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Molecular analysis of pathogenesis on Sjogren's syndrome and its application of new diagnosis and therapy

Research Project

Project/Area Number 17109016
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionThe University of Tokushima

Principal Investigator

HAYASHI Yoshio  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (00127854)

Co-Investigator(Kenkyū-buntansha) ISHIMARU Naozumi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60314879)
ARAKAKI Rieko  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (00193061)
新垣 理恵子  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40231120)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥96,850,000 (Direct Cost: ¥74,500,000、Indirect Cost: ¥22,350,000)
Fiscal Year 2008: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2007: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2006: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2005: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Keywordsシェーグレン症候群 / 唾液腺 / 自己抗原 / α-フォドリン / アポトーシス / システインプロテアーゼ / トレランス / 疾患モデル / RbAp48 / RANKL / Fas / クラスII分子 / IFN-γ / 抹消トレランス / エストロゲン / 性差 / p53 / チトクロムc / 自己免疫疾患
Research Abstract

シェーグレン症候群を含めた自己免疫疾患の大半は原因不明であり疾患非特異的な診断・治療法で対処しているのが世界の現状である。本研究プロジェクトは難治性自己免疫疾患シェーグレン症候群の発症に密接に関連するアポトーシス経路を介した膜タンパク破綻の分子基盤の全容解明による新たな診断・治療法の創出を目的として実施した。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (80 results)

All 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article (32 results) (of which Peer Reviewed: 20 results) Presentation (42 results) Book (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Neonatal exposure to low-dose 2, 3, 7, 8-tetrachlorcdibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance2009

    • Author(s)
      Ishimaru N, Takaji A, Kohashi M,Yamada A, Arakaki R, Kanno J, Hayashi Y
    • Journal Title

      J. Immunol 182

      Pages: 6576-6586

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healty background2009

    • Author(s)
      Arakaki R, Nagaoka A, Ishimaru N, Yamada A, Yoshida S, Hayashi Y
    • Journal Title

      Am. j. Pathol 174

      Pages: 1715-1715

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjogren' s syndrome-like autoimmune exocrinopathy2009

    • Author(s)
      Ishimaru N, Arakaki R, Yoshida S, Yamada A, Noji S, Hayashi Y
    • Journal Title

      J. Exp. Med 205

      Pages: 2915-2927

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of inflammatory bowel disease in Long-Evans Cinnamon rats based on CD4^+CD25^+Foxp3^+ regulatory T cell dysfunction2008

    • Author(s)
      Ishimaru N, Yamada A, Kohashi M, Arakaki R Takahashi T, Izumi K, Hayashi Y
    • Journal Title

      J. Immunol 180

      Pages: 6997-7008

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effective treatment of a mouse model of Sjogren' s syndrome with oral administration of rebamipide2008

    • Author(s)
      Kohashi M, Ishimaru N, Arakaki R ; Hayashi Y
    • Journal Title

      Arthritis Rheum 58

      Pages: 389-400

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of inflammatory bowel disease (IBD) in Long-Evans Cinnamon (LEC) rats based on CD4^+CD25^+Foxp3^+ regulatory T cell dysfunction.2008

    • Author(s)
      Ishimaru N., et al.
    • Journal Title

      J Immunol 180

      Pages: 6997-7008

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.2008

    • Author(s)
      Hikosaka Y., et al.
    • Journal Title

      Immunity 29

      Pages: 438-450

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjogren's syndrome-like autoimmune exocrinopathy.2008

    • Author(s)
      Ishimaru N., et al
    • Journal Title

      J Exp Med 205

      Pages: 2915-29270

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of inflammatory bowel in Long-Evance Cinnamon(LEC)rats based on CD4+CD25+Foxp3+ regulatory T cell dysfunction2008

    • Author(s)
      Ishimaru N.
    • Journal Title

      J. Immunol 180

      Pages: 6997-7008

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass2008

    • Author(s)
      Kinouchi N.
    • Journal Title

      Gene Ther. in press(advance online)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epitope mapping of anti-・-fodrin antibody in a case of early-onset multiple sclerosis2008

    • Author(s)
      Okura Y.
    • Journal Title

      Pediatrics Int. 50

      Pages: 135-137

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective treatment of a mouse model of Sjogren's syndrome with oral administration of rebamipide2008

    • Author(s)
      Kohashi M.
    • Journal Title

      Arthritis Rheum. 58

      Pages: 389-400

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance2007

    • Author(s)
      Izawa T, Ishimaru N, Moriyama K, Kohashi M, Arakaki R, Hayashi Y
    • Journal Title

