Application of functional imaging for pathophisiologic evaluation of cerebrovascular disease and development of methods for stroke prevention

• Project/Area Number: 17209040
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: TSUCHIDA Tatsuro (2006-2008) University of Fukui, 医学部, 助教 (70303386); 米倉 義晴 (2005) 福井大学, 高エネルギー医学研究センター, 教授 (60135572)
• Co-Investigator(Kenkyū-buntansha): OKAZWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813) ; FUJIBAYASHI Yasuhisa 福井大学, 高エネルギー医学研究センター, 教授 (50165411) ; KIMURA Hirohiko 福井大学, 医学部, 教授 (10242596) ; KUDO Takashi 福井大学, 高エネルギー医学研究センター, 准教授 (20330300) ; SADATO Norihiro 自然科学研究機構生理学研究所, 教授 (00273003) ; 土田 龍郎 福井大学, 医学部附属病院, 助手 (70303386)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000); Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2006: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2005: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
• Keywords: 脳血管障害 / 脳循環代謝 / ポジトロン断層撮影 / 磁気共鳴画像(MRI) / 脳虚血 / シングルフォトン断層撮影 / 低酸素耐性 / 脳賦活

Research Abstract

虚血性脳血管障害は頻度の高い病因・死因の一つであり、病態解明および正確な診断は、重篤な脳梗塞を予防するために重要である。本研究では早期診断と予防法の確立に向け、新しい非侵襲的簡便法の開発を行った。O-15ガス検査のための新たな分子プローブを開発するとともに、血管閉塞モデルラットを用い、虚血や低酸素の簡便な評価法や、低酸素が脳組織に及ぼす影響に関する基礎的検討を行った。また、非侵襲的MRI灌流画像法の確立および脳循環代謝の新しい画像化法を開発し, 予防的視点からも意義ある機能画像診断法確立を目指した。

Research Products

• [Journal Article] H_2^<15>Oによる局所脳血流量の測定と臨床応用 (2009)
  • Author(s): 岡沢秀彦、工藤崇
  • Journal Title: Radioisotope 58 Pages: 209-219
  • NAID: 10024781799
  • Peer Reviewed
• [Journal Article] Development of microwave-based automated nucleophilic [^<18>F]fluorination system and its application for the production of [^<18>F]flumazenil (2009)
  • Author(s): Mandap K, Ido T, Kiyono Y, Kobayashi M, Lohith TG, Mori T, Kasamatsu S, Kudo T, Okazawa H, Fujibayashi Y.
  • Journal Title: Nucl Med Biol 36 Pages: 403-409
  • Peer Reviewed
• [Journal Article] Kudo T Clinical impact of hemodynamic parameter measurement for cerebrovascular disease using positron emission tomography and ^<15>O-labeled tracers (2009)
  • Author(s): Okazawa H
  • Journal Title: Ann Nucl Med 23 Pages: 217-227
  • Peer Reviewed
• [Journal Article] PET imaging of redox and energy states in stroke-like episodes of MELAS (2009)
  • Author(s): Ikawa M, Okazawa H, Arakawa K, Kudo T, Kimura H, Fujibayashi Y, Kuriyama M, Yoneda M.
  • Journal Title: Mitochondrion 9 Pages: 144-148
  • Peer Reviewed
• [Journal Article] 脳卒中と分子イメージング (2009)
  • Author(s): 岡沢秀彦、工藤崇、小林正和、清野泰、米田誠、藤林康久
  • Journal Title: 脳神経外科速報 19 Pages: 536-543
  • Peer Reviewed
• [Journal Article] Measurement of glucose metabolism in rat spinal cord slices with dynamic positron autoradiography (2009)
  • Author(s): Fan X, Asai T, Morioka K, Uchida K, Baba H, Tanaka K, Zhuang J, Okazawa H, Fujibayashi Y.
  • Journal Title: Nucl Med Biol 36 Pages: 155-162
  • Peer Reviewed
• [Journal Article] [^<18>F]fluoroacetate as a pro-radiotracer of [^<18>F]fluoroacetate for the measurement of glial metabolism by PET (2009)
  • Author(s): Mori T, Suna LQ, Kobayashi M, Kiyono Y, Okazawa H, Furukawa F, Kawashima H, Welch MJ, Fujibayashi Y
  • Journal Title: Nucl Med Biol 36 Pages: 155-162
  • Peer Reviewed
• [Journal Article] Perspective-taking as part of narrative comprehension : a functional MRI study (2009)
  • Author(s): Mano Y, Harada T, Sugiura M, Saito DN, Sadato N.
  • Journal Title: Neuropsychologia 47 Pages: 813-824
  • Peer Reviewed
• [Journal Article] Visuokinesthetic perception of hand movement is mediated by cerebro-cerebellar interaction between the left cerebellum and right parietal cortex (2009)
  • Author(s): Hagura N, Oouchida Y, Aramaki Y, Okada T, Matsumura M, Sadato N, Naito E.
  • Journal Title: Cereb Cortex 19 Pages: 176-186
  • Peer Reviewed
• [Journal Article] Listening to rhythms activates motor and premotor cortices (2009)
  • Author(s): Bengtsson SL, Ullen F, Ehrsson HH, Hashimoto T, Kito T, Naito E, Forssberg H, Sadato N.
  • Journal Title: Cortex 45 Pages: 62-71
  • Peer Reviewed
• [Journal Article] Neural correlates of the judgment of lying : A functional magnetic resonance imaging study (2009)
  • Author(s): Harada T, Itakura S, Xu F, Lee K, Nakashita S, Saito DN, Sadato N
  • Journal Title: Neurosci Res 63 Pages: 24-34
  • NAID: 10027499140
  • Peer Reviewed
• [Journal Article] Neural correlates of the judgment of lying : A functional magnetic resonance imaging study. (2009)
  • Author(s): Harada T, et al.
  • Journal Title: Neurosci Res 63 Pages: 24-34
  • Peer Reviewed
• [Journal Article] Visuokinesthetic perception of hand movement is mediated by cerebro-cerebellar interaction between the left cerebellum and right parietal cortex. (2009)
  • Author(s): Hagura N, et al.
