Clarification of nociceptive transmission in the primary somatosensory cortex

• Project/Area Number: 17200027
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Kyushu University
• Principal Investigator: YOSHIMURA Megumu Kyushu University, 大学院・医学研究院, 教授 (10140641)
• Co-Investigator(Kenkyū-buntansha): FURUE Hidemasa 九州大学, 大学院・医学研究院, 助教 (20304884) ; 片渕 俊彦 九州大学, 大学院・医学研究院, 准教授 (80177401)
• Co-Investigator(Renkei-kenkyūsha): KATAFUCHI Toshihiko 九州大学, 大学院・医学研究院, 准教授 (80177401)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000); Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2006: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2005: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
• Keywords: in vivo パッチクランプ / 錐体細胞 / bursting / EPSP / 慢性炎症 / 体性感覚野 / 熱刺激 / 冷刺激 / 大脳皮質 / EPSC / 同期化 / GABA / 脳波 / 同期性発火 / in vivoパッチクランプ記録 / 痛覚 / 痛み応答 / 触応答 / oscillation / pyramidalニューロン / 感覚情報処理

Research Abstract

大脳皮質体性感覚野における痛覚情報処理機構を明らかにするため、深層の錐体細胞からin vivo パッチクランプ記録を行い、皮膚への機械的および温度刺激を加えた時の応答を正常と慢性炎症ラットを用いて解析した。Bursting の頻度と活動電位の発生頻度には正常と炎症ラットで変化がなかったが、機械的痛みと熱および冷刺激を加えると、炎症ラットで活動電位を発生する細胞数が明らかに増加した。これはbursting の振幅が増大したか、細胞の興奮性が増加した可能性を示唆する。

Research Products

• [Journal Article] Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro (2009)
  • Author(s): Abe K, Kato G, Katafuchi T, Tamae A, Furue H and Yoshimura M.
  • Journal Title: Neuroscience 159(1) Pages: 316-324
• [Journal Article] Actions of propofol on substantia gelatinosa neurones in rat spinal cord revealed by in vitro and in vivo patch-clamp recordings (2009)
  • Author(s): Takazawa T, Furue H, Nishikawa K, Uta D, Takeshima K, Goto F and Yoshimura M.
  • Journal Title: European Journal of Neuroscience 29(3) Pages: 518-529
• [Journal Article] Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. (2009)
  • Author(s): Kawashiri T., et al.
  • Journal Title: European Journal of Cancer 45 Pages: 154-163
  • Peer Reviewed
• [Journal Article] Actions of propofol on substantia gelatinosa neurones in rat spinal cordrevealed by in vitro and in vivo patch-clamp recordings. (2009)
  • Author(s): Takazawa T., et al.
  • Journal Title: European Journal of Neuroscience 29(3) Pages: 518-528
  • Peer Reviewed
• [Journal Article] Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro. (2009)
  • Author(s): Abe K., et al.
  • Journal Title: Neuroscience 159(1) Pages: 316-324
  • Peer Reviewed
• [Journal Article] Comparison of the action potential blocking effects of the local anesthetics in adult rat dorsal root ganglion neurons. (2009)
  • Author(s): Uta D., et al.
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord. 30(1) Pages: 49-57
  • Peer Reviewed
• [Journal Article] The behavioral and electrophysiological analysis of spinal nociceptive transmission in a murine model of bone cancer pain. (2009)
  • Author(s): Yanagisawa Y., et al.
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord. 30(1) Pages: 58-62
  • Peer Reviewed
• [Journal Article] N-Ethylmaleimide-sensitive fusion protein(NSF)is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation (2008)
  • Author(s): Katano T, Furue H, Okuda-Ashitaka E, Tagaya M, Watanabe M, Yoshimura M and Ito S.
  • Journal Title: European Journal of Neuroscience 27(12) Pages: 3161-3170
• [Journal Article] N-Ethylmaleimide-sensitive fusion protein (NSF)is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation. (2008)
  • Author(s): Fume H., et al.
  • Journal Title: European Journal ofNeuroscience 27(12) Pages: 3161-3170
  • Peer Reviewed
• [Journal Article] Spinal modulation of nociceptive synaptic transmission via activation of TRPA1 and TRPV1. (2008)
  • Author(s): Uta D., et al.
