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Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy

Research Project

Project/Area Number 17109008
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

IMAI Kohzoh  Sapporo Medical University, 学長 (60117603)

Co-Investigator(Kenkyū-buntansha) SHINOMURA Yasuhisa  札幌医科大学, 医学部, 教授 (90162619)
TOYOTA Minoru  札幌医科大学, 医学部, 教授 (70270676)
YAMAMOTO Hiroyuki  札幌医科大学, 医学部, 講師 (40332910)
ARIMURA Yoshiaki  札幌医科大学, 医学部, 講師 (80305218)
SUZUKI Hiromu  札幌医科大学, 医学部, 助教 (20381254)
遠藤 高夫  札幌医科大学, 医学部, 助教授 (40191928)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥110,760,000 (Direct Cost: ¥85,200,000、Indirect Cost: ¥25,560,000)
Fiscal Year 2009: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2008: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2007: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2006: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Fiscal Year 2005: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
KeywordsDNAメチル化 / エピジェネティクス / ヒストン修飾 / 個別化医療 / 遺伝子診断 / 分子標的治療 / メチル化 / 消化器癌 / 遺伝子発現 / 腫瘍マーカー / 分子標的
Research Abstract

Molecular mechanisms how this epigenetic alterations contribute to development of tumors remains to be determined. DNA methylation also leads to silencing of genes involved in cell signaling, which in turn leads to dysregulation of the oncogenic signaling such as Ras, WNT, and microRNA. We found that epigenetic inactivation of IGFBP7 plays a critical role in escaping senescence in CIMP positive colorectal cancers. We also found that epigenetic information can be used to detect cancer cells from colorectal mucosal solution.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (149 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (112 results) (of which Peer Reviewed: 80 results) Presentation (25 results) Book (5 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 1 results)

  • [Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JPJ, Shinomura Y, Tokino T, Toyota M
    • Journal Title

      Carcinogenesis 31

      Pages: 342-349

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype2010

    • Author(s)
      Suzuki H., et al.
    • Journal Title

      Carcinogenesis 31

      Pages: 342-349

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers2010

    • Author(s)
      Wang Y., et al.
    • Journal Title

      J.Gastroenterol. 45

      Pages: 159-170

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of interferon regulatory factor genes in gastric cancer2010

    • Author(s)
      Yamashita M., et al.
    • Journal Title

      Cancer Sci.

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematological malignancies.2009

    • Author(s)
      Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M
    • Journal Title

      Cancer Res 69

      Pages: 8447-8454

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma.2009

    • Author(s)
      Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
    • Journal Title

      Clin Cancer Res 15

      Pages: 4356-4364

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009

    • Author(s)
      Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
    • Journal Title

      J Biol Chem 284

      Pages: 872-883

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy.2009

    • Author(s)
      Toyota M, Suzuki H, Yamashita T, Hirata K, Shinomura Y, Tokino T, Imai K
    • Journal Title

      Cancer Sci 100

      Pages: 787-791

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer.2009

    • Author(s)
      Toyota M, Suzuki H, Yamamoto E, Yamano H, Imai K, Shinomura Y
    • Journal Title

      Epigenomics 1

      Pages: 291-299

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies2009

    • Author(s)
      Taniguchi H., et al.
    • Journal Title

      Cancer Res. 69

      Pages: 8447-8454

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma2009

    • Author(s)
      Nojima M., et al.
    • Journal Title

      Clin Cancer Res. 15

      Pages: 4356-4364

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells2009

    • Author(s)
      Idogawa M., et al.
    • Journal Title

      Clin Cancer Res. 15

      Pages: 3725-3732

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene2009

    • Author(s)
      Sasaki Y., et al.
    • Journal Title

      J Biol Chem. 284

      Pages: 872-883

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity2009

    • Author(s)
      Yabana T., et al.
    • Journal Title

      J.Pathol 218

      Pages: 350-359

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin2009

    • Author(s)
      Adachi Y., et al.
    • Journal Title

      Carcinogenesis 30

      Pages: 1305-1313

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer Epigenomics : Implications of DNA methylation in personalized therapy2009

