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Development of functional polymeirc micelles responding to intracellular microenvironments for cancer chemotherapy

Research Project

Project/Area Number 17200031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

KATAOKA Kazunori  The University of Tokyo, Graduate School of Engineering, Professor (00130245)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Yuichi  The University of Tokyo, Graduate School of Engineering, Associate Professor (00322678)
NISHIYAMA Nobuhiro  The University of Tokyo, Graduate School of Medicine, Associate Professor (10372385)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥47,190,000 (Direct Cost: ¥36,300,000、Indirect Cost: ¥10,890,000)
Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2006: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2005: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Keywordsdrug delivery / polymeric micelles / cancer chemotherapy / chemotherapeutic agents / environment sensitivity / cancer targeted therapy / nanotechnology / がん / 化学療法 / 制がん剤 / ブロック共重合体 / DDS / pH応答性 / ポリエチレングリコール / 抗がん剤 / 細胞内環境応答性 / アドリアマイシン / 放出制御
Research Abstract

Polymeric micelles, the self-assemblies of block copolymers, are a promising nanocarrier system for drug delivery. Indeed, several formulations have been studied in clinical trials. Polymeric micelles are characterized by a size of several tens nm and unique core-shell structure, where the drug-loaded core is surrounded by biocompatible poly(ethylene glycol) (PEG) chains. These characteristics of polymeric micelles allow their longevity in the bloodstream and effective tumor accumulation after their systemic administration. In this project, we have prepared pH-sensitive polymeric micelles, in which adriamycin (ADR) is attached to the side chain of the core-forming segment of the block copolymers via an acid-labile hydrazone bond. The system showed appreciable drug release under intracellular low pH conditions, while exhibiting no drug release under physiological pH conditions. We applied such pH-sensitive polymeric micelles for the treatment of pancreatic cancers, which are known to be intractable due to hypovascularity and thick fibrosis. As a result, pH-sensitive polymeric micelles showed significant antitumor efficacy against subcutaneous pancreatic cancers in mice. Meanwhile, the pH-sensitive micelles were modified with a folate molecule to construct the polymeric micelles with the tumor-targetability. A large number of cancer cells are known to overexpress folate-binding proteins (FBP). The folate-conjugated micelles were more efficiently taken up by the FBP-overexpressing cancer cells, achieving remarkable antitumor effect at much lower ADR concentrations than the non-targeted micelles. These results indicate that the use of the folate-conjugated micelles may lower the effective doses over free ADR, improving the safety of the clinical chemotherapy. Thus, functional pH-sensitive polymeric micelles developed in this study are expected to improve the safety and efficacy of the treatments against intractable malignant tumors.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (128 results)

All 2008 2007 2006 2005 Other

All Journal Article (91 results) (of which Peer Reviewed: 41 results) Presentation (30 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive non-viral gene vectors.2008

    • Author(s)
      S. Takae, K. Kataoka et al.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 6001-6009

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Selection between block-and homo-polyelectrolytes through polyion complex formation in aqueous medium2008

    • Author(s)
      A. Harada, K. Kataoka
    • Journal Title

      Soft Matter 4

      Pages: 162-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dendrimer generation effects on photodynamic efficacy of dendrimer porphyrins and dendrimer-loaded supramolecular nanocarriers2008

    • Author(s)
      Y. Li, K. Kataoka et al.
    • Journal Title

      Chem. Mater. 19

      Pages: 5557-5562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors2008

    • Author(s)
      S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka
    • Journal Title

      J. Am. Chem. Soc. 130(18)

      Pages: 6001-6009

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Selection between block-and homo-polyelectrolytes through polyion complex formation in aqueous medium2008

    • Author(s)
      A. Harada, K. Kataoka
    • Journal Title

      Soft Matter 4(1)

      Pages: 162-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A facile synthesis of azido-terminated heterobifunctional poly (ethylene glycol) s for "Click" conjugation2007

    • Author(s)
      S. Hiki, K. Kataoka
    • Journal Title

      Bioconjugate. Chem. 18

      Pages: 2191-2196

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly (ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes.2007

    • Author(s)
      M. Oishi, K. Kataoka et al.
    • Journal Title

      ChemMedChem 2

      Pages: 1290-1297

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy.2007

    • Author(s)
      K. Miyata, K. Kataoka et al.
    • Journal Title

      J. Control. Release 122

      Pages: 252-260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins.2007

    • Author(s)
      M. Oba, K.K. Kataoka et al.
    • Journal Title

      Bioconjugate Chem. 18

      Pages: 1415-1423

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Optimization of (1, 2-diamino-cyclohexane) platinum (II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity.2007

