Research on a selection reference of chemopreventive agents for cancer and a development of tailor-made medicine for cancer prevention

• Project/Area Number: 17209022
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SAKAI Toshiyuki Kyoto Prefectural University of Medicine, 医学研究科, 教授 (20186993)
• Co-Investigator(Kenkyū-buntansha): SOWA Yoshihiro 京都府立医科大学, 医学研究科, 准教授 (70315935) ; MATSUZAKI Yoichiro 京都府立医科大学, 医学研究科, 助手 (70282522) ; YOSHIDA Tatsushi 京都府立医科大学, 医学研究科, 助教 (80315936) ; YOGOSAWA Shingo 京都府立医科大学, 医学研究科, 助教 (70381936) ; HORINAKA Mano 京都府立医科大学, 医学研究科, 助教 (80512037)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000); Fiscal Year 2008: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000); Fiscal Year 2007: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000); Fiscal Year 2006: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000); Fiscal Year 2005: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
• Keywords: 癌 / 癌抑制遺伝子 / テーラーメイド予防 / p53 / RB / DR5 / TRAIL / p16 / がん / p53-RB経路 / リ・フラウメニ症候群 / 家族性メラノーマ / p15 / MAPK / MEK / Oct-1 / p18 / TPA

Research Abstract

ヒト発癌において最も重要な癌抑制遺伝子p53は、多くの癌で失活している。本研究では、実際的な癌予防を目指し、約800種類の食品由来成分や薬剤を用いてその機能を回復・活性化させる物質の探索を行い、その作用機構を解析した。その結果、ヒト癌細胞に対して細胞増殖抑制効果を有する物質を複数見出した。さらに、その作用機構がp53標的遺伝子の発現量の調節であることを明らかにした。現在、それらを組み合わせ、動物試験により発癌抑制における相乗・相加効果の検討に移った段階である。

Research Products

• [Journal Article] Insight into estrogenicity of phytoestrogens using in silico simulation (2009)
  • Author(s): Sugiyama H, Sowa Y(他6名)
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 139-44
  • Peer Reviewed
• [Journal Article] Death receptor 5 targeting activity-guided isolation of isoflavones from Millettia brandisiana and Ardisia colorata and evaluation of ability to induce TRAIL-mediated apoptosis (2009)
  • Author(s): Kikuchi H, Sakai T(他4名)
  • Journal Title: Bioorg Med Chem 17 Pages: 1181-6
  • Peer Reviewed
• [Journal Article] Nitric oxide sensitizes tumor cells to TRAIL-induced apoptosis via inhibition of the DR5 transcription repressor Yin Yang 1 (2009)
  • Author(s): Huerta-Yepez S, Sakai T(他5名)
  • Journal Title: Nitric Oxide. 20 Pages: 39-52
  • Peer Reviewed
• [Journal Article] Death receptor 5 targeting activity-guided isolation of isoflavones from Millettia brandisiana and Ardisia colorata and evaluation of ability to induce TRAIL-mediated apoptosis. (2009)
  • Author(s): Kikuchi H, et al.
  • Journal Title: Bioorg Med Chem 17(3) Pages: 1181-1186
  • Peer Reviewed
• [Journal Article] Insight into estrogenicity of phytoestrogens using in silico simulation. (2009)
  • Author(s): Sugiyama H, et al.
  • Journal Title: Biochem Biophys Res Commun 379(1) Pages: 139-144
  • Peer Reviewed
• [Journal Article] Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells (2008)
  • Author(s): Yoshida T, Horinaka M, Takara M, Tsuchihashi M, Mukai N, Wakada M, Sakai T
  • Journal Title: Environ Health Prev Med. 13 Pages: 281-7
  • NAID: 10026957710
  • Peer Reviewed
• [Journal Article] a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells (2008)
  • Author(s): Kong D, Aoki S, Sowa Y, Sakai T, Kobayashi M. Smenospongine
  • Journal Title: Mar Drugs 6 Pages: 480-8
  • Peer Reviewed
• [Journal Article] Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with TRAIL (2008)
  • Author(s): Yasuda T, Yoshida T, Goda AE, Horinaka M, Yano K, Shiraishi T, Wakada M, Mizutani Y, Miki T, Sakai T
  • Journal Title: Mol Cancer Res 6 Pages: 1852-60
  • Peer Reviewed
• [Journal Article] Baicalein overcomes TRAIL resistance via two different cell specific pathways in cancer cells but not in normal cells (2008)
  • Author(s): Taniguchi H, Yoshida T, Horinaka M, Yasuda T, Goda AE, Konishi M, Wakada M, Kataoka K, Yoshikawa T, Sakai T
  • Journal Title: Cancer Res. 68 Pages: 8918-27
  • Peer Reviewed
• [Journal Article] Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis (2008)
  • Author(s): Yoshida T, Konishi M, Horinaka M, Yasuda T, Goda AE, Taniguchi H, Yano K, Wakada M, Sakai T
  • Journal Title: Biochem Biophys Res Commun. 375 Pages: 129-33
  • Peer Reviewed
• [Journal Article] Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole (2008)
  • Author(s): Goda AE, Yoshida T, Horinaka M, Yasuda T, Shiraishi T, Wakada M, Sakai T
  • Journal Title: Oncogene. 27 Pages: 3455-45
  • Peer Reviewed
• [Journal Article] a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model (2008)
  • Author(s): Shindoh N, Sowa Y(他13名), Sakai T(他13名)YM753
  • Journal Title: Int J Oncol. 32 Pages: 545-55
  • Peer Reviewed
• [Journal Article] CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells (2008)
  • Author(s): Takagi K, Sowa Y, Cevik OM, Nakanishi R, Sakai T
  • Journal Title: Int J Oncol. 32 Pages: 1105-10
  • Peer Reviewed
• [Journal Article] Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression (2008)
  • Author(s): Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T
  • Journal Title: Oncol Rep. 19 Pages: 721-7
  • Peer Reviewed
• [Journal Article] Arctiin induces cell growth inhibition through the down-regulation of cyclin DI expression. (2008)
  • Author(s): Matsuzaki Y, et al.
