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Pre-Translational Approaches to the Conquest of Immune Disorders by Targeting Fcγ Receptors

Research Project

Project/Area Number 17209017
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionTohoku University

Principal Investigator

TAKAI Toshiyuki  Tohoku University, Tohoku University, Institute of Development, Aging and Cancer, Professer (20187917)

Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2006: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2005: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
KeywordsImmune regulation / Autoimmune disease / Immunoglobulin / Autoantibodies / Intravenous immunoglobulin / Fc receptor / 自己免疫性糖尿病 / 大量免疫グロブリン療法 / NODマウス / 膵島炎 / 樹状細胞 / NK細胞 / シグナル伝達 / 免疫学 / アレルギー・ぜんそく / 糖尿病 / 自己免疫
Research Abstract

Fc receptors play pivotal roles in immune regulation, and their dysregulation leads to immune-related diseases including allergic inflammationand aud autoimmunity. We have obtained in this project the following accomplishments:
1) Establishment of the importance of inhibitory Fcγ receeptor, FcγRIIB, in immune regulation and autoimmune dieseases, such as autoimmune glomerulonephritis.
2) Establishment of animal models for immune disorders by the use of Feγ receptor gene-targeted mice.
3) Establishment of immune cells with the immortalized growth and immune functions by the use of SV40LT-transgenic mice.
Among these, in particular, we have identified the pivotal roles of activating-type Fcγ receptors, but not inhibitory FcγRIB, in the development of autoimmune diabetes of NOD mice. Type 1 diabetes mellitus (T1D) in humans is an organ-specific autoimmune disease in which pancreatic islet β cell are ruptured by autoreactive T cells. NOD mice, the most commonly used animal model of T1D, show ea … More rly infiltration of leukocytes in the islets (insulitis), resulting in islet destruction and diabetes later. NOD mice produce various islet β cell-specific autoantibodies, although it remains a subject of debate regarding whether these autoantibodies contribute to the development of T1D or not. To investigate the possible role of FcγRs in NOD mice, we have generated several FcγR-less NOD lines, namely FcR common γ chain (FcRγ)-deficient ((NOD.γ^<-/->), FcγRIII-deficient (NOD.III^<-/->), FcγRIIB-deficient (NOD.IIB^<-/->), and both FcRγ and Fcγ and FcγRIIB-deficient NOD (NOD.null) mice. We have shown significant protection from diabetes in NOD.γ^<-/->, NOD.III^<-/->, and NOD.null but not in NOD.IIB^<-/-> mice even with grossly comparable production of autoantibodies among them. Insulitis in NOD.γ^<-/-> mice was also alleviated. Adoptive transfer of bone marrow-derived dendritic cells or NK cells from NOD mice rendered NOD.γ^<-/-> animals more susceptible to diabetes, suggesting a possible scenario in which activating FcγRIII on NK cells trigger antibody-dependent effector functions and inflammation. These findings highlight the critical roles of activating FcγRs in the development of T1D, and indicate that FcγRs are novel targets for therapies for T1D. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (83 results)

All 2008 2007 2006 2005

All Journal Article (73 results) (of which Peer Reviewed: 36 results) Presentation (10 results)

  • [Journal Article] Fcγ Receptor Regulation of Citrobacter rodentium Infection2008

    • Author(s)
      Masuda A, et. al.
    • Journal Title

      Infect. Immunity 76

      Pages: 1728-1737

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008

    • Author(s)
      Shinohara M, et. al.
    • Journal Title

      Cell Mar 7;132(5)

      Pages: 794-806

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LIMIR5/CLM7 in ouse versus human cells2008

    • Author(s)
      Yamanishi Y, et. al.
    • Journal Title

      Blood 111

      Pages: 688-698

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Fc γ Receptor Regulation of Citrobacter rodentium Infection2008

