Imaging Study of Dynamic Cellular Signaling

• Project/Area Number: 17109003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: The University of Tokyo
• Principal Investigator: IINO Masamitsu 東大, 医学(系)研究科(研究院), 教授 (50133939)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥117,650,000 (Direct Cost: ¥90,500,000、Indirect Cost: ¥27,150,000); Fiscal Year 2009: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2008: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2007: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2006: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2005: ¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
• Keywords: 細胞内情報伝達 / ニューロン・シナプス機能 / シグナル伝達 / 生体分子 / 脳・神経 / 薬理学 / 生理学

Research Abstract

Ca^<2+> makes bones strong but is also a "switch" for cellular functions. We studied the switching mechanism of Ca^<2+> in the brain and other tissues making use of imaging methods to visualize the switching events. We found new Ca^<2+> switch-dependent mechanisms in the following functions. To keep using neural circuit is required for its maintenance. Glial cells support neuron to extend their processes. Thus, the present study shed new light on the functions of the brain.

Research Products

• [Journal Article] Imaging extrasynaptic glutamate dynamics in the brain (2010)
  • Author(s): Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Iinuma, S., Yamasaki, M., Watanabe, M., Hirose, K., Iino, M.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 107 Pages: 6526-6531
  • Peer Reviewed
• [Journal Article] Temporal switching and cell-to-cell variability in Ca^<2+> release activity in mammalian cells (2009)
  • Author(s): Nakamura, N., Yamazawa, T., Okubo, Y., Iino, M.
  • Journal Title: Mol.Syst.Biol. 5 : 247 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Temporal switching and cel-to-cell variability in Ca^<2+> release activity in mammalian cells. (2009)
  • Author(s): Nakamura, N.
  • Journal Title: Mol. Syst. Biol. 5, 247 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions (2008)
  • Author(s): Kakizawa, S., Moriguchi, S., Ikeda, A., Iino M., Takeshima, H.
  • Journal Title: Cerebellum 7 Pages: 385-391
  • Peer Reviewed
• [Journal Article] Identification of new functions of Ca^<2+> release from intracellular stores in central nervous system (2008)
  • Author(s): Iino, M.
  • Journal Title: Biochem.Biophys.Res.Commun. 369 Pages: 220-224
  • Peer Reviewed
• [Journal Article] Functional crosstaIk between cell-surface and intracellular channels mediated by junotophilins essential for neuronal functions. (2008)
  • Author(s): Kakizawa, S.
  • Journal Title: Cerebellum 7 Pages: 385-391
  • Peer Reviewed
• [Journal Article] Identification of new functions of Ca^<2+> release from intrace‖ular stores in central nervous system (2008)
  • Author(s): Iino, M
  • Journal Title: Biochem. Biophys. Res. Commun. 369 Pages: 220-224
  • Peer Reviewed
• [Journal Article] Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer (2008)
  • Author(s): Yogo, T.
  • Journal Title: Proc.NatAcad.Sci.U.S.A 105 Pages: 28-32
  • Peer Reviewed
• [Journal Article] Regulation of neurite growth by spontaneous Ca^<2+> oscillations in astrocytes (2007)
  • Author(s): Kanemaru, K, Okubo, Y, Hirose, K., Iino M.
  • Journal Title: J.Neurosci. 27 Pages: 8957-8966
  • Peer Reviewed
• [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells (2007)
  • Author(s): Fujiwara, A., Kakizawa, S., Iino, M.
  • Journal Title: Neuropharmacology 52 Pages: 1663-1670
  • Peer Reviewed
• [Journal Article] Optical glutamate sensor for spatiotemporal analysis of synaptic transmission (2007)
  • Author(s): Namiki, S., Sakamoto, H., Iinuma, S., Iino, M., Hirose, K.
  • Journal Title: Eur.J.Neurosci. 25 Pages: 2249-2259
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A, Kondo, H, Kano, M, Watanabe, M, Iino, M., Takeshima, H.
  • Journal Title: EMBO J. 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Regulation of longr-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells (2007)
  • Author(s): Uemura, T.