  • Journal Title: Oncol Rep. 19(3) Pages: 721-727
  • Peer Reviewed
• [Journal Article] CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells (2008)
  • Author(s): Takagi K, et al.
  • Journal Title: Int J Oncol. 32(5) Pages: 1105-1110
  • Peer Reviewed
• [Journal Article] YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model. (2008)
  • Author(s): Shindoh N, et al.
  • Journal Title: Int J Oncol. 32(3) Pages: 545-555
  • Peer Reviewed
• [Journal Article] Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole. (2008)
  • Author(s): Goda A, et al.
  • Journal Title: Oncogene 27(24) Pages: 3435-3445
  • Peer Reviewed
• [Journal Article] Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis. (2008)
  • Author(s): Yoshida T, et al.
  • Journal Title: Biochem Biophys Res Commun. 375(1) Pages: 129-133
  • Peer Reviewed
• [Journal Article] Baicalein overcomes TRAIL resistance via two different cell specific pathways in cancer cells but not in normal cells. (2008)
  • Author(s): Taniguchi H, et al.
  • Journal Title: Cancer Res 68(21) Pages: 8918-8927
  • Peer Reviewed
• [Journal Article] Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with TRAIL. (2008)
  • Author(s): Yasuda T, et al.
  • Journal Title: Mol Cancer Res 6(12) Pages: 1852-1860
  • Peer Reviewed
• [Journal Article] Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces GI arrest or apoptosis in different leukemia cells. (2008)
  • Author(s): Kong D, et al.
  • Journal Title: Mar Drugs 6(3) Pages: 480-488
  • Peer Reviewed
• [Journal Article] Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. (2008)
  • Author(s): Yoshida T, et al.
  • Journal Title: Environmental Health and Preventive Medicine 13(5) Pages: 281-287
  • NAID: 10026957710
  • Peer Reviewed
• [Journal Article] 発癌の分子機構に基づいた癌の“分子標的予防"研究 (2008)
  • Author(s): 曽和義広, 他
  • Journal Title: 医学のあゆみ 227(2) Pages: 147-148
• [Journal Article] 食品成分による癌の「分子標的予防法」の開発 (2008)
  • Author(s): 堀中真野, 他
  • Journal Title: FFIジャーナル 213(6) Pages: 537-544
  • NAID: 40016121757
• [Journal Article] Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. (2008)
  • Author(s): Matsuzaki Y., et. al.
  • Journal Title: Oncology Reports 19(3) Pages: 721-727
  • Peer Reviewed
• [Journal Article] YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model. (2008)
  • Author(s): Shindo N., et. al.
  • Journal Title: International Journal of Oncology 32(3) Pages: 545-555
  • Peer Reviewed
• [Journal Article] Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis (2007)
  • Author(s): Yoshida T, Shiraishi T, Horinaka M, Nakata S, Yasuda T, Goda AE, Wakada M, Mizutani Y, Miki T, Nishikawa A, Sakai T
  • Journal Title: Cancer Sci 98 Pages: 1417-23
  • NAID: 10019998746
  • Peer Reviewed
• [Journal Article] Glycosylation modulates TRAIL-R1/death receptor 4 protein : different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin (2007)
  • Author(s): Yoshida T, Shiraishi T, Horinaka M, Wakada M, Sakai T
  • Journal Title: Oncol Rep. 18 Pages: 1239-42
  • Peer Reviewed
• [Journal Article] Identification of JTP-70902, a p15^<INK4b>-inductive compound, as a novel MEK1/2 inhibitor (2007)
  • Author(s): Yamaguchi T, Yoshida T, Kurachi R, Kakegawa J, Hori Y, Nanayama T, Hayakawa K, Abe H, Takagi K, Matsuzaki Y, Koyama M, Yogosawa S, Sowa Y, Yamori T, Tajima N, Sakai T
  • Journal Title: Cancer Sci. 98 Pages: 1809-16
  • NAID: 10020119466
  • Peer Reviewed
• [Journal Article] The plant alkaloid cryptolepine induces p21^<WAF1/CIP1> and cell cycle arrest in a human osteosarcoma cell line (2007)
  • Author(s): Matsui TA, Sowa Y(他8名), Sakai T(他8名)
  • Journal Title: Int J Oncol. 31 Pages: 915-22
  • Peer Reviewed
• [Journal Article] Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo (2007)
  • Author(s): Matsui TA, Murata H, Sakabe T, Sowa Y, Horie N, Nakanishi R, Sakai T, Kubo T
  • Journal Title: Oncol Rep. 18 Pages: 1263-8
  • Peer Reviewed
• [Journal Article] a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells (2007)
  • Author(s): Yokota T, Matsuzaki Y(他9名), Sakai T(他9名)Sesamin
  • Journal Title: Cancer Sci. 98 Pages: 1447-53