    • Author(s)
      Masuda A, et. al.
    • Journal Title

      Infect. Immunity 76

      Pages: 1728-1737

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008

    • Author(s)
      Shinohara M, et. al.
    • Journal Title

      Cell 132(5)

      Pages: 794-806

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of mouse LMIR5/CLM7 as an activation receptor; differential regulation of LMIR5/CLM7 in ouse versus human cells2008

    • Author(s)
      Yamanishi Y, et. al.
    • Journal Title

      Blood 111

      Pages: 688-698

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 in ouse versus human cells2008

    • Author(s)
      Yamanishi Y, et. al.
    • Journal Title

      Blood 111

      Pages: 688-698

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PI3-kinase activation is required to form the NKG2D immunological sy napse2007

    • Author(s)
      Giurisato E, et. al.
    • Journal Title

      Mol Cell Biol 27(24)

      Pages: 8583-8599

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A CD200 receptor-like protein CD200R3 functions. as an activating rece ptor expressed exclusively on basophils and mast cells2007

    • Author(s)
      Kojima T, et. al.
    • Journal Title

      J. Immunol 179

      Pages: 7093-7100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Critical Negative Regulation of type 1 T cell immunity and immunopat hology by signaling adaptor DAPl2 during intracellular infection2007

    • Author(s)
      Divangahi M, et. al.
    • Journal Title

      J. Immunol 179

      Pages: 4015-4026

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Activating Fcγ receptors participate in the development of autoimmune diabetes in NOD mice2007

    • Author(s)
      Inoue Y, et. al.
    • Journal Title

      J. Immunol 179(2)

      Pages: 764-774

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bong loss2007

    • Author(s)
      Ochi S, et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104(27)

      Pages: 11394-11399

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors2007

    • Author(s)
      Hara H, et. al.
    • Journal Title

      Nat. Immunol 8

      Pages: 619-629

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cis binding between inhibitory receptors and MHC class I can regulatemast cell activation2007

    • Author(s)
      Masuda A, et. al.
    • Journal Title

      J.Exp. Med 204

      Pages: 907-920

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR32007

    • Author(s)
      Izawa K, et a1.
    • Journal Title

      J. Biol. Chem 282(25)

      Pages: 17997-18008

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of MER5 (peroxiredoxin III)knockout mice to LPS-induced oxidative stress2007

    • Author(s)
      Li L, et. al.
    • Journal Title

      Biochem. Biophays. Res. Commun 355(3)

      Pages: 715-721

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production2007

    • Author(s)
      Nakayama M, et. al.
    • Journal Title

      J. Immunol 178(7)

      Pages: 4250-4259

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adaptors DAP12 and FcRγ chain on peritonal macrophages2007

    • Author(s)
      Nakahashi C, et. al.
    • Journal Title

      J. Immunol 178(2)

      Pages: 765-770

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of osteoclast differentiation and function by the CaMK/CREB pathway2007

    • Author(s)
      Sato K, et. al.
    • Journal Title

      Nat. Med 12(12)

      Pages: 1410-1416

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Critical role of the Fc receptor γ-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation2007

    • Author(s)
      Kitamura K, et. al.
    • Journal Title

      J. Immunol 178(1)

      Pages: 480-488

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PI3-Kinase activation is required to form the NKG2D immunological synapse2007

    • Author(s)
      Giurisato E, et. al.
    • Journal Title

      Mol Cell Biol 27(24)

      Pages: 8583-8599

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A CD200 receptor-like protein CD200R3 functions as an activating receptor expressed exclusively on basophils and mast cells2007

    • Author(s)
      Kojima T, et. al.
    • Journal Title

      J. Immunol 179

      Pages: 7093-7100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Critical Negative Regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP 12 during intracellular infection2007

    • Author(s)
      Divangahi M, et. al.
    • Journal Title

      J. Immunol 179

      Pages: 4015-4026

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activating Fc γ receptors participate in the development of autoimmune diabetes in NOD mice2007