    • Author(s)
      H. Cabral, K. Kataoka et al.
    • Journal Title

      J. Control. Release 121

      Pages: 146-155

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transfection Study Using Multicellular Tumor Spheroids for Screening Non-viral Polymeric Gene Vectors with Low Cytotoxicity and High Transfection Efficiencies.2007

    • Author(s)
      M. Han, K. Kataoka et al.
    • Journal Title

      Bioconjugate Chem. 121

      Pages: 38-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ih Vivo Antitumor Activity of the Folate -Conjugated pH-Sensitive Polymeric Micelle Selectively Releasing Adriamycin in the Intracellular Acidic Compartments.2007

    • Author(s)
      Y. Bae, K. Kataoka et al.
    • Journal Title

      J. Control. Release 18

      Pages: 1131-1139

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers: a phy2007

    • Author(s)
      A. Kishimura, K. Kataoka et al.
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 6085-6088

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles.2007

    • Author(s)
      K. Itaka, K. Kataoka et al.
    • Journal Title

      Mol. Ther. 15

      Pages: 1655-1662

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation.2007

    • Author(s)
      D. Akagi, K. Kataoka et al.
    • Journal Title

      Gene Ther. 14

      Pages: 1029-1038

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comprehensive and accurate control of thermosensitivity of poly(2-alkyl-2-oxazoline)s via well-defined gradient or random copolymerization.2007

    • Author(s)
      J.-S. Park, K. Kataoka et al.
    • Journal Title

      Macromolecules 40

      Pages: 3599-3609

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A protein nanocarrier from charge-conversion polymer in response to endosomal pH.2007

    • Author(s)
      Y. Lee, K. Kataoka et al.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 5362-5363

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-betasignaling.2007

    • Author(s)
      M. R. Kano, K. Kataoka et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 3460-3465

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Iron hydroxide nanoparticles coated with poly (ethylene glycol)-poly (asparticacid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imagmg.2007

    • Author(s)
      M. Kumagai, K. Kataoka et al.
    • Journal Title

      Colloids Surf., B Biointerfaces 56

      Pages: 174-181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Preparation and characterization of polyion complex micelles with a novel thermosensitive poly (2-isopropyl-2-oxazoline) shell via the complexation of oppositely charged block ionomers.2007

    • Author(s)
      J.-S. Park, K. Kataoka et al.
    • Journal Title

      Langmuir 23

      Pages: 138-146

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Polyion complex micelles for photodynamic therapy: incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property.2007

    • Author(s)
      W.-D. Jang, K. Kataoka et al.
    • Journal Title

      J. Control. Release 113

      Pages: 73-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble macromolecules.2007

    • Author(s)
      A. Koide, K. Kataoka et al.
    • Journal Title

      J. Am. Chem. Soc. 128

      Pages: 5988-5989

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer.2007

    • Author(s)
      Y. Kakizawa, K. Kataoka et al.
    • Journal Title

      J. Control. Release 111

      Pages: 368-370

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells.2007

    • Author(s)
      N.Kanayama, K. Kataoka et a1.
    • Journal Title

      Chem Med Chem 1

      Pages: 439-444

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer.2007

    • Author(s)
      R. Ideta, K. Kataoka et al.
    • Journal Title

      Nano Lett. 5

      Pages: 2426-2431

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Freeze-dried formulations for in vivo gene delivery of PEG ylated polyplex micelles with disulfide crosslinked cores to the liver.2007

    • Author(s)
      K. Miyata, K. Kataoka et al.
    • Journal Title

      J. Control. Release 109

      Pages: 15-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer.2007

    • Author(s)
      N. Nishiyama, K. Kataoka et al.
    • Journal Title

      Nature Mater. 4

      Pages: 934-941

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats.2007

    • Author(s)
      H. Uchino, K. Kataoka et al.
    • Journal Title

      Br. J. Cancer 93

      Pages: 678-687

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly (ethyleneglycol)-SS-oligodeoxynucleotide conjugate.2007

    • Author(s)
      M. Oishi, K. Kataoka et al.
    • Journal Title

      Biomacromolecules 6

      Pages: 2449-2454

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A facile synthesis of azido-terminated heterobifunctional poly (ethylene glycol) s for "Click" conjugation2007

    • Author(s)
      S. Hiki, K. Kataoka
    • Journal Title

      Bioconjugate. Chem. 18(6)

      Pages: 2191-2196

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dendrimer generation effects on photodynamic efficacy of dendrimer porphyrins and dendrimer-loaded supramolecular nanocarriers2007