  • Journal Title: J.Neurosci 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells (2007)
  • Author(s): Kamikubo, Y.
  • Journal Title: J.Physiol 585 Pages: 549-563
  • Peer Reviewed
• [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins (2007)
  • Author(s): Ikeda, A.
  • Journal Title: Biochem.Biophys.Res.Commun 363 Pages: 835-839
  • Peer Reviewed
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression (2007)
  • Author(s): Kina, S.
  • Journal Title: Neurosci 26 Pages: 2269-2278
  • Peer Reviewed
• [Journal Article] Regulation of neurite growth by spontaneous Ca^<2+>oscillations in astrocytes (2007)
  • Author(s): Kanemaru, K.
  • Journal Title: J.Neurosci 27 Pages: 8957-8966
  • Peer Reviewed
• [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells (2007)
  • Author(s): Fujiwara, A.
  • Journal Title: Neuropharmacology 52 Pages: 1663-1670
  • Peer Reviewed
• [Journal Article] Optical glutamate sensor for spatiotemporal analysis of synaptic transmission (2007)
  • Author(s): Namiki, S.
  • Journal Title: Eur.J.Neurosci 25 Pages: 2249-2259
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity (2007)
  • Author(s): Kakizawa, S.
  • Journal Title: EMBO J 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Kakizawa, S.
  • Journal Title: EMBO J. (in press)
• [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells. (2007)
  • Author(s): Fujiwara, A.
  • Journal Title: Neuropharmacology (in press)
• [Journal Article] Ca^<2+> lightning conveys cell-cell contact information inside the cells (2006)
  • Author(s): Hashido, M., Hayashi, K., Hirose, K., Iino, M.
  • Journal Title: EMBO Rep. 7 Pages: 1117-1123
  • Peer Reviewed
• [Journal Article] Postsynaptic inositol 1, 4, 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF (2006)
  • Author(s): Furutani, K., Okubo, Y., Kakizawa, S., Iino, M.
  • Journal Title: Proc.Nat.Acad.Sci.U.S.A. 103 Pages: 8528-8533
  • Peer Reviewed
• [Journal Article] Ca^<2+> shuttling between endoplasmic reticulum and mitochondria underlying Ca^<2+> oscillations (2006)
  • Author(s): Ishii, K., Hirose, K., Iino, M.
  • Journal Title: EMBO Rep. 7 Pages: 390-396
  • Peer Reviewed
• [Journal Article] Ca^<2+> shuttling between endoplasmic reticulum and mitochondria underlying Ca^<2+> oscillations. (2006)
  • Author(s): Ishii, K.
  • Journal Title: EMBO Rep. 7 Pages: 390-396
• [Journal Article] Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. (2006)
  • Author(s): Furutani, K.
  • Journal Title: Proc.Nat.Acad.Sci.U.S.A. 103 Pages: 8528-8533
• [Journal Article] Ca^<2+> lightning conveys cell-cell contact information inside the cells. (2006)
  • Author(s): Hashido, M.
  • Journal Title: EMBO Rep. 7 Pages: 1117-1123
• [Journal Article] coupling of STIM1 to store-operated Ca^<2+> entry through its constitutive and inducible movement in the endoplasmic reticulum. (2006)
  • Author(s): Baba, Y.
  • Journal Title: Proc.Nat.Acad.Sci.U.S.A. 103 Pages: 16704-16709
• [Journal Article] NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum (2005)
  • Author(s): Namiki, S., Kakizawa, S., Hirose, K., Iino, M.
  • Journal Title: J.Physiol. 566 Pages: 849-863
  • Peer Reviewed
• [Journal Article] BAD detects coincidence of G2/M Phase and growth factor deprivation to regulate apoptosis (2005)
  • Author(s): Hashimoto, A., Hirose, K., Iino, M.