    • Author(s)
      Inoue Y, et. al.
    • Journal Title

      J. Immunol 179(2)

      Pages: 764-774

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss2007

    • Author(s)
      Ochi S, et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104(27)

      Pages: 11394-11399

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation2007

    • Author(s)
      Masuda A, et. al.
    • Journal Title

      J. Exp. Med 204

      Pages: 907-920

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR32007

    • Author(s)
      Izawa K, et. al.
    • Journal Title

      J. Biol. Chem 282(25)

      Pages: 17997-18008

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress2007

    • Author(s)
      Li L, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 355(3)

      Pages: 715-721

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adaptors DAP12 and FcRγ chain on peritoneal macrophages2007

    • Author(s)
      Nakahashi C, et. al.
    • Journal Title

      J. Immunol 178(2)

      Pages: 765-770

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] PI3-kinase activation is required to form the NKG2D immunological synapse2007

    • Author(s)
      Giurisato E, et. al.
    • Journal Title

      Mol Cell Biol 27(24)

      Pages: 8583-8599

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A CD200 receptor-like protein CD200R3 functions as an activating rece ptor expressed exclusively on basophils and mast cells2007

    • Author(s)
      Kojima T, et. al.
    • Journal Title

      J. Immunol 179

      Pages: 7093-7100

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical Negative Regulation of type 1 T cell immunity and immunopat hology by signaling adaptor DAP12 during intracellular infection2007

    • Author(s)
      Divangahi M, et. al.
    • Journal Title

      J. Immunol 179

      Pages: 4015-4026

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activating Fcγ receptors participate in the development of autoimmune diabetes in NOD mice2007

    • Author(s)
      Inoue Y, et. al.
    • Journal Title

      J. Immunol 179

      Pages: 4015-4026

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss2007

    • Author(s)
      Ochi S, et. al.
    • Journal Title

      Proc. Natl. Acad.Sci. USA 104(27)

      Pages: 11394-11399

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of MER5(peroxiredoxin III)knockoutmice to LPS-induced oxidative stress2007

    • Author(s)
      Li L, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 355(3)

      Pages: 715-721

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation2007

    • Author(s)
      Masuda A, et al.
    • Journal Title

      J. Exp. Med 204

      Pages: 907-920

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress2007

    • Author(s)
      Li L, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Paired immunoglobulin-like receptors provide pattern recognition for bacteria2007

    • Author(s)
      Nakayama M, et al.
    • Journal Title

      J. Immunol (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of osteoclast differentiation and function by the CaMK/CREB pathway2007

    • Author(s)
      Sato K, et al.
    • Journal Title

      Nat. Med (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Critical role of the Fc receptor γ-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.2007

    • Author(s)
      Kitarnura K, et al.
    • Journal Title

      J. Immunol 178(1)

      Pages: 480-488

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Critical role of the Fc receptor γ-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.2007

    • Author(s)
      Kitamura K, et al.
    • Journal Title

      J. Immunol 178(1)

      Pages: 480-488

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Plexin-Al and its interaction with DAP12 in immune responses and bone homeostasis.2006

    • Author(s)
      Takegahara N , et. al.
    • Journal Title

      Nat. Cell Biol 8(6)

      Pages: 615-622

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel mast cell lines with enhanced proliferative and degranulative abilities established from temperature-sensitive SV40 large T antigen transgenic mice.2006

    • Author(s)
      Kanehira M , et. al.
    • Journal Title

      J. Biochem (Tokyo) 140(2)

      Pages: 211-220

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Establishment and functional characterization of novel natural killer cell lines derived from a temperature-sensitive SV40 la2006

    • Author(s)
      Iizuka S , et. al.
    • Journal Title

      J. Biochem (Tokyo) 140(2)

      Pages: 255-265

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Vav1 controls DAP10-mediated natural eytotoxicity by regulating actin and microtubule dynamics.2006