  • Journal Title: Pain Research 23(3) Pages: 141-150
  • Peer Reviewed
• [Journal Article] 針鎮痛のメカニズム. (2008)
  • Author(s): 吉村 恵.
  • Journal Title: 日本関節運動学的アプローチ医学会誌 9(1) Pages: 43-49
• [Journal Article] Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation (2007)
  • Author(s): Suzuki SC, Furue H, Koga K, Jiang N, Nohmi, M, Shimazaki Y, Katoh-Fukui Y, Yokoyama M, Yoshimura M, Takeichi M.
  • Journal Title: Journal of Neuroscience 24 Pages: 3466-3476
• [Journal Article] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro (2007)
  • Author(s): Yasaka T, Kato G, Furue H, Rashid MH, Sonohata M, Tamae A, Murata Y, Masuko S and Yoshimura M.
  • Journal Title: Journal of Physiology(London) 581(2) Pages: 603-618
• [Journal Article] Involvement of Kv channel subtypes on GABA release in mechanically dissociated neurons from the rat substantia nigra (2007)
  • Author(s): Shimada H, Uta D, Nabekura J, Yoshimura M.
  • Journal Title: Brain Research 1141 Pages: 74-83
• [Journal Article] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons : in vivo patch-clamp analysis (2007)
  • Author(s): Doi A, Mizuno M, Katafuchi T, Furue H, Koga K and Yoshimura M.
  • Journal Title: European Journal of Neuroscience 26(9) Pages: 2565-2575
• [Journal Article] Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor (2007)
  • Author(s): Tsuda M, Ishii S, Masuda T, Hasegawa S, Nakamura K, Nagata K, Yamashita T, Furue H, Tozaki-Saitoh H, Yoshimura M, Koizumi S, Shimizu T, Inoue K.
  • Journal Title: Journal of Neurochemistry 102(5) Pages: 1658-1668
• [Journal Article] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro. (2007)
  • Author(s): Yasaka T., et. al.
  • Journal Title: Journal of Physiology(London) 581(2) Pages: 603-618
  • Peer Reviewed
• [Journal Article] Involvement of Kv channel subtypes on GABA release in mechanically dissociated neurons from the rat substantia nigra. (2007)
  • Author(s): Shimada H., et. al.
  • Journal Title: Brain Research 1141 Pages: 74-83
  • Peer Reviewed
• [Journal Article] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons: in vivo patch-clamp analysis. (2007)
  • Author(s): Doi A., et. al.
  • Journal Title: European Journal of Neuroscience 26(9) Pages: 2565-2575
  • Peer Reviewed
• [Journal Article] Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. (2007)
  • Author(s): Tsuda M., et. al.
  • Journal Title: Journal of Neurochemistry 102(5) Pages: 1658-1668
  • Peer Reviewed
• [Journal Article] 感覚回路の再生と慢性疼痛 (2007)
  • Author(s): 吉村 恵
  • Journal Title: 脊椎脊髄ジャーナル 20(8) Pages: 879-880
• [Journal Article] Analysis of hypnotic or analgesic effect of anesthetic agents by in-vivo patch clamp recordings from somatosensory cortex in rats. (2007)
  • Author(s): Shiokawa H., et. al.
  • Journal Title: 麻酔 56
  • Peer Reviewed
• [Journal Article] Function of spinal GABA receptor and its modulation. (2007)
  • Author(s): Yoshimura M., et. al.
  • Journal Title: 麻酔 56
  • Peer Reviewed
• [Journal Article] Recent insights into mechanisms for analgesic effect by calcitonin (2007)
  • Author(s): Ito A., et. al.
  • Journal Title: 日本臨床 65(S9) Pages: 386-390
• [Journal Article] Chronic pain and neurotrophic factor. (2007)
  • Author(s): Yoshimura M.
  • Journal Title: 医学のあゆみ 223(9) Pages: 687-691
  • NAID: 40015707332
• [Journal Article] Cadherin08 is Required for the First Relay Synapses to Receive Functional Inputs from Primary Sensory Afferents for Cold Sensation, (2007)
  • Author(s): Suzuki SC. et al.
  • Journal Title: Journal of Neuroscience 27 Pages: 3466-3476
• [Journal Article] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro. (2007)
  • Author(s): Shimada H. et al.
