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Ossification of the Pposterior Longitudinal Ligament

Research Project

Project/Area Number 17209012
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionTokai University (2006-2007)
The University of Tokyo (2005)

Principal Investigator

INOUE Ituro  Tokai University, School of Medicine, Professor (00192500)

Co-Investigator(Kenkyū-buntansha) TAJIMA Atsushi  Tokai University, School of Medicine, Assistant Professor (10396864)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥51,610,000 (Direct Cost: ¥39,700,000、Indirect Cost: ¥11,910,000)
Fiscal Year 2007: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2006: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2005: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
KeywordsOPLL / ectopic ossification / expression profile / association study / SNP / Microarray analysis / アソシエーション・スタディ / 靭帯骨化
Research Abstract

To understand the molecular pathogenesis of ossification of the posterior longitudinal ligament of the spine (OPLL), an ectopic bone formation disease, we performed c_DNA microarray analysis on cultured ligament cells from the OPLL patients to understand the molecular pathogenesis of OPLL.We identified Zinc finger protein145 (PLZF) as one of up-regulated genes and tumor necrosis factor-a stimulated gene6 (TSG-6) and one of down-regulated gene during osteoblastic differentiation. We investigated the roles of PLZF in the regulation of osteoblastic differentiation of h_MSC_s and C2C12 cells.siRNA-mediated gene-silencing of PLZF resulted in a reduction of the expression of osteoblast-specific genes such as the alkaline phosphatase (ALP), collagen 1A1 (COL1A1), Runx2/cbfal (CBFA1), and osteocalcin (OCN) genes in the presence of OS in hMSCs.The overexpression of PLZF can induce CBFA1 induction suggestiong PLZF is an upstream regulator of CBFA1 and thereby might participate in promoting the ossification of spinal ligament cells in OPLL patients. Adenoirus-mediated TSG-6 overexpression in hMSCs resulted in suppression of oseoblastic differentiation induced by either BMP-2 or OS.TSG-6 can bind to BMP-2 directly, thereby could inhibit BMP-2 signaling.Taken together, these findings indicate that PLZF and TSG-6 play important roles in early osteoblastic differentiation.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (51 results)

All 2008 2007 2006 2005 Other

All Journal Article (49 results) (of which Peer Reviewed: 23 results) Book (2 results)

  • [Journal Article] Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians2008

    • Author(s)
      Kimura T, Kobayashi T, Munkhbat B, Oyungerel G, Bilegtsaikhan T, Anar D, Jambaldorj J, Munkhsaikhan S, Munkhtuvshin N, Hayashi H, Oka A, Inoue I, Inoko H.
    • Journal Title

      Hum Genet

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Analysis of expressed sequence tags from liver in cynomolgus monkey(Macacafasciccularis):A systematic identification of drug-metabolizing enzyme genes2008

    • Author(s)
      Uno Y, Suzuki Y, Wakaguri H, Sakamoto Y, Sano H, Osada N, Hashimoto K, Sugano S, Inoue I.
    • Journal Title

      FEBS Let

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Large-scale analysis of Macacafasciccularis transcripts and inference of genetic divergence between M.fasciccularis and M.mulatta2008

    • Author(s)
      Osada N, Hashimoto K, Kameoka Y, Hirata M, Tamura R, Uno Y, Inoue I, Hida M, Suzuki Y, Sugano S, Terao K, Kusuda J, Takahashi I.
    • Journal Title

      BMC Genomics 9

      Pages: 90-90

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Integration of hepatitis B virus DNA into the MPP(mixed lineage leukemia)4 gene and rearrangements of MLL4 in human hepatocellular carcinoma cells2008

    • Author(s)
      Saigo K, Yoshida K, Ikeda R, Sakamoto Y, Murakami Y, Urashima T, Asano T, Kenmochi T, Inoue I.
    • Journal Title

      Hum Mutat 29

      Pages: 703-708

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Further evidence for an association between mandibular height and the growth hormone receptor gene in the Japanese population2008

