A study on molecular and neural mechanism of eyeblink conditioning

• Project/Area Number: 17209002
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Tokushima Bunri University (2006-2008); The University of Tokyo (2005)
• Principal Investigator: KIRINO Yutaka Tokushima Bunri University, 香川薬学部, 教授 (10012668)
• Co-Investigator(Kenkyū-buntansha): KAWAHARA Shigenori 富山大学, 大学院理工学研究部(工学), 教授 (10204752) ; KATSUURA Goro 塩野義製薬(株) (20401226) ; MATSUO Ryota 徳島文理大学, 香川薬学部, 講師 (40334338) ; TOKUMARU Hiroshi 徳島文理大学, 香川薬学部, 准教授 (70262160) ; KITAMURA Yoshiichiro 徳島文理大学, 香川薬学部, 講師 (70348829) ; KISHIMOTO Yasushi 徳島文理大学, 香川薬学部, 助教 (90441592) ; KUBOTA Takashi 徳島文理大学, 香川薬学部, 助教 (90412402) ; 渡辺 恵 徳島文理大学, 香川薬学部, 助教 (80302610)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Satoshi 東京大学, 大学院医学系研究科, 助教 (80302610)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥49,400,000 (Direct Cost: ¥38,000,000、Indirect Cost: ¥11,400,000); Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2007: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2006: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2005: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
• Keywords: 神経科学 / 脳・神経 / 瞬目反射条件づけ / 瞬目反射条件付け / イメージング

Research Abstract

瞬目反射学習と小脳プルキンエ細胞内のシナプス可塑性に関与する機能分子との因果関係を、5種の遺伝子変異マウスを用いて追究し、小脳LTDと学習能の間の強い相関性を明らかにした。条件によっては、小脳以外の上位中枢に強く依存し、小脳に依存しないメカニズムも示唆された。学習と脳波との関係や学習中の小脳神経活動の記録等、新しい実験系の開発を行った。瞬目反射学習の、老化や認知症研究における有用性が示された。

Research Products

• [Journal Article] Dual involvement of G-substrate in motor learning revealed by gene deletion (2009)
  • Author(s): Endo, S., Shutoh, F., Dinh, T. L., Okamoto, T., Ikeda, T., Suzuki, M., Kawahara, S., Yanagihara, D., Sato, Y., Yamada, K., Sakamoto, T., Kirino, Y., Hartell, N. A., Yamaguchi, K., Itohara, S., Nairn, A. C., Greengard, P., Nagao, S. and Ito, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 3525-3530
  • NAID: 120006399303
• [Journal Article] Orexins increase mRNA expressions of neurotrophin-3 in rat primary cortical neuron cultures (2009)
  • Author(s): Yamada, N., Katsuura, G., Tatsuno, I., Asaki, T., Kawahara, S., Ebihara, K., Saito, Y. and Nakao, K.
  • Journal Title: Neurosci. Lett. 450 Pages: 132-135
• [Journal Article] Dual involvement of G-substrate in motor learning revealed by gene deletion (2009)
  • Author(s): Endo, S., Shutoh, F., Dinh, T. L., Okamoto, T., Ikeda, T., Suzuki, M., Kawahara, S., Yanagihara, D., Sato, Y., Yamada, K., Sakamoto, T., Kirino, Y., Hartell, N. A., Yamaguchi, K., Itohara, S., Nairn, A. C, Greengard, P., Nagao, S., Ito M.
  • Journal Title: Proc Natl Acad Sci USA 106(9) Pages: 3525-3530
  • NAID: 120006399303
  • Peer Reviewed
• [Journal Article] Orexins increase mRNA expressions of neurotrophin-3 in rat primary cortical neuron cultures (2009)
  • Author(s): Yamada, N., Katsuura, G., Tatsuno, I., Asaki, T., Kawahara, S., Ebihara, K., Saito, Y., Nakao, K.