    • Author(s)
      Y. Li, W. -D. Jang, N. Nishiyama, A. Kishimura, S. Kawauchi, Y. Morimoto, S. Miake, T. Yamashita, M. Kikuchi, T. Aida, K. Kataoka
    • Journal Title

      Chem. Mater. 19(23)

      Pages: 5557-5562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly (ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes2007

    • Author(s)
      M. Oishi, Y. Nagasaki, N. Nishiyama, K. Itaka, M. Takagi, A. Shimamoto, Y. Furuichi, K. Kataoka
    • Journal Title

      ChemMedChem 2(9)

      Pages: 1290-1297

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy2007

    • Author(s)
      K. Miyata, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka
    • Journal Title

      J. Control. Release 122(3)

      Pages: 252-260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins2007

    • Author(s)
      M. Oba, S. Fukushima, N. Kanayama, K. Aoyagi, N. Nishiyama, H. Koyama, K. Kataoka
    • Journal Title

      Bioconjugate Chem. 18(5)

      Pages: 1415-1423

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optimization of (1,2-diamino-cyclohexane) platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity2007

    • Author(s)
      H. Cabral, N. Nishiyama, K. Kataoka
    • Journal Title

      J. Control. Release 121(3)

      Pages: 146-155

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies2007

    • Author(s)
      M. Han, Y. Bae, N. Nishiyama, K. Miyata, M. Oba, K. Kataoka
    • Journal Title

      J. Control. Release 121(1-2)

      Pages: 38-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments2007

    • Author(s)
      Y. Bae, N. Nishiyama, K. Kataoka
    • Journal Title

      Bioconjugate Chem. 18(4)

      Pages: 11311139-11311139

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers : a physiologically available oxygen carrier2007

    • Author(s)
      A. Kishimura, A. Koide, K. Osada, Y. Yamasaki, K. Kataoka
    • Journal Title

      Angew. Chem. Int. Ed. 46(32)

      Pages: 6085-6088

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles2007

    • Author(s)
      K. Itaka, S. Ohba, K. Miyata, H. Kawaguchi, K. Nakamura, T. Takato, U. -I. Chung, K. Kataoka
    • Journal Title

      Mol. Ther. 15(9)

      Pages: 1655-1662

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation2007

    • Author(s)
      D. Akagi, M. Oba, H. Koyama, N. Nishiyama, S. Fukushima, T. Miyata, H. Nagawa, K. Kataoka
    • Journal Title

      Gene Ther. 14(13)

      Pages: 1029-1038

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comprehensive and accurate control of thermosensitivity of poly (2-alkyl-2-oxazoline) s via well-defined gradient or random copolymerization2007

    • Author(s)
      J. -S. Park, K. Kataoka
    • Journal Title

      Macromolecules 40(10)

      Pages: 3599-3609

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A protein nanocarrier from charge-conversion polymer in response to endosomal pH2007

    • Author(s)
      Y. Lee, S. Fukushima, Y. Bae, S. Hiki, T. Ishii, K. Kataoka
    • Journal Title

      J. Am, Chem. Soc 129(17)

      Pages: 5362-5363

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling2007

    • Author(s)
      M. R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kamiishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, K. Miyazono
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104(9)

      Pages: 3460-3465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Iron hydroxide nanoparticles coated with poly (ethylene glycol)-poly (aspartic acid) block copolymer as novel magnetic resonance agents for in vivo cancer imaging2007

    • Author(s)
      M. Kumagai, Y. Imai, T. NAkamura, Y. Yamasaki, M. Sekino, S. Ueno, K. Hanaoka, K. Kikuchi, T. Nagano, E. Kaneko, K. Shimokado, K. Kataoka
    • Journal Title

      Colloids Surf., B Biointerfaces 56

      Pages: 174-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preparation and characterzation of polyion complex micelles with a novel thermosrnsitive poly (2-isopropyl-2-oxazoline) shell via the complexation of oppositely charged block ionomers2007

    • Author(s)
      J. -S. Park, Y. Akiyama, Y. Yamasaki, K. Kataoka
    • Journal Title

      Langmuir 23(1)

      Pages: 138-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity2007

    • Author(s)
      H. Cabral, K. Kataoka, et. al.
    • Journal Title

      J. Control. Release 121

      Pages: 146-155

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to from polyplex micelles with improved stability and high transfection efficacy2007