  • Peer Reviewed
• [Journal Article] ZD1839 induces p15^<INK4b> and causes G1 arrest by inhibiting the MAPK/ERK pathway (2007)
  • Author(s): Koyama M, Matsuzaki Y, Yogosawa S, Hitomi T, Kawanaka M, Sakai T
  • Journal Title: Mol Cancer Ther. 6 Pages: 1579-87
  • Peer Reviewed
• [Journal Article] Vitamin K2 inhibits the proliferation of HepG2 cells by up-regulating the transcription of p21 gene (2007)
  • Author(s): Liu W, Sakai T(他11名)
  • Journal Title: Hepatol Res. 37 Pages: 360-5
  • NAID: 10020163979
  • Peer Reviewed
• [Journal Article] Halocynthiaxanthin and peridinin, two dietary carotenoids, sensitize colon cancer cell lines to the death ligand TRAIL (2007)
  • Author(s): Yoshida T, Maoka T, Das SK, Kanazawa K, Horinaka M, Wakada M, Satomi, Y, Nishino H, Sakai T
  • Journal Title: Mol Cancer Res. 5 Pages: 615-25
  • Peer Reviewed
• [Journal Article] Prognostic significance of thymidylate synthase expression in patients with prostate cancer undergoing radical prostatectomy (2007)
  • Author(s): Li Y, Sakai T(他8名)
  • Journal Title: Urology. 69 Pages: 988-95
  • Peer Reviewed
• [Journal Article] Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis : up-regulation of DR5 and inhibition of Yin Yang 1 (2007)
  • Author(s): Baritaki S, Sakai T(他3名)
  • Journal Title: Mol Cancer Ther. 6 Pages: 1387-99
  • Peer Reviewed
• [Journal Article] Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines (2007)
  • Author(s): Kouhara J, Yoshida T, Nakata S, Horinaka M, Wakada M, Ueda Y, Yamagishi H, Sakai T
  • Journal Title: Int J Oncol. 30 Pages: 679-87
  • Peer Reviewed
• [Journal Article] Oct-1 is involved in the transcriptional repression of the p15^<INK4b> gene (2007)
  • Author(s): Hitomi T, Matsuzaki Y, Yasuda S, Kawanaka M, Yogosawa S, Koyama M, Tantin D, Sakai T
  • Journal Title: FEBS Lett. 581 Pages: 1087-92
  • Peer Reviewed
• [Journal Article] Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1. (2007)
  • Author(s): Baritaki S., et. al.
  • Journal Title: Molecular Cancer Therapeutics 6(4) Pages: 1387-1399
  • Peer Reviewed
• [Journal Article] Halocynthiaxanthin and peridinin, two dietary carotenoids, sensitize colon cancer cell lines to the death ligand TRAIL. (2007)
  • Author(s): Yoshida T., et. al.
  • Journal Title: Molecular Cancer Research 5(6) Pages: 615-625
  • Peer Reviewed
• [Journal Article] ZD1839 induces p15^<INK4b> and causes G1 arrest by inhibiting the MAPK/ERK pathway. (2007)
  • Author(s): Koyama M., et. al.
  • Journal Title: Molecular Cancer Therapeutics 6(5) Pages: 1579-1587
  • Peer Reviewed
• [Journal Article] The significance of the expression of dihydropyrimidine dehydrogenase in prostate cancer. (2007)
  • Author(s): Li Y., et. al.
  • Journal Title: BJU International 99(3) Pages: 663-668
  • Peer Reviewed
• [Journal Article] Prognostic significance of thymidylate synthase expression in patients with prostate cancer undergoing radical prostatectomy. (2007)
  • Author(s): Li Y., et. al.
  • Journal Title: Urology 69(5) Pages: 988-995
  • Peer Reviewed
• [Journal Article] Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells. (2007)
  • Author(s): Yokota T., et. al.
  • Journal Title: Cancer Science 98(9) Pages: 1447-1453
  • Peer Reviewed
• [Journal Article] Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. (2007)
  • Author(s): Matsui TA., et. al.
  • Journal Title: Oncology Reports 18(5) Pages: 1263-1268
  • Peer Reviewed
• [Journal Article] The plant alkaloid cryptolepine induces p21^<WAF1/CIP1> and cell cycle arrest in a human osteosarcoma cell line. (2007)
  • Author(s): Matsui TA., et. al.
  • Journal Title: International Journal of Oncology 31(4) Pages: 915-922
  • Peer Reviewed
• [Journal Article] Identification of JTP-70902, ap15^<INK4b>-inductive compound, as a novel MEK1/2 inhibitor. (2007)
  • Author(s): Yamaguchi T., et. al.
  • Journal Title: Cancer Science 98(11) Pages: 1809-1816
  • Peer Reviewed
• [Journal Article] Lipoxygenase inhibitors induce death receptor5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. (2007)
  • Author(s): Yoshida T., et. al.
