y., Kakizawa, S., Iino, M.
    • Journal Title

      Proc.Nat.Acad.Sci.U.S.A. 103

      Pages: 8528-8533

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+> shuttling between endoplasmic reticulum and mitochondria underlying Ca^<2+> oscillations2006

    • Author(s)
      Ishii, K., Hirose, K., Iino, M.
    • Journal Title

      EMBO Rep. 7

      Pages: 390-396

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+> shuttling between endoplasmic reticulum and mitochondria underlying Ca^<2+> oscillations.2006

    • Author(s)
      Ishii, K.
    • Journal Title

      EMBO Rep. 7

      Pages: 390-396

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF.2006

    • Author(s)
      Furutani, K.
    • Journal Title

      Proc.Nat.Acad.Sci.U.S.A. 103

      Pages: 8528-8533

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ca^<2+> lightning conveys cell-cell contact information inside the cells.2006

    • Author(s)
      Hashido, M.
    • Journal Title

      EMBO Rep. 7

      Pages: 1117-1123

    • Related Report
      2006 Annual Research Report
  • [Journal Article] coupling of STIM1 to store-operated Ca^<2+> entry through its constitutive and inducible movement in the endoplasmic reticulum.2006

    • Author(s)
      Baba, Y.
    • Journal Title

      Proc.Nat.Acad.Sci.U.S.A. 103

      Pages: 16704-16709

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum2005

    • Author(s)
      Namiki, S., Kakizawa, S., Hirose, K., Iino, M.
    • Journal Title

      J.Physiol. 566

      Pages: 849-863

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] BAD detects coincidence of G2/M Phase and growth factor deprivation to regulate apoptosis2005

    • Author(s)
      Hashimoto, A., Hirose, K., Iino, M.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 26225-26232

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Ca^<2+>-dependent increase in oxygen consumption by mitochondria in single mammalian central neurons.2005

    • Author(s)
      Hayakawa Y
    • Journal Title

      Cell Calcium 37

      Pages: 359-370

    • Related Report
      2005 Annual Research Report
  • [Journal Article] BAD detects coincidence of G2/M Phase and growth factor deprivation to regulate apoptosls.2005

    • Author(s)
      Hashimoto, A
    • Journal Title

      J.Biol.Chem. 280

      Pages: 26225-26232

    • Related Report
      2005 Annual Research Report
  • [Journal Article] NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum.2005

    • Author(s)
      Namiki, S.
    • Journal Title

      J.Physlol. 566

      Pages: 849-863

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain.2005

    • Author(s)
      Kakizawa, S.
    • Journal Title

      Proc.Nat.Acad.Sci.U.S.A. 102

      Pages: 19180-19185

    • Related Report
      2005 Annual Research Report
  • [Presentation] NO activation of RyRs in the brain2009

    • Author(s)
      Iino, M.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Waterville Valley Resort, NH, USA
    • Year and Date
      2009-06-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Temporal switching and cel-to-cell variability in Ca^<2+> release activity in mammalian cells2009

    • Author(s)
      Nakamura N.
    • Organizer
      2009 Cold Spring Harbor Laboratory Meeting on Computational Cell Biology
    • Place of Presentation
      Cold Spring Habor Laboratory(New York, USA)
    • Year and Date
      2009-03-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞のスイッチとしてのカルシウム2009

    • Author(s)
      飯野正光
    • Organizer
      第178回 生命科学フォーラム
    • Place of Presentation
      日本プレスセンター(東京都千代田区)
    • Year and Date
      2009-03-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intracellular Ca^<2+> release mechanisms and central nervous system functions2009

    • Author(s)
      Iino, M.
    • Organizer
      4th Japan-China Joint Meeting of Basic and Clinical Pharmacology
    • Place of Presentation
      パシフィコ横浜, 横浜市
    • Year and Date
      2009-03-18
    • Related Report
      2008 Final Research Report
  • [Presentation] lntracellular Ca^<2+> reIease mechanisms and central nervous system functions2009

    • Author(s)
      Iino M.
    • Organizer
      4th Japan-China Joint Meeting of Basic and Clinical Pharmacology
    • Place of Presentation
      Pacifico Yokohama(Yokohama-shi. Kanagawa)
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化2009