    • Author(s)
      Tomoyasu Y, Yamaguchi T, Tajima A, Nakajima T, Inoue I, Maki K.
    • Journal Title

      Am J Ortho and Dento Ortho

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Citrin/mitochondrial glycerol 3-phosphate dehydrogenase double-knockout mice recapitulate features of human citrin deficiency2008

    • Author(s)
      Saheki T, Iijima M, Li MX, Kobayashi K, Horiuchi M, Ushikai M, Okumura F, Meng XJ, Inoue I, Tajima A, Moriyama M, Eto K, Kadowaki T, Sinasac DS, Tsui LC, Tsuji M, Okano A, Kobayashi T.
    • Journal Title

      J Biol Chem 282

      Pages: 25041-254052

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genome-wide association analysis with selective genotyping identifiescandidate loci for adult height at 8g21.13 and 15q22.33-q23 in Mongolians2008

    • Author(s)
      Kimura, T, Kobayashi, T, Munkhbat, B, Oyungerel, G, Bilegtsaikhan, T, Anar, D, Jambaldorj, J, Munkhsaikhan, S, Munkhtuvshin, N, Hayashi, H, Oka, A, Inoue, I, Inoko, H
    • Journal Title

      Hum Genet (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Large-scale analysis of Macacafasciccularis transcripts and inference of genetic divergence between M.fasciccularis and M.mulatta2008

    • Author(s)
      Osada, N, Hashimoto, K, Kameoka, Y, Hirata, M, Tamura, R, Uno, Y, Inoue, I, Hida, M, Suzuki, Y, Sugano, S, Terao, K, Kusuda, J, Takahashi, I
    • Journal Title

      BMC Genomics 9

      Pages: 90-90

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Integration of hepatitis B virus DNA into the MPP(mixed lineage leukemia)4gene and rearrangements of MLL4 in human hepatocellular carcinoma cells2008

    • Author(s)
      Saigo, K, Yoshida, K, Ikeda, R, Sakamoto, Y, Murakami, Y, Urashima, T, Asano, T, Kenmochi, T, Inoue, I
    • Journal Title

      Hum Mutati 29

      Pages: 703-708

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Further evidence for an association between mandibular height and the growth hormone receptor gene in the Japanese population2008

    • Author(s)
      Tomoyasu Y, Yamaguchi T, Tajima A, Nakajima T, Inoue I, Maki K.
    • Journal Title

      Am J Ortho and Dento Ortho (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression changes during the chondrogenic differentiation of human mesenchymal stem cells2008

    • Author(s)
      Ikeda R, Tukahara S, Yoshida K, Inoue I.
    • Journal Title

      J Biol sci (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression changes during the chondrogenic differentiation of human mesenchymal stem cells2007

    • Author(s)
      Ikeda R, Tsukahara S, Yoshida K, Inoue I.
    • Journal Title

      J Biol Sci 7

      Pages: 729-736

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation2007

    • Author(s)
      Ikeda R, Yoshida K, Inoue I.
    • Journal Title

      J Cell Biochem 101

      Pages: 147-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Citrin/mitochondrial glycerol 3-phosphate dehydrogenase double-knockout mice recapitulate features of human citrin deficiency2007

    • Author(s)
      Saheki, T, Iijima, M, Li, MX, Kobayashi, K, Horiuchi, M, Ushikai, M, Okumura, F, Meng, XJ, Inoue, I, Tajima, A, Moriyama, M, Eto, K, Kadowaki, T, Sinasac, DS, Tsui, LC, Tsuji, M, Okano, A, Kobayashi, T
    • Journal Title

      J BiolChem 282

      Pages: 25041-25052

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene expression changes during the chondrogenic differentiation of human mesenchymal stem cells2007

    • Author(s)
      Ikeda, R, Tsukahara, S, Yoshida, K, Inoue, I
    • Journal Title