  • Journal Title: Neurosci Lett 450(2) Pages: 132-135
  • Peer Reviewed
• [Journal Article] Neural and molecular mechanisms of microcognition in Limax (2008)
  • Author(s): Watanabe, S., Kirino, Y. and Gelperin, A.
  • Journal Title: Learn. Mem. 15 Pages: 633-642
• [Journal Article] Nitric oxide-cyclic guanosine monophosphate signaling in the local circuit of the cricket abdominal nervous system (2008)
  • Author(s): Aonuma, H., Kitamura, Y., Niwa, K., Ogawa, H., Oka K
  • Journal Title: Neuroscience 157(4) Pages: 749-761
  • Peer Reviewed
• [Journal Article] Neural and molecular mechanisms of microcognition in Limax (2008)
  • Author(s): Watanabe, S., Kirino, Y., Gelperin, A.
  • Journal Title: Learn Mem 15(9) Pages: 633-642
  • Peer Reviewed
• [Journal Article] Nitric oxide is involved in appetitive but not aversive olfactory learning in the land slug Limax valentianus (2008)
  • Author(s): Yabumoto, T., Takanashi, F., Kirino, Y., Watanabe, S.
  • Journal Title: Learn Mem 15(4) Pages: 229-232
  • Peer Reviewed
• [Journal Article] Orexin decreases mRNA expressions of NMDA and AMPA receptor subunits in rat primary neuron cultures (2008)
  • Author(s): Yamada, N., Katsuura, G., Tatsuno, I., Asaki, T., Kawahara, S., Ebihara, K., Saito, Y., Nakao, K.
  • Journal Title: Peptides 29(9) Pages: 1582-1587
  • Peer Reviewed
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluR δ 2 (2008)
  • Author(s): Kakegawa, W, et. al.
  • Journal Title: Journal of Neuroscience 28 Pages: 1460-1468
  • Peer Reviewed
• [Journal Article] Impaired motor functions in mice lacking the RNA-binding protein Hzf (2008)
  • Author(s): Iijima, T, et. al.
  • Journal Title: Neuroscience Research 58 Pages: 183-189
  • Peer Reviewed
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2 (2007)
  • Author(s): Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M. and Yuzaki, M.
  • Journal Title: J. Neurosci. 28 Pages: 1460-1468
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, H., Kano, M., Watanabe, M., Iino, M. and Takeshima, H.
  • Journal Title: EMBO Journal 26 Pages: 1924-1933
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression (2007)
  • Author(s): Kina, S., Tezuka, T. Kusakawa, S. Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. and Yamamoto, T.
  • Journal Title: Eur. J. Neurosci. 26 Pages: 2269-2278
• [Journal Article] Impaired motor functions in mice lacking the RNA-binding protein Hzf (2007)
  • Author(s): Iijima, T., Ogura, H., Takatsuki, K., Kawahara, S., Wakabayashi, K., Nakayama, D., Fujioka, M., Kimura, Y., Bernstein, A., Okano, H. J., Kirino, Y. and Okano, H.
  • Journal Title: Neurosci. Res. 58 Pages: 183-189
  • NAID: 10024415208
• [Journal Article] Selective calcium imaging of olfactory interneurons in a land mollusk (2007)
  • Author(s): Watanabe, S. and Kirino, Y.
  • Journal Title: Neurosci. Lett. 417 Pages: 246-249
• [Journal Article] Junctophilin-mediated channel crostalk essential for cerebellar synaptic plasticity (2007)
  • Author(s): Kakizawa, S, et. al.
  • Journal Title: EMBO Journal 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learing and crrebellar long-term depression (2007)
  • Author(s): Kina, S, et. al.
  • Journal Title: European Journal of Neuoscience 26 Pages: 2269-2278
  • Peer Reviewed
• [Journal Article] A novel kruppel-like factor is induced by neuronal activity and by sensory input in the central nervous system of the terrestrial slug (2006)
  • Author(s): Fukunaga, S., Matsuo, R., Hoshino, S. and Kirino, Y.
