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Molecular mechanic sum of the regulation and dies regulation of bone homeostasis and Development of therapeutic approaches

Research Project

Project/Area Number 17209035
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionThe University of Tokushima

Principal Investigator

MATSUMOTO Toshio  The University of Tokushima, Institute of Health Biorsciences, Graduate School, Professor (20157374)

Co-Investigator(Kenkyū-buntansha) ABE Masahiro  The University of Tokushima, Institute of Health Biorsciences, Graduate School, Associate Professor (80263812)
AKAIKE Masashi  The University of Tokushima, Universry Medical and Dental Hospital, Lecturer (90271080)
KIDO Shinsuke  The University of Tokushima, Institute of Health Biorsciences, Graduate School, Research Associate (30437652)
井上 大輔  徳島大学, バイオヘルスサイエンス研究部, 講師 (60314853)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000)
Fiscal Year 2007: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2006: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2005: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
KeywordsMechanical stress / Interleukin-11 (IL-11) / AFosB / Multiple myeloma / Wnt signal / Angiogenesis / Gluencorticoid / Endothelial cells / g / DeltaFosB
Research Abstract

In order to clarify the regulatory mechanisms for maintaining structural and functional homeostasis of skeletal system, as well as to elucidate the molecular mechanisms for the development of disorders caused by disruption of the skeletal homeostatic system, the present study was conducted in the following three areas :
(1) Elucidation of the mechanism of bone formation and the pathogenesis of disorders due to impaired bone formation: We have identified ΔFosB as an early response gene to mechanical load to the bone (JBMR'04). Rapidly induced ΔFosB forms heterodimers with JunD), and stimulated its target genes. IL-11 is one of the target genes, and ΔFosB /JunD heterodimer binds to a putative AP-1 site on the IL-11 gene promoter We also found that echanical stimuli enhances phosphorylation of Smadl via an activation of PECd without stimulation by BMP-2, and that phosphorylated Smadl forms complex with ΔFosB/JunD on the IL-11 gene promote fir full transcriptional activation of I-11 gene.
(2 … More ) Elucidation of the pathogenic mechanisms 'for the destructive bone lesions by multiple myeloma: We have previously found that multiple myeloma enhances osteoclastic bone resorption via the production of MIP-1, a C-C chemokine. (Blood '02, '04) In the present study, we found that myeloma cells constitutively secrete sFRP-2, an inhibitor of Wnt signaling, which strongly inhibits osteoblast differentiation. In addition, TGF-β also suppressed terminal differentiation of osteoblasts. Because TGF-β is released from bone matrix by enhanced bone resorption, these results imply that there is a strong suppression ofbone formation in myeloma-bone microenvironment. If a TGF-β antagonist was added, the suppressed bone formation by myeloma cells was ameliorated, and the restoration of terminal osteoblastic differentiation markedly suppressed myeloma cell growth. These results are consistent with the notion that there is a vicious cycle in myeloma-bone microenvironment, in which myeloma cells enhance bone resorption and suppress bone formation to extend bone destruction, and myeloma cell-derived sFRP-2 as well as TGF-β released from the bone matrix by the enhanced bone resorption co-operatively suppress bone formation. Furthermore, the suppression of osteoblast maturation provides a suitable environment for myeloma cell growth which can be called "myeloma niche". Wnt inhibitors and TGF-β antagonists can be targets for the development of new therapeutic modalities.
(3) Elucidation of the pathogenic mechanisms for disorders caused by disturbances in skeletal circulation: We have previously reported that glucocorticoid excess suppresses endothelium-dependent vasodilatory responses via a reduction in NO by an enhanced production of superoxides in the endothelium (Circ Res '03). We further found that glucocorticoid excess markedly suppresses urinary NOx excretion and aortic eNOS expression. In addition, pitavastatin antagonizes the effects of glucocorticoids. These observations support our hypothesis that glucocorticoid excess causes circulatory disturbances in microvessels of the femoral neck, which plays an important role in the development of idiopathic osteonecrosis of the femoral neck. Statins with high systemic blood levels can be a new candidate for the prevention of superoxide-induced circulatory disturbances. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (104 results)

All 2008 2007 2006 2005

All Journal Article (79 results) (of which Peer Reviewed: 35 results) Presentation (19 results) Book (2 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 3 results)

  • [Journal Article] Pitavastatin, an HMG-CoA Reductase Inhibitor, Exerts eNOS-independent Protective Actions against Angiotensin II-Induced Cardiovascular Remodeling and Renal Insufficiency.2008