    • Author(s)
      Toyota M., et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 787-791

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers : involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth2009

    • Author(s)
      Mita H., et al.
    • Journal Title

      BMC Cancer 9

      Pages: 198-198

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer2009

    • Author(s)
      Toyota M., et al.
    • Journal Title

      Epigenomics 1

      Pages: 291-299

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen2009

    • Author(s)
      Yamaoka S., et al.
    • Journal Title

      World J Gastroenterol. 15

      Pages: 5579-5585

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventing oxidative stress : a new role for XBP12009

    • Author(s)
      Liu Y., et al.
    • Journal Title

      Cell Death Diff. 16

      Pages: 847-857

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells2009

    • Author(s)
      Ueno K., et al.
    • Journal Title

      Br J Cancer 101

      Pages: 1374-1381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008

    • Author(s)
      Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Res 68

      Pages: 4123-4132

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA hypermethylation contributes incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.2008

    • Author(s)
      Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
    • Journal Title

      Gastroenterol 135

      Pages: 142-151

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A requirement for DICER to maintain full promoter CpG Island hypermethylation in human cancer cells.2008

    • Author(s)
      Ting A, Suzuki H, Cope L, Schuebel K, Lee B, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
    • Journal Title

      Cancer Res 68

      Pages: 2570-2575

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008

    • Author(s)
      Sasaki Y, Ohshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Mol Cancer Res 6

      Pages: 395-406

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
    • Journal Title

      Cancer Sci 99

      Pages: 958-966

    • NAID

      10024006089

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Carcinogenesis 29

      Pages: 1312-1318

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The hsitone deacetylase inhibitor FK288 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008

    • Author(s)
      Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Mol Cancer Ther 7

      Pages: 779-787

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008

    • Author(s)
      Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
    • Journal Title

      J. Gastroenterol 43

      Pages: 378-389

    • NAID

      10021268741

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008

    • Author(s)
      Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 17

      Pages: 2555-2564

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008

    • Author(s)
      Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
    • Journal Title

      Pharmacogenomics 9

      Pages: 1917-1928

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008

    • Author(s)
      Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
    • Journal Title

      British J Cancer 98

      Pages: 1147-1156

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carcinogenesis and microsatellite instability : the interrelationship between genetics and epigenetics.2008

    • Author(s)
      Imai K., et al.
    • Journal Title

      Carcinogenesis 29

      Pages: 673-680

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA hypermethylation contributes incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.2008

    • Author(s)
      Kawamura YI., et al.
    • Journal Title

      Gastroenterol. 135

      Pages: 142-151

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008

    • Author(s)
      Toyota M., et al.
    • Journal Title

      Cancer Res. 68

      Pages: 4123-4132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A requirement for DICER to maintain full promoter CpG Island hypermethylation in human cancer cells.2008

    • Author(s)
      Ting A., et al.
    • Journal Title

      Cancer Res. 68

      Pages: 2670-2675

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R., et al.
    • Journal Title

      Carcinogenesis 29

      Pages: 1312-1318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The hsitone deacetylase inhibitor FK288 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008

    • Author(s)
      Sasaki Y., et al.
    • Journal Title

      Mol. Cancer Ther. 7

      Pages: 779-787

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008

    • Author(s)
      Suzuki H., et al.
    • Journal Title

      Pharmacogenomics 9

      Pages: 1917-1928

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008

    • Author(s)
      Sasaki Y., et al.
    • Journal Title

      Mol. Cancer Res. 6

      Pages: 395-406

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008

    • Author(s)
      Takagi H., et al.
    • Journal Title

      J. Gastroenterol. 43

      Pages: 378-389

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008

    • Author(s)
      Suzuki H., et al.
    • Journal Title

      Br. J. Cancer 98

      Pages: 1147-1156

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T., et al.
    • Journal Title

