Personalized medicine for oral cancer based on the bioinformatics

• Project/Area Number: 17209063
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: HAMAKAWA Hiroyuki Ehime University, 大学院・医学系研究科, 教授 (20127905)
• Co-Investigator(Kenkyū-buntansha): 新谷 悟 昭和大学, 歯学部, 教授 (80294429) ; 中城 公一 愛媛大学, 大学院・医学系研究科, 准教授 (90314880) ; 住田 知樹 愛媛大学, 医学部附属病院, 講師 (50314951)
• Co-Investigator(Renkei-kenkyūsha): SHINTANI Satoru 昭和大学, 歯学部, 教授 (80294429) ; NAKASHIRO Koichi 愛媛大学, 大学院・医学系研究科, 准教授 (90314880) ; SUMIDA Tomoki 愛媛大学, 医学部・附属病院, 講師 (50314951)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000); Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2006: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2005: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
• Keywords: 口腔癌 / 分子遺伝子学的診断 / 頸部リンパ節転移診断 / 腫瘍マーカー / 個別治療 / 分子標的治療 / RNA干渉 / Akt1 / 遺伝子診断 / 個別化治療 / 個別遺伝子診断 / リンパ節転移診断 / 合成siRNA

Research Abstract

従来、口腔癌の治療法は病理組織診断と進行病期により決定されてきた。本研究では、口腔癌の治療法の決定に新たに分子遺伝子学診断を加え、その結果に応じた個別治療を確立することにより、口腔癌の飛躍的な治療成績の向上を目指した。口腔癌組織を用いたトランスクリプトームおよびプロテオ-ム解析を駆使した結果、頸部リンパ節転移の正確な診断および放射線・抗癌薬に対する感受性予測のためのマーカー分子と有用な治療標的分子および腫瘍マーカーを同定することに成功した(特願 2005-182322、特願 2007-203371)。