  • Journal Title: Brain Research 1141 Pages: 74-83
• [Journal Article] Cell type specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of rhe rat spinal dorsal horn in vitro (2007)
  • Author(s): Yasaka T. et al.
  • Journal Title: Journal of Physiology(London) (in press)
• [Journal Article] Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats (2006)
  • Author(s): Kato G, Yasaka T, Katafuchi T, Furue H, Mizuno M, Iwamoto Y and Yoshimura M.
  • Journal Title: Journal of Neuroscience 26(6) Pages: 1787-1794
• [Journal Article] Narimatsu E, Yoshimura M and Namiki A. Changes in properties of substantia gelatinosa neurons after surgical incision in the rat : In vivo patch-clamp analysis (2006)
  • Author(s): Kawamata M, Furue H, Kozuka Y, Narimatsu E, Yoshimura M and Namiki A.
  • Journal Title: Anesthesiology 104 Pages: 432-440
• [Journal Article] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors (2006)
  • Author(s): Shiokawa H, Nakatsuka T, Furue H, Tsuda M, Katafuchi T, Inoue K and Yoshimura M.
  • Journal Title: Journal of Physiology(London) 573(Pt3) Pages: 753-763
• [Journal Article] Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice (2006)
  • Author(s): Rashid MH, Furue H, Yoshimura M and Ueda H.
  • Journal Title: Pain 125(1-2) Pages: 125-135
• [Journal Article] Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. (2006)
  • Author(s): Kato G.et al.
  • Journal Title: Journal of Neuroscience 26・6 Pages: 1787-1794
• [Journal Article] Changes in properties of substantia gelatinosa neurons agter surgical incision in the rat : In vivo patch-clamp analysis. (2006)
  • Author(s): Kawamata M. et al.
  • Journal Title: Anesthesiology 104 Pages: 432-440
• [Journal Article] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors. (2006)
  • Author(s): Shiokawa H. et al.
  • Journal Title: Journal of Physiology(London) 573.3 Pages: 753-763
• [Journal Article] Tonic inhibitory role of aplha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice. (2006)
  • Author(s): Rashid MH. et al.
  • Journal Title: Pain 125・1-2 Pages: 125-135
• [Journal Article] Mechanisms for the Anti-nociceptive Actions of the Descending Noradrenergic and Serotonergic Systems in the Spinal Cord. (2006)
  • Author(s): Yoshimura M. et al.
  • Journal Title: Journal Pharmacological Sciences 101 Pages: 107-117
  • NAID: 10018237576
• [Journal Article] Possible involvement of brain cytokines and 5-HT system in chronic fatigue syndrome. (2006)
  • Author(s): Katafuchi T.
  • Journal Title: International Congress Series Psychosomatic Medicine 1287 Pages: 251-255
• [Journal Article] Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedia medulla revealed by in vivo patch-clamp analysis in rats. (2006)
  • Author(s): Kato G et al.
  • Journal Title: Journal of Neuroscience 26・6 Pages: 1787-1794
• [Journal Article] Changes in properties of substantia gelatinosa neurons after surgical incision in the rat: In vivo patch-clamp analysis. (2006)
  • Author(s): Kawamata M et al.
  • Journal Title: Anesthesiology 104・3 Pages: 432-440
• [Journal Article] Direct inhibition of substantia gelatinosa neurones in the spinal cord by activation of dopamine D2-like receptors (2005)
  • Author(s): Tamae A, Nakatsuka T, Koga K, Kato G, Furue H, Katafuchi T and Yoshimura M.
  • Journal Title: Journal of Physiology(London) 568(Pt1) Pages: 243-253
• [Journal Article] activation of primary afferent fibers evaluated by sine-wave electrical stimulation (2005)
  • Author(s): Koga K, Furue H, Rashid MH, Takaki A, Katafuchi T and Yoshimura M.
  • Journal Title: Molecular Pain 1(1) Pages: 13-13
• [Journal Article] Action of neuropeptide Y on nociceptive transmission in substantia gelatinosa of the adult rat spinal dorsal horn (2005)
  • Author(s): Miyakawa A, Furue H, Katafuchi T, Jiang N, Yasaka T, Kato G and Yoshimura M.
