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Population based study of genetic risk and gene-environment interaction in lifestyle-related diseases including coronary artery diseases(KING Study)

Research Project

Project/Area Number 17209021
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionAichi Gakuin University (2006-2007)
Nagoya University (2005)

Principal Investigator

YOKOTA Mitsuhiro  Aichi Gakuin University, School of Dentistry, Professor (50201851)

Co-Investigator(Kenkyū-buntansha) NAGATA Kohzo  Nagoya University, School of Medicine, Assistant Professor (20378227)
OBATA Koji  Aichi-Gakuin University, School of Dentistry, Associate Professor (40378229)
IZAWA Hideo  Nagoya University, Graduate School of Medicine, Lecturer (80402569)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2007: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2006: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2005: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
KeywordsInvestigation of Genetic Risk of Cardiovascular Di / King Study / Cohort Study / Lifestyle Related-Disease / Genome-Wide and Candidate Gene Association Study / Odds Ratio / Susceptibility Gene / DNA Bank / 心筋梗塞 / KING study / 症例-対照関連解
Research Abstract

Atherosclerotic CAD is a major health problem around the world. The CAD is believed to be multifactorial and to result from many genes, each with a relatively small effect, working alone or in combination with modifier genes and/or environmental factors.
Despite the years of research, the genetic basis of CAD or myocardial infarction (MI) remains to be fully elucidated. In this paper, we highlight emerging knowledge and paradigms from a number of technologies to identify susceptibility genes to MI.
The coronary artery disease (CAD) results from the combination of multiple genetic and environmental factors. We describe the genetic approaches researchers are using to advance understanding and preventing of CAD. The genetic identification of the future development of risk factors will lead to genome-informed tailored prevention

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (75 results)

All 2008 2007 2006 2005 Other

All Journal Article (52 results) (of which Peer Reviewed: 19 results) Presentation (20 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion2007

    • Author(s)
      Hisashi Umeda
    • Journal Title

      Circulation Journal 70

      Pages: 232-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Investigation of the relationship between sample size and risk factors for complex diseases based on a simulation study2007

    • Author(s)
      Yasuyuki Tomita
    • Journal Title

      Chem-Bio Informatics Journal 7(1)

      Pages: 1-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea:A preliminary study2007

    • Author(s)
      Akiko Noda
    • Journal Title

      Chest 131

      Pages: 1694-1701

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Adolescent obesity adversely affects blood pressure and resting heart rate2007

    • Author(s)
      Reizo Baba
    • Journal Title

      Circulation Journal 71

      Pages: 722-726

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Investigation of the relationship between sample size and risk factors for complex diseases based on a simulation study.2007

    • Author(s)
      Yasuyuki Tomita
    • Journal Title

      Chem-Bio Informatics Journal 7(1)

      Pages: 1-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea : A preliminary study.2007

    • Author(s)
      Akiko Noda
    • Journal Title

      Chest 131

      Pages: 1694-1701

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Adolescent obesity adversely affects blood pressure and resting heart rate.2007

    • Author(s)
      Reizo Baba
    • Journal Title

      Circulation Journal 71

      Pages: 722-726

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Mechanisms underlying the impairment of ischemia-induced neovascularization in MMP-2-deficient mice.2007

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      Circulation Research 100

      Pages: 904-913

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of endogenous Mstl prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.2007

    • Author(s)
      Mari Odashima
    • Journal Title

      Circulation Research 100

      Pages: 1344-1352

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: A preliminary study2007

    • Author(s)
      Akiko Noda
    • Journal Title

      Chest 131

      Pages: 1694-1701

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 循環器分野における個別化医療への展開-心筋梗塞感受性遺伝子の探索-2007

    • Author(s)
      宮田聖子
    • Journal Title

      最新医学 9月増刊号

      Pages: 281-291

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Mechanisms underlying the impairment of ischemia-induced neovascularization in MMP-2-deficient mice.2007

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      Circulation Research (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sex differences in the relationships between electrocardiographic abnormalities and the extent of left ventricular hypertrophy by echocardiography2006

    • Author(s)
      Hikari Ochi
    • Journal Title

      Annals of Noninvasive Electrocardiology 11

      Pages: 222-229

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women2006

    • Author(s)
      Kiyoyasu Yamada
    • Journal Title

      Annals of Nuclear Medicine 20

      Pages: 677-681

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential myolysis of myocardium and skeletal muscle in hamsters with dilated cardiomyopathy:Beneficial protective effect of diltiazem2006