    • Author(s)
      Graham DB , et. al.
    • Journal Title

      J. Immunol 177(4)

      Pages: 2349-2355

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP122006

    • Author(s)
      Blasius AL , et. al.
    • Journal Title

      Blood 107(6)

      Pages: 2474-2476

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Fc receptors: their diverse functions in immunity and immune disorders2006

    • Author(s)
      Takai T.
    • Journal Title

      Springer Semin Immunopathol (Review) Dec;28(4)

      Pages: 303-304

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis2006

    • Author(s)
      Takegahara N et. al.
    • Journal Title

      Nat. Cell Biol 8(6)

      Pages: 615-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel mast cell lines with enhanced proliferative and degranulative abilities established from temperature-sensitive SV40 large T antigen transgenic mice2006

    • Author(s)
      Kanehira M, et. al.
    • Journal Title

      J. Biochem (Tokyo) 140(2)

      Pages: 211-220

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Establishment and functional characterization of novel natural killer cell lines derived from a temperature-sensitive SV40 large T antigen transgenic mouse2006

    • Author(s)
      Iizuka S, et. al.
    • Journal Title

      J. Biochem (Tokyo) 1402

      Pages: 255-265

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics2006

    • Author(s)
      Graham DB, et. al.
    • Journal Title

      J. Immunol 177(4)

      Pages: 2349-2355

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Siglec-H is an IPC-specific receptor that modulates type IIFN secretion through DAP122006

    • Author(s)
      Blasius AL, et. al.
    • Journal Title

      Blood 107(6)

      Pages: 2474-2476

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Fc receptors: their diverse functions in immunity and immune disorders2006

    • Author(s)
      Takai T.
    • Journal Title

      Springer Semin Immunopathol (Review) Dec 28(4)

      Pages: 303-304

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Plexin-Al and its interaction with DAP12 in immune responses and bone homeostasis.2006

    • Author(s)
      Takegahara N, et al.
    • Journal Title

      Nat. Cell Biol. 8(6)

      Pages: 615-622

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel mast cell lines with enhanced proliferative and degranulative abilities established from temperature-sensitive SV40 large T antigen transgenic mice.2006

    • Author(s)
      Kanehira M, et al.
    • Journal Title

      J. Biochem. (Tokyo) 140(2)

      Pages: 211-220

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Establishment and functional characterization of novel natural killer cell lines derived from a temperature-sensitive SV40 large T antigen transgenic mouse.2006

    • Author(s)
      Iizuka S, et al.
    • Journal Title

      J. Biochem. (Tokyo) 140(2)

      Pages: 255-265

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hydronephrosis associated with anti-urothelial and anti-nuclear autoantibodies in BALB/c-Fcgr2b^+Pdcd1^+ mice.2005

    • Author(s)
      Okazaki T , et. al.
    • Journal Title

      J. Exp. Med 202

      Pages: 1643-1648

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis.2005

    • Author(s)
      Turnbull IR , et. al.
    • Journal Title

      J. Exp. Med 202(3)

      Pages: 363-369

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005

    • Author(s)
      Xie X , et. al.
    • Journal Title

      Biol. Reprod 73(3)

      Pages: 510-518

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The src-family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.2005

    • Author(s)
      Zhang H , et. al.
    • Journal Title

      Immunity 22

      Pages: 235-246

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A novel recognition system for MHC class I molecules constituted by PIR2005

    • Author(s)
      Takai T.
    • Journal Title

      Adv. Immunol (Review) 88

      Pages: 161-192

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Paired Immunoglobulin-like Receptors and their MHC class I recognition2005

    • Author(s)
      Takai T.
    • Journal Title

      Immunology (Review) 115(4)

      Pages: 433-440

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Fc receptors and their role in immune regulation and autoimmunity2005

    • Author(s)
      Takai T.
    • Journal Title

      J. Clin. Immunol (Review) 25

      Pages: 1-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hydronephrosis associated with anti-urothelial and anti-nuclear autoantibodies inBALB/c-Fcgr2b^<-/->lPdcdlh^<-/-> mice2005