    • Author(s)
      K. Miyata, K. Kataoka, et. al.
    • Journal Title

      J. Control. Release 122

      Pages: 252-260

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins2007

    • Author(s)
      M. Oba, K. Kataoka, et. al.
    • Journal Title

      Bioconjugate Chem 18

      Pages: 1415-1423

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-signaling2007

    • Author(s)
      Kano, MR, Nishiyama, N et al.
    • Journal Title

      Proc. Natl. Acad. Sci., USA 104(9)

      Pages: 3460-3465

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Preparation and characterization of polyion complex micelles with a novel thermosensitive poly(2-isopropy1-2-oxazoline) shell via the complexation of oppositely charged block ionomers2007

    • Author(s)
      Park, J-S, Kataoka, K etal.
    • Journal Title

      Langmuir 23(1)

      Pages: 138-146

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Precise control of lower critical solution temperature of thermosensitive poly (2-isopropyl-2-oxazoline) via gradient copolymerization with 2-ethyl-2-oxazoline as a hydrophilic comonomer.2006

    • Author(s)
      J.-S. Park, K. Kataoka
    • Journal Title

      Macromolecules 39

      Pages: 6622-6630

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Precise control of lower critical solution temperature thermosensitive poly (2-isopropyl-2-oxazoline) via gradient copolymerization with 2-ethyl-2-oxazoline as a hydrophilic comonomer2006

    • Author(s)
      J. -S. Park, K. Kataoka
    • Journal Title

      Macromolecules 39(19)

      Pages: 6622-6630

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Polyion complex micelles for photodynamic therapy : incorporation of dendritic photosensitizer excitable atlong wavelength relevant to improved tissue-penetrating property2006

    • Author(s)
      W. -D. Jang, Y. Nakagishi, N. Nishiyama, S. Kawauchi, Y. Morimoto, M. Kikuchi, K. Kataoka
    • Journal Title

      J. Cotrol. Release 113(1)

      Pages: 73-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Semipermeable polymer vesicle (PlCsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers : physiologically stable micro-/nanocontainers of water-soluble macromolecules2006

    • Author(s)
      A. Koide, A. Kishimura, K. Osada, W. -D. Jang, Y. Yamasaki, K. Kataoka
    • Journal Title

      J. Am. Chem. Soc. 128(18)

      Pages: 5988-5989

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer2006

    • Author(s)
      Y. Kakizawa, S. Furukawa, A. Ishii, K. Kataoka
    • Journal Title

      J. Comtrol. Release 111(3)

      Pages: 368-370

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells2006

    • Author(s)
      N. Kanayama, S. Fukushima, N. Nishiyama, K. Itaka, W. -D. Jang, K. Miyata, Y. Yamasaki, U. -I. Chung, K. Kataoka
    • Journal Title

      ChemMedChem 1(4)

      Pages: 439-444

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection2006

    • Author(s)
      Arnia, Kataoka, K et al.
    • Journal Title

      Journal of Controlled Release 115(2)

      Pages: 208-215

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers : physiologically stable micro-/nanocontainers of water-soluble macromolecules.2006

    • Author(s)
      Koide, A, Kataoka, K et al.
    • Journal Title

      Journal of the American Chemical Society 128(18)

      Pages: 5988-5989

    • Related Report
      2006 Annual Research Report
  • [Journal Article] pH-responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector.2006

    • Author(s)
      Oishi, M, Kataoka, K et al.
    • Journal Title

      Bioconjugate Chemistry 17(3)

      Pages: 677-688

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer.2006

    • Author(s)
      Kakizawa, Y, Kataoka, K et al.
    • Journal Title

      Journal of Controlled Release 111(3)

      Pages: 368-370

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nanostructured devices based on block copolymer assemblies for drug delivery : designing structures for enhanced drug function2006

    • Author(s)
      N.Nishiyama, K.Kataoka
    • Journal Title

      Adv.Polym.Sci.(Polymer Therapeutics II) 193

      Pages: 67-101

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of stable lysozyme-entrapped polyion complex (PIC) micelles with crosslinked core by glutaraldehyde.2005

    • Author(s)
      X. Yuan, K. Kataoka et al.
    • Journal Title

      Polymer 46

      Pages: 7749-7758

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.2005

    • Author(s)
      Y. Bae, K. Kataoka et al.
    • Journal Title

      Mol. BioSyst. 1

      Pages: 242-250

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A synthetic block copolymer regulates S1 nuclease fragmentation of supercoiled plasmid DNA.2005