    • Author(s)
      大久保洋平
    • Organizer
      第82回 日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜(神奈川県横浜市)
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経突起伸長におけるアストロサイト自発カルシウムオシレーションの役割2009

    • Author(s)
      金丸和典
    • Organizer
      第82回 日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜(神奈川県横浜市)
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大脳皮質感覚野におけるグルタミン酸蛍光イメージング2009

    • Author(s)
      関谷敬
    • Organizer
      第82回 日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜(神奈川県横浜市)
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] リアノジン受容体を介した一酸化窒素によるカルシウム放出機構2009

    • Author(s)
      山澤徳志子
    • Organizer
      第82回 日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜(神奈川県横浜市)
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳類細胞におけるカルシウム放出活性の経時的変化および細胞間不均一性2009

    • Author(s)
      中村直俊
    • Organizer
      第82回 日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜(神奈川県横浜市)
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] バーグマングリアの機能維持におけるイノシトール1,4,5-三リン酸シグナルの役割2009

    • Author(s)
      間下雅士
    • Organizer
      第82回 日本薬理学会年会
    • Place of Presentation
      パシフイコ横浜(神奈川県横浜市)
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] アストロサイトのN-カドヘリン発現を制御する新規因子の機能解析2009

    • Author(s)
      金丸和典
    • Organizer
      生理研究会「神経系の発生/分化/再生に関する研究の新展開」
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2009-03-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳におけるNOシグナル機構2009

    • Author(s)
      飯野正光
    • Organizer
      第21回 蔵王カンファレンス
    • Place of Presentation
      蔵王四季のホテル(山形県山形市)
    • Year and Date
      2009-01-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of neurite growth by spontaneous Ca^<2+> oscillations in astrocytes2008

    • Author(s)
      Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington Convention Center, Wahsington DC, USA
    • Year and Date
      2008-11-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of neurite growth by spontaneous Ca^<2+> oscillations in astrocytes2008

    • Author(s)
      Kanemaru K.
    • Organizer
      Neuroscience2008(北米神経科学会)
    • Place of Presentation
      Convention Center(Washington, DC, USA)
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] In vivo imaging of intercellular messengers released from neurons2008

    • Author(s)
      Sekiya, H., Namiki, S., Sakamoto, H., Sho Iinuma, Hirose, K., Iino, M.
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington Convention Center, Wahsington DC, USA
    • Year and Date
      2008-11-16
    • Related Report
      2008 Final Research Report
  • [Presentation] In vivo imaging of intercellular messengers released from neurons2008

    • Author(s)
      Sekiya H.
    • Organizer
      Neuroscience2008(北米神経科学会)
    • Place of Presentation
      Convention Center(Washington, DC, USA)
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 一酸化窒素(NO)によるCa^<2+>シグナル活性化機構2008

    • Author(s)
      山澤徳志子
    • Organizer
      第119回 日本薬理学会関東部会
    • Place of Presentation
      主婦会館プラザエフ(東京都千代田区)
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] リアノジン受容体を介するカルシウム放出活性の経時的なスイッチングがもたらす細胞間不均一性2008

    • Author(s)
      中村直俊
    • Organizer
      生理学研究所研究会「細胞機能を制御するシグナリング機構の普遍性と特異性」
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化2008

    • Author(s)
      大久保洋平
    • Organizer
      第31回 日本神経科学大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] バーグマングリアの機能維持における神経活動依存的Ca^<2+>シグナルの役割2008

    • Author(s)
      間下雅士
    • Organizer
      第118回日本薬理学会関東部会
    • Place of Presentation
      星薬科大学(東京都品川区)
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional roles of IP_3-induced Ca^<2+> release in the central nervous system2008

    • Author(s)
      Iino, M.
    • Organizer
      Yamagata International Symposium
    • Place of Presentation
      山形テルサ, 山形市
    • Year and Date
      2008-05-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional roIes of IP_3-induced Ca^<2+> rerease in the centraI nervous system2008

    • Author(s)
      Iino M.
    • Organizer
      Yamagata Intermational Symposium
    • Place of Presentation
      Yamagata Terrsa(yamagata-shi, Yamagata)
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] In vivo imaging of intercellular messengers released from neurons2008

