|Budget Amount *help
¥113,490,000 (Direct Cost: ¥87,300,000、Indirect Cost: ¥26,190,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2008: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2007: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2006: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2005: ¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000)
Nucleotide excision repair (NER) is a versatile DNA repair system that removes a wide range of DNA lesions including UV-damage and oxidative DNA damage. The importance of NER is indicated by the study of xeroderma pigmentosum patients who show a high incidence of skin cancer and neurological abnormalities, and are deficient in NER. Transcription-blocking DNA damage in active genes is repaired by transcription-coupled NER (TCR). There are two autosomal recessive disorders that are specifically deficient in TCR : Cockayne syndrome (CS) and UV-sensitive syndrome (UV^sS). CS is characterized by photosensitivity and abnormal physical and neurological development. On the other hand, UV^sS patients show photosensitivity and mild freckling with no skin tumors. In this study, molecular mechanism of TCR and molecular pathogenesis of XP, CS and UV^sS have been analyzed.