  • Journal Title: Cereb Cortex 19 Pages: 176-186
  • Peer Reviewed
• [Journal Article] Perspective-taking as part of narrative comprehension : a functional MRI study. (2009)
  • Author(s): Mano Y, et al.
  • Journal Title: Neuropsychologia 47 Pages: 813-824
  • Peer Reviewed
• [Journal Article] Measurement of glucose metabolism in rat spinal cord slices with dynamic positron autoradiography. (2009)
  • Author(s): Fan X, et al.
  • Journal Title: Nucl Med Biol 36 Pages: 183-189
  • Peer Reviewed
• [Journal Article] Neurological improvement associated with resolution of irradiation-induced myelopathy : serial magnetic resonance imaging and positron emission tomography findings. (2009)
  • Author(s): Uchida K, et al.
  • Journal Title: J Neuroimaging (in press)
  • Peer Reviewed
• [Journal Article] Relationship between plasma leptin level and brain structure in elderly : Avoxel-based morphometric study. (2009)
  • Author(s): Narita K, et al.
  • Journal Title: Biol Psychiatry (in press)
  • Peer Reviewed
• [Journal Article] Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. (2009)
  • Author(s): Tsujikawa T, et al.
  • Journal Title: Brain Dev (in press)
  • Peer Reviewed
• [Journal Article] PET imaging of redox and energy states in stroke-like episodes of MELAS. (2009)
  • Author(s): Ikawa M, et al.
  • Journal Title: Mitochondrion (in press)
  • Peer Reviewed
• [Journal Article] Development of microwave-based automated nucleophilic [^<18>F] fluorination system and its application for the production of [^<18>F] flumazenil. (2009)
  • Author(s): Mandap K, et al.
  • Journal Title: Nucl Med Biol (in press)
  • Peer Reviewed
• [Journal Article] Clinical impact of hemodynamic parameter measurement for cerebrovascular disease using positron emission tomography and ^<15>O-labeled tracers. (2009)
  • Author(s): Okazawa H, Kudo T
  • Journal Title: Ann Nucl Med (in press)
  • NAID: 10025135879
  • Peer Reviewed
• [Journal Article] PETで脳の働きを診る (2008)
  • Author(s): 岡沢秀彦
  • Journal Title: PETジャーナル 1(依頼原稿) Pages: 25-27
• [Journal Article] 脳卒中治療に関連した分子プローブの開発と臨床応用の可能性 (2008)
  • Author(s): 岡沢秀彦、小林正和、辻川哲也、工藤崇、清野泰、藤林康久、Lohith TG, Tiwari VN
  • Journal Title: 脳卒中 30 Pages: 817-821
  • NAID: 10024937209
• [Journal Article] Visual image reconstruction from human brain activity using a combination of multiscale local image decoders (2008)
  • Author(s): Miyawaki Y, Uchida H, Yamashita O, Sato MA, Morito Y, Tanabe HC, Sadato N, Kamitani Y.
  • Journal Title: Neuron 60 Pages: 915-929
  • Peer Reviewed
• [Journal Article] Asymmetric control mechanisms of bimanual coordination : an application of directed connectivity analysis to kinematic and functional MRI data (2008)
  • Author(s): Maki Y, Wong KF, Sugiura M, Ozaki T, Sadato N.
  • Journal Title: Neuroimage 42 Pages: 1295-1304
  • Peer Reviewed
• [Journal Article] The neural basis of academic achievement motivation (2008)
  • Author(s): Mizuno K, Tanaka M, Ishii A, Tanabe HC, Onoe H, Sadato N, Watanabe Y.
  • Journal Title: Neuroimage 42 Pages: 369-378
  • Peer Reviewed
• [Journal Article] Functional segregation of the inferior frontal gyrus for syntactic processes : a functional magnetic-resonance imaging study (2008)
  • Author(s): Uchiyama Y, Toyoda H, Honda M, Yoshida H, Kochiyama T, Ebe K, Sadato N.
  • Journal Title: Neurosci Res 61 Pages: 309-318
  • Peer Reviewed
• [Journal Article] Cultural specificity in amygdala response to fear faces (2008)
  • Author(s): Chiao JY, Iidaka T, Gordon HL, Nogawa J, Bar M, Aminoff E, Sadato N, Ambady N.
  • Journal Title: J Cogn Neurosci 21 Pages: 2167-2174
  • Peer Reviewed
• [Journal Article] Processing of social and monetary rewards in the human striatum (2008)
  • Author(s): Izuma K, Saito DN, Sadato N.
  • Journal Title: Neuron 58 Pages: 284-294
  • Peer Reviewed
• [Journal Article] Hemispheric asymmetry of Hemispheric asymmetry of frequency-dependent suppression in the ipsilateral primary motor cortex during finger movement : a functional magnetic resonance imaging study (2008)
  • Author(s): Hayashi MJ, Saito DN, Aramaki Y, Asai T,c Fujibayashi Y, Sadato N.
  • Journal Title: Cereb Cortex 18
  • Peer Reviewed
• [Journal Article] Tactile-visual integration in the posterior parietal cortex: a functional magnetic resonance imaging study (2008)
  • Author(s): Nakashita S, Saito DN, Kochiyama T, Honda M, Tanabe HC, Sadato N.
  • Journal Title: Brain Res Bull 75 Pages: 513-525
  • Peer Reviewed
• [Journal Article] The role of the right prefrontal cortex in self-evaluation of the face: a functional magnetic resonance imaging study (2008)
  • Author(s): Morita T, Itakura S, Saito DN, Nakashita S, Harada T, Kochiyama T, Sadato N.
  • Journal Title: J Cogn Neurosci 20 Pages: 342-355
  • NAID: 130007039521
  • Peer Reviewed
• [Journal Article] Cross-modal integration during vowel identification in audiovisual speech : a functional magnetic resonance imaging study (2008)
  • Author(s): Murase M, Saito DN, Kochiyama T, Tanabe HC, Tanaka S, Harada T, Aramaki Y, Honda M, Sadato N.