    • Author(s)
      Yagi S
    • Journal Title

      Circ Res 102

      Pages: 68-76

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells.2008

    • Author(s)
      Wang W
    • Journal Title

      Lung Cancer (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of Teriparatide on Bone Mineral Density and Biochemical Markers in Japanese Women with Postmenopausal Osteoporosis:a6-month Dose-response Study.2008

    • Author(s)
      Miyauchi A
    • Journal Title

      J Bone Miner Metab (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical usefulness of measurement of fibroblast growth factor 23(FGF23)in hypophosphatemic patients Proposal of diagnostic criteria using FGF23 measurement.2008

    • Author(s)
      Endo I
    • Journal Title

      Bone (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Causes and differential diagnosis of hypocalcemia-Recommendation proposed by expert panel supported by Ministry of Health, Labour and Welfare, Japan-.2008

    • Author(s)
      Fukumoto S
    • Journal Title

      Endocr J (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pitavastatin, an HMG-CoA Reductase Inhibitor, Exerts eNOS-independent Protective Actions against Angiotensin II-Induced Cardiovascular Remodeling and Renal Insufficiency2008

    • Author(s)
      Yagi, S., et. al.
    • Journal Title

      Circ Res 102

      Pages: 68-76

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chimeric and humanized anti-HMI.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells2008

    • Author(s)
      Wang, W., et. al.
    • Journal Title

      Lung Cancer (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of Teriparatide on Bone Mineral Density and Biochemical Markers in Japanese Women with Postmenopausal Osteoporosis : a 6-month Dose-response Study2008

    • Author(s)
      Miyauchi, A., et. al.
    • Journal Title

      J Bone Miner Metab (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical usefulness of measurement of fibroblast growth factor 23(FGF23) in hypophosphatemic patients Proposal of diagnostic criteria using FGF23 measurement2008

    • Author(s)
      Endo, I., et. al.
    • Journal Title

      Bone (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Causes and differential diagnosis of hypocalcemia -Recommendation proposed by expert panel supported by Ministry of Health, Labour and Welfare, Japan -2008

    • Author(s)
      Fukumoto., et. al.
    • Journal Title

      Endocr J (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A single chain Fv diabody against HLA-A molecules specifically induces myeloma cell death in the bone marrow environment2007

    • Author(s)
      Sekimoto E
    • Journal Title

      Cancer Res 67

      Pages: 1184-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Myeloma cell-osteoclast interaction enhances angiogenesis together with boneresorption: a role for VEGF and osteopontin2007

    • Author(s)
      Tanaka Y
    • Journal Title

      Clin Cancer Res 13

      Pages: 816-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Therapy with Bortezomib plus Dexamethasone Induces Osteoblast Activation in Responsive Patients with Multiple Myeloma.2007

    • Author(s)
      Ozaki S
    • Journal Title

      Int J Hematol 86

      Pages: 180-185

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.2007

    • Author(s)
      Aihara K
    • Journal Title

      J Clin Invest 117

      Pages: 1486-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Improvement of cardiac diastolic function and prognosis after autologous peripheral blood stem cell transplantation in AL cardiac amyloidosis.2007

    • Author(s)
      Yagi S
    • Journal Title

      Intern Med 46

      Pages: 1705-1710

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Soluble insulin Receptor ectodomain is elevated in the plasma of patients with diabetes.2007

    • Author(s)
      Obata, T
    • Journal Title

      Diabetes 56

      Pages: 2028-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects.2007

    • Author(s)
      Matsumoto T
    • Journal Title

      J Steroid Biochem Mol Biol 103

      Pages: 584-586

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A single chain Fv diabody against HLA-A molecules specifically induces myeloma cell deathin the bone marrow environment2007

    • Author(s)
      Sekimoto, E., et. al.
    • Journal Title

      Cancer Res 67

      Pages: 1184-1192

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption : a role for vascular endothelial cell growth factor and osteopontin2007

    • Author(s)
      Tanaka, Y., et. al.
    • Journal Title

      Clin Cancer Res 13

      Pages: 816-823

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Therapy with Bortezomib plus Dexamethasone Induces Osteoblast Activation in Responsive Patients with Multiple Myeloma2007