      Cancer Sci. 99

      Pages: 958-966

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008

    • Author(s)
      Yamamoto E., et al.
    • Journal Title

      Cancer Epidemiol. Biormarker. Prev. 17

      Pages: 2555-2564

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frizzled-7 as a potential therapeutic target in colorectal cancer.2008

    • Author(s)
      Ueno K., et al.
    • Journal Title

      Neoplasia 10

      Pages: 697-705

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma.2008

    • Author(s)
      Nosho K., et al.
    • Journal Title

      Hum Pathol. 39

      Pages: 767-775

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma.2008

    • Author(s)
      Nosho K, et. al.
    • Journal Title

      Human Pathol. 39(In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafths, as a novel target of the p53 family members.2008

    • Author(s)
      Sasaki Y, et. al.
    • Journal Title

      Mol Cancer Res. 6

      Pages: 395-406

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008

    • Author(s)
      Suzuki H, et. al.
    • Journal Title

      Brit J. Cancer 98

      Pages: 1147-1156

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R, et. al.
    • Journal Title

      Carcinogenesis 29(In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008

    • Author(s)
      Imai T, et. al.
    • Journal Title

      Cancer Sci 99(In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene amplification and overexpression of PRDM14 in breast cancer2007

    • Author(s)
      Nishikawa N, Toyota M, Suzuki H, Homma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
    • Journal Title

      Cancer Res 67

      Pages: 9649-9657

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparing the DNA hypermethylation with gene mutations in human colorectal cancer.2007

    • Author(s)
      Schuebel KE, Chen E, Cope Lm Glockner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N, Herman JG, Baylin SB
    • Journal Title

      Plos Genet 3

      Pages: 1709-1723

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Sci 98

      Pages: 88-95

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
    • Journal Title

      Oncogene 26

      Pages: 4699-4713

    • NAID

      130004927598

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007

    • Author(s)
      Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Itoh F, Tokino T
    • Journal Title

      Clin Cancer Res 13

      Pages: 4786-4794

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007

    • Author(s)
      Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
    • Journal Title

      Carcinogenesis 28

      Pages: 2459-2466

    • NAID

      130004436413

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrated genetic and epigenetic analysis identifies colon cancer corresponding to three different subclasses of disease.2007

    • Author(s)
      Shen L, et. al.
    • Journal Title

      Proc Natl Acad Sci USA. 104

      Pages: 18654-18659

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene amplification and overexpression of PRDM14 in breast cancer.2007

    • Author(s)
      Nishikawa N, et. al.
    • Journal Title

      Cancer Res 67

      Pages: 9649-9657

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparing the DNA hypermethylation with gene mutations in human colorectal cancer.2007

    • Author(s)
      Schuebel KE, et. al.
    • Journal Title

      Plos Genet. 3

      Pages: 1709-1723

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] E-cadherin gene promoter hypermethylation in H. pylori-induced enlarged fold gastritis.2007

    • Author(s)
      Miyazaki T, et. al.
    • Journal Title

      Helicobacter 12

      Pages: 523-531

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007

    • Author(s)
      Sato H, et. al.
    • Journal Title

      Carcinogenesis 28

      Pages: 2459-2466

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima M, et. al.
    • Journal Title

      Oncogene 26

      Pages: 4699-4713

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer.2007

    • Author(s)
      Taniguchi H, et. al.
    • Journal Title

      J. Pathol. 213

      Pages: 131-139

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability.2007

    • Author(s)
      Hirata T, et. al.
    • Journal Title

      J. Pathol. 211

      Pages: 516-523

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of PRDM family genes identified PRDM5 asa target of epigenetic silencing in colorectal and gastric cancer.2007

    • Author(s)
      Watanabe Y, et. al.
    • Journal Title

      Clin Cancer Res 13

      Pages: 4786-4794

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Akino K, et. al.
    • Journal Title

      Cancer Sci. 98

      Pages: 88-95

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of adenoviras-mediated p53 family gene transfer on osteosarcoma cell lines.2007