  • Journal Title: J.Biol.Chem. 280 Pages: 26225-26232
  • Peer Reviewed
• [Journal Article] Rapid Ca^<2+>-dependent increase in oxygen consumption by mitochondria in single mammalian central neurons. (2005)
  • Author(s): Hayakawa Y
  • Journal Title: Cell Calcium 37 Pages: 359-370
• [Journal Article] BAD detects coincidence of G2/M Phase and growth factor deprivation to regulate apoptosls. (2005)
  • Author(s): Hashimoto, A
  • Journal Title: J.Biol.Chem. 280 Pages: 26225-26232
• [Journal Article] NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum. (2005)
  • Author(s): Namiki, S.
  • Journal Title: J.Physlol. 566 Pages: 849-863
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa, S.
  • Journal Title: Proc.Nat.Acad.Sci.U.S.A. 102 Pages: 19180-19185
• [Presentation] NO activation of RyRs in the brain (2009)
  • Author(s): Iino, M.
  • Organizer: Gordon Research Conference
  • Place of Presentation: Waterville Valley Resort, NH, USA
  • Year and Date: 2009-06-16
• [Presentation] Temporal switching and cel-to-cell variability in Ca^<2+> release activity in mammalian cells (2009)
  • Author(s): Nakamura N.
  • Organizer: 2009 Cold Spring Harbor Laboratory Meeting on Computational Cell Biology
  • Place of Presentation: Cold Spring Habor Laboratory(New York, USA)
  • Year and Date: 2009-03-25
• [Presentation] 細胞のスイッチとしてのカルシウム (2009)
  • Author(s): 飯野正光
  • Organizer: 第178回 生命科学フォーラム
  • Place of Presentation: 日本プレスセンター(東京都千代田区)
  • Year and Date: 2009-03-25
• [Presentation] Intracellular Ca^<2+> release mechanisms and central nervous system functions (2009)
  • Author(s): Iino, M.
  • Organizer: 4th Japan-China Joint Meeting of Basic and Clinical Pharmacology
  • Place of Presentation: パシフィコ横浜, 横浜市
  • Year and Date: 2009-03-18
• [Presentation] lntracellular Ca^<2+> reIease mechanisms and central nervous system functions (2009)
  • Author(s): Iino M.
  • Organizer: 4th Japan-China Joint Meeting of Basic and Clinical Pharmacology
  • Place of Presentation: Pacifico Yokohama(Yokohama-shi. Kanagawa)
  • Year and Date: 2009-03-18
• [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化 (2009)
  • Author(s): 大久保洋平
  • Organizer: 第82回 日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2009-03-18
• [Presentation] 神経突起伸長におけるアストロサイト自発カルシウムオシレーションの役割 (2009)
  • Author(s): 金丸和典
  • Organizer: 第82回 日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2009-03-18
• [Presentation] 大脳皮質感覚野におけるグルタミン酸蛍光イメージング (2009)
  • Author(s): 関谷敬
  • Organizer: 第82回 日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2009-03-18
• [Presentation] リアノジン受容体を介した一酸化窒素によるカルシウム放出機構 (2009)
  • Author(s): 山澤徳志子
  • Organizer: 第82回 日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2009-03-17
• [Presentation] 哺乳類細胞におけるカルシウム放出活性の経時的変化および細胞間不均一性 (2009)
  • Author(s): 中村直俊
  • Organizer: 第82回 日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2009-03-16
• [Presentation] バーグマングリアの機能維持におけるイノシトール1,4,5-三リン酸シグナルの役割 (2009)
  • Author(s): 間下雅士
  • Organizer: 第82回 日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(神奈川県横浜市)
  • Year and Date: 2009-03-16
• [Presentation] アストロサイトのN-カドヘリン発現を制御する新規因子の機能解析 (2009)
  • Author(s): 金丸和典
  • Organizer: 生理研究会「神経系の発生/分化/再生に関する研究の新展開」
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県岡崎市)
  • Year and Date: 2009-03-13
• [Presentation] 脳におけるNOシグナル機構 (2009)
  • Author(s): 飯野正光
  • Organizer: 第21回 蔵王カンファレンス
  • Place of Presentation: 蔵王四季のホテル(山形県山形市)
  • Year and Date: 2009-01-29
• [Presentation] Regulation of neurite growth by spontaneous Ca^<2+> oscillations in astrocytes (2008)
  • Author(s): Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington Convention Center, Wahsington DC, USA
  • Year and Date: 2008-11-17
• [Presentation] Regulation of neurite growth by spontaneous Ca^<2+> oscillations in astrocytes (2008)
  • Author(s): Kanemaru K.