  • Journal Title: Neurosci Lett 434 Pages: 71-76
  • Peer Reviewed
• [Journal Article] Neural codes for somatosensory two-point discrimination in inferior parietal lobule : an fMRI study (2008)
  • Author(s): Akatsuka K, Noguchi Y, Harada T, Sadato N, Kakigi R.
  • Journal Title: Neuroimage 40 Pages: 852-858
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): Toyoda H, Kashikura K, Okada T, Nakashita S, Honda M, Yonekura Y, Kawaguchi H, Maki A, Sadato N.
  • Journal Title: Neuroimage 39 Pages: 997-1013
  • Peer Reviewed
• [Journal Article] Neuroprotective effect of chronic lithium treatment against hypoxia in specific brain regions with upregulation of cAMP response element binding protein and brain-derived neurotrophic factor but not nerve growth factor : comparison with acute lithium treatment (2008)
  • Author(s): Omata N, Murata T, Takamatsu S, Maruoka N, Mitsuya H, Yonekura Y, Fujibayashi Y, Wada Y.
  • Journal Title: Bipolar Disord 10 Pages: 213-8
  • Peer Reviewed
• [Journal Article] Automatic synthesis of ethyl [^<18>F]fluoroacetate and its first PET imaging (2008)
  • Author(s): Sun L-Q, Mori T, Kobayashi M, Okazawa H, Furukawa T, Fujibayashi Y.
  • Journal Title: 2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE art.no.4535848 Pages: 2537-2540
  • Peer Reviewed
• [Journal Article] ^<18>F-FDG PET of common enhancing malignant brain tumors (2008)
  • Author(s): Kosaka N, Tsuchida T, Uematsu H, Kimura H Okazawa H, Itoh H.
  • Journal Title: AJR 190
  • Peer Reviewed
• [Journal Article] Effects of vitamin Esupplementation on plasma membrane permeabilization and fluidization induced by chlorpromazine in the rat brain (2008)
  • Author(s): Maruoka N, Murata T, Omata N, Takashima Y, Fujibayashi Y, Wada Y.
  • Journal Title: J Psychopharmacology 22 Pages: 119-127
  • Peer Reviewed
• [Journal Article] Reproducibility of semi-quantitative parameters in FDG-PET using two different PET scanners : Influence of attenuation correction method and examination interval (2008)
  • Author(s): Kamibayashi T, Tsuchida T, Demura Y, Tsujikawa T, Okazawa H, Kudoh T, Kimura H.
  • Journal Title: Mol Imaging Biol 10 Pages: 162-166
  • NAID: 120001493896
  • Peer Reviewed
• [Journal Article] Grading of brain glioma with 1-11C-acetate PET : comparison with ^<18>F-FDG PET (2008)
  • Author(s): Tsuchida T, Takeuchi H, Okazawa H, Tsujikawa T, Fujibayashi Y.
  • Journal Title: Nucl Med Biol 35 Pages: 171-176
  • Peer Reviewed
• [Journal Article] Shorter examination method for the diagnosis of misery perfusion using count-based OEF elevation in ^<15>O-Gas PET (2008)
  • Author(s): Kobayashi M, Kudo T, Tsujikawa T, Isozaki M, Arai Y, Fujibayashi Y, Okazawa H.
  • Journal Title: J Nucl Med 49 Pages: 242-246
  • Peer Reviewed
• [Journal Article] Neuroprotective effect of chronic lithium treatment against hypoxia in specific brain regions with upregulation of cAMP response element binding protein and brain-derived neurotrophic factor but not nerve growth factor : comparison with acute lithium treatment. (2008)
  • Author(s): Omata N, et al.
  • Journal Title: Bipolar Disord 10 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Source of nonlinearity of the BOLD response revealed by simultaneous fMRI and NIRS. (2008)
  • Author(s): Toyoda H, et al.
  • Journal Title: Neuroimage 39 Pages: 997-1013
  • Peer Reviewed
• [Journal Article] Neural codes for somatosensory two-point discrimination in inferior parietal lobule : an fMRI study. (2008)
  • Author(s): Akatsuka K, et al.
  • Journal Title: Neuroimage 40 Pages: 852-858
  • Peer Reviewed
• [Journal Article] The role of the right prefrontal cortex in self-evaluation of the face : a functional magnetic resonance imaging study. (2008)
  • Author(s): Morita T, et al.
  • Journal Title: J Cogn Neurosci 20 Pages: 342-355
  • Peer Reviewed
• [Journal Article] Cross-modal integration during vowel identification in audiovisual speech : a functional magnetic resonance imaging study. (2008)
  • Author(s): Murase M, et al.
  • Journal Title: Neurosci Lett. 434 Pages: 71-76
  • Peer Reviewed
• [Journal Article] Tactile-visual integration in the posterior parietal cortex : a functional magnetic resonance imaging study. (2008)
  • Author(s): Nakashita S, et al.
  • Journal Title: Brain Res Bull 75 Pages: 513-525
  • Peer Reviewed
• [Journal Article] Hemispheric asymmetry of frequency-dependent suppression in the ipsilateral primary motor cortex during finger movement : a functional magnetic resonance imaging study. (2008)
  • Author(s): Hayashi MJ, et al.
  • Journal Title: Cereb Cortex 18 Pages: 1932-1940
  • Peer Reviewed
• [Journal Article] Processing of social and monetary rewards in the human striatum. (2008)
  • Author(s): Izuma K, et al.
  • Journal Title: Neuron 58 Pages: 284-294
  • Peer Reviewed
• [Journal Article] Functional segregation of the inferior frontal gyrus for syntactic processes : a functional magnetic-resonance imaging study. (2008)
  • Author(s): Uchiyama Y, et al.
  • Journal Title: Neurosci Res 61 Pages: 309-318
  • Peer Reviewed
• [Journal Article] The neural basis of academic achievement motivation. (2008)
  • Author(s): Mizuno K, et al.