  • Journal Title: Cancer Science 98(9) Pages: 1417-1423
  • NAID: 10019998746
  • Peer Reviewed
• [Journal Article] Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin. (2007)
  • Author(s): Yoshida T., et. al.
  • Journal Title: Oncology Reports 18(5) Pages: 1239-1242
  • Peer Reviewed
• [Journal Article] Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene. (2007)
  • Author(s): Hitomi T. et al.
  • Journal Title: FEBS Lett. 581(6) Pages: 1087-1092
• [Journal Article] A novel synthetic drug, LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells (2006)
  • Author(s): Izumi M, Yogosawa S, Aoki S, Watanabe H, Kamiyama J, Takahara Y, Sowa Y, Kobayashi M, Hosoi H, Sugimoto T, Sakai T
  • Journal Title: Int J Oncol. 29 Pages: 169-73
  • Peer Reviewed
• [Journal Article] 15-Deoxy-Δ^<12, 14>-prostaglandin J_2 induces death receptor 5 expression through mRNA stabilization independently of PPARγ and potentiates TRAIL-induced apoptosis (2006)
  • Author(s): Nakata S, Yoshida T, Shiraishi T, Horinaka M, Kouhara J, Wakada M, Sakai T
  • Journal Title: Mol Cancer Ther. 5 Pages: 1827-35
  • Peer Reviewed
• [Journal Article] The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand (2006)
  • Author(s): Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Sakai T
  • Journal Title: Mol Cancer Ther. 5 Pages: 945-51
  • Peer Reviewed
• [Journal Article] Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells (2006)
  • Author(s): Matsui TA, Sowa Y, Yoshida T, Murata H, Horinaka M, Wakada M, Nakanishi R, Sakabe T, Kubo T, Sakai T
  • Journal Title: Carcinogenesis. 27 Pages: 1768-77
  • Peer Reviewed
• [Journal Article] Lysocellin, a metabolite of the novel drug 'alopestatin', induces G1 arrest and prevents cytotoxicity induced by etoposide (2006)
  • Author(s): Takahara Y, Yogosawa S(他12名), Sakai T(他12名)
  • Journal Title: Int J Oncol. 28 Pages: 823-9
  • Peer Reviewed
• [Journal Article] Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner (2006)
  • Author(s): Aoki S, Kong D, Suna H, Sowa Y, Sakai T, Setiawan A, Kobayashi M
  • Journal Title: Biochem Biophys Res Commun. 342 Pages: 101-6
  • Peer Reviewed
• [Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells (2006)
  • Author(s): Hasegawa H, Yoshida T(他14名), Sakai T(他14名)
  • Journal Title: Blood. 107 Pages: 679-88
  • Peer Reviewed
• [Journal Article] Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoposis in colon cancer cell lines. (2006)
  • Author(s): Kouhara J. et al.
  • Journal Title: Int. J. Oncol. 30(3) Pages: 679-687
• [Journal Article] 15-Deoxy-Δ^<12,14>-prostaglandin J_2 induces death receptor 5 expression through mRNA stabilization independently of PPAR_γ and potentiates TRAIL-induced apoptosis. (2006)
  • Author(s): Nakata S. et al.
  • Journal Title: Mol. Cancer Ther. 5(7) Pages: 1827-1835
• [Journal Article] Lysocellin, a metabolite of the novel drug "alopestatin", induces G1 arrest and prevents cytotoxicity induced by etoposide. (2006)
  • Author(s): Takahara Y. et al.
  • Journal Title: Int J Oncol 28 Pages: 823-829
• [Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells. (2006)
  • Author(s): Hasegawa H et al.
  • Journal Title: Blood 107(2) Pages: 679-688
• [Journal Article] Galectin-1 interacts with the α5β1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27 (2005)
  • Author(s): Fischer C, Sakai T(他8名)
  • Journal Title: J Biol Chem. 280 Pages: 37266-77
  • Peer Reviewed
• [Journal Article] Fucoxanthin induces cell cycle arrest at G_0/G_1 phase in human colon carcinoma cells through up-regulation of p21^<WAF1/Cip1> (2005)
  • Author(s): Das SK, Hashimoto T, Shimizu K, Yoshida T, Sakai T, Sowa Y, Komoto A, Kanazawa K
  • Journal Title: Biochim Biophys Acta. 1726 Pages: 328-35
  • Peer Reviewed
• [Journal Article] Artepillin C in Brazilian propolis induces G_0/G_1 arrest via stimulation of Cip1/p21 expression in human colon cancer cells (2005)
  • Author(s): Shimizu K, Das SK, Hashimoto T, Sowa Y, Yoshida T, Sakai T, Matsuura Y, Kanazawa K
  • Journal Title: Mol Carcinog. 44 Pages: 293-9
  • Peer Reviewed
• [Journal Article] Quercetin induces gadd45 expression through a p53-independent pathway (2005)
  • Author(s): Yoshida T, Maeda A, Horinaka M, Shiraishi T, Nakata S, Wakada M, Yogosawa S, Sakai T
  • Journal Title: Oncol Rep. 14 Pages: 1299-303
  • Peer Reviewed
• [Journal Article] A new cancer diagnostic system based on a CDK profiling technology (2005)
  • Author(s): Ishihara H, Sowa Y(他16名), Sakai T(他16名)
  • Journal Title: Biochem Biophys Acta. 1741 Pages: 226-33
