The effect of fragile fracture and bone marker to activity of daily living and death

• Project/Area Number: 17207021
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 生理人類学
• Research Institution: Nagasaki University
• Principal Investigator: AOYAGI Kiyoshi Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (80295071)
• Co-Investigator(Kenkyū-buntansha): ABE Yasuyo 長崎大学, 大学院・医歯薬学総合研究科, 助教 (90372771) ; TAKAMURA Noboru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30295068) ; SHIBDO Hiroyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30107677) ; OSAKI Makoto 長崎大学, 大学院・医歯薬学総合研究科, 講師 (20380959) ; MEDA Takahiro 長崎大学, 大学院・医歯薬学総合研究科 (40284674) ; 中里 未央 長崎大学, 大学院・医歯薬学総合研究科, 助教 (00380973)
• Co-Investigator(Renkei-kenkyūsha): YE ZHAOJIA 長崎大学, 大学院・医歯薬学総合研究科, 助教 (80457499)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2006: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2005: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 人類学 / 老化 / 骨粗鬆症 / 骨折 / 骨代謝マーカー / 死亡 / 日常生活動作

Research Abstract

横断調査で、年齢群別尿中NTX/Crについて、男性では各年齢群においてほぼ一定を示したが、女性では40歳代から50歳代にかけて高くなった。また、女性では骨量と骨折者の割合に有意差がみられ、全てのADL項目で骨折なしと答えた対象者に比べ骨折ありと答えた対象者の不自由者割合が高かった。縦断調査では1998-99年にコホート設定された女性を対象とした。死亡に対する年齢調整オッズ比を計算したところ、踵骨骨量(スティッフネス)の減少は死亡と有意な関連を示した。