    • Author(s)
      Ohshima Y, et. al.
    • Journal Title

      Cancer Biol Ther. 6

      Pages: 1058-1066

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability.2007

    • Author(s)
      Miyamoto N, et. al.
    • Journal Title

      Cancer Lett. 254

      Pages: 42-53

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer.2007

    • Author(s)
      Hosokawa M, et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 2568-2576

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ku70 and poly(ADP-ribose)polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage.2007

    • Author(s)
      Idogawa M K, et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 911-918

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1(early invasive)colorectal cancers.2007

    • Author(s)
      Nosho K, et. al.
    • Journal Title

      Carcinogenesis 28

      Pages: 1364-1370

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flat-type colorectal advanced adenomas(laterally spreading tumors)have different genetic and epigenetic alterations from protruded-type advanced adenomas.2007

    • Author(s)
      Takahashi T, et. al.
    • Journal Title

      Mod Pathol. 20

      Pages: 139-147

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells.2007

    • Author(s)
      Murayama Y, et. al.
    • Journal Title

      J. Cell Physiol. 216(In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima M et al.
    • Journal Title

      Oncogene (Published on line Feb 5, 2007)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer.2007

    • Author(s)
      Hosokawa M et al.
    • Journal Title

      Cancer Res 67・6

      Pages: 2568-2576

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation : possible linkage of DNA damage recognition and Wnt signaling.2007

    • Author(s)
      Idogawa M et al.
    • Journal Title

      Cancer Res 67・3

      Pages: 911-918

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Akino K et al.
    • Journal Title

      Cancer Science 98・1

      Pages: 88-95

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability.2007

    • Author(s)
      Hirata T et al.
    • Journal Title

      J Pathol 211・5

      Pages: 516-523

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.2007

    • Author(s)
      Davalos V et al.
    • Journal Title

      Oncogene 26・2

      Pages: 308-311

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006

    • Author(s)
      Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
    • Journal Title

      Cancer 106

      Pages: 1467-1479

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Res 66

      Pages: 4574-4583

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparing antibody and small-molecule therapies for cancer.2006

    • Author(s)
      Imai K, Takaoka A
    • Journal Title

      Nat Rev Cancer 6・9

      Pages: 714-727

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R et al.
    • Journal Title

      Cancer Res 66・9

      Pages: 4574-4583

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 2-methoxywstradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation.2006

    • Author(s)
      Zou H et al.
    • Journal Title

      Clin Cancer Res 12・21

      Pages: 6532-6539

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006

    • Author(s)
      Kusano M et al.
    • Journal Title

      Cancer 106・7

      Pages: 1467-1479

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours.2006

    • Author(s)
      Mikami M et al.
    • Journal Title

      Eur J Cancer 42・17

      Pages: 3065-72

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines.2006

    • Author(s)
      Terasawa K et al.
    • Journal Title

      Br J Cancer 94・6

      Pages: 914-921

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of ribosomal protein L13 in human gastric cancer.2006

    • Author(s)
      Kobayashi T et al.
    • Journal Title

      Int J Mol Med 18・1

      Pages: 161-170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.2006

    • Author(s)
      Nosho K et al.
    • Journal Title

      Eur J Cancer 42・14

      Pages: 2374-2381

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The RAS effector RASSF2 is a novel tumor suppressor in colorectal cancer.2006

    • Author(s)
      Akino K et al.
    • Journal Title

      Gastroenterol. 129・1

      Pages: 156-169

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.2006

    • Author(s)
      Idogawa M et al.
    • Journal Title

      Gastroenterol. 128・7

      Pages: 1919-1936

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparative genome analysis identified the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R. et al.
    • Journal Title

      Cancer Res. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus.2006

    • Author(s)
      Kusano et al.
    • Journal Title

      Cancer 106・7

      Pages: 1467-1479

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005

    • Author(s)
      Murai M, Toyota M, Suzuki H, Satoh A, Akino K, Mita H, Tokino T, Imai K
    • Journal Title

      Clin Cancer Res 11

      Pages: 1021-1027

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in hematopietic tumors.2005

    • Author(s)
      Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Ishida T, Tokino T, Imai K
    • Journal Title