      Blood 1110

      Pages: 242-250

    • NAID

      40016915514

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing the dynamics of p21(Waf1/Cip1)cyclin-dependent kinase inhibitor expression in living animals2007

    • Author(s)
      Ohtani N.
    • Journal Title

      Proc. Nat1. Acad. Sci. USA. 104

      Pages: 15034-15039

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance2007

    • Author(s)
      Izawa T.
    • Journal Title

      Blood 110

      Pages: 242-250

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T細胞レセプターシグナルとNF-κB2007

    • Author(s)
      石丸 直澄
    • Journal Title

      臨床免疫・アレルギー科 48

      Pages: 29-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance2007

    • Author(s)
      Izawa T.
    • Journal Title

      Blood (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of nave T cell function by the NF-kB2 pathway2006

    • Author(s)
      Ishimaru N, Kishimoto H, Hayashi Y, Sprent J
    • Journal Title

      Nature Immunol 7

      Pages: 763-771

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel role of RbAp48 for tissue-specific. estrogen deficiency-dependent apoptosis in the exocrine glands2006

    • Author(s)
      Ishimaru N, Arakaki R, Omotehara F, Yamada K, Mishima K, Saito I, Hayashi Y
    • Journal Title

      Mol. Cell. Biol 26

      Pages: 2924-2935

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCR7-dependent cortex-to medulla migration of positively selected thymocytes is essential for establishing central tolerance2006

    • Author(s)
      Kurobe H, Cunlan Liu C, UenoT, Saito F, Ohigashi I, Seach N, Arakaki R, Hayashi Y, Kitagawa T, Lipp M, Richard L. Boyd R, Takahama Y
    • Journal Title

      Immunity 24

      Pages: 1-13

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of naive T cell function by the NF-kB2 pathway.2006

    • Author(s)
      Ishimaru N.
    • Journal Title

      Nature Immunol 7

      Pages: 763-771

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is dispensable for T-cell maturation and thymic export but is essential for establishing central tolerance.2006

    • Author(s)
      Kurobe H.
    • Journal Title

      Immunity 24

      Pages: 165-177

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ubiquitin ligase Cbl-b down-regulates bone formation through suppression of IGF-1 signaling in osteoblasts during denavation.2006

    • Author(s)
      Suzue N.
    • Journal Title

      J.Bone Miner.Res. 21

      Pages: 722-734

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Catechin : Specific inhibitor for caspase-3, 7, and 2, and the prevention of apoptosis at the cell and animal levels2006

    • Author(s)
      Katunuma N.
    • Journal Title

      FEBS Let 580

      Pages: 741-746

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Epitope mapping of anti-α-fodrin autoantibody in juvenile Siogren's syndrome : epitope spreading and difference in major epitope between primary and secondary cases.2006

    • Author(s)
      Shiari R.
    • Journal Title

      J.Rheumatol. 33

      Pages: 722-734

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel role for RBAp48 for tissue-specific, estrogen-deficiency dependent apoptosis in the exocrine glands.2006

    • Author(s)
      Ishimaru N
    • Journal Title

      Molecular Cellular Biology (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Catechin : Specific inhibitor for caspase-3,7, and 2, and the prevention of apoptosis at the cell and animal levels.2006

    • Author(s)
      Katsunuma N
    • Journal Title

      FEBS Letter (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is dispensable for T-cell maturation and thymic export but is essential for establishing central tolerance.2006

    • Author(s)
      Kurobe H
    • Journal Title

      Immunity 24

      Pages: 165-177

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutations in the fibroblast growth factor 10 gene are associated with aplasia of lacrimal' and salivary glands (ALSG)2005

    • Author(s)
      Entesarian M, Matsson H, Klar J, Bergendal B, Olson L, Arakaki R, Hayashi Y, Ohuchi H, Falhat B, Bolstad AI, Jonsson R, Wahren-Herlenius M, Dahl N
    • Journal Title

      Nature Genetics 37

      Pages: 125-127

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in the fibroblast growth factor 10 gene are associated with plasia of lacrimal- and salivary glands (ALSG).2005

    • Author(s)
      Entesarian M
    • Journal Title

      Nature Genetics 37

      Pages: 125-127

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Analysis of in vivo role of α-fodrin autoantigen in primary Sjogren's syndrome.2005