      J BiolSci 7

      Pages: 729-736

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation2007

    • Author(s)
      Ikeda, R, Yoshida, K, Inoue, I
    • Journal Title

      J Cell Biochem 101

      Pages: 147-154

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Citrin/mitochondrial glycerol 3-phosphate dehydrogenase double-knockout micerecapitulate features of human citrin deficiency2007

    • Author(s)
      Saheki T, Iijima M, Li MX, Kobayashi k, Horiuchi M, Ushikai M, Okumura F, Meng XJ, Inoue I, Tajima A, Moriyama M, Eto K, Kadowakir T, Sinasac DS, Tsui LC, Tsuji M, Okano A, Kobayashi T.
    • Journal Title

      J Biol Chem 282

      Pages: 25041-254052

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of ephrin A1 in brain arteriovenous malformation.2007

    • Author(s)
      Sasahara A, Kasuya H, Akagawa H, Ujue H, Kubo O, Sasaki T, Onda H, sakamoto Y, Krischek B, Hori T, Inoue I.
    • Journal Title

      Neurosurg Rev 30

      Pages: 299-305

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic defferentiatin.2007

    • Author(s)
      Ikeda R, Yoshida K, Inoue I.
    • Journal Title

      J Cell Biochem 101

      Pages: 147-154

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation2007

    • Author(s)
      Ikeda R, Yoshida K, Inoue I
    • Journal Title

      J Cell Biochem in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pathopysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress2006

    • Author(s)
      Iwasawa T, Iwasaki K, Sawada T, Okada A, Ueyama K, Motomura S, Harata S, Inoue I, Toh S, Furukawa K-I.
    • Journal Title

      Calcif Tissue Int 79

      Pages: 422-430

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The small heat shock protein alphaB-crystallin inhibits differentiation-induced caspase 3 activation and myogenic differentiation2006

    • Author(s)
      Ikeda R, Yoshida K, Ushiyama M, Yamaguchi T, Iwashita K, Futagawa T, Shibayama Y, Oiso S, Takeda Y, Kariyazono H, Furukawa T, Nakamura K, Akiyama S, Inoue I, Yamada K.
    • Journal Title

      BiolPharm Bull 29

      Pages: 815-819

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor alpha stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by OS and BMP-22006

    • Author(s)
      Tsukahara S, Ikeda R, Goto S, Yoshida K, Mitsumori R, Sakamoto Y, Tajima A, Yokoyama T, Toh S, Furukawa K, Inoue I.
    • Journal Title

      Biochem J 398

      Pages: 595-603

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine2006

    • Author(s)
      Horikoshi T, Maeda K, Kawaguchi Y, Chiba K, Mori K, Koshizuka Y, Hirabayashi S, Sugimori K, Matsumoto M, Kawaguchi H, Takahashi M, Inoue H, Kimura T, Matsusue Y, Inoue I, Baba H, Nakamura K, Ikegawa S.
    • Journal Title

      Hum Genet 119

      Pages: 611-616

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients2006

    • Author(s)
      Krischek B, Kasuya H, Akagawa H, Tajima A, Narita A, Onda H, Hori T, Inoue I
    • Journal Title

      J Neurosurg 105

      Pages: 717-722

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Zebrafish numb homologue:phylogenetic evolution and involvement in regulation of left-right asymmetry2006

    • Author(s)
      Niikura Y, Tabata Y, Tajima A, Inoue I, Arai K, Watanabe S.
    • Journal Title

      Mech Dev 123

      Pages: 407-414

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic susceptibility to OPLL2006

    • Author(s)
      Inoue I.In: Yonenobu K, Nakamura K, Toyama Y
    • Journal Title

      Ossification of the posterior longitudinal ligament.

