| Project/Area Number |
17209056
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Tazuke Kofukai Medical Research Institute (2006-2007)
Kyoto University (2005) |
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Principal Investigator |
SUZUKI Yoshihisa Tazuke Kofukai Medical Research Institute, 3rd Division, Medical Research Institute, Chief Researcher (30243025)
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| Co-Investigator(Kenkyū-buntansha) |
IDE Chizka Aino University, Department of Anatomy and Neurobiology, Professor (70010080)
TANIHARA Masao Nara Institute of Science and Technology, Graduate School of Material Science, Professor (50294286)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2007: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2006: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2005: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
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| Keywords | central nerve / peripheral nerve / regeneration / bone marrow / spinal cord / 再生医療 / マトリクス / ペプチド / トランスレーショナル / 移植・再生医療 / 神経科学 |
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| Research Abstract |
(1) The neurosphere cells were injected into the cerebrospinal fluid through the 4th ventricle of young rats that had been given a contusion injury at T8-9 of the spinal cord. The grafted stem cells survived well in the host spinal cord and were cell integrated into the host tissue, extending their processes around nerve fibers in the same manner as astrocyte.
(2) The spinal cord of the young rat was injured by contusion at the level of T8-9, and the BMSCs from the bone marrow were infused into the cerebrospinal fluid through the 4th ventricle. BMSCs attached to the spinal surface and a few invaded the lesion. The recovery of locomotion was better, and the cavity volume was smaller in the rat with implantation than in the control rats.
(3) Based on these studies, we aimed at the clinical application, and actually planned a clinical trial of spinal cord injury treatment by transplanting patient's autologous BMSCs into CSF. We have experienced one case. Motor and sensory scores gradually but apparently improved at 1 and 3 months compared with the scores before the transplantation.
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