      British J Cancer 92

      Pages: 1165-1172

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RAS effector RASSF2 is a novel tumor suppressor in colorectal cancer.2005

    • Author(s)
      Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa JP, Hinoda Y, Imai K, Tokino T
    • Journal Title

      Gastroenterol 129

      Pages: 156-169

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.2005

    • Author(s)
      Alazzouzi H et al.
    • Journal Title

      Cancer Res. 65・22

      Pages: 10170-10173

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.2005

    • Author(s)
      Taniguchi H. et al.
    • Journal Title

      Oncogene 24・53

      Pages: 7946-7952

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005

    • Author(s)
      Murai M. et al.
    • Journal Title

      Clin Cancer Res. 11・3

      Pages: 1021-1027

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts.2005

    • Author(s)
      Min et al.
    • Journal Title

      Gut 54・5

      Pages: 591-600

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein.2005

    • Author(s)
      Naishiro et al.
    • Journal Title

      Oncogene 24・19

      Pages: 3141-3153

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tumour matrilysin expression predicts metastatic potential of stage I (pT1) colon and rectal cancers.2005

    • Author(s)
      Kurokawa S et al.
    • Journal Title

      Gut 54・12

      Pages: 1751-1758

    • Related Report
      2005 Annual Research Report
  • [Journal Article] BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes.2005

    • Author(s)
      Domingo E.
    • Journal Title

      Oncogene 24・24

      Pages: 3995-3998

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.2005

    • Author(s)
      Nosho K. et al.
    • Journal Title

      Carcinogenesis 26・5

      Pages: 892-999

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in hematopietic tumors.2005

    • Author(s)
      Murai M. et al.
    • Journal Title

      British J.Cancer 92・6

      Pages: 1165-1172

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors.2005

    • Author(s)
      Ogi K.et al.
    • Journal Title

      Cancer Biol.Ther. 4・7

      Pages: 773-780

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines.2005

    • Author(s)
      Terasawa K. et al.
    • Journal Title

      British J.Cancer 94・6

      Pages: 914-921

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005

    • Author(s)
      Abe T.et al.
    • Journal Title

      J.Gsstroenterol. 40・5

      Pages: 504-510

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of T-fimbrin in the response to DNA damage : silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.2005

    • Author(s)
      Ikeda H. et al.
    • Journal Title

      Int J Oncol. 27・4

      Pages: 933-940

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sulindac enhances the proteasome inhibitor bortezomib-mediated oxidative stress and anticancer activity.2005

    • Author(s)
      Minami T. et al.
    • Journal Title

      Clin Cancer Res. 11・14

      Pages: 5248-5256

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epigenetic inactivation of interferon regulatory factor genes in gastric cancer.

    • Author(s)
      Yamashita M, Toyota M, Suzuki H, Nojima M, Yamamoto E, Kamimae S, Watanabe Y, Kai M, Akashi H, Maruyama R, Sasaki Y, Yamano H, Sugai T, Shinomura Y, Imai K, Tokino T, Itoh F
    • Journal Title

      Cancer Sci (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Colorectal Cancer Epigenetics2009

    • Author(s)
      Toyota M., Imai K.
    • Organizer
      International Society for Oncology and Biomarkers 37^<Th> Meeting
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2009-09-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規エピゲノム法の開発と消化器癌発生の分子機構.2009

    • Author(s)
      豊田 実, 他
    • Organizer
      第5回日本消化管学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of epigenetic changes in cancer immunothelapy.2009

    • Author(s)
      Toyota M, Imai K
    • Organizer
      US-Japan Workshop on Immunological Molecular Markers in Oncology
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 大腸癌のシグナル経路異常におけるDNAメチル化の役割2008

    • Author(s)
      豊田 実, 他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Epigenetic gene silencing and micro RNA in human colon cancer.2008

    • Author(s)
      Toyota M, et al.
    • Organizer
      36th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of DNA methylation changes in signaling pathway.2008