  • Peer Reviewed
• [Journal Article] The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells (2005)
  • Author(s): Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Nakanishi R, Nishino H, Sakai T
  • Journal Title: Biochem Biophys Res Commun 333 Pages: 833-8
  • Peer Reviewed
• [Journal Article] Luteolin induces apoptosis via death receptor 5 up-regulation in human malignant tumor cells (2005)
  • Author(s): Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Nakanishi R, Nishino H, Matsui H, Sakai T
  • Journal Title: Oncogene. 24 Pages: 7180-9
  • Peer Reviewed
• [Journal Article] Tunicamycin enhances TRAIL-induced apoptosis in human prostate cancer cells (2005)
  • Author(s): Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T
  • Journal Title: Cancer Res. 65 Pages: 6364-70
  • Peer Reviewed
• [Journal Article] 15-Deoxy-Δ^<12, 14>-prostaglandin J_2 activates the expression of p15^<INK4b> gene, a cyclin-dependent kinase inhibitor (2005)
  • Author(s): Matsuzaki Y, Koyama M, Hitomi T, Takaoka Y, Kawanaka M, Sakai T
  • Journal Title: Int J Oncol. 27 Pages: 497-503
  • Peer Reviewed
• [Journal Article] Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein (2005)
  • Author(s): Yoshida T, Shiraishi T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T
  • Journal Title: Cancer Res. 65 Pages: 5662-7
  • Peer Reviewed
• [Journal Article] INK4 family-a promising target for'gene-regulating chemoprevention'and 'molecular-targeting prevention'of cancer- (2005)
  • Author(s): Matsuzaki Y, Sakai T
  • Journal Title: Environ Health Prev Med 10 Pages: 72-7
  • Peer Reviewed
• [Journal Article] Inhibitory effects of cancer cell proliferation by novel histone deacetylase inhibitors involve p21/WAF1 induction and G2/M arrest (2005)
  • Author(s): Maeda T, Nagaoka Y, Kawai Y, Takagaki N, Yasuda C, Yogosawa S, Sowa Y, Sakai T, Uesato S
  • Journal Title: Biol Pharm Bull. 28 Pages: 849-53
  • Peer Reviewed
• [Journal Article] Hes1 directly controls cell proliferation through the transcriptional repression of p27^<Kip1> (2005)
  • Author(s): Murata K, Sakai T(他6名)
  • Journal Title: Mol Cell Biol. 25 Pages: 4262-71
  • Peer Reviewed
• [Journal Article] Differential response at the hGABP/E4TF1 site of retinoblastoma gene promoter in human testicular seminoma cells (2005)
  • Author(s): Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T
  • Journal Title: Oncol Rep. 13 Pages: 871-4
  • Peer Reviewed
• [Journal Article] Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway (2005)
  • Author(s): Takagaki N, Sowa Y, Oki T, Nakanishi R, Yogosawa S, Sakai T
  • Journal Title: Int J Oncol. 26 Pages: 185-9
  • Peer Reviewed
• [Journal Article] Inhibitory effects of cancer cell proliferation by novel histone deacetylase inhibitors involve p21/WAF1 induction and G2/M arrest. (2005)
  • Author(s): Maeda T. et al.
  • Journal Title: Biol Pharm Bull 28(5) Pages: 849-853
• [Journal Article] Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. (2005)
  • Author(s): Murata K. et al.
  • Journal Title: Mol Cell Biol 25(10) Pages: 4262-4271
• [Journal Article] Fucoxanthin induces cell cycle arrest at G(0)/G(1) phase in human colon carcinoma cells through up-regulation of p21 (WAF1/Cip1). (2005)
  • Author(s): Das SK et al.
  • Journal Title: Biochem Biophys Acta 1726(3) Pages: 328-335
• [Journal Article] Artepillin C in Brazilian propolis induces G0/G1 arrest via stimulation of Cip1/p21 expression in human colon cancer cells. (2005)
  • Author(s): Shimizu K et al.
  • Journal Title: Mol Carcinog 44(4) Pages: 293-299
• [Journal Article] Quercetin induces gadd45 expression through a p53-independent pathway. (2005)
  • Author(s): Yoshida T et al.
  • Journal Title: Oncol Rep 14 Pages: 1299-1303
• [Journal Article] The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells. (2005)
  • Author(s): Horinaka M et al.
  • Journal Title: Biochem Biophys Res Commun 333 Pages: 833-838
• [Journal Article] Luteolin induces apoptosis via death receptor 5 up-regulation in human malignant tumor cells. (2005)
  • Author(s): Horinaka M et al.
  • Journal Title: Oncogene 24 Pages: 7180-7189
• [Journal Article] Proteasome inhibitor MG132 induces Death Receptor 5 through CCAAT/enhancer-binding protein homologous protein. (2005)
  • Author(s): Yoshida T et al.
  • Journal Title: Cancer Res 65 Pages: 5662-5667
• [Journal Article] Tunicamycin enhances TRAIL-induced apoptosis in human prostate cancer cells. (2005)
  • Author(s): Shiraishi T et al.