  • Organizer: Neuroscience2008(北米神経科学会)
  • Place of Presentation: Convention Center(Washington, DC, USA)
  • Year and Date: 2008-11-17
• [Presentation] In vivo imaging of intercellular messengers released from neurons (2008)
  • Author(s): Sekiya, H., Namiki, S., Sakamoto, H., Sho Iinuma, Hirose, K., Iino, M.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington Convention Center, Wahsington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] In vivo imaging of intercellular messengers released from neurons (2008)
  • Author(s): Sekiya H.
  • Organizer: Neuroscience2008(北米神経科学会)
  • Place of Presentation: Convention Center(Washington, DC, USA)
  • Year and Date: 2008-11-16
• [Presentation] 一酸化窒素(NO)によるCa^<2+>シグナル活性化機構 (2008)
  • Author(s): 山澤徳志子
  • Organizer: 第119回 日本薬理学会関東部会
  • Place of Presentation: 主婦会館プラザエフ(東京都千代田区)
  • Year and Date: 2008-10-04
• [Presentation] リアノジン受容体を介するカルシウム放出活性の経時的なスイッチングがもたらす細胞間不均一性 (2008)
  • Author(s): 中村直俊
  • Organizer: 生理学研究所研究会「細胞機能を制御するシグナリング機構の普遍性と特異性」
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県岡崎市)
  • Year and Date: 2008-10-03
• [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化 (2008)
  • Author(s): 大久保洋平
  • Organizer: 第31回 日本神経科学大会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2008-07-09
• [Presentation] バーグマングリアの機能維持における神経活動依存的Ca^<2+>シグナルの役割 (2008)
  • Author(s): 間下雅士
  • Organizer: 第118回日本薬理学会関東部会
  • Place of Presentation: 星薬科大学(東京都品川区)
  • Year and Date: 2008-06-07
• [Presentation] Functional roles of IP_3-induced Ca^<2+> release in the central nervous system (2008)
  • Author(s): Iino, M.
  • Organizer: Yamagata International Symposium
  • Place of Presentation: 山形テルサ, 山形市
  • Year and Date: 2008-05-24
• [Presentation] Functional roIes of IP_3-induced Ca^<2+> rerease in the centraI nervous system (2008)
  • Author(s): Iino M.
  • Organizer: Yamagata Intermational Symposium
  • Place of Presentation: Yamagata Terrsa(yamagata-shi, Yamagata)
  • Year and Date: 2008-05-23
• [Presentation] In vivo imaging of intercellular messengers released from neurons (2008)
  • Author(s): 関谷敬
  • Organizer: 2008年度国際ワークショップ「多光子励起イメージングの最前線」
  • Place of Presentation: 岡崎カンファレンスセンター(愛知県岡崎市)
  • Year and Date: 2008-04-18
• [Presentation] シナプス後膜IP3シグナルによるシナプス前終末機能維持はBDNFを介する (2008)
  • Author(s): 柿澤 昌
  • Organizer: 第85回日本生理学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] Ga^<2+>関連シグナルイメージングによる中枢神経系機能解析 (2008)
  • Author(s): 飯野 正光
  • Organizer: 特定領域「膜輸送複合体」公開シンポジウム特別講演
  • Place of Presentation: 東京
  • Year and Date: 2008-03-22
• [Presentation] 神経活動に引き起こされる脳血流動態の蛍光イメージング (2008)
  • Author(s): 関谷 敬
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-19
• [Presentation] リアノジン受容体のカルシウム放出活性の細胞間不均一性 (2008)
  • Author(s): 中村 直俊
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化 (2008)
  • Author(s): 大久保 洋平
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] 小胞体膜上Ca2+センサー蛋白質STIM1の微小管による輸送 (2008)
  • Author(s): 林 健二
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] バーグマングリアの機能維持におけるイノシトール1,4,5-三リン酸シグナルの役割 (2008)
  • Author(s): 間下 雅士
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] 神経活動に引き起こされる脳血流動態の蛍光イメージング (2007)
  • Author(s): 関谷 敬
  • Organizer: 第17回日本循環薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-30
• [Presentation] Regulation of Neurite Growth by Spontaneous Ca^<2+> Oscillations in Astrocytes (2007)
  • Author(s): Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2007-11-05
• [Presentation] Regulation of Neurite Growth by Spontaneous Ca^<2+>Oscillations in Astrocytes. (2007)
  • Author(s): Kanemaru, K.