    • Author(s)
      K.Osada, K. Kataoka et al.
    • Journal Title

      Angew. Chem. Int. Ed. 44

      Pages: 3544-3548

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel.2005

    • Author(s)
      T. Hamaguchi, K. Kataoka et al.
    • Journal Title

      Br. J. Cancer 92

      Pages: 1240-1246

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Stabilization of lysozyme-incorporated polyion complex micelles by the ω-end derivatization of poly (ethylene glycol)-poly (α, β-aspartic acid) block copolymers with hydrophobic groups.2005

    • Author(s)
      X. Yuan, K. Kataoka et al.
    • Journal Title

      Langmuir 21

      Pages: 2668-2674

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PE Gylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular genedelivery.2005

    • Author(s)
      S. Fukushima, K. Kataoka et al.
    • Journal Title

      J. Am. Chem. Soc. 127

      Pages: 2810-2811

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lactosylated poly (ethylene glycol)-si RNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.2005

    • Author(s)
      M. Oishi, K. Kataoka et al.
    • Journal Title

      J. Am. Chem. Soc. 127

      Pages: 1624-1625

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.2005

    • Author(s)
      Y. Bae, K. Kataoka et al.
    • Journal Title

      Bioconjugate Chem. 16

      Pages: 122-130

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with poly (ethylene glycol) to enhance intracellular photodynamicefficacy.2005

    • Author(s)
      W. -D. Jang, K. Kataoka et al.
    • Journal Title

      Angew. Chem. Int. Ed. 44

      Pages: 419-423

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Preparation and biological properties of dichloro (1,2-diaminocyclohexane) platinum (II) (DACHPt)-loaded polymeric micelles.2005

    • Author(s)
      H. Cabral, K. Kataoka et a1.
    • Journal Title

      J.Control. Release 101

      Pages: 223-232

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nanotechnologh-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer2005

    • Author(s)
      R. Ideta, F. Tasaka, W. -D. Jang, N. Nishiyama, G. -D. Zhang, A. Harada, Y. Yanagi, Y. Tamaki, T. Aida, K. Kataoka
    • Journal Title

      Nano Lett. 5(12)

      Pages: 2426-2431

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver2005

    • Author(s)
      K. Miyata, Y. Kakizawa, N. Nishiyama, Y. Yamasaki, T. Watanabe, M. Kohara, K. Kataoka
    • Journal Title

      J. Control. Release 109(1-3)

      Pages: 15-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer2005

    • Author(s)
      N. Nishiyama, A. Iriyama, W. -D. Jang, K. Miyata, K. Itaka, Y. Inoue, H. Takahashi, Y. Yanagi, Y. Tamaki, H. Koyama, K. Kataoka
    • Journal Title

      Nature Mater 4(12)

      Pages: 934-341

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats2005

    • Author(s)
      H. Uchino, Y. Matsumura, T. Negishi, F. Koizumi, T. Hayashi, T. Honda, N. Nishiyama, K. Kataoka, S. Naito, T. Kakizoe
    • Journal Title

      Br. J. Cancer 93(6)

      Pages: 678-687

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide : polyion complex (PIC) micelles based on poly (ethylene glycol)-SS-oligodeoxynucleotide conjugate2005

    • Author(s)
      M. Oishi, T. Hayama, Y. Akiyama, S. Takae, A. Hara, Y. Yamasaki, F. Nagatsugi, S. Sasaki, Y. Nagasaki, K. Kataoka
    • Journal Title

      Biomacromolecules 6(5)

      Pages: 2449-2454

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of stable lysozyme-entrapped polyion complex (PIC) micelles with crosslinked core by glutaraldehyde2005

    • Author(s)
      X. Yuan, Y. Yamasaki, A. Harada, K. Kataoka
    • Journal Title

      Polymer 46(18)

      Pages: 7749-7758

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multifunctional polymeric micelles with folate-mediated cancer cell argeting and pH-triggered drug releasing properties for active intracellular drug delivery2005

    • Author(s)
      Y. Bae, W. -D. Jang, N. Nishiyama, S. Fukushima, K. Kataoka
    • Journal Title

      Mol. BioSyst 1(3)

      Pages: 242-250

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A synthetic blockcopolymer regulates S1 nuclease fragmentation of supercoiled plasmid DNA2005

    • Author(s)
      K. Osada, Y. Yamasaki, S. Katayose, K. Kataoka
    • Journal Title

      Angew. Chem. Int. Ed. 44(23)

      Pages: 3544-3548

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel2005

    • Author(s)
      T. Hamaguchi, Y. Matsumura, M. Suzuki, K. Shimizu, R. Goda, I. Nakamura, I. Nakatomi, M. Yokoyama, K. Kataoka, T. Kakizoe
    • Journal Title