  • Journal Title: Neuroimage 42 Pages: 369-378
  • Peer Reviewed
• [Journal Article] Asymmetric control mechanisms of bimanual coordination : an application of directed connectivity analysis to kinematic and functional MRI data. (2008)
  • Author(s): Maki Y, et al.
  • Journal Title: Neuroimage 42 Pages: 1295-1304
  • Peer Reviewed
• [Journal Article] Visual image reconstruction from human brain activity using a combination of multiscale. local image decoders. (2008)
  • Author(s): Miyawaki Y, et al.
  • Journal Title: Neuron 60 Pages: 915-929
  • Peer Reviewed
• [Journal Article] 脳卒中治療に関連した分子プローブの開発と臨床応用の可能性 (2008)
  • Author(s): 岡沢秀彦, 他
  • Journal Title: 脳卒中 30 Pages: 817-821
  • NAID: 10024937209
  • Peer Reviewed
• [Journal Article] Preparation and evaluation of ethyl [^<18>F]fluoroacetate as a pro-radiotracer of [^<18>F]fluoroacetate for the measurement of glial metabolism by PET. (2008)
  • Author(s): Mori T, et al.
  • Journal Title: Neurosci Res 63 Pages: 24-34
  • Peer Reviewed
• [Journal Article] Source of nonlinearity of the BOLD response revealed by simultaneous fMRI and NIRS. (2008)
  • Author(s): Toyoda, H., et. al.
  • Journal Title: Neuroimage 39・3 Pages: 852-858
  • Peer Reviewed
• [Journal Article] Frontoparietal network involved in successful retrieval from episodic memory. Spatial and temporal analyses using fMRI and ERP. (2008)
  • Author(s): Kobayashi, M., et. al.
  • Journal Title: J Nucl Med 49・2 Pages: 1349-1360
  • Peer Reviewed
• [Journal Article] The role of the right prefrontal cortex in self-evaluation of the face: a functionalmagnetic resonance imaging study. (2008)
  • Author(s): Morita, T., et. al.
  • Journal Title: J Cogn Neurosci 20・2 Pages: 342-355
  • Peer Reviewed
• [Journal Article] Cross-modal integration during vowel identification in audiovisual speech: Afunctional magnetic resonance imaging study. (2008)
  • Author(s): Murase, M., et. al.
  • Journal Title: Neurosci Lett 434・1 Pages: 71-76
  • Peer Reviewed
• [Journal Article] Tactile-visual integration in the posterior parietal cortex: A functional magnetic resonance imaging study. (2008)
  • Author(s): Nakashita, S., et. al.
  • Journal Title: Brain Res Bull 75・5 Pages: 513-525
  • Peer Reviewed
• [Journal Article] A comparative study of the plasma membrane permeabilization and fluidization induced by antipsychotic drugs in the rat brain (2007)
  • Author(s): Murata T, Maruoka N, Omata N, Takashima Y, Fujibayashi Y, Yonekura Y, Wada Y.
  • Journal Title: Int J Neuropsychopharmacol 10 Pages: 683-689
  • NAID: 120000807644
  • Peer Reviewed
• [Journal Article] The role of the human ventralpremotor cortex in counting successive stimuli (2007)
  • Author(s): Kansaku K, Carver B, Johnson A, Matsuda K, Sadato N, Hallett M.
  • Journal Title: Exp Brain Res 178 Pages: 339-350
  • Peer Reviewed
• [Journal Article] Topological and chronological features of the impairment of glucose metabolism induced by 1-methyl-4-phenylpyridiniumion(MPP+)in rat brain slices (2007)
  • Author(s): Maruoka N, Murata T, Omata N, Takashima Y, Fujibayashi Y, Wada Y.
  • Journal Title: J Neural Transmissio 114 Pages: 1155-115
  • Peer Reviewed
• [Journal Article] Biphasic mechanism of the toxicity induced by 1-methyl-4-phenylpyridiniumion(MPP+)as revealed by dynamic changes in glucose metabolism in rat brain slices (2007)
  • Author(s): Maruoka N, Murata T, Omata N, Takashima Y, Fujibayashi Y, Wada Y.
  • Journal Title: Neurotoxicology 28 Pages: 672-678
  • Peer Reviewed
• [Journal Article] Effects of haloperidol and its pyridinium metabolite on plasma membrane permeability and fluidity in the rat brain (2007)
  • Author(s): Murata T, Maruoka N, Omata N, Takashima Y, Igarashi K, Kasuya F, Fujibayashi Y, Wada Y.
  • Journal Title: Prog Neuro-psychoph 31 Pages: 848-857
  • Peer Reviewed
• [Journal Article] Neural substrates of intermanual transfer of a newly acquired motor skill (2007)
  • Author(s): Perez MA, Tanaka S, Wise SP, Sadato N, Tanabe HC, Willingham DT, Cohen LG.
  • Journal Title: Curr Biol 17 Pages: 1896-1902
  • Peer Reviewed
• [Journal Article] Human brain activation in response to olfactory stimulation by intravenous administration of odorants (2007)
  • Author(s): Miyanari A, Kaneoke Y, Noguchi Y, Honda M, Sadato N, Sagara Y, Kakigi R.
  • Journal Title: Neurosci Lett 423 Pages: 6-11
  • Peer Reviewed
• [Journal Article] Activity in the posterior parietal cortex mediates visual dominance over kinesthesia (2007)
  • Author(s): Hagura N, Takei T, Hirose S, Aramaki Y, Matsumura M, Sadato N, Naito E.
  • Journal Title: J Neurosci 27 Pages: 7047-53
  • Peer Reviewed
• [Journal Article] Voluntary attention changes the speed of perceptual neural processing (2007)
  • Author(s): Noguchi Y, Tanabe HC, Sadato N, Hoshiyama M, Kakigi R.
  • Journal Title: Eur J Neurosci 25 Pages: 3163-3172
  • Peer Reviewed
• [Journal Article] Human limb-specific and non-limbspecific brain representations during kinesthetic illusory movements of the upper and lower extremities (2007)
  • Author(s): Naito E, Nakashima T, Kito T, Aramaki Y, Okada T, Sadato N.