    • Author(s)
      Toyota M, et al.
    • Organizer
      AACR Special Conference on Cancer Research : Cancer Epigenetics
    • Place of Presentation
      Boston, USA
    • Year and Date
      2008-05-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Epigenetic gene silencing and microRNA in human colon cancer. Symposium2008

    • Author(s)
      Toyota M, Imai K
    • Organizer
      36th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of DNA methylation changes in signaling pathway.2008

    • Author(s)
      Toyota M, Imai K
    • Organizer
      AACR Special Conference on Cancer Research: Cancer Epigenetics
    • Place of Presentation
      Boston, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Epigenetic silencing of genes involved in signaling pathways in gastric cancer. Symposium2007

    • Author(s)
      Toyota M, Imai K
    • Organizer
      5th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Plaque, Czech Republic
    • Related Report
      2009 Final Research Report
  • [Presentation] Frequent epigenetic inactivation of DICKKOPF family genes in gastrointestinal tumors.2007

    • Author(s)
      Suzuki H, Toyota M, Maruyama R, Imai K, Shinomura Y
    • Organizer
      35th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Plaque, Czech Republic
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007

    • Author(s)
      Toyota M, Suzuki H, Maruyama R, Akino K, Watanabe Y, Sasaki Y, Imai K, Tokino T, Shinomura Y
    • Organizer
      98th Annual Meeting of American Association for Cancer Research.
    • Place of Presentation
      Los Angeles
    • Related Report
      2009 Final Research Report
  • [Presentation] Epigenetic silencing of genes involved in signaling pathway. Symposium2007

    • Author(s)
      Toyota M, Suzuki H, Shinomura Y, Tokino T, Imai K
    • Organizer
      The 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Epigenetic silencing of genes involved in signaling pathways in gastric cancer.2007

    • Author(s)
      Toyota M, et. al.
    • Organizer
      35th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ku70 and poly(ADP-ribose)polymerase-l(PARP-l)competetively regulate β-catenin/TCF-4-mediated gene transactivation.2007

    • Author(s)
      Idogawa M, et. al.
    • Organizer
      American Association for Cancer Research, Annual Meeting 2007
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report
  • [Presentation] Treatment with IGF-I receptor tyrosine kinase inhibitor, NVP-AEW 541,for gastrointestinal carcinomas.2007

    • Author(s)
      Adachi Y, et. al.
    • Organizer
      American Association for Cancer Research, Annual Meeting 2007
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report
  • [Presentation] The global identification of non coding RNA regulated by p53.2007

    • Author(s)
      Maruyama R, et. al.
    • Organizer
      American Association for Cancer Research, Annual Meeting 2007
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genomic amplification of K-ras in gastric cancer identified by digital genome scanning.2007

    • Author(s)
      Mita H, et. al.
    • Organizer
      American Association for Cancer Research, Annual Meeting 2007
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report
  • [Presentation] Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability.2007

    • Author(s)
      Miyamoto N, et. al.
    • Organizer
      Digestive Disease Week 2007
    • Place of Presentation
      Washington
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epigenetic downregulation of the receptor tyrosine kinase EphA6 in human colorectal cancers.2007

    • Author(s)
      Maehata T, et. al.
    • Organizer
      Digestive Disease Week 2007
    • Place of Presentation
      Washington
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization of immune escape phenotype of human gastric cancers with and those without high-frequency microsatellite instability.2007

    • Author(s)
      Hirata T, et. al.
    • Organizer
      Digestive Disease Week 2007
    • Place of Presentation
      Washington
    • Related Report
      2007 Annual Research Report
  • [Presentation] IGF-I receptor is a candidate molecurar target for both human esophageal squamous cell carcinoma and adenocarcinoma.2007

    • Author(s)
      Adachi Y, et. al.
    • Organizer
      35 Congress of the International Society for Oncodevelopmental Biology and Medicine.
    • Place of Presentation
      Prague
    • Related Report
      2007 Annual Research Report
  • [Presentation] The positive transcription elongation factor B mediates myocyte enhancer factor 2-dependent transcription.2007