    • Author(s)
      Yosuke Kato
    • Journal Title

      Circulation Journal 70

      Pages: 1497-1502

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure2006

    • Author(s)
      Masako Saka
    • Journal Title

      Journal of Cardiovascular Pharmacology 47

      Pages: 770-779

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prognostic value of pacing-induced mechanical alternans in patients with mild to moderate idiopathic dilated cardiomyopathy in sinus rhythm2006

    • Author(s)
      Akihiro Hirashiki
    • Journal Title

      Journal of the American College of Cardiology 47

      Pages: 1382-1389

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Classification method for predicting the development of myocardial infarction by using the interaction between genetic and environmental factors2006

    • Author(s)
      Yasuyuki Tomita
    • Journal Title

      Transactions on Bioinformatics(IPSJ Digital Courier) 47(2)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Sex differences in the relationships between electrocardiographic abnormalities and the extent of left ventricular hypertrophy by echocardiography.2006

    • Author(s)
      Hikari Ochi
    • Journal Title

      Annals of Noninvasive Electrocardiology 11(3)

      Pages: 222-229

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women.2006

    • Author(s)
      Kiyoyasu Yamada
    • Journal Title

      Annals of Nuclear Medicine 20(10)

      Pages: 677-681

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion.2006

    • Author(s)
      Hisashi Umeda
    • Journal Title

      Circulation Journal 70

      Pages: 232-238

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Differential myolysis of myocardium and skeletal muscle in hamsters with dilated cardiomyopathy : Beneficial protective effect of diltiazem.2006

    • Author(s)
      Yosuke Kato
    • Journal Title

      Circulation Journal 70

      Pages: 1497-1502

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.2006

    • Author(s)
      Masako Saka
    • Journal Title

      Journal of Cardiovascular Pharmacology 47

      Pages: 770-779

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] Pacing-induced mechanical alternans could predict poor prognosis in patients with ideopathic dilated cardiomyopathy in sinus rhythm.2006

    • Author(s)
      Akihiro Hirashiki
    • Journal Title

      Journal of the American College of Cardiology 47

      Pages: 1382-1389

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.2006

    • Author(s)
      Sahoko Ichihara
    • Journal Title

      Cardiovascular Research 69

      Pages: 726-735

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Localization of cysteine protease, Cathepsin S, to the surface of vascular smooth muscle cells by association with Integrin αvβ3.2006

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      American Journal of Pathology 168

      Pages: 685-964

    • Related Report
      2006 Annual Research Report 2005 Annual Research Report
  • [Journal Article] Prognostic value of pacing-induced mechanical alternans in patients with mild to moderate idiopathic dilated cardiomyopathy in sinus rhythm.2006

    • Author(s)
      Akihiro Hirashiki
    • Journal Title

      Journal of the American College of Cardiology 47

      Pages: 1382-1389

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.2006

    • Author(s)
      Kohzo Nagata
    • Journal Title

      Hypertension 47

      Pages: 656-654

    • NAID

      130004245524

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure2006

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      Hypertension 48

      Pages: 979-987

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatine : Potential role of the RhoA -extracellular signal-regulated kinase serum response factor signalling Pathway.2006

    • Author(s)
      Masako Saka
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology 33

      Pages: 1164-1171

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Classification method for predicting the development of myocardial infarction by using the interaction between genetic and environmental factors.2006

    • Author(s)
      Yasuyuki Tomita
    • Journal Title

      Transactions on Bioinformatics(IPSJ Digital Courier) 47(2)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Attenuation of cardiac dysfunction by a PPAR-αagonist is associated with down-regulation of redox-regulated transcription factors.2006

    • Author(s)
      Sahoko Ichiara
    • Journal Title

      Journal of Molecular and Cellular Cardiology 41

      Pages: 318-329

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.2006

    • Author(s)
      Sahoko Ichihara
    • Journal Title

      Biochemical and Biophysical Research Communications 350

      Pages: 105-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure2006

    • Author(s)
      Sahoko Ichihara
    • Journal Title

      Cardiovasucular Research 69

      Pages: 726-735

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy:a pilot study2005

    • Author(s)
      Hideo Izawa
    • Journal Title

      Circulation 112

      Pages: 2940-2945

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomypathy ptients2005

    • Author(s)
      Satoru Ohshima
    • Journal Title

      Journal of the American College of Cardiology 46

      Pages: 2061-2068

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mechanisms of the inhibitory effect of Epigallocatechinα3βallate on cultured human vascular smooth muscle cell invasion2005

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology 25

      Pages: 1864-1870

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway2005

    • Author(s)
      Koji Obata
    • Journal Title

      Biochemical and Biophysical Research Communications 338

      Pages: 1299-1305

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats2005

    • Author(s)
      Jinglan Xu
    • Journal Title

      Hypertension 46

      Pages: 719-724

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Myocardial 1231-MIBG scintigraphy reflects left ventricular functional reserve in patients with nonobstructive hypertrophic cardiomyopathy2005