    • Author(s)
      Miyazaki K
    • Journal Title

      American Journal of Pathology 167

      Pages: 1051-1059

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice.2005

    • Author(s)
      Kuroda N
    • Journal Title

      Journal of Immunology 174

      Pages: 1862-1870

    • Related Report
      2005 Annual Research Report
  • [Presentation] Neonatal exposure to low-dose 2, 3, 4, 7, 8-tetrachloro-dibenzo---p-dioxin (TCDD) causes autoimmunity due to the disruption of T cell tolerance2008

    • Author(s)
      Ishimaru N. et.al.
    • Organizer
      第38回免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification and functional analysis of CDI1c+E220+dendritic clls induced by estrogen deficiency in salivaryglands2008

    • Author(s)
      Arakaki R. et.al.
    • Organizer
      第38回に本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Therapeutic analysis for autoimmune diabetes in NOD mice using specific inhibitor for cathepsin L.2008

    • Author(s)
      Yamada A., et al
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification and functional analysis of CD11c+B220+dendritic cells induced by estrogen deficiency in salivary glands.2008

    • Author(s)
      Arakaki R
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 外分泌腺における異所性MHC class II発現に対するエストロゲン欠乏の役割2008

    • Author(s)
      新垣 理恵子
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪・品川(東京)
    • Year and Date
      2008-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] エストロゲン欠乏による外分泌腺上皮クラスII発現の誘導メカニズム2008

    • Author(s)
      新垣理恵子
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 自己免疫病と性差2008

    • Author(s)
      石丸直澄等
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] I型糖尿病モデルマウスにおけるカテプシンL阻害剤を用いた治療学的解析2008

    • Author(s)
      山田安希子等
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自己免疫疾患におけるT細胞の制御機構2008

    • Author(s)
      石丸 直澄
    • Organizer
      口腔医科学フロンティア
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2008-02-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] lRbAp48トランスジェニックマウスを用いたシェーグレン症候群モデルの確立とINFγ産出上皮細胞の解析2007

    • Author(s)
      lshimaru N. et.al
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2008 Final Research Report
  • [Presentation] RbAp48トランスジェニックマウスを用いたシェーグレン症候群モデルの確立とIFNγ産出上皮細胞の解析2007

    • Author(s)
      ISHIMARU Naozumi
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪・品川(東京)
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance2007

    • Author(s)
      Izawa T et.al.
    • Organizer
      第37回に本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance2007

    • Author(s)
      IZAWA Takashi
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪・品川(東京)
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] NF-κB1欠損マウスの加齢に伴うT細胞機能の解析2007

    • Author(s)
      YAMADA Akiko
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪・品川(東京)
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] シェーグレン症候群モデルマウスへのTCDD投与による影響2007

    • Author(s)
      小橋真之ら
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群モデルマウスへのTCDD投与による影響2007

    • Author(s)
      KOHASHI Masayuki
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪・品川(東京)
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 自己免疫疾患モデルにおけるNF-κBを介したT細胞活性化機構の解析2007

    • Author(s)
      OKUNO Miho
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪・品川(東京)
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Autoimmune Exocrinopathy Resembling Sjogren's Syndrome in Rbap48 Transgenic Mice2007

    • Author(s)
      Yoshio Hayashi
    • Organizer
      AMERICAN COLLEGE OF RHEUMATOLOGY
    • Place of Presentation
      New Boston Convention and Exhibition Center
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 唾液腺アポトーシスと自己免疫2007

    • Author(s)
      石丸 直澄
    • Organizer
      第18回日本口腔病理学会総会・学術大会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of autoimmune exocrinopathy resembling Sjogren's syndrome in RbAp48 transgenic mice2007

    • Author(s)
      Hayashi Y
    • Organizer
      The 71^<st> Annual Meeting of the American College of Rheumatology
    • Place of Presentation
      Boston
    • Related Report
      2008 Final Research Report
  • [Presentation] NF-kB2 pathway in T cell activation for autoimmunity2006

    • Author(s)
      Ishimaru N. et.al.
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Taking advantage of saliva for immune test2006

    • Author(s)
      Ishimaru N.et.al.
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunoregulatory role RANKL-stimulated dendritic cells on on autoimmune arthritis in MRL/lpr mice2006

    • Author(s)
      Izawa T. et.al.
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] The crucial signaling pathway of dendritic cells in metal allergy2006

    • Author(s)
      Wei Hua et.al.
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of rebamipide administration on Sjogren's syndrome mouse model2006

    • Author(s)
      Kohashi M. et.al.
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群加齢モデルマウスにおける自問質性肺病変の解析2006