  • Journal Title: Limax valentianus, J. Neurobiol. 66 Pages: 169-181
• [Journal Article] In vitro odor-aversion conditioning in a terrestrial mollusk (2006)
  • Author(s): Inoue, T., Murakami, M., Watanabe, S., Inokuma, Y. and Kirino, Y,
  • Journal Title: J. Neurophysiol. 95 Pages: 3898-3903
• [Journal Article] Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning (2006)
  • Author(s): Kishimoto, Y. and Kano, M.
  • Journal Title: J. Neurosci. 26 Pages: 8829-8837
• [Journal Article] Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response (2006)
  • Author(s): Kishimoto, Y., Nakazawa, K., Tonegawa, S., Kirino, Y. and Kano, M.
  • Journal Title: J. Neurosci. 26 Pages: 1562-1570
• [Journal Article] Change of Purkinje cell activity during classical conditioning in decerebrate guinea pig (2006)
  • Author(s): Kotani, S., Kawahara, S. and Kirino, Y.
  • Journal Title: Brain Res. 1068 Pages: 70-81
• [Journal Article] Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning (2006)
  • Author(s): Takehara-Nishiuchi, K., Nakao, K., Kawahara, S., Matsuki, N. and Kirino, Y.
  • Journal Title: J. Neurosci. 26 Pages: 5049-5058
  • NAID: 120006399305
• [Journal Article] A novel kruppel-like factor is induced by neuronal activity and by sensory input in the central nervous system of the terrestrial slug Limax valentianus (2006)
  • Author(s): Fukunaga, S
  • Journal Title: J.Neurobiol. 66 Pages: 169-181
• [Journal Article] Purkinje cell activity during classical eyeblink conditioning in decerebrate guinea pigs (2006)
  • Author(s): Kotani, S
  • Journal Title: Brain Res. 1068 Pages: 70-81
• [Journal Article] Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response. (2006)
  • Author(s): Kishimoto Y
  • Journal Title: J.Neurosci. 26 Pages: 1562-1570
• [Journal Article] Systems consolidation requires postlearning activation of NMDA receptors in te medial prefrontal cortex in trace eyeblink conditioning (2006)
  • Author(s): Takehara-Nishiuchi, K
  • Journal Title: J.Neurosci. 26 Pages: 5049-5058
• [Journal Article] In vitro odor-aversion conditioning in a terrestrial mollusk (2006)
  • Author(s): Inoue, T
  • Journal Title: J.Neurophysiol. 95 Pages: 3898-3903
• [Journal Article] Mapping of odor-related neuronal activity using a fluorescent derivative of glucose (2006)
  • Author(s): Ito, I
  • Journal Title: Neurosci.Lett. 398 Pages: 224-229
• [Journal Article] Depletion of serotonin selectively impairs short-term memory without affecting long-term memory in odor learning in the terrestrial slug limax valentianus (2006)
  • Author(s): Shirahata, T.
  • Journal Title: Learn.Mem. 13 Pages: 267-270
• [Journal Article] The procerebrum is necessary for odor-aversion learning in the terrestrial slug Limax valentianus (2006)
  • Author(s): Kasai, Y.
  • Journal Title: Learn.Mem. 13 Pages: 482-488
• [Journal Article] Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning (2006)
  • Author(s): Kishimoto, Y.
  • Journal Title: J.Neurosci. 26 Pages: 8829-8837
• [Journal Article] Air movement evokes electro-olfactogram oscillations in the olfactory epithelium and modulates the olfactry processing in a slug (2006)
  • Author(s): Ito, I.
  • Journal Title: J.Neurophysiol. 96 Pages: 1939-1948
• [Journal Article] A novel kruppel-like factor is induced by neuronal activity and by sensory input in the central nervous system of the terrestrial slug Limax valentianus. (2006)
  • Author(s): Fukunaga, S.
  • Journal Title: J.Neurobiol. 66 Pages: 169-181
• [Journal Article] NMDA receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunitδ2 mutant mice (2005)
  • Author(s): Kato, Y., Takatsuki, K., Kawahara, S., Fukunaga, S., Mori, H., Mishina, M. and Kirino, Y.