    • Author(s)
      関谷敬
    • Organizer
      2008年度国際ワークショップ「多光子励起イメージングの最前線」
    • Place of Presentation
      岡崎カンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] シナプス後膜IP3シグナルによるシナプス前終末機能維持はBDNFを介する2008

    • Author(s)
      柿澤 昌
    • Organizer
      第85回日本生理学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ga^<2+>関連シグナルイメージングによる中枢神経系機能解析2008

    • Author(s)
      飯野 正光
    • Organizer
      特定領域「膜輸送複合体」公開シンポジウム特別講演
    • Place of Presentation
      東京
    • Year and Date
      2008-03-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経活動に引き起こされる脳血流動態の蛍光イメージング2008

    • Author(s)
      関谷 敬
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] リアノジン受容体のカルシウム放出活性の細胞間不均一性2008

    • Author(s)
      中村 直俊
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化2008

    • Author(s)
      大久保 洋平
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 小胞体膜上Ca2+センサー蛋白質STIM1の微小管による輸送2008

    • Author(s)
      林 健二
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] バーグマングリアの機能維持におけるイノシトール1,4,5-三リン酸シグナルの役割2008

    • Author(s)
      間下 雅士
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経活動に引き起こされる脳血流動態の蛍光イメージング2007

    • Author(s)
      関谷 敬
    • Organizer
      第17回日本循環薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of Neurite Growth by Spontaneous Ca^<2+> Oscillations in Astrocytes2007

    • Author(s)
      Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2007-11-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of Neurite Growth by Spontaneous Ca^<2+>Oscillations in Astrocytes.2007

    • Author(s)
      Kanemaru, K.
    • Organizer
      The 37th Annuai Meeting of the Society for Neuroscience
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for cerebellar long-term depression2007

    • Author(s)
      Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, K., Kano, M., Watanabe, M., Iino, M., Takeshima, H.
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2007-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channelsessential for oerebellar longterm depression.2007

    • Author(s)
      Kakizawa, S.
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経突起伸長におけるアストロサイト自発的Ca2+^オシレーションの役割2007

    • Author(s)
      金丸 和典
    • Organizer
      第117回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化2007

    • Author(s)
      大久保 洋平
    • Organizer
      生理研研究会「細胞機能を制御するシグナリング機構の普遍性と特異性」
    • Place of Presentation
      岡崎
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化2007

    • Author(s)
      大久保 洋平
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of IP_3-induced Ca^<2+> release in the regulation of synaptic functions and neuron-glia interactions2007

    • Author(s)
      Iino, M.
    • Organizer
      統合脳シンポジウム
    • Place of Presentation
      北海道厚生年金会館, 札幌
    • Year and Date
      2007-08-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Roles of IP3-induced Ca^<2+>release in the regulation of synaptic functions and neuron-gliainteraCtions.2007

    • Author(s)
      Iino, M.
    • Organizer
      統合脳国際シンポジウム
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-08-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ca^<2+>lightning conveys cell-cell contact information inside the celis.2007

    • Author(s)
      Hayashi, K.
    • Organizer
      The 5th Korea-Japan Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      慶州(韓国)
    • Year and Date
      2007-07-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] リアノジン受容体の機能的発現のスイッチング2007

    • Author(s)
      中村 直俊
    • Organizer
      第49回日本平滑筋学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2007-07-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] カルシウムシグナルによる細胞機能のスイッチング機構2007

    • Author(s)
      飯野 正光
    • Organizer
      HRC研究会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] カルシウムシグナルによる細胞機能のスイッチング基本メ力ニズムの解明から未知機能の探索まで2007

    • Author(s)
      飯野 正光
    • Organizer
      奈良医学会
    • Place of Presentation
      橿原
    • Year and Date
      2007-06-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 小胞体上におけるSTIMIの運動性がストア作動性力ルシウム流入に関与している2007

    • Author(s)
      林 健二
    • Organizer
      第116回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞のスイッチとしてのカルシウムー平滑筋収縮から転写制御、神経成長まで-2007

    • Author(s)
      飯野 正光
    • Organizer
      関東心血管フォーラム
    • Place of Presentation
      軽井沢
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Visualzation of cerebrovascular movement by two-photon microscopy2007