  • Journal Title: Eur J Neurosci 25 Pages: 3476-3487
  • Peer Reviewed
• [Journal Article] Neural correlates of perceptual difference between itching and pain : a human fMRI study (2007)
  • Author(s): Mochizuki H, Sadato N, Saito DN, Toyoda H, Tashiro M, Okamura N, Yanai K.
  • Journal Title: Neuroimage 36 Pages: 706-717
  • Peer Reviewed
• [Journal Article] Effects of chlorpromazine on plasma membrane permeability and fluidity in the rat brain : A dynamic positron autoradiography and fluorescence polarization study (2007)
  • Author(s): Maruoka N, Murata T, Omata N, Takashima Y, Tanii H, Yonekura Y, Fujibayashi Y, Wada Y.
  • Journal Title: Prog Neuro-psychoph 31 Pages: 178-186
  • Peer Reviewed
• [Journal Article] Can reductions in baseline CBF and vasoreactivity detect misery perfusion in chronic cerebrovascular disease (2007)
  • Author(s): Okazawa H, Tsuchida T, Kobayashi M, Arai Y, Pagani M, Isozaki M, Yonekura Y.
  • Journal Title: Eur J Nucl Med Mol Imaging 34 Pages: 121-129
  • Peer Reviewed
• [Journal Article] The role of the human ventral premotor cortex in counting successive stimuli. (2007)
  • Author(s): Kansaku, K., et. al.
  • Journal Title: Exp Brain Res. 178・4 Pages: 339-350
  • Peer Reviewed
• [Journal Article] Neural correlates of perceptual difference between itching and pain: a humanfMRI study. (2007)
  • Author(s): Mochizuki, H., et. al.
  • Journal Title: Neuroimage 36・3 Pages: 706-717
  • Peer Reviewed
• [Journal Article] Human limb-specific and non-limb-specific brain representations during kinesthetic illusory movements of the upper and lower extremities. (2007)
  • Author(s): Naito, E., et. al.
  • Journal Title: Eur J Neurosci 25・11 Pages: 347-387
  • Peer Reviewed
• [Journal Article] Voluntary attention changes the speed of perceptual neural processing. (2007)
  • Author(s): Noguchi, Y., et. al.
  • Journal Title: Eur J Neurosci 25・10 Pages: 3163-3172
  • Peer Reviewed
• [Journal Article] Activity in the posterior parietal cortex mediates visual dominance over kinesthesia. (2007)
  • Author(s): Hagura, N., et. al.
  • Journal Title: J Neurosci 27・26 Pages: 7047-7053
  • Peer Reviewed
• [Journal Article] Human brain activation in response to olfactory stimulation by intravenous administration of odorants. (2007)
  • Author(s): Miyanari, A., et. al.
  • Journal Title: Neurosci Lett 423・1 Pages: 6-11
  • Peer Reviewed
• [Journal Article] Neural substrates of intermanual transfer of a newly acquired motor skill. (2007)
  • Author(s): Perez, M. A., et. al.
  • Journal Title: Curr Biol 17・21 Pages: 1896-1902
  • Peer Reviewed
• [Journal Article] Can reductions in baseline CBF and vasoreactivity detect misery perfusion in chronic cerebrovascular disease? (2007)
  • Author(s): Okazawa, H., et al.
  • Journal Title: Eur J Nucl Med Mol Imaging 34・1 Pages: 121-129
• [Journal Article] The representation of the human oral area in the somatosensory cortex : a functional MRI study (2006)
  • Author(s): Miyamoto JJ, Honda M, Saito DN, Okada T, Ono T, Ohyama K, Sadato N.
  • Journal Title: Cereb Cortex 16 Pages: 669-675
  • Peer Reviewed
• [Journal Article] Brain processing of the signals ascending through unmyelinated C fibers in humans : an event-related functional magnetic resonance imaging study (2006)
  • Author(s): Qiu Y, Noguchi Y, Honda M, Nakata H, Tamura Y, Tanaka S, Sadato N.
  • Journal Title: Cereb Cortex 16 Pages: 1289-1295
  • Peer Reviewed
• [Journal Article] Neural correlates of the spontaneous phase transition during bimanual coordination (2006)
  • Author(s): Aramaki Y, Honda M, Okada T, Sadato N.
  • Journal Title: Cereb Cortex 16 Pages: 1338-1348
  • Peer Reviewed
• [Journal Article] Hemodynamic and electrophysiological relationship involved in human face processing : evidence from a combined fMRI-ERP study (2006)
  • Author(s): Iidaka T, Matsumoto A, Haneda K, Okada T, Sadato N.
  • Journal Title: Brain Cogn 30 Pages: 176-186
  • Peer Reviewed
• [Journal Article] Neural correlates of counting of sequential sensory and motor events in the human brain (2006)
  • Author(s): Kansaku K, Johnson A, Grillon ML, Garraux G, Sadato N, Hallett M.
  • Journal Title: Neuroimag 31 Pages: 649-660
  • Peer Reviewed
• [Journal Article] Suppression of the non-dominant motor cortex during bimanual symmetric finger movement : a functional magnetic resonance imaging study (2006)
  • Author(s): Aramaki Y, Honda M, Sadato N.
  • Journal Title: Neuroscience 141 Pages: 2147-2153
  • Peer Reviewed
• [Journal Article] Multisensory activation of the intraparietal area when classifying grating orientation : a functional magnetic resonance imaging study (2006)
  • Author(s): Kitada R, Kito T, Saito DN, Kochiyama T, Matsumura M, Sadato N, Lederman SJ.
  • Journal Title: J Neurosci 26 Pages: 7491-7501
  • Peer Reviewed
• [Journal Article] Frontoparietal network involved in successful retrieval from episodic memory. Spatial and temporal analyses using fMRI and ERP (2006)
  • Author(s): Iidaka T, Matsumoto A, Nogawa J, Yamamoto Y, Sadato N.
  • Journal Title: Cereb Cortex 16 Pages: 1349-1360
  • Peer Reviewed
• [Journal Article] Cross-modal plasticity in the blind revealed by functional neuroimaging (2006)
  • Author(s): Sadato N.