      Br. J. Cancer 92

      Pages: 1240-1246

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stabilization of lysozyme-incorporated polyion complex micelles by the ω-end derivatization of poly(ethylene glycol)-poly (α,β-aspartic acid) block copolymers with hydrophobic groups2005

    • Author(s)
      X. Yuan, A. Harada, Y. Yamasaki, K. Kataoka
    • Journal Title

      Langmuir 21(7)

      Pages: 2668-2674

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery2005

    • Author(s)
      S. Fukushima, K. Miyata, N. Nishiyama, N. Kanayama, Y. Yamasaki, K. Kataoka
    • Journal Title

      J. Am. Chem. Soc. 127(9)

      Pages: 2810-2811

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lactosylated poly (ethylene glycol)-siRNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells2005

    • Author(s)
      M. Oishi, Y. Nagasaki, K. Itaka, N. Nishiyama, K. Kataoka
    • Journal Title

      J. Am. Chem. Soc. 127(6)

      Pages: 1624-1625

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property : Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy2005

    • Author(s)
      Y. Bae, N. Nishiyama, S. Fukushima, H. Koyama, Y. Matsumura, K. Kataoka
    • Journal Title

      Bioconjugate Chem. 16(1)

      Pages: 122-130

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with poly (ethylene glycol) to enhance ntracellular photodynamic efficacy2005

    • Author(s)
      W. -D. Jang, N. Nishiyama, G. -D. Zhang, A. Harada, D. -L. Jiang, S. Kawauchi, Y. Morimoto, M. Kikuchi, H. Koyama, T. Aida, K. Kataoka, K. Kataoka
    • Journal Title

      Angew. Chem. Int. Ed. 44(3)

      Pages: 419-423

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preparation and biological properties of dichloro (1,2-diaminocyclohexane) platinum(II)(DACHPt)-loaded polymeric micelles2005

    • Author(s)
      H. Cabral, N. Nishiyama, S. Okazaki, H. Koyama, K. Kataoka
    • Journal Title

      J. Control. Release 101(1-3)

      Pages: 223-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery2005

    • Author(s)
      Y.Bae, K.Kataoka et al.
    • Journal Title

      Molecular BioSystems 1・3

      Pages: 242-250

    • Related Report
      2005 Annual Research Report
  • [Journal Article] NK105 a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel2005

    • Author(s)
      T.Hamaguchi, K.kataoka et al.
    • Journal Title

      Br.J.Cancer 92・7

      Pages: 1240-1246

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property. Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy2005

    • Author(s)
      Y.Bac, K.Kataoka et al.
    • Journal Title

      Bioconjug.Chem. 16・1

      Pages: 122-130

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Preparation and biological properties of dichloro(1,2-diaminocyclohexane) platinum(II)(DACHPt)-loaded polymeric micelles2005

    • Author(s)
      H.Cabral, Kataoka et al.
    • Journal Title

      J.Control.Release 101・1-3

      Pages: 223-232

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats2005

    • Author(s)
      H.Uchino, Kataoka et al.
    • Journal Title

      Br.J.Cancer 93・6

      Pages: 678-687

    • Related Report
      2005 Annual Research Report
  • [Presentation] Multimolecular-assembly of smart block copolymers as nanocarriers for gene and drug delivery.2007

    • Author(s)
      K. Kataoka
    • Organizer
      7th International Gel Symposium (GelSympo 2007)
    • Place of Presentation
      University of Tokyo, Tokyo, Japan
    • Year and Date
      2007-08-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Multimolecular-assembly of smart block copolymers as nanocarriers for gene and drug delivery2007

    • Author(s)
      K. Kataoka
    • Organizer
      7th International Gel Symposium (GelSympo 2007)
    • Place of Presentation
      University of Tokyo, Tokyo, Japan
    • Year and Date
      2007-08-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery.2007

    • Author(s)
      K. Kataoka
    • Organizer
      International Conference on Materials for Advanced Technologies 2007 (ICMAT 2007)
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre, Singapore
    • Year and Date
      2007-07-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery2007

    • Author(s)
      K. Kataoka
    • Organizer
      International Conference on Materials for Advanced Technologies 2007 (ICMAT 2007)
    • Place of Presentation
      Singapore International Convention & Exhibition Centre, Singapore
    • Year and Date
      2007-07-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polymeric-micellar nanodevice for smart gene vector.2007

    • Author(s)
      K. Kataoka
    • Organizer
      13th Annual Meeting of Japan Society for Gene Therapy
    • Place of Presentation
      International Conference Hall, Aichi Cancer Center, Nagoya, Japan
    • Year and Date
      2007-06-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polymeric-micellar nanodevice for smart gene vector2007