      Pages: 19-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pathopysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress2006

    • Author(s)
      Iwasawa, T, Iwasaki, K, Sawada, T, Okada, A, Ueyama, K, Motomura, S, Harata, S, Inoue, I, Toh, S, Furukawa, K-I
    • Journal Title

      Calcif Tissue Int 79

      Pages: 422-430

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The small heat shock protein alphaB-crystallin inhibits differentiation-induced caspase 3 activation and myogenic differentiation2006

    • Author(s)
      Ikeda, R, Yoshida, K, Ushiyama, M, Yamaguchi, T, Iwashita, K Futagawa, T, Shibayama, Y, Oiso, S, Takeda, Y, Kariyazono, H, Furukawa, T, Nakamura, K, Akiyama, S, Inoue, I, Yamada, K
    • Journal Title

      BiolPharm Bull 29

      Pages: 815-819

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tumor necrosis factor alpha stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by OS and BMP-22006

    • Author(s)
      Tsukahara, S, Ikeda, R, Goto, S, Yoshida, K, Mitsumori, R, Sakamoto, Y, Tajima, A, Yokoyama, T, Toh, S, Furukawa, K, Inoue, I
    • Journal Title

      Biochem 398

      Pages: 595-603

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine2006

    • Author(s)
      Horikoshi, T, Maeda, K, Kawaguchi, Y, Chiba, K, Mori, K, Koshizuka, Y, Hirabayashi, S, Sugimori, K, Matsumoto, M, Kawaguchi, H, Takahashi, M, Inoue, H, Kimura, T, Matsusue, Y, Inoue, I, Baba, H, Nakamura, K, Ikegawa, S
    • Journal Title

      Hum Genet 119

      Pages: 611-616

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients2006

    • Author(s)
      Krischek, B, Kasuya, H, Akagawa, H, Tajima, A, Narita, A, Onda, H, Hori, T, Inoue, I
    • Journal Title

      J Neurosurg 105

      Pages: 717-722

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Zebrafish numb homologue : phylogenetic evolution and involvement in regulation of2006

    • Author(s)
      Niikura, Y, Tabata, Y, Tajima, A, Inoue, I, Arai, K, Watanabe, S
    • Journal Title

      left-right asymmetry 123

      Pages: 407-414

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K-I Psthopysiological roles of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress2006

    • Author(s)
      Iwasawa T, Iwasaki K, Sawada T, Okada A, Ueyama K, Motomura S, Harata S, Inoue I, Toh S, Furukawa
    • Journal Title

      Calcif Tissue Int 79

      Pages: 422-430

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine.2006

    • Author(s)
      Horikoshi T, Maeda K, Kawaguchi Y, Chiba K, Mori K, Koshizuka Y, Hirabayashi S, Sugimori K, Matsumoto M, Kawaguchi H, Takahashi M, Inoue H, Kimura T, Matsusue Y, Inoue I, Baba H, Nakamura K, Ikegawa S
    • Journal Title

      Hum Genet 119

      Pages: 611-616

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The small heat shock protein alphaB-crystallin inhibits differentiation-induced caspase 3 activation and myogenic differentiation.2006

    • Author(s)
      Ikeda R, Yoshida K, Ushiyama M, Yamaguchi T, Iwashita K, Futagawa T, Shibayama Y, Oiso S, Takeda Y, Kariyazono H, Furukawa T, Nakamura K, Akiyama S, Inoue I, Yamada K, Krischnek B
    • Journal Title

      Biol Pharm Bull 29

      Pages: 815-819

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Tumor necrosis factor alpha stimulated gone-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by OS and BMP-2.2006

    • Author(s)
      Tsukahara S, Ikeda R, Goto S, Yoshida K, Mitsumori R, Sakamoto Y, Tajima A, Yokoyama T, Toh S, Furukawa K, Inoue I
    • Journal Title

      Biochem J 398

      Pages: 595-603

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PLZF and TSG-6 identified by gene expression analysis play roles in the pathogenesis of OPLL.2006

    • Author(s)
      Inoue I, Ikeda R, Tsukahara S
    • Journal Title

      J Pharmacol Sci 100

      Pages: 205-210

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA12005

    • Author(s)
      Ikeda R, Yoshida K, Tsukahara S, Sakamoto Y, Tanaka H, Furukawa-K, Inoue I.
    • Journal Title