  • Journal Title: Suppl Clin Neurophysiol 59 Pages: 75-79
  • Peer Reviewed
• [Journal Article] Neural substrates of sarcasm : a functional magnetic-resonance imaging study (2006)
  • Author(s): Uchiyama H, Seki A, Kageyama H, Saito DN, Koeda T, Ohno K, Sadato N.
  • Journal Title: Brain Res 1124 Pages: 100-110
  • Peer Reviewed
• [Journal Article] Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study (2006)
  • Author(s): Iidaka T, Matsumoto A, Ozaki N, Suzuki T, Iwata N, Yamamoto Y, Okada T, Sadato N.
  • Journal Title: Brain Res 1125 Pages: 85-93
  • Peer Reviewed
• [Journal Article] Practice makes perfect : the neural substrates of tactile discrimination by Mah-Jong experts include the primary visual cortex (2006)
  • Author(s): Saito DN, Okada T, Honda M, Yonekura Y, Sadato N.
  • Journal Title: BMC Neurosci 7 Pages: 79-79
  • Peer Reviewed
• [Journal Article] New approach to fully automated synthesis of sodium [^<18>F]fluoroacetate-a simple and fast method using a commercial synthesizer (2006)
  • Author(s): Sun LQ, Mori T, Dence CS, Ponde DE, Welch MJ, Furukawa T, Yonekura Y, Fujibayashi Y.
  • Journal Title: Nucl Med Biol 33 Pages: 153-158
  • Peer Reviewed
• [Journal Article] Diagnosis of misery perfusion using noninvasive O-15 gas PET (2006)
  • Author(s): Kobayashi M, Okazawa H, Tsuchida T, Kawai K, Fujibayashi Y, Yonekura Y.
  • Journal Title: J Nucl Med 47 Pages: 1581-1586
  • Peer Reviewed
• [Journal Article] Region-specific induction of hypoxic tolerance by expression of stress proteins and antioxidant enzymes (2006)
  • Author(s): Omata N, Murata T, Takamatsu S, Maruoka N, Mitsuya H, Yonekura Y, Fujibayashi Y, Wada Y.
  • Journal Title: Neurol Sci 27 Pages: 74-77
  • Peer Reviewed
• [Journal Article] Focal glucose hypermetabolism in interictal state of West syndrome (2006)
  • Author(s): Kumada T, Okazawa H, Yamauchi H, Kitoh T, Ito M.
  • Journal Title: Pediatr Neurol 34 Pages: 47-50
  • Peer Reviewed
• [Journal Article] Effects of 5-HT_<1B/1D> receptor agonist rizatriptan on cerebral blood flow and blood volume in normal circulation (2006)
  • Author(s): Okazawa H, Tsuchida T, Pagani M, Mori T, Kobayashi M, Tanaka F, Yonekura Y.
  • Journal Title: J Cereb Blood Flow Metab 26 Pages: 92-98
  • NAID: 120000807612
  • Peer Reviewed
• [Journal Article] The representation of the human oral area in the somatosensory cortex : a functional MRI study. (2006)
  • Author(s): Miyamoto, JJ., et al.
  • Journal Title: Cere Cortex 16・5 Pages: 669-675
• [Journal Article] Neural correlates of counting of sequential sensory and motor events in the human brain. (2006)
  • Author(s): Kansaku, K., et al.
  • Journal Title: Neuroimage 31・2 Pages: 649-660
• [Journal Article] Diagnosis of misery perfusion using noninvasive O-15 gas PET. (2006)
  • Author(s): Kobayashi, M., et al.
  • Journal Title: J Nucl Med 47・10 Pages: 1581-1586
• [Journal Article] Suppression of the non-dominant motor cortex during bimanual symmetric finger movement : a functional magnetic resonance imaging study. (2006)
  • Author(s): Aramaki, Y., et al.
  • Journal Title: Neuroscience 141・9 Pages: 2147-2153
• [Journal Article] Perfusion imaging of meningioma by using continuous arterial spin-labeling : comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features. (2006)
  • Author(s): Kimura, H., et al.
  • Journal Title: AJNR Am J Neuroradiol 22・2 Pages: 189-198
• [Journal Article] Neural correlates of the spontaneous phase transition during bimanual coordination. (2006)
  • Author(s): Aramaki, Y, et al.
  • Journal Title: Cereb Cortex 16・9 Pages: 1338-1348
• [Journal Article] Multisensory activation of the intraparietal area when classifying grating orientation : a functional magnetic resonance imaging study. (2006)
  • Author(s): Kitada, R., et al.
  • Journal Title: J Neurosci 26・28 Pages: 7491-7501
• [Journal Article] Frontoparietal network involved in successful retrieval from episodic memory. Spatial and temporal analyses using fMRI and ERP. (2006)
  • Author(s): Iidaka, T., et al.
  • Journal Title: Cereb Cortex 16・9 Pages: 1349-1360
• [Journal Article] Neural substrates of sarcasm : a functional magnetic-resonance imaging study. (2006)
  • Author(s): Uchiyama, H., et al.
  • Journal Title: Brain Res 1124・1 Pages: 100-110
• [Journal Article] Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study. (2006)
  • Author(s): Iidaka, T., et al.
  • Journal Title: Brain Res 1125・1 Pages: 85-93
• [Journal Article] Effects of 5-HT_<1B/1D> receptor agonist rizatriptan on cerebral blood flow and blood volume in normal circulation. (2006)
  • Author(s): Okazawa, H., et al.
  • Journal Title: J Cereb Blood Flow Metab 26・1 Pages: 92-98
• [Journal Article] Focal glucose hypermetabolism in interictal state of West syndrome. (2006)
  • Author(s): Kumada, T., et al.
  • Journal Title: Pediatr Neurol 34・1 Pages: 47-50
• [Journal Article] PETの可能性と限界-脳血管障害に対する血管拡張負荷試験の意義と新しい指標による脳循環評価の試み- (2005)
  • Author(s): 岡沢秀彦
  • Journal Title: 脳卒中 27 Pages: 643-647
  • NAID: 10020404176
• [Journal Article] Altered patterns of blood flow response during visual stimulation in carotid artery occlusive disease (2005)
  • Author(s): Yamauchi H, Kudoh T, Sugimoto K, Takahashi M, Kishibe Y, Okazawa H.