    • Author(s)
      Satoshi Isobe
    • Journal Title

      Journal of the American College of Cardiology 46

      Pages: 909-916

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy : a pilot study.2005

    • Author(s)
      Hideo Izawa
    • Journal Title

      Circulation 112

      Pages: 2940-2945

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomypathy ptients.2005

    • Author(s)
      Satoru Ohshima
    • Journal Title

      Journal of the American College of Cardiology 46

      Pages: 2061-2068

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Mechanisms of the inhibitory effect of Epigallocatechina3Ballate on cultured human vascular smooth muscle cell invasion.2005

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology 25

      Pages: 1864-1870

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway.2005

    • Author(s)
      Koji Obata
    • Journal Title

      Biochemical and Biophysical Research Communications 338

      Pages: 1299-1305

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats.2005

    • Author(s)
      Jinglan Xu
    • Journal Title

      Hypertension 46

      Pages: 719-724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Myocardial 123I-MIBG scintigraphy reflects left ventricular functional reserve in patients with nonobstructive hypertrophic cardiomyopathy.2005

    • Author(s)
      Satoshi Isobe
    • Journal Title

      Journal of the American College of Cardiology 46

      Pages: 909-916

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mechanisms of the inhibitory effect of Epigal locatechin α3βallate on cultured human vascular smooth muscle cell invasion.2005

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology 25

      Pages: 1864-1870

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nicorandil promotes myocardial capillary and arteriolar growth in the failin heart of Dahl salt-sensitive hypertensive rats.2005

    • Author(s)
      Jinglan Xu
    • Journal Title

      Hypertension 46

      Pages: 719-724

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Myocardial 123I-MIBG scintigraphy reflects left ventricular functional reserve in patients with nonobstructive hypertrophic cardiomyopathy.2005

    • Author(s)
      Satoshi Isobe
    • Journal Title

      Journal of Nuclear Medicine 46

      Pages: 909-916

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prediction of the genetic risk of coronary artery disease from polymorphisms in candidate genes.2005

    • Author(s)
      Mitsuhiro Yokota
    • Journal Title

      Japanese Heart Journal 44 supple.

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prognostic value of pacing-induced mechanical alternans in patients with mild to moderate idiopathic dilated cardiomyopathy in sinus rhythm.

    • Author(s)
      Akihiro Hirashiki
    • Journal Title

      Journal of the American College of Cardiology (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.

    • Author(s)
      Kohzo Nagata
    • Journal Title

      Hypertension (in press)

    • NAID

      130004245524

    • Related Report
      2005 Annual Research Report
  • [Presentation] Long-term Nifedipine attenuates myocardial collagen remodeling and prevents diastolic dysfunction through antioxidative stress in Dahl salt-sensitive hypertensive rats2007

    • Author(s)
      Takashi Yamada
    • Organizer
      13th World Congress on Heart Disease
    • Place of Presentation
      Vancouver,Canada
    • Year and Date
      2007-07-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hypertension : Basic and clinical : Long-term Nifedipine attenuates myocardial collagen remodeling and prevents diastolic dysfunction through antioxidative stress in Dahl salt-sensitive hypertensive rats.2007

    • Author(s)
      Takashi Yamada
    • Organizer
      13th World Congress on Heart Disease
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2007-07-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] New insights into the pathogenesis and management of heart failure,pulmonary circulation aspects:Prognostic value of pacing-induced mechanical alternans in patients with mild to moderate idiopathic dilated cardiomyopathy in sinus rhythm2007

    • Author(s)
      Akihiro Hirashiki
    • Organizer
      13th World Congress on Heart Disease
    • Place of Presentation
      Vancouver,Canada
    • Year and Date
      2007-07-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] New insights into the pathogenesis and management of heart failure, pulmonary circulation aspects : Prognostic value of pacing-induced mechanical alternans in patients with mild to moderate idiopathic dilated cardiomyopathy in sinus rhythm.2007

    • Author(s)
      Akihiro Hirashiki
    • Organizer
      13th World Congress on Heart Disease
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2007-07-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] New concepts in translational cardiac research: Comprehensive approaches for identification of susceptibility genes to myocardial infarction.2007

    • Author(s)
      Mitsuhiro Yokota
    • Organizer
      13th World Congress on Heart Disease
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2007-07-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] A Therapeutic Role of Mineralocorticoid Receptor Antagonism in Heart Failure2006