  • Organizer: The 37th Annuai Meeting of the Society for Neuroscience
  • Place of Presentation: サンディエゴ
  • Year and Date: 2007-11-05
• [Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for cerebellar long-term depression (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, K., Kano, M., Watanabe, M., Iino, M., Takeshima, H.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2007-11-03
• [Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channelsessential for oerebellar longterm depression. (2007)
  • Author(s): Kakizawa, S.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: サンディエゴ
  • Year and Date: 2007-11-03
• [Presentation] 神経突起伸長におけるアストロサイト自発的Ca2+^オシレーションの役割 (2007)
  • Author(s): 金丸 和典
  • Organizer: 第117回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
• [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化 (2007)
  • Author(s): 大久保 洋平
  • Organizer: 生理研研究会「細胞機能を制御するシグナリング機構の普遍性と特異性」
  • Place of Presentation: 岡崎
  • Year and Date: 2007-10-04
• [Presentation] 蛍光グルタミン酸指示分子を用いたシナプス間隙からのグルタミン酸漏出の可視化 (2007)
  • Author(s): 大久保 洋平
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] Roles of IP_3-induced Ca^<2+> release in the regulation of synaptic functions and neuron-glia interactions (2007)
  • Author(s): Iino, M.
  • Organizer: 統合脳シンポジウム
  • Place of Presentation: 北海道厚生年金会館, 札幌
  • Year and Date: 2007-08-22
• [Presentation] Roles of IP3-induced Ca^<2+>release in the regulation of synaptic functions and neuron-gliainteraCtions. (2007)
  • Author(s): Iino, M.
  • Organizer: 統合脳国際シンポジウム
  • Place of Presentation: Sapporo
  • Year and Date: 2007-08-22
• [Presentation] Ca^<2+>lightning conveys cell-cell contact information inside the celis. (2007)
  • Author(s): Hayashi, K.
  • Organizer: The 5th Korea-Japan Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: 慶州(韓国)
  • Year and Date: 2007-07-10
• [Presentation] リアノジン受容体の機能的発現のスイッチング (2007)
  • Author(s): 中村 直俊
  • Organizer: 第49回日本平滑筋学会総会
  • Place of Presentation: 奈良
  • Year and Date: 2007-07-05
• [Presentation] カルシウムシグナルによる細胞機能のスイッチング機構 (2007)
  • Author(s): 飯野 正光
  • Organizer: HRC研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-06-29
• [Presentation] カルシウムシグナルによる細胞機能のスイッチング基本メ力ニズムの解明から未知機能の探索まで (2007)
  • Author(s): 飯野 正光
  • Organizer: 奈良医学会
  • Place of Presentation: 橿原
  • Year and Date: 2007-06-12
• [Presentation] 小胞体上におけるSTIMIの運動性がストア作動性力ルシウム流入に関与している (2007)
  • Author(s): 林 健二
  • Organizer: 第116回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-02
• [Presentation] 細胞のスイッチとしてのカルシウムー平滑筋収縮から転写制御、神経成長まで- (2007)
  • Author(s): 飯野 正光
  • Organizer: 関東心血管フォーラム
  • Place of Presentation: 軽井沢
  • Year and Date: 2007-05-19
• [Presentation] Visualzation of cerebrovascular movement by two-photon microscopy (2007)
  • Author(s): Sekiya, H., Okubo, Y., Iino, M.