  • Journal Title: Cancer Res 65 Pages: 6364-6370
• [Journal Article] Differential response at the hGABP/E4TF1 site of retinoblastoma gane in human testicular seminoma cells. (2005)
  • Author(s): Shiraishi T et al.
  • Journal Title: Oncol Rep 13 Pages: 871-874
• [Journal Article] A new cancer diagnostic system based on a CDK pro filing technology. (2005)
  • Author(s): Ishihara H. et al.
  • Journal Title: Biochem Biophys Acta 1741(3) Pages: 226-233
• [Journal Article] 15-deoxy-D12,14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. (2005)
  • Author(s): Matsuzaki Y. et al.
  • Journal Title: Int J Oncol 27(2) Pages: 497-503
• [Journal Article] INK4 family-A promising target for ‘Gene-regulating chemoprevention' and ‘Molecular-targeting prevention' of cancer-. (2005)
  • Author(s): Matsuzaki Y. et al.
  • Journal Title: Environ Health Prev Med 10 Pages: 72-77
  • NAID: 110002703950
• [Journal Article] Nitric oxide sensitizes tumor cells to TRAIL-induced apoptosis via inhibition of the DR5 transcription repressor Yin Yang I.
  • Author(s): Huerta-Yepez S, et al.
  • Journal Title: Nitric Oxide (印刷中)
  • Peer Reviewed
• [Journal Article] Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole.
  • Author(s): Goda AE., et. al.
  • Journal Title: Oncogene (印刷中)
  • Peer Reviewed
• [Journal Article] Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis : upregulation of DR5 and inhibition of YY1
  • Author(s): Baritaki S. et al.
  • Journal Title: Mol. Cancer Ther. (印刷中)
• [Journal Article] ZD 1839 Induces p15INK4b and causes G1 arrest by inhibiting the MAPK/ERK pathway.
  • Author(s): Koyama M. et al.
  • Journal Title: Mol. Cancer Res. (印刷中)
• [Journal Article] Halocynthiaxanthin and peridinin, two dietary carotenoids, sensitize colon cancer cell lines to the death ligand TRAIL..
  • Author(s): Yoshida T. et al.
  • Journal Title: Mol. Cancer Res. (印刷中)
• [Journal Article] The significance of the expression of dihydropyrimidine dehydrogenase
  • Author(s): Li Y.et al.
  • Journal Title: BJU Int. (印刷中)
• [Journal Article] A novel synthetic drug LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells.
  • Author(s): Izumi M. et al.
  • Journal Title: Int J Oncol (印刷中)
• [Journal Article] Dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand.
  • Author(s): Horinaka M et al.
  • Journal Title: Mol Cancer Ther (印刷中)
• [Journal Article] Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.
  • Author(s): Matsui T. et al.
  • Journal Title: Carcinogenesis (印刷中)
• [Presentation] インドール-3-カルビノールとゲニステイン併用による細胞死増強効果とそのメカニズム (2009)
  • Author(s): 中村吉隆, 他
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-30
• [Presentation] ククルビタシンBによる活性酸素種を介した細胞周期停止及びアポトーシスの誘導 (2009)
  • Author(s): 安田周祐, 他
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-30
• [Presentation] イソリキリチゲニンはヒト大腸癌細胞に対してTRAIL誘導性アポトーシスを増強する (2009)
  • Author(s): 堀中真野, 他
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-30
• [Presentation] インドールー3-カルビノールとゲニスティン併用による細胞死増強効果とそのメカニズム (2009)
  • Author(s): 中村吉隆, 他
  • Organizer: 日本衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-30
• [Presentation] ククルビタシンBによる活性酸素種を介した細胞周期停止及びアポトーシスの誘導 (2009)
  • Author(s): 安田周祐, 他
  • Organizer: 日本衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-30
• [Presentation] イソリキリチゲニンはヒト大腸癌細胞に対してTRAIL誘導性アポトーシスを増強する (2009)
  • Author(s): 堀中真野, 他
  • Organizer: 日本衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-30
• [Presentation] ニンニク成分diallyl trisulfideによるROSを介したヒト大腸癌細胞増殖抑制機構の解析 (2009)
  • Author(s): 曽和義広, 他
  • Organizer: 分子予防環境医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-23
• [Presentation] 植物成分による分子標的癌予防の提案 (2009)
  • Author(s): 堀中真野, 他
  • Organizer: 分子予防環境医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-23
• [Presentation] バイカレインによる癌細胞特異的なDR5遺伝子の発現誘導とTRAIL感受性増強機構の解析 (2008)
  • Author(s): 堀中真野, 他
  • Organizer: 日本フードファクター学会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-17
• [Presentation] ニンニク成分diallyl trisulfideによるROSを介したヒト大腸癌細胞増殖抑制機構の解析 (2008)
  • Author(s): 曽和義広, 他
  • Organizer: 日本フードファクター学会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-17
• [Presentation] Studies on natural constituents inducing expression of death receptor 5. (2008)
  • Author(s): Ohtsuki T, et al.
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Lipoxygenase inhibitors induce DR5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis (2008)
  • Author(s): Horinaka M, et al.
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole (2008)
  • Author(s): Goda A, et al.
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Allopurinol enhances TRAIL-induced apoptosis through DR5 up-regulation in human prostate cancer cells. (2008)
  • Author(s): Yasuda T, et al.