  • Journal Title: Neuroscience 134(2) Pages: 595-604
• [Journal Article] Actions of brain-derived neurotrophic factor on the spinal nociceptive transmission during inflammation (2005)
  • Author(s): Matayoshi S, Jiang N, Katafuchi T, Koga K, Furue H, Yasaka T, Nakatsuka T, Zhou XF, Kawasaki Y, Tanaka N and Yoshimura M.
  • Journal Title: Journal of Physiology(London) 569(Pt2) Pages: 685-695
• [Journal Article] In vivo and in vitro patch-clamp recording analysis of the process of sensory transmission in the spinal cord and sensory cortex. (2005)
  • Author(s): Yoshimura M et al.
  • Journal Title: Journal of Physiological Anthropology and Applied Human Science 24・1 Pages: 93-97
  • NAID: 110002528851
• [Journal Article] Selective activation of primary afferent fibers evaluated by sine-wave electrical stimulation. (2005)
  • Author(s): Koga K et al.
  • Journal Title: Molecular Pain 1・1 Pages: 13-13
• [Journal Article] Modulation of glutamate-induced outward current by prostaglandin E2 in rat dissociated preoptic neurons. (2005)
  • Author(s): Katafuchi T et al.
  • Journal Title: Brain Research 1037・1-2 Pages: 180-186
• [Journal Article] Action of neuropeptide Y on nociceptive transmission in substantia gelatinosa of the adult rat spinal dorsal horn. (2005)
  • Author(s): Miyakawa A et al.
  • Journal Title: Neuroscience 134・2 Pages: 595-604
• [Journal Article] Actions of brain-derived neurotrophic factor on the spinal nociceptive transmisison during inflammation. (2005)
  • Author(s): Matayoshi S et al.
  • Journal Title: Journal of Physiology (London) 569・2 Pages: 685-695
• [Journal Article] Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activation of dopamine D2-likereceptors. (2005)
  • Author(s): Tamae A et al.
  • Journal Title: Journal of Physiology (London) 568・1 Pages: 243-253
• [Journal Article] Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats. (2005)
  • Author(s): Katafuchi T et al.
  • Journal Title: European Journal of Neuroscience 22 Pages: 2817-2826
• [Journal Article] Functional roles of post-synaptic ATP P2X receptors in spinal deep dorsal horn neurons. (2005)
  • Author(s): Shiokawa H et al.
  • Journal Title: Pain Research 20・1 Pages: 1-7
• [Journal Article] Functional role of postsynaptic dopamine receptors in substantia gelatinosa neurons of the spinal cord. (2005)
  • Author(s): Nakatsuka T et al.
  • Journal Title: Pain Research 20・3 Pages: 105-110
• [Journal Article] Spinal anti-nociceptive effect of calcitonin in an osteoporotic model rats -Functional recovery of descending serotonergic inhibition- (2005)
  • Author(s): Furue H et al.
  • Journal Title: CLINICAL CALCIUM 15・3 Pages: 483-487
• [Presentation] 痒み情報を伝達する一次求心線維の電気生理学的特徴. (2008)
  • Author(s): 蜂須賀 淳一., et al.
  • Organizer: 第11回皮膚・免疫アレルギー懇話会
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-11-29
• [Presentation] Electrophysiological property of itch sensing primary afferents. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: 18th International Symposium of Itch
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-10-25
• [Presentation] ハリ鎮痛と下行性痛覚抑制系. (2008)
  • Author(s): 吉村 恵.
  • Organizer: 第3回佐賀整形外科手術侵襲・疼痛研究会
  • Place of Presentation: 佐賀
  • Year and Date: 2008-08-09
• [Presentation] 脊髄由来の疼痛up to date. (2008)
  • Author(s): 吉村 恵.
  • Organizer: 第15回スパインフロンティア
  • Place of Presentation: 北海道
  • Year and Date: 2008-07-25
• [Presentation] 成熟ラットの後根神経節細胞を用いた局所麻酔薬の活動電位抑制効果の比較 (2008)
  • Author(s): 歌 大介, et. al.
  • Organizer: 第30回脊髄機能診断学研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] ガン性癒痛モデルにおける痛覚伝達系異常の行動学的および電気生理学的解析 (2008)
  • Author(s): 柳澤 義和, et. al.