    • Author(s)
      Ozaki, S., et. al.
    • Journal Title

      Int J Hematol 86

      Pages: 180-185

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice2007

    • Author(s)
      Aihara, K., et. al.
    • Journal Title

      J Clin Invest 117

      Pages: 1486-1489

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Improvement of cardiac diastolic function and prognosis after autologous peripheral blood stem cell transplantation in AL cardiac amyloidosis2007

    • Author(s)
      Yagi, S., et. al.
    • Journal Title

      Intern Med 46

      Pages: 1705-1710

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes2007

    • Author(s)
      Obata, T., et. al.
    • Journal Title

      Diabetes 56

      Pages: 2028-2035

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects2007

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      J Steroid Biochem Mol Biol 103

      Pages: 584-586

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice2007

    • Author(s)
      Aihara, K
    • Journal Title

      J Clin Invest 117

      Pages: 1486-1489

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pitavastatin,an HMG-CoA Reductase Inhibitor,Exerts eNOS-independent Protective Actions against Angiotensin II-Induced Cardiovascullar Remodeling and Renal Insufficiency2007

    • Author(s)
      Yagi, S
    • Journal Title

      Circ Res 102

      Pages: 68-76

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble insulin Receptor ectodomain is elevated in the plasma of patients with diabetes2007

    • Author(s)
      Obata, T
    • Journal Title

      Diabetes 56

      Pages: 2028-2035

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single chain Fv diabody against HLA-A molecules specifically induces myeloma cell in the bone marrow environment.2007

    • Author(s)
      Sekimoto, E
    • Journal Title

      Cancer Res 67

      Pages: 21184-21192

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resporption:a role for VEGF and osteopontin2007

    • Author(s)
      Tanaka, Y
    • Journal Title

      Clin Cancer Res 13

      Pages: 816-823

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single chain Fv diabody against HLA-A molecules specifically induces myeloma cell death in the bone marrow environment2007

    • Author(s)
      Sekimoto E
    • Journal Title

      Cancer Res 67・3

      Pages: 1184-1192

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption : a role for VEGF and osteopontin2007

    • Author(s)
      Tanaka Y
    • Journal Title

      Clin Cancer Res 13・3

      Pages: 816-823

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Biochemical markers of bone turnover predict bone loss in perimenopausal women but not in postmenopausal women-the Japanese Population-based Osteoporosis (JPOS) Cohort Study2006

    • Author(s)
      Iki M
    • Journal Title

      Osteoporos Int 17・7

      Pages: 1086-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daily nasal spray of hPTH (1-34) for 3 months increases bone mass in osteoporotic subjects: a pilot study2006

    • Author(s)
      Matsumoto T
    • Journal Title

      Osteoporos Int 17・10

      Pages: 1532-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bone destruction in multiple myeloma.2006

    • Author(s)
      Matsumoto T
    • Journal Title

      Ann N Y Acad Sci 1068

      Pages: 319-326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myeloma2006

    • Author(s)
      Abe M
    • Journal Title

      Leukemia 20・7

      Pages: 1313-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Parkin enhances mitochondrial biogenesis in proliferating cells2006

    • Author(s)
      Kuroda Y
    • Journal Title

      Hum Mol Genet 15・6

      Pages: 883-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a conventional non-radioisotope method to quantify HM1.24 antigens: Correlation of HM1.24 levels and ADCC activity of the humanized antibody against HM1.24.2006

    • Author(s)
      Kawai S
    • Journal Title

      Leuk Res 30

      Pages: 949-956

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Antitumor activity of humanized monoclonal antibody against HM1.24 antigen in human myeloma xenograft models.2006

    • Author(s)
      Kawai S
    • Journal Title

      Oncol Rep 15

      Pages: 361-367

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Skeletal Development and Remodeling2006

    • Author(s)
      Matsumoto TAbe, M.
    • Journal Title

      Health, Diseaase, and Aging (Edited by Mone Zaidi) Bone destruction in multiple myeloma, The New York Academy of Sciences

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] BAFF and APRIL as osteoclast-derived survival factors for myeloma cells : a rationale for TACI-Fc treatment in patients with multiple myeloma2006

    • Author(s)
      Abe, M., et. al.
    • Journal Title

      Leukemia 20

      Pages: 1313-1315

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Parkin enhances mitochondria] biogenesis in proliferating cells2006

    • Author(s)
      Kuroda, Y., Azuma H, Matsumoto, T, et. al.
    • Journal Title

      Hum Mol Genet 15

      Pages: 883-895

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Construction of a conventionalnon-radioisotope method to quantify HM1.24 antigens : Correlation of HM1.24 levels and ADCC activity of the humanized antibody against HM1.242006