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Baicalein overcomes TRAIL resistance via two different cell specific pathways in cancer cells but not in normal cells. (2008)
  • Author(s): Taniguchi H, et al.
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Identification of p15^<INK4b> -inductive compound, as a novel MEK 1/2 inhibitor (2008)
  • Author(s): Sowa Y., et al.
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] dipyridamoleによるp53変異型腫瘍細胞株に対するTRAIL感受性増強効果に関する検討 (2008)
  • Author(s): Goda A, et al.
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-27
• [Presentation] 熱帯植物由来のデスレセプター誘導作用をもつ天然物 (2008)
  • Author(s): 大槻崇, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-27
• [Presentation] CDK阻害因子p15^<INK4b>誘導化合物の探索と新規MEK阻害剤としての同定 (2008)
  • Author(s): 曽和義広, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] CDK阻害剤による5-FU感受性増強効果に関する検討 (2008)
  • Author(s): 高木浩一, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] 食品成分を用いた癌の「分子標的併用予防法」 (2008)
  • Author(s): 酒井敏行, 他
  • Organizer: がん予防大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-23
• [Presentation] ニンニク成分diallyl trisulfideによるROSを介した癌細胞増殖抑制機構の解析 (2008)
  • Author(s): 曽和義広, 他
  • Organizer: がん予防大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-23
• [Presentation] NDGAによるDR5遺伝子の発現誘導とTRAIL誘導性アポトーシスの増強 (2008)
  • Author(s): 堀中真野, 他
  • Organizer: がん予防大会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-23
• [Presentation] Gefitinib induces p15^<INK4b> and causes GI arrest by inhibiting the MAPK/ERK pathway. (2008)
  • Author(s): Koyama M., et al.
  • Organizer: American Association for Cancer Research
  • Place of Presentation: San Diego, CA, U.S.A.
  • Year and Date: 2008-04-15
• [Presentation] p53 inactivation upregulates p73 expression through E2F mediated transcriptional regulation. (2008)
  • Author(s): Tophkhane C., et al.
  • Organizer: American Association for Cancer Research
  • Place of Presentation: San Diego, CA, U.S.A.
  • Year and Date: 2008-04-14
• [Presentation] 発癌分子を標的とした合理的癌予防法の基礎的研究 (2008)
  • Author(s): 酒井敏行
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-30
• [Presentation] baicaleinはDR5発現を上昇させ癌細胞特異的にTRAIL誘導性アポトーシスを増強する (2008)
  • Author(s): 谷口浩也, 他
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-30
• [Presentation] ホルモン非依存性前立腺癌に対するアロプリノールのtumor necrosis factor-related apoptosis-inducing ligand(TRAIL)を介したアポトーシスの増強 (2008)
  • Author(s): 安田考志, 他
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-30
• [Presentation] 発癌分子を標的とした合理的癌予防法の基礎的研究 (2008)
  • Author(s): 酒井 敏行
  • Organizer: 日本衛生学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-30
• [Presentation] baicaleinはDR5発現を上昇させ癌細胞特異的にTRAIL誘導性アポトーシスを増強する (2008)
  • Author(s): 谷口 浩也, 他
  • Organizer: 日本衛生学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-30
• [Presentation] ホルモン非依存性前立腺癌に対するアロプリノールのtumor necrosis factor-related apoptosis-inducing ligand(TRAIL)を介したアポトーシスの増強 (2008)
  • Author(s): 安田 考志, 他
  • Organizer: 日本衛生学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-30
• [Presentation] Molecular-targeting cancer chemoprevention using p53-RB pathway (2007)
  • Author(s): Sowa Y., et. al.
  • Organizer: International Symposium on Translational Research
  • Place of Presentation: Lonavala, Mumbai, India
  • Year and Date: 2007-12-12
• [Presentation] Dietary flavonoids enhance TRAIL-induced apoptosis in Cancer Cells. (2007)
  • Author(s): Sakai T., et. al.
  • Organizer: International Conference on Food Factors for Health Promotion
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2007-12-01
• [Presentation] Halocynthiaxanthin sensitizes colon cancer cells to the TRAIL-induced apoptosis (2007)
  • Author(s): Yoshida T., et. al.
  • Organizer: International Conference on Food Factors for Health Promotion
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2007-11-29
• [Presentation] Dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand. (2007)
  • Author(s): Horinaka M., et. al.
  • Organizer: International Conference on Food Factors for Health Promotion
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2007-11-28
• [Presentation] カロテノイドHalocynthiaxanthin、PeridininはDR5遺伝子の発現を誘導し、TRAIL誘導性アポトーシスを増強する (2007)
  • Author(s): 堀中 真野, 他
  • Organizer: 分子予防環境医学研究会
  • Place of Presentation: 北九州
  • Year and Date: 2007-10-26
• [Presentation] Gefitinib induces p15^<INK4b> and causes G1 arrest by inhibiting the MAPK/ERK Pathway (2007)
  • Author(s): Koyama M., et. al.
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] p53-RB pathway as a final target for a variety of molecular-targeting chemotherapeutic agents (2007)
  • Author(s): Sakai T.
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] Studies on death receptor 5 inducing natural products of tropical medicine plants. (2007)
  • Author(s): Ohtsuki T., et. al.