  • Organizer: 第30回脊髄機能診断学研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] Bursting activity mediated by glutamatergic inputs in the primary somatosensory cortex in vivo (2008)
  • Author(s): Yoshimura M.
  • Organizer: The 3rd International Conference of Neurons and Brain Diseases
  • Place of Presentation: Seoul, Korea
• [Presentation] In vivo パッチクランプ法を用いた脊髄痛覚伝達におけるCa^<2+>透過性AMPA受容体の機能解析. (2008)
  • Author(s): 古江 秀昌., et al.
  • Organizer: 第10回ブレインサイエンス研究会
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Actions of noradrenaline and midazolam on inhibitory aynaptic responsesevoked in substantia gelatinosa neurons ofthe rat spinal cord. (2008)
  • Author(s): Maeda A., et al.
  • Organizer: The 55th Annual Meeting of Japanese Society of Anesthesiologists
  • Place of Presentation: Yokohama, Japan
• [Presentation] Enhancement of excitatory and inhibitory synaptic transmission in the rat spinal dorsal horn by stimulation of the locus coeruleus in vitro. (2008)
  • Author(s): Fume H., et al.
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Tokyo, Japan
• [Presentation] Functional loss of menthol-sensitive synaptic inputs to spinal dorsal hornneurons in cadherin-8 deficient mice. (2008)
  • Author(s): Fume H., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Plastic changes in descending serotonergic inhibition of spinal noxious mechanical synaptic transmission following ovariectomy. (2008)
  • Author(s): Fume H., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] In vivo patch-clamp analysis of descending spinal modulation from locuscoeruleus in rats. (2008)
  • Author(s): Fume H., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] The behavioral and electrophysiological analysis of spinal nociceptive transmission in a murine model of bone cancer pain. (2008)
  • Author(s): Yanagisawa Y., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Electrophysiological and morphological analyzes of excitatory effect of TRPA1 agonists on synaptic transmission in excitatory interneurons in the adult rat spinal dorsal horn neurons. (2008)
  • Author(s): Uta D., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Electrophysiological property of itch sensing primary afferents. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] The kinetics changes of inhibitory synaptic responses during inflammation in the rat. (2008)
  • Author(s): Shimada H., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Plastic change in the spinal nociceptive transmission mediated byCa^<2+>-permeable AMPA receptors in vivo after inflammation. (2008)
  • Author(s): Furue H., et al.
  • Organizer: The 30th Annual Meeting ofJapanese Association for the Study of Pain
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Comparison of blocking effect of the local anesthetics on primary afferent synaptic transmission of the adult rat spinal dorsal horn neurons。 (2008)
  • Author(s): Uta D., et al.
  • Organizer: The 30th Annual Meeting ofJapanese Association for the Study of Pain
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Mechanisms of itch sensation in DRG neurons revealed by in vivo intracellular recordings. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: The 30th Annual Meeting ofJapanese Association for the Study of Pain
  • Place of Presentation: Fukuoka, Japan
• [Presentation] The changes of inhibitory synaptic responses in rat complete freund's adjuvant model. (2008)
  • Author(s): Shimada H., et al.
  • Organizer: The 30th Annual Meeting ofJapanese Association for the Study of Pain
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Bursting activity mediated by glutamatergic inputs in the primary somatosensory cortex in vivo. (2008)
  • Author(s): Yoshimura M.
  • Organizer: The 3^<rd>International Conference of Neurons and Brain Diseases
  • Place of Presentation: Seoul, Korea
• [Presentation] Stimulation of the locus coeruleus increases excitatory transmission onto dorsalhorn neurons of the rat in vivo. (2008)
  • Author(s): Fume H., et al.
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow, UK
• [Presentation] Brain mechanisms of immunologically induced fatigue in the rat. (2008)
  • Author(s): Katafuchi T., et al.