    • Author(s)
      Okazaki T, et. al.
    • Journal Title

      J. Exp. Med 202

      Pages: 1643-1648

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis2005

    • Author(s)
      TurnbuMR, etal.
    • Journal Title

      J. Exp. Med 202(3)

      Pages: 363-369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy2005

    • Author(s)
      Xie X, et. al.
    • Journal Title

      Biol. Reprod 73(3)

      Pages: 510-518

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The src-family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B2005

    • Author(s)
      Zhang H, et. al.
    • Journal Title

      Immunity 22

      Pages: 235-246

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hydronephrosis associated with antiurothelial and antinuclear autontibodies in BALB/c-Fcgr2b-/-Pdcd1-/-mice.2005

    • Author(s)
      Okazaki I, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, Honjo T
    • Journal Title

      J. Exp. Med. 202

      Pages: 1643-1648

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis.2005

    • Author(s)
      Turnbull R, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M
    • Journal Title

      J. Exp. Med. 202(3)

      Pages: 363-369

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005

    • Author(s)
      Xie X, He H, Colonna M, Seya T, Takai T, Croy BA
    • Journal Title

      Biol Reprod 73(3)

      Pages: 510-518

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.2005

    • Author(s)
      Zhang H, Meng F, Chu C-L, Takai T, Lowell C
    • Journal Title

      Immunity 22

      Pages: 235-246

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel recognition system for MHC class I molecules constituted by PIR.2005

    • Author(s)
      Takai T
    • Journal Title

      immunology (Review) 88

      Pages: 161-192

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Paired immunoglobulin-like Receptors and their MHC class I Recognition.2005

    • Author(s)
      Takai T
    • Journal Title

      immunology (Review) 115(4)

      Pages: 433-440

    • Related Report
      2005 Annual Research Report
  • [Presentation] Involvement of F_cγ receptors in the autoimmune type I diabetes of NOD mice.2005

    • Author(s)
      Inoue Y, Nakamura A, Takai T
    • Organizer
      第35回 日本免疫学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Enhanced MHC class I-restricted antigen presentation by Paired immunoglobulin-like receptor (PIR) -B deficient dendritic cell.2005

    • Author(s)
      Endo S, Nakamura A, Takai T
    • Organizer
      第35回 目本免疫学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] NK細胞の活性化CD200レセプターを介した新たな標的細胞認識機構2005

    • Author(s)
      石川哲、白鳥行大、荒瀬規子、高井俊行
    • Organizer
      第35回 日本免疫学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Plexin-Al utilizes the Trem-2/DAP12 receptor complex as a co-receptor in the immune system.2005

    • Author(s)
      Takegahara N, Kumanogoh A, Takamatsu H, Takai T, Kikutani H
    • Organizer
      第35回 日本免疫学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新しい自己認識レセプターPIRによる免疫制御と疾患2005

    • Author(s)
      高井俊行
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of Fcy receptors in the autoimmune type I diabetes of NOD mice2005

    • Author(s)
      Inoue Y, Nakamura A, Takai T
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Enhanced MHC class I-restricted antigen presentation by Paired immunoglobulin-like receptor (PIR)-B deficient dendritic cell2005

    • Author(s)
      Endo S, Nakamura A, Takai T
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel target recognition mechanism by NK cells by activating CD200 receptor2005

    • Author(s)
      Ishikawa T, Shiratori K, Arase, Takai T
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Plexin-A1 utilizes the Trem-2/DAP12 receptor complex as a co-receptor in the immune system2005

    • Author(s)
      Takegahara N, Kumanogoh A, Takamatsu H, Takai T, Kikutani H
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunre diseases regulated by a novel self-recognizing receptor, PIR2005

    • Author(s)
      Takai T
    • Organizer
      Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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