  • Journal Title: Neuroscience 135 Pages: 1017-1023
• [Journal Article] Role of hippocampal NMDA receptors in trace eyeblink conditioning (2005)
  • Author(s): Sakamoto, T., Takatsuki, K., Kawahara, S., Kirino, Y., Niki, H. and Mishina, M.
  • Journal Title: Brain Res. 1039 Pages: 130-136
• [Journal Article] Characterization of hippocampal theta rhythm in wild-type mice and glutamate receptor subunitδ2 mutant mice during eyeblink conditioning with a short trace interval (2005)
  • Author(s): Takatsuki, K., Kawahara, S., Mishina, M. and Kirino, Y.
  • Journal Title: Brain Res. 1063 Pages: 159-167
• [Journal Article] NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace but not delay eyeblink conditioning (2005)
  • Author(s): Takehara-Nishiuchi, K., Kawahara, S., and Kirino, Y.
  • Journal Title: Learn. Mem. 12 Pages: 606-614
  • NAID: 120006399290
• [Journal Article] Role of hippocampal NMDA receptors in trace eyeblink conditioning (2005)
  • Author(s): Sakamoto, T.
  • Journal Title: Brain Research 1039 Pages: 130-136
• [Journal Article] NMDA receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunit δ2 mutant mice. (2005)
  • Author(s): Kato, Y.
  • Journal Title: Neuroscience 135 Pages: 1017-1023
• [Journal Article] Characterization of hippocampal theta rhythm in wild-type mice and glutamate receptor subunit δ2 mutant mice during eyeblink conditioning with a short trace interval. (2005)
  • Author(s): Takatsuki, K.
  • Journal Title: Brain Research 1063 Pages: 159-167
• [Journal Article] NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace but not delay eyeblink conditioning. (2005)
  • Author(s): Takehara-Nishiuchi, K.
  • Journal Title: Learning and Memory 12 Pages: 606-614
• [Journal Article] Impaired motor functions in mice lacking the RNA-binding protein Hzf
  • Author(s): Iijima, T.
  • Journal Title: Neurosc.Res. (in press)
• [Journal Article] Change of Purkinje cell activity during classical conditioning in decerebrate guinea pig.
  • Author(s): Kotani, S.
  • Journal Title: Brain Research (in press)
• [Presentation] テトラサイクリン遺伝子発現誘導系を利用した記憶学習の分子過程の解明 (2009)
  • Author(s): 岸本泰司,原田武志,平井良枝,中尾晴美,中尾和貴,饗場 篤,桐野 豊
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都
• [Presentation] 小脳依存性学習に対するアナンダミド分解酵素阻害の効果 (2009)
  • Author(s): 中山順子,奥 郁子,岸本泰司,桐野 豊
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都
• [Presentation] 運動記憶形成における小脳顆粒細胞シナプス機能の解明 (2008)
  • Author(s): 岸本泰司, 和田教男, 桐野豊, 狩野方伸, 中西重忠
  • Organizer: 第1回日本生物物理学会中国四国支部大会
  • Place of Presentation: 高知
  • Year and Date: 2008-06-16
• [Presentation] 野生型マウスの加齢による聴性脳幹反応の変化 (2008)
  • Author(s): 北村美一郎, 桐野豊
  • Organizer: 第1回日本生物物理学会中国四国支部大会
  • Place of Presentation: 高知