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: Okinawa, Japan
• [Presentation] セロトニンを介した脊髄痛覚シナプス伝達抑制の可塑的変化-In vivo パッチクランプ法を用いた解析-. (2008)
  • Author(s): 古江 秀昌., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] In vivo パッチクランプ法を用いたラット一次体性感覚野における痛覚応答の解析. (2008)
  • Author(s): 古賀 浩平., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] CaMK IVノックアウトマウスを用いた行動薬理的および電気生理学的検討. (2008)
  • Author(s): 歌 大介., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] ガン性疼痛モデルにおける痛覚伝達系異常の行動学的および電気生理学的解析. (2008)
  • Author(s): 柳澤 義和., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] ラット炎症性疼痛モデルにおけるGABA ・ グリシンの相互作用. (2008)
  • Author(s): 島田秀樹., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] Inputs of the noxious heat sensation to the spinal dorsal horn revealed by invivo patch-clamp recordings. (2008)
  • Author(s): Yoshimura M., et al.
  • Organizer: Current Trends in Biomedicine Workshop : Understanding Pain : From Transduction to Sensation
  • Place of Presentation: Baeza, Spain
• [Presentation] 癌性疼痛モデルにおける痛覚伝達系異常の電気生理学的解析. (2008)
  • Author(s): Yanagisawa Y., et al.
  • Organizer: The 23rd Annual Research Meeting of the Japanese Orthopaedic Association
  • Place of Presentation: Kyoto, Japan
• [Presentation] In vivo patch-clamp analysis of nociceptive synaptic transmission through calcium-permeable AMPA receptors in substantia gelatinosa neurons of the rat spinal dorsal hom following inflammation. (2008)
  • Author(s): Furue H., et al.
  • Organizer: The 38th Annual Meeting ofthe Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Roles of Calcium / Calmodulin-dependent protein kinase IV on nociceptive transmission in substantia gelatinosa ofthe adult mouse spinal cord. (2008)
  • Author(s): Uta D., et al.
  • Organizer: The 38th Annual Meeting ofthe Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Electrophysiological analysis of itch sensing primary afferents. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Behavioral and electrophysiological analyses of spinal nociceptive transmission in a murine model of cancer-induced bone pain. (2008)
  • Author(s): Yanagisawa Y., et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Increased mechanical synaptic inputs to the rat spinal dorsal horn in vivo following inflammation. (2008)
  • Author(s): Furue H., et. al.
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo, Japan
• [Presentation] Selective modulation of excitatory synaptic transmission in excitatory interneurons in the adult rat spinal dorsal horn through TRPA1 agonist-sensitive C fibres (2008)
  • Author(s): Uta D., et. al.
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo, Japan
• [Presentation] In vivo intracellular recording analysis of itch signal transduction in rat dorsal root ganglion cells. (2008)
  • Author(s): Hachisuka J., et. al.
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo,Japan
• [Presentation] In vivo intracellular recording analysis of action potentials elicited by 5-HT-induced itch stimuli in rat dorsal root ganelion neurons (2007)
  • Author(s): Hachisuka J., et. al.
  • Organizer: 17th International Symposium of Itch
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2007-09-15
• [Presentation] Activation of TRPA1 reduces C afferent-evoked excitatory synaptic transmission but enhances the miniature release in substantia gelatinosa of the adult rat spinal cord (2007)
  • Author(s): Uta D., et. al.
  • Organizer: The 29th Annual Meeting of JASP
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2007-07-07
• [Presentation] Electrophysiotogical analysis of effects of Neurotropin on serotonergic neurons in the Nucleus Raphe Magnus. (2007)
  • Author(s): Okai H., et. al.
  • Organizer: The 29th Annual Meeting of JASP
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2007-07-07
• [Presentation] In vivoパッチクランプ記録法を用いた下行性痛覚伝達系の作用機序-シナプス前抑制vsシナプス後抑制-. (2007)
  • Author(s): 吉村 恵
  • Organizer: 第21回日本ニューロモデュレーション学会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-12
• [Presentation] Modulation of sensory inputs from inflamed region to the primary sensory cortex (2007)
  • Author(s): Yoshimura M, Koga K and Furue H.
  • Organizer: The 2nd International Symposium on Design of Artificial Environments
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Cortical membrane potential fluctuations may be modified by thalamocortical inputs in rat barrel cortex in vivo (2007)
  • Author(s): Mizuno M, Doi A, Yasaka T, Furue H, Aou S and Yoshimura M.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Modification of bursting activities in somatosensory cortex in inflamed-rats in vivo (2007)
  • Author(s): Koga K, Shiokawa H, Mizuno M, Doi A, Mizuguchi-Takase H, Furue H and Yoshimura M.