    • Author(s)
      Mitsuhiro Yokota
    • Organizer
      3rd Asian Pacific Congress of Heart Failure
    • Place of Presentation
      Taipei,Taiwan
    • Year and Date
      2006-10-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A Therapeutic Role of Mineralocorticoid Receptor Antagonism in Heart Failure.2006

    • Author(s)
      Mitsuhiro Yokota
    • Organizer
      3rd Asian Pacific Congress of Heart Failure
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2006-10-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roundtable Discussion 10循環器ゲノム研究の現状と展望 8.Prediction of the genetic risk of myocardial infarction2006

    • Author(s)
      Mitsuhiro Yokota
    • Organizer
      第70回日本循環器学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Predictive value of surrogate markers of effective reperfusion on greater myocardial salvage in patients with acute myocardial infarction2006

    • Author(s)
      Hisashi Umeda
    • Organizer
      第70回日本循環器学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pitavastatine increases survival and suppresses an activation in myocardial endothelin-1 system during the transition to heart failure in hypertensive rat2006

    • Author(s)
      Masako Saka
    • Organizer
      第70回日本循環器学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-03-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Minaralcorticoid receptor antagonist added to ACE inhibitor improves LV diastolic dysfunction by decreasing oxidative stress in hypertensive rats2006

    • Author(s)
      Hirotaka Kimata
    • Organizer
      第70回日本循環器学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tc-99m-sestamibi washout rate could be reflected delayed myocardial relaxation in patients with hypertrophic cardiomyopathy2006

    • Author(s)
      Kazumasa Unno
    • Organizer
      第70回日本循環器学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Correlation of regional left ventricular wall thickness with regional myocardial systolic function,but not with diastolic function,in hypertrophic cardiomyopathy2005

    • Author(s)
      Tomoko S.Kato
    • Organizer
      American Heart Association, 78th Scientific Session
    • Place of Presentation
      Dallas,USA
    • Year and Date
      2005-11-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Calcineurin inhibition by ZAKI-4β overexpression attenuates hypertrophy but increases diastolic stiffness following pressure overload2005

    • Author(s)
      Ricardo J.Gelpi
    • Organizer
      American Heart Association, 78th Scientific Session
    • Place of Presentation
      Dallas,USA
    • Year and Date
      2005-11-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Correlation of regional left ventricular wall thickness with regional myocardial systolic function, but not with diastolic function, in hypertrophic cardiomyopathy.2005

    • Author(s)
      Tomoko S. Kato
    • Organizer
      American Heart Association, 78th Scientific Session
    • Place of Presentation
      Dallas, USA
    • Year and Date
      2005-11-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Calcineurin inhibition by ZAKI-4B overexpression attenuates hypertrophy but increases diastolic stiffness following pressure overload.2005

    • Author(s)
      Ricardo J. Gelpi
    • Organizer
      American Heart Association, 78th Scientific Session
    • Place of Presentation
      Dallas, USA
    • Year and Date
      2005-11-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 循環器に於けるバイオインフォーマティクス1. 循環器疾患感受性遺伝子同定におけるバイオインフォーマティクスの応用2005

    • Author(s)
      井澤 英夫
    • Organizer
      第53回日本心臓病学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2005-09-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 循環器に於けるバイオインフォーマティクス2. 二項検定に基づく遺伝子多型環境因子の組み合わせ解析による心筋梗塞発症要因の推定2005

    • Author(s)
      本多 裕之
    • Organizer
      第53回日本心臓病学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2005-09-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac sympathetic dysfunction is related to downregulation of gene expression of SERCA2 and impaired myocardial contractile reserve in dilated cardiomyopathy2005

    • Author(s)
      Satoru Ohshima
    • Organizer
      52th Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Toronto,Canada
    • Year and Date
      2005-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac sympathetic dysfunction is related to downregulation of gene expression of SERCA2 and impaired myocardial contractile reserve in dilated cardiomyopathy.2005

    • Author(s)
      Satoru Ohshima
    • Organizer
      52th Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2005-06-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 心筋梗塞のリスク検査方法2008

    • Inventor(s)
      横田 充弘
    • Industrial Property Rights Holder
      横田 充弘
    • Industrial Property Number
      2008-053196
    • Filing Date
      2008-03-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 動脈硬化性疾患のリスク検査法及びリスク検査用キット2007

    • Inventor(s)
      横田 充弘
    • Industrial Property Rights Holder
      横田 充弘
    • Industrial Property Number
      2007-305320
    • Filing Date
      2007-11-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 動脈硬化性疾患のリスク検査法及びリスク検査用キット2007

    • Inventor(s)
      横田充弘
    • Industrial Property Rights Holder
      横田充弘
    • Industrial Property Number
      2007-305320
    • Filing Date
      2007-11-27
    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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