Research Products

• [Journal Article] Availability of Cardio-Ankle Vascular Index(CAVI) as a Screening Tool for Atherosclerosis (2008)
  • Author(s): Kadota K, Takamura N, Aoyagi K, et.al.
  • Journal Title: Circulation Journal 72(2) Pages: 304-308
  • NAID: 110006571061
  • Peer Reviewed
• [Journal Article] Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis. (2008)
  • Author(s): Kadota K, Aoyagi K, et al.
  • Journal Title: Circulation Journal 72 Pages: 304-308
  • NAID: 110006571061
  • Peer Reviewed
• [Journal Article] 地域在住中高年女性における新規椎体骨折とQOL (2007)
  • Author(s): 青柳潔
  • Journal Title: Osteoporosis Japan 15(3) Pages: 182-184
• [Journal Article] Fear of Falling among Community-dwelling Elderly Women Receiving Visiting Nursing Services in Japan (2007)
  • Author(s): Takai K.
  • Journal Title: Acta Med Nagasaki 52 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Determinants of Self-Rated Health among Community-Dwelling Women Aged 40 Years and Over in Japan (2006)
  • Author(s): Kanagae M, Abe Y, Honda S, Takamura N, Kusano Y, Takemoto T, Aoyagi K.
  • Journal Title: Tohoku J Exp Med 210(1) Pages: 11-19
  • NAID: 10019283569
  • Peer Reviewed
• [Journal Article] Physique, body composition and maximum oxygen consumption of selected soccer players of kunimi high school, Nagasaki, Japan (2006)
  • Author(s): Tahara Y, Aoyagi K. et.al.
  • Journal Title: J Physiol Anthropol 25(4) Pages: 291-297
  • NAID: 110004751595
  • Peer Reviewed
• [Journal Article] Prevalence and involvement patterns of radiographic hand osteoarthritis in Japanese women: the Hizen-Oshima Study (2006)
  • Author(s): Toba N, Sakai A, Aoyagi K, Yoshida S, Honda S, Nakamura T.
  • Journal Title: J Bone Miner Metab 24(4) Pages: 344-348
  • NAID: 10018193715
  • Peer Reviewed
• [Journal Article] Ethnic-, gender-, and age-related differences in femorotibial angle, femoral antetorsion, and tibiofibular torsion : cross-sectional study among healthy Japanese and Australian Caucasians (2006)
  • Author(s): Tamari K, Tinley P, Briffa K, Aoyagi K.
  • Journal Title: Clin Anat 19(1) Pages: 59-67
  • Peer Reviewed
• [Journal Article] Obesity and Cardiovascular Risk Factors among Men and Women Aged 40 Years and Older in a Rural Area of Japan (2006)
  • Author(s): Aoyagi K., Kusano Y, Takamura N, Abe Y, Osaki M, Une H
  • Journal Title: J Physiol Anthropol 25(6) Pages: 371-375
  • NAID: 110006200723
• [Journal Article] Self-perceived Oral Health of the Elderly in a Rural Area, Japan (2006)
  • Author(s): Ugarte JL, Aoyage K et al.
  • Journal Title: Acta Med Nagasaki 51(3) Pages: 89-94
• [Journal Article] Determinants of Self-Rated Health among Community-Dwelling Women Aged 40 Years and Over in Japan (2006)
  • Author(s): Kanagae M, Aoyagi K et al.
  • Journal Title: Tohoku J Exp Med 210(1) Pages: 11-19
  • NAID: 10019283569
• [Journal Article] Prevalence and involvement patterns of radiographic hand osteoarthritis in Japanese women : the Hizen-Oshima Study (2006)
  • Author(s): Toba N, Aoyagi K, Yoshida S, Hond S, Nakamura T et al.
  • Journal Title: J Bone Miner Metab 24(4) Pages: 344-348
  • NAID: 10018193715
• [Journal Article] Early prediction of rheumatoid arthritis by serological variable and magnetic resonance imaging of the wrists and finger joints : results from prospective clinical examination (2006)
  • Author(s): Tamai M, Aoyagi K, et al.
  • Journal Title: Ann Rheum Dis 65(1) Pages: 134-135
• [Journal Article] Ethnic-, gender-, and age-related differences in femorotibial angle, femoral antetorsion, and tibiofibular torsion : cross-sectional study among healthy Japanese and Australian Caucasians (2006)
  • Author(s): Tamari K, Tinley P, Briffa K, Aoyagi K
  • Journal Title: Clin Anat 19(1) Pages: 59-67
• [Journal Article] 骨粗鬆症リスク評価ツール(FOSTA)の前腕骨骨密度による骨粗鬆症識別能 (2005)
  • Author(s): 富田雅人、青柳潔ら
  • Journal Title: 整形外科と災害外科 54(4) Pages: 631-633
• [Journal Article] Relationship between falls and physical performance measures among community-dwelling elderly women in Japan (2005)
  • Author(s): Morita M, Takamura N, Kusano Y, Abe Y, Moji K, Takemoto T, Aoyagi K.
  • Journal Title: Aging Clin Exp Res 17(3) Pages: 211-216
  • Peer Reviewed
• [Journal Article] 変形性股関節症における臼蓋骨棘形成の程度と橈骨、腰椎骨量値との関連 (2005)
  • Author(s): 岡野邦彦
  • Journal Title: Hip Joint 31 Pages: 179-181
• [Journal Article] 関節リウマチの早期診断基準案 (2005)
  • Author(s): 玉井慎美
  • Journal Title: 臨床リウマチ 17 Pages: 23-27
• [Journal Article] Plasma concentrations of adrenomedullin and ghrelin in hemodialysis patients with sustained and episodic hypotension (2005)
  • Author(s): Iwanaga K
  • Journal Title: Endocr J 52・1 Pages: 23-28
• [Journal Article] Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia (2005)
  • Author(s): Ito M
  • Journal Title: Osteoporos Int 16・9 Pages: 1042-1048
• [Journal Article] Pilot study on the use of tourniquet : a risk factor for pulmonary thromboembolism after total knee arthroplasty? (2005)
  • Author(s): Nishiguchi M
  • Journal Title: Thromb Res 115・4 Pages: 271-276
• [Presentation] The association of stiffness index and cross-linked N-telopeptides of type 1 collagen with any clinical fractures differs with age and gender. (2008)
  • Author(s): Abe Y, Aoyagi K.
  • Organizer: ASBMR 30th Annual Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2008-09-14
• [Presentation] The association of stiffness index and cross-linked N-telopeptides of type I collagen with any clinical fractures differs with age and gender (2008)
  • Author(s): Abe Y, Aoyagi K.
  • Organizer: ASBMR 30th Annual Me
  • Place of Presentation: Montreal, Canada
• [Presentation] Height Loss and Decreased Physical Function in Japanese Women:The Hizen-Osima study (2007)
  • Author(s): Aoyagi K.
  • Organizer: ASBMR 29th Annual Meeting
  • Place of Presentation: Honolulu,USA
  • Year and Date: 2007-09-17
• [Presentation] Height Loss and Decreased Physical Function in Japanese Women : The Hizen-Oshima Study (2007)
  • Author(s): Aoyagi K, Abe Y.
  • Organizer: ASBMR 29th Annual Meeting
  • Place of Presentation: Honolulu, USA
• [Presentation] Performance of a Simple Clinical Tool (FOSTA) for Identifying Undiagnosed Osteoporosis Patients in Japanese Women : Multicenter Study (2006)
  • Author(s): Abe Y, Aoyagi K.
  • Organizer: ASBMR 28th Annual Meeting
  • Place of Presentation: Philadelphia, USA
• [Presentation] Prediction of Vertebral Fracture Risk by Radiographic Absorptiometry and Quantitative Ultrasound in Japanese Women (2005)
  • Author(s): Abe Y, Aoyagi K.
  • Organizer: ASBMR 27h Annual Meeting
  • Place of Presentation: Nashville, USA