Development of inner ear regenerative medicine using animal models for inner ear diseases
| Project/Area Number |
17209054
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
ITO Juichi Kyoto University, Graduate School of medicine, Professor (90176339)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Jun National Hospital Organization Kyoto Meclical Center, 政策医療企画研究部, Researcher (30252448)
NAKAGAWA Takayuki KYOTO UNIVERSITY, Graduate School of medicine, Assistant Professor (50335270)
KOJIMA Ken KYOTO UNIVERSITY, Graduate School of medicine, Researcher of COE (60378685)
HIRAUMI Harukazu KYOTO UNIVERSITY, Graduate School of medicine, Assistant Professor (10374167)
MIURA Makoto KYOTO UNIVERSITY, Graduate School of medicine, Lecturer (70263077)
藤野 清大 京都大学, 医学研究科, 助手 (50359832)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000)
Fiscal Year 2007: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2006: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2005: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
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| Keywords | Cell transplantation / hearing loss / spiral ligament / spiral ganglion / Bone marrow-derived stromal cell / Hematopoietic stem cell / Neural stem cells / ES cell / ラセン靭帯 / 胚性幹細胞 / 骨髓由来細胞 / 有毛細胞 / ラセン神経節細胞 / 幹細胞 / 骨髄間葉系細胞 / 神経栄養因子 |
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| Research Abstract |
The aim of this project was to establish animal models of inner ear degeneration as the hack of fixture clinical application. We used four animal models in this project, a mouse model for degeneration of the spiral ligament, a mouse model for age-related hearing loss, a rat model for degeneration of the cochlear nerve and a guinea pig model for degeneration of the spiral ganglion. We have established a mouse model for degeneration of the spiral ligament, which shows selective degeneration of spiral ligament fibrocytes and loss of the endocochlear potential Transplantation of bone marro-derived stromal cells results in functional recovery of the endocochlear potential. Studies on a model for age-related hearing loss have revealed roles of hematopoietic stem rills in age related hearing has Studies on a model for degeneration of the cochlear nerve have demonstrated the potential of spiral ganglion neuron-derived cells for regeneration of the cochlear nerve. Studies on a model for degeneration of the spiral ganglion have demonstrated the functional restoration of spiral ganglions by transplantation of ES cell-derived neural progenitors. These findings demonstrate the feasibility of a cell transplantation approach for inner ear regeneration in humans.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Bone marrow-derived cells expressing Mal are constitutively present as resident tissue macrophages in the mouse cochlea
Author(s)
Okano, T., Nakagawa, T., Kita, T., Rada, S., Yoshimoto, M., Nakahata, T
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Journal Title
J Neurosci Res. (in-print)
Description
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[Presentation] Therapeutic effect of IGF-1-Hydrogel therapy on noise-induced hearing loss in guinea pigs2007
Author(s)
Nakagawa T, Lee KY, Ono K, Okano T, Matsumoto M, Hiraumi H, Tabata Y, Lee SH, Ito J.
Organizer
The 30th Midwinter Meeting of Association for Research in Otolaryngology
Place of Presentation
Denver, Colorado, USA
Description
「研究成果報告書概要(和文)」より
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[Presentation] Ito J2007
Author(s)
Nakagawa, T., Okano, T., Lee, K., Y
Organizer
Local delivery of IGF1 by gelatin hydrogels for hearing loss. 2007 American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, Washington DC
Place of Presentation
USA
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Ito J2007
Author(s)
Nakagawa, T., Lee, KY, Ono, K., Okano, T., Matsumoto, M., Hiraumi, H., Tabata, Y., Lee, SH
Organizer
Therapeutic effect of IGF-1-Hydrogel therapy on noise-induced hearing loss in guinea pigs. The 30th Midwinter Meeting of Association for Research in Otolaryngology(Denver, Colorado)
Place of Presentation
USA
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Ito J2007
Author(s)
Okano, T., Nakagawa, T., Kita, T., Kada, S
Organizer
Dynamic mobilization of microglia/microphage in the mouse inner ear. The 30th Midwinter Meeting of Association for Research in Otolaryngology(Denver, Colorado)
Place of Presentation
USA
Description
「研究成果報告書概要(欧文)」より
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[Book] メディカルバイオ2008
Author(s)
中川隆之
Total Pages
6
Publisher
オーム社
Description
「研究成果報告書概要(和文)」より
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[Book] 実験医学2007
Author(s)
中川隆之、吉川弥生、伊藤壽一
Total Pages
6
Publisher
実験医学社
Description
「研究成果報告書概要(和文)」より
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