      J Biol Chem 280

      Pages: 8523-8530

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] COL6A1,the candidate gene for ossification of posterior longitudinal ligament,is associated with diffuse idiopathic skeletal hyperostosis in Japanese2005

    • Author(s)
      Tsukahara S, Miyazawa N, Akagawa H, Forejtova S, Pavelka K, Tanaka T, Toh S, Tajima A, Akiyama I, Inoue I.
    • Journal Title

      Spine 30

      Pages: 2321-2324

    • NAID

      10020578412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genome-wide linkage analysis of mandibularprognathism in Korean and Japanese patients2005

    • Author(s)
      Yamaguchi T, Park S-B, Narita A, Maki K, Inoue I.
    • Journal Title

      J Dent Res 84

      Pages: 255-259

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evidence for natural selection in the HAVCR1 gene : high degree of amino-acid variability in the mucin domain of human HAVCR1 protein.2005

    • Author(s)
      Nakajima T, Wooding S, Satta Y, Jinnai N, Goto S, Hayasaka I, Saitou N, Guan-Jun J, Tokunaga K, Jorde LB, Emi M, Inoue I.
    • Journal Title

      Genes Immun 6

      Pages: 398-406

    • Related Report
      2005 Annual Research Report
  • [Journal Article] PLZF promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1.2005

    • Author(s)
      Ikeda R, Yoshida K, Tsukahara S, Sakamoto Y, Tanaka H, Furukawa-K, Inoue I.
    • Journal Title

      J Biol Chem 280

      Pages: 8523-8530

    • Related Report
      2005 Annual Research Report
  • [Journal Article] COL6A1, the candidate gene for ossification of posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese.2005

    • Author(s)
      Tsukahara S, Miyazawa N, Akagawa H, Forejtova S, Pavelka K, Tanaka T, Toh S, Tajima A, Akiyama I, Inoue I.
    • Journal Title

      Spine 30

      Pages: 2321-2324

    • NAID

      10020578412

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genome-wide linkage analysis of mandibular prognathism in Korean and Japanese patients.2005

    • Author(s)
      Yamaguchi T, Park S-B, Narita A, Maki K, Inoue I.
    • Journal Title

      J Dent Res 84

      Pages: 255-259

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Analysis of expressed sequence tags from liver in cynomolgus monkey(Macacafasciccularis) : A systematic identification of drug-metabolizing enzyme genes

    • Author(s)
      Uno, Y, Suzuki, Y, Wakaguri, H, Sakamoto, Y, Sano, H, Osada, N, Hashimoto, K, Sugano, S, Inoue, I
    • Journal Title

      FEBS Lat (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Further evidence for an association between mandibular height and the growth hormone receptor gene in the Japanese population

    • Author(s)
      Tomoyasu, Y, Yamaguchi, T, Tajima, A, Nakajima, T, Inoue, I, Maid, K
    • Journal Title

      Am J Ortho and Dente Ortho (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PLZF and TSG-6 identified by gene expression analysis play roles in the pathogenesis of OPLL.

    • Author(s)
      Inoue I, Tsukahara S.
    • Journal Title

      J Pharmacol Sci (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Zebrafish numb homologue : phylogenetic evolution and involvement in regulation of left-right asymmetry.

    • Author(s)
      Niikura Y, Tabata Y, Tajima A, Inoue I, Arai K, Watanabe S.
    • Journal Title

      Mech Dev (in press)

    • Related Report
      2005 Annual Research Report
  • [Book] Ossification of the posterior longitudinal ligament.2006

    • Author(s)
      Inoue I, Yonenobu K, Nakamura K, Toyama Y(eds)
    • Total Pages
      305
    • Publisher
      Springer,Tokyo
    • Related Report
      2006 Annual Research Report
  • [Book] Ossification of the posterior longitudinal ligament.

    • Author(s)
      Inoue I.(Yonenobu K, Nakamura K, Toyama Y(eds))
    • Publisher
      Springer, Tokyo(in press)
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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