| Co-Investigator(Kenkyū-buntansha) |
SHINOMURA Yasuhisa 札幌医科大学, 医学部, 教授 (90162619)
TOYOTA Minoru 札幌医科大学, 医学部, 教授 (70270676)
YAMAMOTO Hiroyuki 札幌医科大学, 医学部, 講師 (40332910)
ARIMURA Yoshiaki 札幌医科大学, 医学部, 講師 (80305218)
SUZUKI Hiromu 札幌医科大学, 医学部, 助教 (20381254)
遠藤 高夫 札幌医科大学, 医学部, 助教授 (40191928)
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| Budget Amount *help |
¥110,760,000 (Direct Cost: ¥85,200,000、Indirect Cost: ¥25,560,000)
Fiscal Year 2009: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2008: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2007: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2006: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Fiscal Year 2005: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
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| Research Abstract |
Molecular mechanisms how this epigenetic alterations contribute to development of tumors remains to be determined. DNA methylation also leads to silencing of genes involved in cell signaling, which in turn leads to dysregulation of the oncogenic signaling such as Ras, WNT, and microRNA. We found that epigenetic inactivation of IGFBP7 plays a critical role in escaping senescence in CIMP positive colorectal cancers. We also found that epigenetic information can be used to detect cancer cells from colorectal mucosal solution.
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