  • Organizer: The 5th US/Japan Workshop on Molecular and Cellular Aspects of Vascular Smooth Muscle Function
  • Place of Presentation: Outrigger Keahou Beach Resort, Hawaii, USA
  • Year and Date: 2007-01-09
• [Presentation] Synaptic maintenance by activity dependent IP_3-Ca^<2+> signaling in cerebellar Purkinje cells (2006)
  • Author(s): Iino, M.
  • Organizer: FAOPS 2006 (The 6th Congress of the Federation of Asian and Oseanian Physiological Societies)
  • Place of Presentation: JW Marriott Hotel, Seoul, Korea
  • Year and Date: 2006-10-18
• [Presentation] Visualization of Glutamate Spillover from Synaptic Clefts Using a Novel Fluorescent Glutamate Indicator (2006)
  • Author(s): Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Sho Iinuma, Hirose, K., Iino, M.
  • Organizer: The 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Georgia World Congress Center, Atlanta, USA
  • Year and Date: 2006-10-18
• [Presentation] Cell signaling downstream of cell-cell contact (2006)
  • Author(s): Iino, M.
  • Organizer: FAOPS 2006 (The 6th Congress of the Federation of Asian and Oseanian Physiological Societies
  • Place of Presentation: JW Marriott Hotel, Seoul, Korea
  • Year and Date: 2006-10-17
• [Presentation] Spontaneous Ca^<2+> signals in astrocytes promote neurite outgrowth (2006)
  • Author(s): Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
  • Organizer: The 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Georgia World Congress Center, Atlanta, USA
  • Year and Date: 2006-10-17
• [Presentation] Metabotropic glutamate receptor-mediated postsynaptic inositol 1, 4, 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF (2006)
  • Author(s): Furutani, K., Okubo, Y., Kakizawa, S., Iino, M.
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Austria Center Vienna, Vienna, Austria
  • Year and Date: 2006-07-09
• [Presentation] Visualization of nitric oxide signaling inducing input-specific and frequency-dependent long-term potentiation of parallel-fiber-Purkinje cell synapses in the mouse cerebellum (2006)
  • Author(s): Kakizawa S., Namiki, S., Hirose, K., Iino M.
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Austria Center Vienna, Vienna, Austria
  • Year and Date: 2006-07-09
• [Presentation] Mechanisms of IP_3 receptor-mediated Ca^<2+> oscillations (2006)
  • Author(s): Iino, M.
  • Organizer: Gordon Research Conference
  • Place of Presentation: Colby-Sawyer College, New London, USA
  • Year and Date: 2006-06-07
• [Presentation] Spontaneous Ca^<2+> transients in astrocytes promote neurite outgrowth (2005)
  • Author(s): Kanemaru, K., Okubo, Y., Hirose, K., Iino, M.
  • Organizer: The 35th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington Convention Center, Wahington D. C., USA
  • Year and Date: 2005-11-14
• [Presentation] Visualization of nitric oxide signaling inducing input-specific and frequency-dependent long-term potentiation in the mouse cerebellum (2005)
  • Author(s): Kakizawa, S., Namiki, S., Hirose, K., Iino, M.
  • Organizer: The 35th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington Convention Center, Wahington D. C., USA
  • Year and Date: 2005-11-14
• [Presentation] Maintenance of presynaptic function of cerebellar parallel fiber-Purkinje cell synapses by metabotropic glutamate receptor-mediated postsynaptic activity (2005)
  • Author(s): Furutani, K., Okubo, Y., Kakizawa, S., Iino, M.
  • Organizer: The 35th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington Convention Center, Wahington D. C., USA
  • Year and Date: 2005-11-12
• [Presentation] Regulation of cell function by Ca^<2+> oscillation (2005)
  • Author(s): Iino, M.
  • Organizer: International Symposium Celebrating 40th Anniversary of Troponin Discovery
  • Place of Presentation: 岡崎コンファレンスセンター, 岡崎市
  • Year and Date: 2005-10-27
• [Remarks] 新聞掲載 : 朝日新聞2006年5月25日夕刊「勘が鈍る」科学で立証
  • URL: http://calcium.cmp.m.u-tokyo.ac.jp/