    • Author(s)
      表原文江ら
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] NFS/sldマウス舌下腺におけるNkx2.3の発現・機能解析2006

    • Author(s)
      佐藤亜紀ら
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-04-30
    • Related Report
      2008 Final Research Report
  • [Presentation] NF-kBシグナルを介した自己免疫疾患の発症機序2006

    • Author(s)
      石丸直澄ら
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-04-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Cathepsin L-inhibitor prevents proinsulin peptide processing and autoimmune diabetes in nonobase diabetic(NOD) mice2006

    • Author(s)
      Hayashi Y. et.al.
    • Organizer
      International Sympojium on Medical and Biological Perspective in Protease and Their Inhibitors
    • Place of Presentation
      Awaji, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] RANKL刺激活性化DCを介したMRL/lprマウス関節炎の病態修飾2005

    • Author(s)
      井澤俊ら
    • Organizer
      第35回日本免疫学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-12-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunoregulation of NF-kBfor T cell activation in autoimmune disease2005

    • Author(s)
      Ishimaru N. et.al.
    • Organizer
      第35回日本免疫学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-12-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Mアレルギーにおける樹状細胞及びT細胞の活性化機構2005

    • Author(s)
      渡邊恵ら
    • Organizer
      第35回日本免疫学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群モデルマウスにおけるレバミピドの治療効果の検討2005

    • Author(s)
      小橋真之ら
    • Organizer
      第35回日本免疫学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群加齢モデルマウスにおける聞質性肺病変の解析2005

    • Author(s)
      表原文江ら
    • Organizer
      第35回日本免疫学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 自己免疫疾患におけるFN-kBを介したT細胞活性化機構の解析2005

    • Author(s)
      石丸直澄ら
    • Organizer
      第94回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-04-16
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群発症の分子基盤2005

    • Author(s)
      林良夫
    • Organizer
      第94回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] RANKL刺激樹状細胞移入によるMRL/lprマウス関節リウマチ病変の解析2005

    • Author(s)
      大嶋淳ら
    • Organizer
      第94回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] シェーグレン症候群発症における自己抗原120kDa-フォドリンの意義2005

    • Author(s)
      表原文江ら
    • Organizer
      第94回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] RbAp48遺伝子導入マウスにみられるシェーグレン症候群類似病変の解析2005

    • Author(s)
      新垣理恵子ら
    • Organizer
      第94回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Involvement of interstitial pneumonia in Sjogren's syndrome mouse model with aging2005

    • Author(s)
      Hayashi Y. et.al.
    • Organizer
      T Cell Immunity & Aging
    • Place of Presentation
      Freudenstadt-Lauterbad
    • Related Report
      2008 Final Research Report
  • [Presentation] Possible mechanism of autoimmune exocrinopathy resembling Sjogren's syndrome through RbAp48 overexpression2005

    • Author(s)
      Hayashi Y. et.al.
    • Organizer
      Gordon Research Conference on Salivary Glads & Exocrine Secretion
    • Place of Presentation
      Ventura
    • Related Report
      2008 Final Research Report
  • [Presentation] 自己演繹疾患におけるT細胞の制御機構

    • Author(s)
      石丸直澄
    • Organizer
      第6回口腔医科学フロンティア
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Book] Autoimmunity-Aging Mouse Model for Autoimmune Disease2009

    • Author(s)
      Hayashi Y., et al
    • Publisher
      Handbook on Immunosenescence Springe
    • Related Report
      2008 Annual Research Report
  • [Book] 口唇生検の診断「シェーグレン症候群の診断と治療」2009

    • Author(s)
      林良夫等
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report
  • [Book] 口腔内科2008

    • Author(s)
      林良夫
    • Publisher
      株式会社飛鳥出版室
    • Related Report
      2008 Final Research Report
  • [Book] Annual Review糖尿病・代謝・内分泌2006(エストロゲンと自己免疫疾患)2006

    • Author(s)
      林 良夫
    • Total Pages
      6
    • Publisher
      中外医学社
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] Composition containingα-fodrin, orα-fodrinfragment protein2004

    • Inventor(s)
      HayashiY, HiromuSugino
    • Industrial Property Rights Holder
      Yoshio Hayashi
    • Filing Date
      2004-03-09
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 疾患の予防・治療剤及びそのスクリーニング方法」2003

    • Inventor(s)
      林良夫
    • Industrial Property Rights Holder
      興和株式会社
    • Industrial Property Number
      2003-123959
    • Filing Date
      2003-04-28
    • Related Report
      2008 Final Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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