  • Organizer: Second International Congress on Neuropathic Pain
  • Place of Presentation: Berlin, Germany
• [Presentation] In vivo patch clamp analysis of synaptic responses evoked in primary somatosensory cortex in inflamed rats (2007)
  • Author(s): Koga K, Shiokawa H, Mizuno M, Doi A, Takase-Mizuguchi H, Furue H and Yoshimura M.
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
• [Presentation] Analysis of hypnotic or analgesic effect of anesthetic agents by in-vivo patch clamp recordings from somatosensory cortex in rats (2007)
  • Author(s): Shiokawa H, Yoshimura M and Takahashi S.
  • Organizer: The 54^<th> Annual Meeting of Japanese Society of Anesthesiologists
  • Place of Presentation: Hokkaido, Japan
• [Presentation] Serotonin system in poly I:C-induced fatigue model in rats (2007)
  • Author(s): Katafuchi T., et. al.
  • Organizer: International Symposium: Interaction of the nervous and immune systems in health and diseas
  • Place of Presentation: St.Petersburg, Russia
• [Presentation] Analogy of A-beta afferents termination in pathological conditions with immature state. (2007)
  • Author(s): Yoshimura M., et. al.
  • Organizer: Second International Congress on Neuropathic Pain
  • Place of Presentation: Berlin, Germany
• [Presentation] Modification of bursting activities in somatosensory cortex in inflamed-rats in vivo (2007)
  • Author(s): Koga K, et. al.
  • Organizer: Second International Congress on Neuropathic Pain
  • Place of Presentation: Berlin, -Germany
• [Presentation] Increased noxious mechanical synaptic inputs to the rat spinal dorsal horn from A delta and C fibers: in vivo patch-clamp and intracellular recordings from spinal an ddorsal root ganglionn eurons (2007)
  • Author(s): Hachisuka J., et. al.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] The effects of momoamines on lumber motoneurons in transverse slices from young adult rat using whole-cell patch-clamp recording (2007)
  • Author(s): Hisamitsu R., et. al.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Electrophysiological and morphological analyzes of excitatory effect of TRPAl agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): Uta D., et. al.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] In vivo and slice patch-clamp analyses of plastic changes in descending inhibition of spinal noxious mechanical synaptic transmission in ovariectomized rats. (2007)
  • Author(s): Furue H., et. al.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Intra-and translaminar neuronal connectivity of superficial spinal dorsal hornneurons demonstrated by laser scanning photostimulation. (2007)
  • Author(s): Kato G., et. al.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Cortical membrane potential fluctuations may be modified by thalamocortical inputs in rat barrel cortexm vivo (2007)
  • Author(s): Mizuno M., et. al.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Functional loss of synaptic inputs to spinal superficial dorsal horn neurons through cold-sensitive afferent fibers in cadherin-8 deficient mice (2007)
  • Author(s): Furue H., et. al.
  • Organizer: The 7th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Sendai, Japan
• [Presentation] Functional role of GABA receptor and its modification in the spinal dorsal horn (2007)
  • Author(s): Yoshimura M., et. al.
  • Organizer: The 54th Annual Meeting of Japanese Society of Anesthesiologists
  • Place of Presentation: Sapporo, Japan
• [Presentation] Analysis of hypnotic or analgesic effect of anesthetic agents by in-vivo patch clamp recordings from somatosensory cortex in rats. (2007)
  • Author(s): Shiokawa H., et. al.
  • Organizer: The 54th Annual Meeting of Japanese Society of Anesthesiologists
  • Place of Presentation: Sapporo, Japan
• [Presentation] Plastic modification of TRP channel activities in the spinal dorsal horn following peripheral nerve injury (2007)
  • Author(s): Yoshimura M., et. al.
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
• [Presentation] Impairment of afferent synaptic inputs for mechanical and cold sensation to substantia gelationsa neurons of the rat spinal dorsal hom through cadherin-8 expressing synaptic glomeruli. (2007)
  • Author(s): Furue H., et. al.
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
• [Presentation] In vivo patch-clamp analysis of plastic changes in descending serotonergic inhibition of noxious mechanical transmission to substantia gelatiosa neurons through 5-HT1A receptors in ovariectomized rats. (2007)
  • Author(s): Omori Y., et. al.