    • Author(s)
      K. Kataoka
    • Organizer
      13th Annual Meeting of Japan Society for Gene Therapy
    • Place of Presentation
      International Conference Hall, Aichi Cancer Center, Nagoya, Japan
    • Year and Date
      2007-06-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Engineered supra-macromolecular assemblies as nanocarriers for gene and drug delivery.2007

    • Author(s)
      K. Kataoka
    • Organizer
      International Workshop on "Polymers in Medicine and Biology: 2007" (Sponsored by The Division of Polymer Chemistry, American Chemical Society)
    • Place of Presentation
      Santa Rosa, California, USA
    • Year and Date
      2007-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Engineered supra-macromolecular assemblies as nanocarriers for gene and drug delivery2007

    • Author(s)
      K. Kataoka
    • Organizer
      International Workshop on "Polymers in Medicine and Biology : 2007"(Sponsored by The Division of Polymer Chemistry, American Chemical Society)
    • Place of Presentation
      Santa Rosa, California, USA
    • Year and Date
      2007-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart supra-molecular assemblies of block copolymers as nanocarriers for gene and drug delivery-Challenge to intracellular nanomedicine-.2007

    • Author(s)
      K. Kataoka
    • Organizer
      1st BMTI Colloquium
    • Place of Presentation
      University of Twente, The Netherlands
    • Year and Date
      2007-04-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart supra-molecular assemblies of block copolymers as nanocarriers for gene and drug Delivery-Challenge to intracellular nanomedicine-2007

    • Author(s)
      K. Kataoka
    • Organizer
      1st BMTI Colloquium
    • Place of Presentation
      University of Twente, The Netherlands
    • Year and Date
      2007-04-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Light-induced gene and drug delivery by supramolecular nanocarrier.2007

    • Author(s)
      K. Kataoka
    • Organizer
      Pharmaceutical Sciences World Congress 2007 Symposium "What is the future of smart, feed-back, on-demand drug delivery systems"
    • Place of Presentation
      Amsterdam RAI, The Netherlands
    • Year and Date
      2007-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Light-induced gene and drug delivery by supramolecular nanocarrier2007

    • Author(s)
      K. Kataoka
    • Organizer
      Pharmaceutical Sciences World Congress 2007 Symposium "What is the future of smart, feed-back, on-demand drug delivery systems"
    • Place of Presentation
      Amsterdam RAI, The Netherlands
    • Year and Date
      2007-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Self-organized nanodevices of smart block copolymers for gene and drug delivery.2007

    • Author(s)
      K. Kataoka
    • Organizer
      4th International Conference on Molecular Electronics and Bioelectronics (M & BE4)
    • Place of Presentation
      Takeda Hall, The Unviersity of Tokyo, Tokyo, Japan
    • Year and Date
      2007-03-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Self-organized nanodevices of smart block copolymers for gene and drug delivery2007

    • Author(s)
      K. Kataoka
    • Organizer
      4th International Conference on Molecular Electronics and Bioelectronics (M&BE4)
    • Place of Presentation
      Takeda Hall, The University of Tokyo, Tokyo, Japan
    • Year and Date
      2007-03-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery.2007

    • Author(s)
      K. Kataoka
    • Organizer
      International Symposium on Polymer Therapeutics (ISPT-07)
    • Place of Presentation
      Freie University Berlin, Germany
    • Year and Date
      2007-02-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery2007

    • Author(s)
      K. Kataoka
    • Organizer
      International Symposium on Polymer Therapeutics (ISPT-07)
    • Place of Presentation
      Freie University Berlin, Germany
    • Year and Date
      2007-02-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Self-organized nanodevices of smart block copolymers as nanocarriers for gene and drug delivery〜Challenge to intracellular nanomedicine〜.2006

    • Author(s)
      K. Kataoka
    • Organizer
      13th Yonsei International Symposium for Cancer Reserch: Emerging Role of Nanomedicine: Opprotunities and Challenges
    • Place of Presentation
      Yonsei University, Seoul, Korea
    • Year and Date
      2006-11-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Self-organized nanodevices of smart block copolymers as nanocarriers for gene and drug delivery 〜 Challenge to intracellular nanomedicine 〜2006

    • Author(s)
      K. Kataoka
    • Organizer
      13th Yonsei International Symposium for Cancer Reserch : Emerging Role of Nanomedicine : Opprotunities and Challenges
    • Place of Presentation
      Yonsei University, Seoul, Korea
    • Year and Date
      2006-11-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart supra-macromolecular assemblies as nanocarriers for gene and drug delivery.2006