    • Author(s)
      Kawai, S., et. al.
    • Journal Title

      Leuk Res 30

      Pages: 949-956

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Antitumor activity of humanized monoclonal antibody against HM1.24 antigen in human myeloma xenograft models2006

    • Author(s)
      Kawai, S., et. al.
    • Journal Title

      Oncol Rep 15

      Pages: 361-367

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Biochemical markers of bone turnover predict bone loss in perimenopausal women but not in postmenopausal women-the Tapanese Population-based Osteoporosis(JPOS) Cohort Study2006

    • Author(s)
      Iki, M., et. al.
    • Journal Title

      Osteoporos Int 17

      Pages: 1086-1095

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects : a pilot study2006

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      Osteoporos Int 17

      Pages: 1532-1538

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Bone destruction in multiple myeloma2006

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      Ann N Y Acad Sci 1068

      Pages: 319-326

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Skeletal Development and Remodeling in Health, Diseaase, and Aging (Edited by Mone Zaidi) Bone destruction in multiple myeloma2006

    • Author(s)
      Matsumoto, T
    • Journal Title

      The New York Academy of Sciences

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] BAFF and APRIL as osteoclast-derived survival factors for myeloma cells : a rationale for TACI-Fc treatment in patients with multiple myeloma2006

    • Author(s)
      Abe M
    • Journal Title

      Leukemia 20・7

      Pages: 1313-1315

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects : a pilot study2006

    • Author(s)
      Matsumoto T
    • Journal Title

      Osteoporos Int 17・10

      Pages: 1532-1538

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Myeloma-Bone Interaction : A Vicious Cycle.2006

    • Author(s)
      Matsumoto T
    • Journal Title

      BoneKEy-Osteovision (http://www.bonekey-ibms.org/cgi/content/full/ibmske) 3・3

      Pages: 8-14

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Antitumor activity of humanized monoclonal antibody against HM1.24 antigen in human myeloma xenograft models2006

    • Author(s)
      Kawai S
    • Journal Title

      Oncol Rep 15・2

      Pages: 361-367

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Myeloma cells suppress bone formation by secreting a soluble Wntinhibitor, sFRP-2.2005

    • Author(s)
      Oshima T
    • Journal Title

      Blood 106(9)

      Pages: 3160-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Malignant B-lymphoid cells with bone lesions express receptor activator of nuclear factor-kappaB ligand and vascular endothelial growth factor to enhance osteoclastogenesis.2005

    • Author(s)
      Shibata H
    • Journal Title

      Clin Cancer Res 11・17

      Pages: 6109-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of HM1.24 peptide-specific cytotoxic T lymphocytes by using peripheral blood stem cell harvests in patients with multiple myeloma.2005

    • Author(s)
      Jalili A
    • Journal Title

      Blood 106・10

      Pages: 3538-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New Active Vitamin D, ED-71,Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation: A Randomized, Double Blind, Placebo-controlled Clinical Trial.2005

    • Author(s)
      Matsumoto T
    • Journal Title

      J Clin Endocrinol Metab 90・9

      Pages: 5031-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors.2005

    • Author(s)
      Ito Y
    • Journal Title

      Bone 37・6

      Pages: 842-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines on the management and treatment of glucocorticoid-induced osteoporosis of the Japanese Society for Bone and Mineral Research (2004).2005

    • Author(s)
      Nawata H
    • Journal Title

      J Bone Miner Metab 23・2

      Pages: 105-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia.2005

    • Author(s)
      Iwase T
    • Journal Title

      Circulation 111

      Pages: 356-362

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis2005

    • Author(s)
      Ikeda Y
    • Journal Title

      J Biol Chem 183・1

      Pages: 29661-29666

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia.2005

    • Author(s)
      Iwase T
    • Journal Title

      Cardiovasc Res 11

      Pages: 543-551

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression.2005

    • Author(s)
      Kato M
    • Journal Title

      Athrerosclerosis 183・1

      Pages: 49-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery.2005

    • Author(s)
      Yoshida T
    • Journal Title

      Atherosclerosis 178・1

      Pages: 39-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-22005

    • Author(s)
      Oshima, T., et. al.
    • Journal Title

      Blood 106

      Pages: 3160-3165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Malignant B-lymphoid cells with bone lesions express receptor activator of nuclear factor-kappaB ligand and vascular endothelial growth factor to enhance osteoclastogenesis2005