  • Year and Date: 2008-06-16
• [Presentation] マウス聴性脳幹反応の加齢による変化 (2008)
  • Author(s): 北村 美一郎, 他
  • Organizer: 第128年会日本薬学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] マウス瞬目反射条件付けの画像解析 (2008)
  • Author(s): 臼井弘児,水上愛理,川原茂敬
  • Organizer: 第31 回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] DBA/2 マウスの瞬目反射条件付けにおける小脳依存性 (2008)
  • Author(s): 川原茂敬,龍崎優一郎,西澤 遼,的場圭亮,堀内嵩大
  • Organizer: 第31 回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] モノアシルグリセロールリパーゼ(MGL)阻害による瞬目反射条件付け記憶の消去障害 (2008)
  • Author(s): 岸本泰司,桐野 豊
  • Organizer: 第31 回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 瞬目反射学習における文脈依存的弁別学習と応答の海馬の状態への依存性 (2008)
  • Author(s): 徳田慶太,西川倫正,川原茂敬
  • Organizer: 第31 回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Tet-OFF 遺伝子発現システムを用いた小脳学習におけるMAPK/ERK kinase 1 の機能解析 (2008)
  • Author(s): 岸本泰司,原田武志,平井良枝,中尾晴美,中尾和貴,桐野 豊,饗場 篤
  • Organizer: 第45 回日本生物物理学会年会
  • Place of Presentation: 福岡
• [Presentation] 野生型マウスC57BL/6Jにおける聴性脳幹反応の加齢に伴う変化 (2008)
  • Author(s): 北村美一郎,桐野 豊
  • Organizer: 第45 回日本生物物理学会年会
  • Place of Presentation: 福岡
• [Presentation] 肥満モデルマウスの瞬目反射条件付け学習におけるカンナビノイドシステムの関与 (2008)
  • Author(s): 窪田剛志,桐野 豊
  • Organizer: 第45 回日本生物物理学会年会
  • Place of Presentation: 福岡
• [Presentation] ヒト-動物共通学習パラダイムを用いたMAPK/ERK kinase 1 の分子機能解析 (2008)
  • Author(s): 岸本泰司,原田武志,饗場 篤
  • Organizer: 第2 回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 京都
• [Presentation] マウス瞬目反射条件付けの画像解析 (2008)
  • Author(s): 臼井弘児, 水上愛理, 川原茂敬
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] DBA/2マウスの瞬目反射条件付けにおける小脳依存性 (2008)
  • Author(s): 川原茂敬, 龍崎優一郎, 西澤遼, 的場圭亮, 堀内嵩大
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] モノアシルグリセロールリパーゼ(MGL)阻害による瞬目反射条件付け記憶の消去障害 (2008)
  • Author(s): 岸本泰司, 桐野豊
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 小脳破壊マウスは瞬目反射条件付け痕跡課題の学習にcaudal anterior cingulate cortexを必要とするが、小脳非破壊マウスは必要としない (2008)
  • Author(s): 神徳隆之, 堀内嵩大, 川原茂敬
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 瞬目反射学習における文脈依存的弁別学習と応答の海馬の状態への依存性 (2008)
  • Author(s): 徳田慶太, 西川倫正, 川原茂敬
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Tet-OFF遺伝子発現システムを用いた小脳学習におけるMAPK/ERK kinase 1の機能解析 (2008)
  • Author(s): 岸本泰司, 原田武志, 平井良枝, 中尾晴美, 中尾和貴, 桐野豊, 饗場篤
  • Organizer: 第45回日本生物物理学会年会
  • Place of Presentation: 福岡
• [Presentation] 野生型マウスC57BL/6Jにおける聴性脳幹反応の加齢に伴う変化 (2008)
  • Author(s): 北村美一郎, 桐野豊
  • Organizer: 第45回日本生物物理学会年会
  • Place of Presentation: 福岡
• [Presentation] 肥満モデルマウスの瞬目反射条件付け学習におけるカンナビノイドシステムの関与 (2008)
  • Author(s): 窪田剛志, 桐野豊
  • Organizer: 第45回日本生物物理学会年会
  • Place of Presentation: 福岡
• [Presentation] ヒト-動物共通学習パラダイムを用いたMAPK/ERK kinase 1の分子機能解析 (2008)
  • Author(s): 岸本泰司, 原田武志, 饗場篤
  • Organizer: 第2回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 京都