    • Author(s)
      Nojima M, et. al.
    • Organizer
      35 Congress of the International Society for Oncodevelopmental Biology and Medicine.
    • Place of Presentation
      Prague
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tumor suppression by apoptosis induced with anti-erbB-2 chimeric monoclonal antibody.2007

    • Author(s)
      Kato Y, et. al.
    • Organizer
      35 Congress of the International Society for Oncodevelopmental Biology and Medicine.
    • Place of Presentation
      Prague
    • Related Report
      2007 Annual Research Report
  • [Presentation] DNA methylation changes in cancer: application to diagnosis and therapy. Symposium2006

    • Author(s)
      Toyota M, Suzuki H, Shinomura Y, Imai K
    • Organizer
      34th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Pasadena, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Epigenetic inactivation of TCF2 in human tumors2006

    • Author(s)
      Toyota M, Terasawa K, Sagae S, Ogi K, Suzuki H, Maruyama R, Shinomura Y, Saito T, Imai K, Tokino T
    • Organizer
      97th Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Final Research Report
  • [Book] エピジェネティクス-メチル化とヒストン修飾. がんの分子標的治療2008

    • Author(s)
      今井浩三、豊田実, 鶴尾隆. (編集)
    • Publisher
      南山堂
    • Related Report
      2009 Final Research Report
  • [Book] 消化管と遺伝子異常. 消化管病理標本の読み方改訂2版2008

    • Author(s)
      豊田実、今井浩三、篠村恭久, 中村眞一. (編集)
    • Publisher
      日本メディカルセンター
    • Related Report
      2009 Final Research Report
  • [Book] 消化管病理標本の読み方改訂2版.2008

    • Author(s)
      豊田 実, 他
    • Total Pages
      228
    • Publisher
      日本メディカルセンター.
    • Related Report
      2008 Annual Research Report
  • [Book] The role and clinical implication of DNA methylation in gastrointestinal cancer. Recent Advances in Gastrointestinal Carcinogenesis.2006

    • Author(s)
      Toyota M, Suzuki H, Maruyama R, Tarasawa I, Yamamoto E, Tokino T, Imai K, Shinomura Y
    • Publisher
      Edited by Bamba H and Ota S, Transworld Research Network, Kerala, India
    • Related Report
      2009 Final Research Report
  • [Book] Recent Advances in Gastrointestinal Carcinogenesis2006

    • Author(s)
      Toyota M et al.
    • Total Pages
      247
    • Publisher
      Transworld Research Network
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規遺伝子ACMG1のメチル化を指標とする胃癌の診断方法2009

    • Inventor(s)
      豊田実、今井浩三、株式会社ジェネティックラボ
    • Industrial Property Rights Holder
      豊田実、株式会社ジェネティックラボ
    • Acquisition Date
      2009-12-18
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] Method for detection of diseases using colonic mucosa2009

    • Inventor(s)
      豊田実, 今井浩三
    • Industrial Property Rights Holder
      札幌医科大学
    • Filing Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 癌の検出方法および検出用キット、ならびに癌治療剤2008

    • Inventor(s)
      今井浩三
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Number
      2008-121671
    • Filing Date
      2008-05-07
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 癌の検出方法および検出用キット、ならびに癌治療剤.2008

    • Inventor(s)
      鈴木 拓, 豊田 実, 今井浩三, 他2名
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Number
      2008-121671
    • Filing Date
      2008-05-07
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006

    • Inventor(s)
      今井浩三
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Number
      2006-134878
    • Acquisition Date
      2006-05-12
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 胃粘膜洗浄液を利用した疾患関連マーカー検出法2006

    • Inventor(s)
      今井浩三, 豊田実他
    • Industrial Property Rights Holder
      北海道聖マリアンナ医科大学
    • Industrial Property Number
      2006-134878
    • Filing Date
      2006-05-15
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] ACMG1のメチル化を指標とする胃癌の診断方法2005

    • Inventor(s)
      今井 浩三
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Number
      2005-220779
    • Filing Date
      2005-07-29
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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