    • Author(s)
      K. Kataoka
    • Organizer
      4th Sweden-Japan Workshop on Bio-Nanotechnology
    • Place of Presentation
      National Institute for Materials Science, Tsukuba, Japan
    • Year and Date
      2006-11-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart supra-macromolecular assemblies as nanocarriers for gene and drug delivery2006

    • Author(s)
      K. Kataoka
    • Organizer
      4th Sweden-Japan Workshop on Bio-Nanotechnology
    • Place of Presentation
      National Institute for materials Science, Tsukuba, Japan
    • Year and Date
      2006-11-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery.2005

    • Author(s)
      K. Kataoka
    • Organizer
      11th Asian Chemical Congress
    • Place of Presentation
      University of Korea, Korea
    • Year and Date
      2005-08-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery2005

    • Author(s)
      K. Kataoka
    • Organizer
      11th Asian Chemical Congress
    • Place of Presentation
      University of Korea, Korea
    • Year and Date
      2005-08-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery.2005

    • Author(s)
      K. Kataoka
    • Organizer
      The 8th SPSJ International Polymer Conference (IPC 2005)
    • Place of Presentation
      Fukuoka Convention Center, Japan
    • Year and Date
      2005-07-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polylmeric micelles as nanocarriers for gene and drung delivery2005

    • Author(s)
      K. Kataoka
    • Organizer
      The 8th SPSJ International Polymer Conference (IPC 2002)
    • Place of Presentation
      Fukuoka Convention Center, Japan
    • Year and Date
      2005-07-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery.2005

    • Author(s)
      K. Kataoka
    • Organizer
      EuroConference on Biomaterials, Biosensors and Analytical Technique (ESF Research Conferences)
    • Place of Presentation
      Sant Feliu de Guixols, Spain
    • Year and Date
      2005-06-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery2005

    • Author(s)
      K. Kataoka
    • Organizer
      EuroConference on Biomaterials, Biosensors and Analytical Technique (ESF Research Conferences)
    • Place of Presentation
      Sant Feliu de Guixols, Spain
    • Year and Date
      2005-06-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polymeric micelles as nanocarriers for gene and drug delivery-challenge to intracellular nano-medicine-.2005

    • Author(s)
      K. Kataoka
    • Organizer
      5th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Hakone, Japan
    • Year and Date
      2005-05-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polymeric micelles as nanocarriers for gene and drug delivery-challenge to intracellular nano-medicine-2005

    • Author(s)
      K. Kataoka
    • Organizer
      5th Retrometabolism Based Drug Design and Targeting Conference
    • Place of Presentation
      Hakone, Japan
    • Year and Date
      2005-05-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Clemson award for basic research presentation: smart polymeric micelles as nanocarrier for gene and drug delivery.2005

    • Author(s)
      K. Kataoka
    • Organizer
      Society for Biomaterials 30th Annual Meeting
    • Place of Presentation
      Memphis Cook Convention Center Memphis, TN, USA
    • Year and Date
      2005-04-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Clemson award for basic research presentation : smart polymeric micelles as nanocarrier for gene and drug delivery2005

    • Author(s)
      K. Kataoka
    • Organizer
      Society for Biomaterials 30th Annual Meeting, Memphis Cook Convention Center Memphis
    • Place of Presentation
      TN, USA
    • Year and Date
      2005-04-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] インテリジェント高分子ミセルからのDDS2006

    • Author(s)
      Younsoo Bae, 片岡一則
    • Publisher
      最新医学(最新医学社)
    • Related Report
      2006 Annual Research Report
  • [Book] Polymeric Drug Delivery Systems : Polymer Assemblies(Drugs and pharmaceutical science,Vol.143)2005

    • Author(s)
      Y.Bae, K.Kataoka
    • Total Pages
      530
    • Publisher
      Marcel Dekker(New York)
    • Related Report
      2005 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/research/research2-1.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/research/research2-1.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] ポリエチレングリコールの結合した核酸のコンジュゲートとリン酸カルシウムの有機-無機ハイブリッド型ナノ粒子2007

    • Inventor(s)
      片岡 一則, 他4名
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2007-280803
    • Filing Date
      2007-10-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] TGF-βシグナル阻害剤と抗腫瘍剤の組み合わせ使用2006

    • Inventor(s)
      西山伸宏, 他4名
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2006-02-01
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] pH応答性高分子ミセルの調製に用いる新規ブロック共重合体及びその製造法の提供2005

    • Inventor(s)
      片岡一則 他4名
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2005-035233
    • Filing Date
      2005-04-22
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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