    • Author(s)
      Shibata, H., et. al.
    • Journal Title

      Clin Cancer Res 11

      Pages: 6109-6115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Induction of HM1.24 peptide-specific cytotoxic T lymphocytes by using peripheral-blood stem-cell harvests in patients with multiple myeloma2005

    • Author(s)
      Jalili, A., NishiokaY, Matsumoto, T, et. al.
    • Journal Title

      Blood 106

      Pages: 3538-3545

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial2005

    • Author(s)
      Matsumoto, T., et. al.
    • Journal Title

      J Clin Endocrinol Metab 90

      Pages: 5031-5036

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors2005

    • Author(s)
      Ito, Y., et. al.
    • Journal Title

      Bone 37

      Pages: 842-849

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Guidelines on the management and treatment of glucocorticoid-induced osteoporosis of the Japanese Society for Bone and Mineral Research(2004)2005

    • Author(s)
      Nawata, H., et. al.
    • Journal Title

      J Bone Miner Metab 23

      Pages: 105-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia2005

    • Author(s)
      Iwase, T., et. al.
    • Journal Title

      Circulation 111

      Pages: 356-362

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation ofAngiotensin II-induced Cardiac Fibrosis2005

    • Author(s)
      Ikeda, Y., et. al.
    • Journal Title

      J Biol Chem 280

      Pages: 29661-29666

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of angiogenic potency between mesenchytnal stem cells and mononuclear cells in a rat model of hindlimb ischemia2005

    • Author(s)
      Iwase, T., et. al.
    • Journal Title

      Cardiovasc Res 66

      Pages: 543-551

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Aspirin inhibits thrombin action on endothelial cellsvia up-regulation of aminopeptidase N/CD13 expression2005

    • Author(s)
      Kato, M., et. al.
    • Journal Title

      Atherosclerosis 183

      Pages: 49-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A(mtTFA) expression in injured rat carotid artery2005

    • Author(s)
      Yoshida, T., et. al.
    • Journal Title

      Atherosclerosis 178

      Pages: 39-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis.2005

    • Author(s)
      Ikeda Y
    • Journal Title

      J Biol Chem 280・33

      Pages: 29661-29666

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia.2005

    • Author(s)
      Iwase T
    • Journal Title

      Circulation 113・3

      Pages: 356-362

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia.2005

    • Author(s)
      Iwase T
    • Journal Title

      Cardiovasc Res 66・3

      Pages: 543-551

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD 13 expression.2005

    • Author(s)
      Kato M
    • Journal Title

      Athrerosclerosis 183・1

      Pages: 49-55

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A New Active Vitamin D,ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation : A Randomized, Double Blind, Placebo-controlled Clinical Trial.2005

    • Author(s)
      Matsumoto T
    • Journal Title

      J Clin Endocrinol Metab 90・9

      Pages: 5031-5036

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2.2005

    • Author(s)
      Oshima T
    • Journal Title

      Blood 106(9)

      Pages: 3160-3165

    • Related Report
      2005 Annual Research Report
  • [Presentation] Pathophysiology of Osteoporosis2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      The Korean Society of Osteoporosis,International Symposium 2007
    • Place of Presentation
      Seoul,Korean
    • Year and Date
      2007-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Korean Society of Osteoporosis2007

    • Author(s)
      Matsumoto, T
    • Organizer
      Pathophysiology of Osteoporosis, International Symposium 2007
    • Place of Presentation
      Seoul, Korean
    • Year and Date
      2007-12-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ホルモン依存癌治療における骨病変とその管理2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      第19回 日本内分泌外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cancer Treatment-induced Bone Diseases and Their Management2007

    • Author(s)
      Matsumoto, T
    • Organizer
      The 19th Japan Association of Endocrine. Surgeons
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨と遺伝子・骨代謝メカニズム2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      第27回 日本医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetics of bone metabolism2007

    • Author(s)
      Matsumoto, T
    • Organizer
      The 27th The Japanese Association of Medical Sciences
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-04-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE,AND AGING2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      Bone Loss in Myeloma New York Academy of Sciences Meeting
    • Place of Presentation
      New York, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bone Remodeling and Treatment of Osteoporosis2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      Annual Meeting of the Korean Endocrine Society
    • Place of Presentation
      Seoul,Korea
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanical stress-induced signaling of Osteoblast Differentiation-Interaction between Smad and AP-1 signaling-2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      The 16th IAA Humans in Space Symposium
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Therapeutic Opportunities Mechanism and Therapeutics in Myeloma Bone Disease2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      Molecular Signaling in Bone Remodeling Therapeutic Opportunities
    • Place of Presentation
      Sydney
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE, AND AGING USA2007