    • Author(s)
      Sekiya, H., Okubo, Y., Iino, M.
    • Organizer
      The 5th US/Japan Workshop on Molecular and Cellular Aspects of Vascular Smooth Muscle Function
    • Place of Presentation
      Outrigger Keahou Beach Resort, Hawaii, USA
    • Year and Date
      2007-01-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Synaptic maintenance by activity dependent IP_3-Ca^<2+> signaling in cerebellar Purkinje cells2006

    • Author(s)
      Iino, M.
    • Organizer
      FAOPS 2006 (The 6th Congress of the Federation of Asian and Oseanian Physiological Societies)
    • Place of Presentation
      JW Marriott Hotel, Seoul, Korea
    • Year and Date
      2006-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization of Glutamate Spillover from Synaptic Clefts Using a Novel Fluorescent Glutamate Indicator2006

    • Author(s)
      Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Sho Iinuma, Hirose, K., Iino, M.
    • Organizer
      The 36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Georgia World Congress Center, Atlanta, USA
    • Year and Date
      2006-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell signaling downstream of cell-cell contact2006

    • Author(s)
      Iino, M.
    • Organizer
      FAOPS 2006 (The 6th Congress of the Federation of Asian and Oseanian Physiological Societies
    • Place of Presentation
      JW Marriott Hotel, Seoul, Korea
    • Year and Date
      2006-10-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Spontaneous Ca^<2+> signals in astrocytes promote neurite outgrowth2006

    • Author(s)
      Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
    • Organizer
      The 36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Georgia World Congress Center, Atlanta, USA
    • Year and Date
      2006-10-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Metabotropic glutamate receptor-mediated postsynaptic inositol 1, 4, 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF2006

    • Author(s)
      Furutani, K., Okubo, Y., Kakizawa, S., Iino, M.
    • Organizer
      5th Forum of European Neuroscience
    • Place of Presentation
      Austria Center Vienna, Vienna, Austria
    • Year and Date
      2006-07-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization of nitric oxide signaling inducing input-specific and frequency-dependent long-term potentiation of parallel-fiber-Purkinje cell synapses in the mouse cerebellum2006

    • Author(s)
      Kakizawa S., Namiki, S., Hirose, K., Iino M.
    • Organizer
      5th Forum of European Neuroscience
    • Place of Presentation
      Austria Center Vienna, Vienna, Austria
    • Year and Date
      2006-07-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanisms of IP_3 receptor-mediated Ca^<2+> oscillations2006

    • Author(s)
      Iino, M.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Colby-Sawyer College, New London, USA
    • Year and Date
      2006-06-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Spontaneous Ca^<2+> transients in astrocytes promote neurite outgrowth2005

    • Author(s)
      Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
    • Organizer
      The 35th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington Convention Center, Wahington D. C., USA
    • Year and Date
      2005-11-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Visualization of nitric oxide signaling inducing input-specific and frequency-dependent long-term potentiation in the mouse cerebellum2005

    • Author(s)
      Kakizawa, S., Namiki, S., Hirose, K., Iino, M.
    • Organizer
      The 35th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington Convention Center, Wahington D. C., USA
    • Year and Date
      2005-11-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Maintenance of presynaptic function of cerebellar parallel fiber-Purkinje cell synapses by metabotropic glutamate receptor-mediated postsynaptic activity2005

    • Author(s)
      Furutani, K., Okubo, Y., Kakizawa, S., Iino, M.
    • Organizer
      The 35th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington Convention Center, Wahington D. C., USA
    • Year and Date
      2005-11-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of cell function by Ca^<2+> oscillation2005

    • Author(s)
      Iino, M.
    • Organizer
      International Symposium Celebrating 40th Anniversary of Troponin Discovery
    • Place of Presentation
      岡崎コンファレンスセンター, 岡崎市
    • Year and Date
      2005-10-27
    • Related Report
      2008 Final Research Report
  • [Remarks] 新聞掲載 : 朝日新聞2006年5月25日夕刊「勘が鈍る」科学で立証

    • URL

      http://calcium.cmp.m.u-tokyo.ac.jp/

    • Related Report
      2008 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2017-05-19  

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