• [Presentation] 瞬目反射条件付けの自家蛍光イメージング (2007)
  • Author(s): 渡辺 恵, 他
  • Organizer: 日本生物物理学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] 加齢によるマウス聴性脳幹反応の変化 (2007)
  • Author(s): 北村 美一郎, 他
  • Organizer: 第45回日本生物物理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] マウス瞬目反射学習におけるNOの役割 (2007)
  • Author(s): 北村 美一郎, 他
  • Organizer: 第1回日本生物物理学会四国支部大会
  • Place of Presentation: 香川県さぬき市
  • Year and Date: 2007-06-16
• [Presentation] 若齢および老齢マウスの瞬目反射条件付けに対するNMDA 受容体阻害薬の効果 (2007)
  • Author(s): 鈴木令子,王 芳,浅木敏之,勝浦五郎,桐野豊,川原茂敬
  • Organizer: 第80 回日本薬理学会年会
  • Place of Presentation: 名古屋
• [Presentation] 小脳依存性瞬目反射条件付けにおける内在性カンナビノイド受容体CB1 の役割 (2007)
  • Author(s): 岸本泰司,狩野方伸
  • Organizer: 第84 回日本生理学会大会
  • Place of Presentation: 大阪
• [Presentation] 肥満モデルマウスの瞬目反射条件付け学習におけるカンナビノイドの関与 (2007)
  • Author(s): 窪田剛志,川原茂敬,桐野 豊
  • Organizer: 第127 回日本薬学会年会
  • Place of Presentation: 富山
• [Presentation] Cbln1欠損マウスを用いた小脳学習および海馬学習におけるCbln1 の機能解析 (2007)
  • Author(s): 江見恭一,幸田和久,川原茂敬,柚崎通介
  • Organizer: 第30 回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 加齢によるマウス聴性脳幹反応の変化 (2007)
  • Author(s): 北村美一郎,桐野 豊
  • Organizer: 第45 回日本生物物理学会年会
  • Place of Presentation: 横浜
• [Presentation] 瞬目反射条件付けの自家蛍光イメージング (2007)
  • Author(s): 渡辺 恵,川原茂敬
  • Organizer: 第45 回日本生物物理学会
  • Place of Presentation: 横浜
• [Presentation] ラット瞬目反射学習での同側小脳依存性 (2007)
  • Author(s): 堀内 嵩大, 他
  • Organizer: 日本神経科学学会
  • Place of Presentation: 横浜
• [Presentation] Cbln1欠損マウスを用いた小脳学習および海馬学習におけるCbln1の機能解析 (2007)
  • Author(s): 江見 恭一, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Trace eyeblink conditioning in an intracerebroventdcular streptozotocin-induced dementia model (2007)
  • Author(s): Wang F, et. al.
  • Organizer: China-Japan Joint Meeting of Basic and Clinical Phamla cology
  • Place of Presentation: 大連,中国
• [Presentation] Ipsilateral cerebellum is crucial but not essental for rat eyeblink conditioning (2007)
  • Author(s): Hoduchi, T, et. al.
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego,USA
• [Presentation] Eyeblink conditioning and Morris water maze in senescence-accelerated mice SAMP8 (2006)
  • Author(s): Kirino, Y., Kato, Y., Kawahara, S., Sakaguchi, I., Ishibashi, C., Takeyama, C., Takahara, Y., Katsuura, G.
  • Organizer: 36th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Atlanta, USA
• [Book] 生物物理学ハンドブック (2007)
  • Author(s): 石渡信一,桂 勲,桐野 豊,美宅茂樹 編
  • Total Pages: 662
  • Publisher: 朝倉書店
• [Book] 生物物理学ハンドブック (2007)
  • Author(s): 石渡 信一, 他
  • Total Pages: 662
  • Publisher: 朝倉書店
• [Remarks] 徳島文理大学 香川薬学部 生物物理学講座 ホームページ
  • URL: http://kp.bunri-u.ac.jp/kph16/index.html
• [Remarks] 徳島文理大学香川薬学部生物物理学講座ホームページ
  • URL: http://kp.bunri-u.ac.jp/kph16/index.html