  • Journal Title: Neuroimag 25 Pages: 554-560
  • Peer Reviewed
• [Journal Article] Altered patterns of blood flow response during visual stimulation in carotid artery occlusive disease. (2005)
  • Author(s): Yamauchi, H., et al.
  • Journal Title: Neuroimage 25・2 Pages: 554-560
• [Journal Article] Cross-modal integration and plastic changes revealed by lip movement, random-dot motion and sign languages in the hearing and deaf. (2005)
  • Author(s): Sadato, N., et al.
  • Journal Title: Cerebral Cortex 15・8 Pages: 1113-1122
• [Journal Article] Hemispheric asymmetry emerges at distinct parts of the occipitotemporal cortex for objects, logograms and phonograms : a functional MRI study. (2005)
  • Author(s): Nakamura, K., et al.
  • Journal Title: Neuroimage 28・3 Pages: 521-528
• [Journal Article] Removing the effects of task-related motion using independent-component analysis. (2005)
  • Author(s): Kochiyama, T., et al.
  • Journal Title: Neuroimage 25・3 Pages: 802-814
• [Journal Article] Multislice continuous arterial spin-labeled perfusion MRI in patients with chronic occlusive cerebrovascular disease : a correlative study with CO_2 PET validation. (2005)
  • Author(s): Kimura, H., et al.
  • Journal Title: J Magn Reson Imaging 22・2 Pages: 189-198
• [Journal Article] Magnetic field strength increase yields significantly greater contrast-to-noise ratio increase : Measured using BOLD contrast in the primary visual area. (2005)
  • Author(s): Okada, T., et al.
  • Journal Title: Acad Radiol 12・2 Pages: 142-147
• [Journal Article] 画像診断ABC:機器の進歩とその利用 脳循環障害 (2005)
  • Author(s): 岡沢 秀彦
  • Journal Title: 医薬ジャーナル 41・11 Pages: 2575-2780
• [Journal Article] Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images
  • Author(s): Tsujikawa T, Yoneda M, Shimizu Y, Uematsu H Toyooka M, Ikawa M, Kudo T, Okazawa H, Kuriyama M, Kimura H.
  • Journal Title: Brain Dev (in press)
  • NAID: 10027213011
  • Peer Reviewed
• [Journal Article] Relationship between plasma leptin level and brain structure in elderly : A voxel-based morphometric study
  • Author(s): Narita K, Kosaka H, Okazawa H, Murata T, Wada Y.
  • Journal Title: Biol Psychiatry (in press)
  • Peer Reviewed
• [Journal Article] Neurological improvement associated with resolution of irradiation-induced myelopathy : serial magnetic resonance imaging and positron emission tomography findings
  • Author(s): Uchida K, Nakajima H, Takamura T, Kobayashi S, Tsuchida T, Okazawa H, Baba H.
  • Journal Title: J Neuroimaging (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Neural basis of individualistic and collectivistic views of self
  • Author(s): Chiao JY, Harada T, Komeda H, Li Z, Mano Y, Saito D, Parrish TB, Sadato N, Iidaka T.
  • Journal Title: Brain Mapp (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 脳主幹動脈病変に起因する脳虚血におけるtype 2 ischemia群の長期予後調査 (2009)
  • Author(s): 磯崎誠, 他
  • Organizer: 第34回日本脳卒中学会総会
  • Place of Presentation: 松江
  • Year and Date: 2009-03-21
• [Presentation] 脳血管反応性(CVR)低下は外科的治療の適応となりうるか (2009)
  • Author(s): 磯崎誠, 他
  • Organizer: 第32回日本脳神経CI学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-06
• [Presentation] 新規小動物用PET装置における^<15>O標識水を用いた脳循環代謝測定の検討 (2008)
  • Author(s): 小林正和, 他
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-25
• [Presentation] シンポジウム 機能画像の基礎 (2008)
  • Author(s): 岡沢秀彦
  • Organizer: 第48回目本核医学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-25
• [Presentation] Assessment of emission-based segmented attenuation correction method without transmission scan on small animal PET. (2008)
  • Author(s): Kobayashi M, et al.
  • Organizer: 2008 Worl Molecular Imaging Congress
  • Place of Presentation: Nice (France)
  • Year and Date: 2008-09-12
• [Presentation] Changes in glucose metabolic rate of rat spinal cord slices by neuronal perturbations measured by positron autoradiography. (2008)
  • Author(s): Asai T, 他
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Clinical PET imaging using Cu-62-ATSM. SNM Continuing Education Course : "Hypoxic Imaging : Nitroimidazole vs. Cu-ATSM" (2008)
  • Author(s): Okazawa H.
  • Organizer: The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans(USA)
  • Year and Date: 2008-06-18
• [Presentation] Effect of transmission protocol on statistical analysis of brain ^<18>F-FDGPET ; Comparison between pre- and post-injection transmission scans. (2008)
  • Author(s): Kobayashi M, et al.
  • Organizer: Human Brain Mapping 2008
  • Place of Presentation: Melbourne (Australia)
  • Year and Date: 2008-06-17
• [Presentation] Clinical PET imaging using Cu-62-ATSM. (2008)
  • Author(s): Okazawa H.
  • Organizer: The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans (USA)
  • Year and Date: 2008-06-16
• [Presentation] Emission segmented attenuation correction method without transmission scan can accurately measure tracer concentration on small animal PET. (2008)
  • Author(s): Kobayashi M, et al.
  • Organizer: The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans (USA)
  • Year and Date: 2008-06-16
• [Presentation] Effect of L-systeine on bimding efficiency of hemoglobin-vesicles for development of an injectable 0-15 labeling system. (2008)
  • Author(s): Tiwari VN, et al.