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
• [Presentation] Patch-clamp analysis of membrane properties of bursting neurons in the young adult rat ventral horn in vitro. (2007)
  • Author(s): Hisamitsu R., et. al.
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
• [Presentation] ラット後根神経節細胞からのin vivo細胞内記録法開発-痒みのシグナル伝達の解析-. (2007)
  • Author(s): 蜂須賀 淳一, et. al.
  • Organizer: 第58回西日本生理学会
  • Place of Presentation: 福岡
• [Presentation] 炎症ラット脊髄膠様質におけるAMPA受容体Ca2+透過性の可塑的変化-In vivoパッチクランプ法を用いた解析- (2007)
  • Author(s): 古江 秀昌, et. al.
  • Organizer: 第58回西日本生理学会
  • Place of Presentation: 福岡
• [Presentation] Behavioral and electrophysiological analyses of spinal nociceptive transmission in a murine model of cancer-induced bone pain (2007)
  • Author(s): Yanagizawa Y., et. al.
  • Organizer: The 22nd Annual Research Meeting of the Japanese Orthopaedic Association
  • Place of Presentation: Shizuoka, Japan
• [Presentation] Central sensitization induced by switching of subunit in AMPA receptor following inflammatory pain (2007)
  • Author(s): Katano T., et. al.
  • Organizer: The 30th Annual Meeting of the Molecular Biology Society of Japan and The 80th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Yokohama, Japan
• [Presentation] Sensory processing and functional reorganization of sensory transmission in the postnatal spinal dorsal horn (2005)
  • Author(s): Yoshimura M.
  • Organizer: The 11th World Congress of Pain
  • Place of Presentation: Sydney, Australia
• [Presentation] In vivo patch-clamp analysis of slow bursting in the rat somatosensory cortex (2005)
  • Author(s): Doi A, Mizuno M, Furue H, Katafuchi T and Yoshimura M.
  • Organizer: The Fifth Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Kitakyushu, Japan
• [Presentation] Mechanisms of oscillation and sensory processing in the rat somatosensory cortex-In vivo patch-clamp analysis- (2005)
  • Author(s): Yoshimura M. Matayoshi S, Furue H, Koga K, Katafuchi T, Yasaka T and Nakatsuka T.
  • Organizer: The 82nd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sendai
• [Book] In vivo patch-clamp technique. In : Patch-Clamp Analysis : advanced techniques, Second Edition.(Ed. By Walz W.) (2007)
  • Author(s): Furue H, Katafuchi T and Yoshimura M.
  • Publisher: Humana Press Inc., Totowa
• [Book] Spinal glutamate receptors. In : Molecular Pain.(Ed. Zhuo M.) (2007)
  • Author(s): Yoshimura M.
  • Publisher: Higher Education Press, Beijing, P. R. China
• [Book] Whole-cell patch-clamp recording in vivo. In : Molecular Pain. (Ed. Zhuo M.) (2007)
  • Author(s): Yoshimura M.
  • Publisher: Higher Education Press, Beijing, P. R. China
• [Book] Patch-Clamp Analysis:advanced techniques (2007)
  • Author(s): Furue H., et. al.
  • Total Pages: 475
  • Publisher: Humana Press
• [Book] 人工環境デザインハンドブック (2007)
  • Author(s): 片渕 俊彦, et. al.
  • Total Pages: 461
  • Publisher: 丸善
• [Book] Patch-Clamp analysis : advanced techniques, Second Edition. (2007)
  • Author(s): Furue H. et al.
  • Publisher: Humana Press Inc.(in press)
• [Book] Cytokines and Brain, Neuroimmune Biology (2007)
  • Author(s): Katafuchi T.
  • Publisher: Elsevier Science B, V., Amsterdam(in press)
• [Book] 大脳皮質からのin vivo パッチクランプ法開発In : ブレインサイエンスレビュー2005(伊藤正男、河合述史編) (2005)
  • Author(s): 古江秀昌
  • Publisher: クバプロ・(株)ブレインサイエンス振興財団
• [Book] ブレインサイエンスレビュー2005 (2005)
  • Author(s): 古江 秀昌
  • Total Pages: 263
  • Publisher: クバプロ