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Dietary carotenoid, halocynthiaxanthin, sensitizes colon cancer cells to the TRAIL-induced apoptosis (2007)
  • Author(s): Yoshida T., et. al.
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand (2007)
  • Author(s): Horinaka M., et. al.
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Fenretinide up-regulates DR5 and induces synergistic apoptosis with TRAIL in colon cancer cell lines. (2007)
  • Author(s): Kouhara J., et. al.
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] アピゲニンは腫瘍細胞のDR5を安定化させ、TRAIL誘導性apoptosisに対する感受性を相乗的に増強する (2007)
  • Author(s): 堀中 真野, 他
  • Organizer: がん予防大会(日本がん予防学会)
  • Place of Presentation: 東京
  • Year and Date: 2007-07-12
• [Presentation] カロテノイドhalocynthiaxanthinとTRAILの併用は大腸癌細胞に強力にアポトーシスを誘導する (2007)
  • Author(s): 吉田 達士, 他
  • Organizer: がん予防大会(日本がん予防学会)
  • Place of Presentation: 東京
  • Year and Date: 2007-07-12
• [Presentation] 癌の「分子標的併用療法・予防法」の開発-apigeninによるDR5遺伝子の発現誘導とTRAIL誘導性アポトーシスの増強- (2007)
  • Author(s): 堀中 真野, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-06
• [Presentation] 新規ヒストン脱アセチル化酵素阻害薬YM753のin vitro癌細胞増殖阻害メカニズムの検討 (2007)
  • Author(s): 新堂 信昭, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-06
• [Presentation] 新規ヒストン脱アセチル化酵素阻害薬YM753のin vivo抗腫瘍作用 (2007)
  • Author(s): 森 政道, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-06
• [Presentation] ゲフィチニブはMAPK/ERK経路の阻害によってp15^<INK4b>を誘導し、G1期停止を引き起こす (2007)
  • Author(s): 小山 真, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-06
• [Presentation] リソセリンによるG1期停止と、そのプロドラッグ「アロペスタチン」の抗癌剤による副作用軽減効果 (2007)
  • Author(s): 与五沢 真吾, 他
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-05
• [Presentation] Dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand. (2007)
  • Author(s): Horinaka M., et. al.
  • Organizer: American Association for Cancer Research
  • Place of Presentation: Los Angeles, CA, U. S. A.
  • Year and Date: 2007-04-18
• [Presentation] 15-Deoxy-Δ^<12, 14>-PGJ_2はDR5のmRNAを安定化させて誘導し、TRAILによる腫瘍細胞へのアポトーシスを増強する (2007)
  • Author(s): 若田未来, 他
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-28
• [Presentation] カロテノイドhalocynthiaxanthinは抗腫瘍性リガンドTRAILによる大腸癌細胞へのアポトーシスを増強する (2007)
  • Author(s): 吉田達士, 他
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-28
• [Presentation] アピゲニンはDR5遺伝子の発現を誘導し、TRAIL誘導性アポトーシスを増強する (2007)
  • Author(s): 堀中真野, 他
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-28
• [Presentation] 癌の「分子標的併用予防法」の開発-ルテオリンによるDR5遺伝子の発現誘導とTRAIL誘導性アポトーシスの増強- (2006)
  • Author(s): 堀中真野, 他
  • Organizer: 第76回日本衛生学会総会
  • Place of Presentation: 山口
  • Year and Date: 2006-03-26
• [Presentation] 癌の「分子標的併用予防法」の開発-FenretinideによるDR5遺伝子の発現誘導とTRAIL誘導性アポトーシスの増強- (2006)
  • Author(s): 甲原純二, 他
  • Organizer: 第76回日本衛生学会総会
  • Place of Presentation: 山口
  • Year and Date: 2006-03-26
• [Presentation] S状結腸粘膜mRNA発現量測定による大腸癌高危険度指標の開発 (2006)
  • Author(s): 石川秀樹, 他
  • Organizer: 第76回日本衛生学会総会
  • Place of Presentation: 山口
  • Year and Date: 2006-03-26
• [Presentation] アルクチインによるサイクリンD1発現抑制 (2006)
  • Author(s): 松崎洋一郎, 他
  • Organizer: 第76回日本衛生学会総会
  • Place of Presentation: 山口
  • Year and Date: 2006-03-26
• [Presentation] カイメン由来物質がヒト神経芽腫細胞株に細胞死を誘導する (2006)
  • Author(s): 和泉守篤, 他
  • Organizer: 第76回日本衛生学会総会
  • Place of Presentation: 山口
  • Year and Date: 2006-03-26
• [Book] アンチエイジング・ヘルスフード (2008)
  • Author(s): 曽和義広
  • Total Pages: 7
  • Publisher: サイエンスフォーラム
• [Book] アンチエイジング・ヘルスフード (2008)
  • Author(s): 曽和義広, 他
  • Total Pages: 7
  • Publisher: サイエンスフォーラム
• [Remarks]
  • URL: http://www.f.kpu-m.ac.jp/k/pubmed/
• [Remarks]
  • URL: http://www2.kpu-m.ac.jp/~pubmed/
• [Remarks]
  • URL: http://www2.kpu-m.ac.jp/~pubmed/