  • Organizer: The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans (USA)
  • Year and Date: 2008-06-16
• [Presentation] 新規小動物用PET装置を利用した正常ラットの脳血流量測定 (2008)
  • Author(s): 小林正和, 他
  • Organizer: 第3回日本分子イメージング学会総会・学術集会
  • Place of Presentation: さいたま
  • Year and Date: 2008-05-22
• [Presentation] Role of intravenous Adenosine-tri-phosphate(ATP) on human cerebral blood flow : assessed by bolus ^<15>O-labeled water PET study. (2008)
  • Author(s): Hussain R, et al.
  • Organizer: 36th Annual Meeting British Nuclear Medicine Society
  • Place of Presentation: Edinburgh (UK)
  • Year and Date: 2008-05-10
• [Presentation] 教育講演 1. PET (2008)
  • Author(s): 岡沢秀彦
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-05
• [Presentation] 0-15 water PETによる脳内微小循環とトレーサー到達時間の定量 (2008)
  • Author(s): 岡沢秀彦, 他
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-05
• [Presentation] [^<18>F]FDG-脳PET画像を用いた統計学的解析法におけるPreおよびPost-Transmission撮像法の影響 (2008)
  • Author(s): 小林正和, 他
  • Organizer: 第64回日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-05
• [Presentation] Clinical Application of Molecular Imaging (2008)
  • Author(s): Okazawa H.
  • Organizer: The 12^<th> Conference of Peace through Mind/Brain Science
  • Place of Presentation: Hamamatsu
  • Year and Date: 2008-02-06
• [Presentation] 脳変性疾患の診断における脳血流SPECTの有用性 (2007)
  • Author(s): 岡沢秀彦
  • Organizer: 第11回FITテクニカルカンファレンス(日本核医学技術学会、第64回北陸地方会)特別講演
  • Place of Presentation: 金沢
  • Year and Date: 2007-11-17
• [Presentation] 核医学によるエネルギー代謝とレドックス状態の機能イメージング (2007)
  • Author(s): 米田 誠、他
  • Organizer: 第5回神経科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-09-22
• [Presentation] 微小循環の定量的評価と虚血性脳疾患への応用 (2007)
  • Author(s): 岡沢秀彦
  • Organizer: 第9回静岡県脳循環代謝核医学研究会特別講演
  • Place of Presentation: 静岡
  • Year and Date: 2007-07-21
• [Presentation] Importance of baseline CBF evaluation for detection of critical hemodynamic status in cerebrovascular disease: Comparison with acetzolamide test using PET. (2007)
  • Author(s): Okazawa, H., et. al.
  • Organizer: The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function
  • Place of Presentation: Osaka
• [Presentation] Accurate delay correction for quantitative measurement of cerebral blood flow and arterial-to-capillary blood volume(V_0). (2007)
  • Author(s): Okazawa, H., et. al.
  • Organizer: The 8th International Conference on Quantification of Brain Function with PET
  • Place of Presentation: Osaka
• [Presentation] Possibility of scan time reduction for count-based OEF elevation in O-15 gas PET. (2007)
  • Author(s): Kobayashi, M., et. al.
  • Organizer: The 8th International Conference on Quantification of Brain Function with PET
  • Place of Presentation: Osaka
• [Presentation] Potential of shorter examination time for diagnosis of misery perfusion using count-based OEF increase in 0-15 gasPET. (2007)
  • Author(s): Kobayashi, M., et. al.
  • Organizer: The 54th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Washington D. C.(USA)
• [Presentation] 定性的脳PET検査での貧困灌流判定法の検討 (2007)
  • Author(s): 小林正和、他
  • Organizer: 第45回日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜
• [Presentation] 非侵襲的な定量性保持を目指したmicro PET性能評価 (2007)
  • Author(s): 小林正和、他
  • Organizer: 第2回日本分子イメージング学会
  • Place of Presentation: 福井
• [Presentation] 無採血脳PET検査法を用いた貧困灌流領域診断における短時間撮像の検討 (2007)
  • Author(s): 小林正和、他
  • Organizer: 第47回日本核医学会総会
  • Place of Presentation: 仙台
• [Presentation] MELAS脳卒中様発作における酸化ストレスとエネルギー代謝のPETによる機能イメージング (2007)
  • Author(s): 井川正道、他
  • Organizer: 第7回日本ミトコンドリア学会
  • Place of Presentation: 鹿児島
• [Presentation] PET and univariate analysis. "The clinical impact of statistical methods in the assessment of brain diseases with PET and SPECT" (2005)
  • Author(s): Okazawa H.
  • Organizer: Annual Congress of the European Association of Nuclear Medicine,(Symposium)
  • Place of Presentation: Istanbul(Turkey)
  • Year and Date: 2005-10-16
• [Book] 5.腫瘍の分子イメージング3)低酸素イメージング遺伝子医学MOOK9「ますます広がる分子イメージング技術」 (2008)
  • Author(s): 岡沢秀彦
  • Publisher: (株)メディカルドゥ
• [Book] ますます広がる分子イメージング技術(5章 3.低酸素イメージング) (2008)
  • Author(s): 岡沢秀彦
  • Publisher: メデイカルドゥ
• [Book] 「2検査・診断法」5章脳循環・脳代謝測定法総論脳神経外科学大系 (2006)
  • Author(s): 岡沢秀彦、米倉義晴
  • Publisher: 中山書店
• [Book] 脳神経外科学大系「2,検査・診断法」5章脳循環・脳代謝測定法 総論 (2006)
  • Author(s): 岡沢秀彦, 米倉義晴
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www1.fukui-med.ac.jp/birc/index.html
• [Patent(Industrial Property Rights)] PET薬剤創出装置およびその作動方法 (2008)
  • Inventor(s): 小林正和、岡沢秀彦
  • Industrial Property Rights Holder: 小林正和、岡沢秀彦
  • Filing Date: 2008-07-11
• [Patent(Industrial Property Rights)] PET薬剤創出装置およびその作動方法 (2008)
  • Inventor(s): 小林正和, 岡沢秀彦
  • Industrial Property Rights Holder: 小林正和, 岡沢秀彦
  • Filing Date: 2008-07-11