    • Author(s)
      Matsumoto, T
    • Organizer
      Bone Loss in Myeloma New York Academy of Sciences Meeting
    • Place of Presentation
      New York
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bone Remodeling and Treatment of Osteoporosis2007

    • Author(s)
      Matsumoto, T
    • Organizer
      Annual Meeting of the Korean Endocrine Society
    • Place of Presentation
      Seoul, Korea
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanical Stress-Induced signaling of osteoblast Differentiation -Interaction Between Smad and AP-1 signaling-2007

    • Author(s)
      Matsumoto, T
    • Organizer
      The 16th IAA Humans in Space Symposium
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism and Therapeutics in Myeloma Bone Disease2007

    • Author(s)
      Matsumoto, T
    • Organizer
      Molecular Signaling in Bone Remodeling : Therapeutic Opportunities
    • Place of Presentation
      Sydney
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bone Remodeling and Treatment of Osteoporosis2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      Annual Meeting of the Korean Endocrine Society
    • Place of Presentation
      Seoul, Korean
    • Related Report
      2007 Annual Research Report
  • [Presentation] Interaction between Smad and AP-1 signaling2007

    • Author(s)
      Toshio Matsumoto
    • Organizer
      The 16th IAA Humans in Space Symposium Mechanical stress-induced signaling of osteoblast differentiation
    • Place of Presentation
      Beijing, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Therapeutic Opportunities Mechanism and Therapeutics in Myeloma Bone Disease2007

    • Author(s)
      Toshi Matsumoto
    • Organizer
      Molecula Signaling in Bone Remodeling
    • Place of Presentation
      Sydney,Australia
    • Related Report
      2007 Annual Research Report
  • [Presentation] MIP-1 PRODUCED BY MYELOMA CELLS ENHANCES BONE DESTRUCTION,MYELOMA CELL SURVIVAL,AND SUPPRESSES DENDRITIC CELL FORMATION2006

    • Author(s)
      Toshio Matsumoto
    • Organizer
      Vth International Conference on Cancer Induced Bone Diseases
    • Place of Presentation
      Davos, Switzerland
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MIP-1 PRODUCED BY MYELOMA CELLS Bone ENHANCES BONE DESTRUCTION, MYELOMA CELL SURVIVAL, AND SUPPRESSES DENDRITIC CELL FORMATION2006

    • Author(s)
      Matsumoto, T
    • Organizer
      Vth International Conference on Cancer Induced iseases
    • Place of Presentation
      Davos, Switzerland
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Skeletal Development and Remodeling in Health, Diseaase, and Aging (Edited by Mone Zaidi) Bone destruction in multiple myeloma2006

    • Author(s)
      Matsumoto, T
    • Publisher
      The New York Academy of Sciences
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Skeletal Development and Remodeling in Health, Diseaase, and Aging (Edited by Mone Zaidi)2006

    • Author(s)
      Matsumoto T
    • Total Pages
      575
    • Publisher
      The New York Academy of Sciences
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] HLAクラスIを認識する抗体を有効成分として含有する化学療法剤耐性癌治療剤、およびその利用2008

    • Inventor(s)
      松本 俊夫、尾崎 修治、安倍 正博
    • Industrial Property Rights Holder
      徳島大学、中外製薬
    • Filing Date
      2008-03-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] エリスロポエチンを用いた虚血性疾患の治療2007

    • Inventor(s)
      松本 俊夫、北川 哲也、安倍 正博、赤池 雅史、永吉 和成、山本 要、樋口 正人
    • Industrial Property Rights Holder
      徳島大学, 中外製薬
    • Filing Date
      2007-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] 抗HLA抗体を利用した新規医薬品2006

    • Inventor(s)
      松本 俊夫、尾崎 修治、安倍 正博
    • Industrial Property Rights Holder
      徳島大学, 中外製薬
    • Filing Date
      2006-05-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] 抗HLA抗体を利用した新規医薬品2006

    • Inventor(s)
      松本俊夫, 尾崎修治, 安倍正博
    • Industrial Property Rights Holder
      徳島大学, 中外製薬
    • Filing Date
      2006-05-18
    • Acquisition Date
      2006-11-23
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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