Research Products

• [Journal Article] Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma (2009)
  • Author(s): Ishikawa T, Nakashiro K, Klosek SK, Goda H, Hara S, Uchida D, Hamakawa H
  • Journal Title: Oncol Rep 21 Pages: 707-712
  • Peer Reviewed
• [Journal Article] CD151 regulates HGF-stimulated morphogenesis of human breast cancer cells (2009)
  • Author(s): Klosek SK, Nakashiro K, Hara S, Goda H Hasegawa H, Hamakawa H
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 1097-1100
  • Peer Reviewed
• [Journal Article] Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription (2008)
  • Author(s): Isokane M, Hieda M, Hirakawa S, Shudou M, Nakashiro K, Hashimoto K, Hamakawa H, Higashiyama S
  • Journal Title: J Cell Sci 121 Pages: 3608-3618
  • Peer Reviewed
• [Journal Article] Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma (2008)
  • Author(s): Klosek SK, Nakashiro K, Hara S, Goda H, Hamakawa H
  • Journal Title: Oncol Rep 20 Pages: 873-878
  • Peer Reviewed
• [Journal Article] etection of lymph node micrometastases in patients with squamous carcinoma of the head and neck (2008)
  • Author(s): Ferlito A, Rinaldo A, Devaney KO, Nakashiro K, Hamakawa H
  • Journal Title: Eur Arch Otorhinolaryngol 265 Pages: 1147-1153
  • Peer Reviewed
• [Journal Article] Ferlito A. Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer (2008)
  • Author(s): Hamakawa H, Nakashiro K, Sumida T, Shintani S, Myers JN, Takes RP, Rinaldo A
  • Journal Title: Head Neck 30 Pages: 800-809
  • Peer Reviewed
• [Journal Article] Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells (2008)
  • Author(s): Hara S, Nakashiro K, Goda H, Hamakawa H
  • Journal Title: Biochem Biophys Res Commun 370 Pages: 123-128
  • Peer Reviewed
• [Journal Article] Multi-institutional phase II trial of S-1 in patients with oral squamous cell carcinoma (2008)
  • Author(s): Harada K, Sato M, Ueyama Y, Nagayama M, Hamakawa H, Nagahata S, Yoshimura Y, Osaki T, Ryoke K
  • Journal Title: Anticancer Drugs 19 Pages: 85-90
  • Peer Reviewed
• [Journal Article] Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array (2008)
  • Author(s): Nakaya K, Yamagata H, Arita N, Nakashiro K, Nose M, Miki T, Hamakawa H
  • Journal Title: Oncogene 26 Pages: 5300-5308
  • Peer Reviewed
• [Journal Article] Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer (2008)
  • Author(s): Hamakawa H, et al.
  • Journal Title: Head Neck 30 Pages: 800-809
  • Peer Reviewed
• [Journal Article] Detection of lymph node micrometastases in patients with squamous carcinoma of the head and neck (2008)
  • Author(s): Ferlito A, Rinaldo A, Devaney KO, Nakashiro K, Hamakawa H
  • Journal Title: Eur Arch Otorhinolaryngol 265 Pages: 1147-1153
  • Peer Reviewed
• [Journal Article] Role of Akt isoforms in HGF-induced growth of human salivary gland cancer cells (2008)
  • Author(s): Hara S, et. al.
  • Journal Title: Biochem Biophys Res Commun (in press)
  • Peer Reviewed
• [Journal Article] Multi-institutional phase II trial of S-1 in patients with oral squamous cell carcinoma (2008)
  • Author(s): Harada K, et. al.
  • Journal Title: Anticancer Drugs 19 Pages: 85-90
  • Peer Reviewed
• [Journal Article] Growth inhibition of human salivary gland tumor cells by introduction of pogesterone receptor and progesterone treatment (2007)
  • Author(s): Yoshimura T, Sumida T, Liu S, Onishi A, Shintani S, Desprez PY, Hamakawa H
  • Journal Title: Endocrine-Related Cancer 14 Pages: 1107-1116
  • Peer Reviewed
• [Journal Article] Growth inhibition of human salivary gland tumor cells by introduction of pogesterone receptor and progesterone treatment (2007)
  • Author(s): Yoshimura T, et. al.
  • Journal Title: Endocrine-Related Cancer 14 Pages: 1107-1116
  • Peer Reviewed
• [Journal Article] Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array (2007)
  • Author(s): Nakaya K, et. al.
  • Journal Title: Oncogene 26 Pages: 5300-5308
  • Peer Reviewed
• [Journal Article] Genome microarray(アレイCGH法)を用いた口腔癌抑制遺伝子のスクリーニング法の検討 (2007)
  • Author(s): 中谷輝一郎, 山縣 英久, 中城 公一, 浜川 裕之, 三木 哲郎
  • Journal Title: 愛媛医学 26・1 Pages: 12-16
• [Journal Article] P53-dependent radiosensitizing effects of Hsp90 inhibitor 17-allylamino-17-demethoxygel -danamycin on human oral squamous cell carcinoma cell lines (2006)
  • Author(s): Shintani S, Zhang T, Aslam A, Klosek SK, Yoshimura T, Hamakawa H
  • Journal Title: Int J Oncol 29 Pages: 1111-1117
  • Peer Reviewed
• [Journal Article] Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells (2006)
  • Author(s): Hara S, Nakashiro K, Klosek SK, Ishikawa T, Shintani S, Hamakawa H
  • Journal Title: Oral Oncol 42 Pages: 593-598
  • Peer Reviewed
• [Journal Article] CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma (2006)
  • Author(s): Ishikawa T, Nakashiro K, Hara S, Klosek SK, Li C, Shintani S, Hamakawa H
  • Journal Title: Int J Oncol 28 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Inactivation of AR activates HGF/c-Met system in human prostatic carcinoma cells (2006)
  • Author(s): Maeda A, Nakashiro K, Hara S, Sasaki T, Miwa Y, Tanji N, Yokoyama M, Hamakawa H, Oyasu R
  • Journal Title: Biochem Biophys Res Commun 347 Pages: 1158-1165
  • Peer Reviewed
• [Journal Article] Detection of p16 promoter methylation in the serum of oral cancer patients (2006)
  • Author(s): Nakahara Y, Shintani S, Mihara M, Hino S, Hamakawa H
  • Journal Title: Int J Oral Maxillofac Surg 35 Pages: 362-365
  • Peer Reviewed
• [Journal Article] Detection of p16 promoter methylation in the serum of oral cancer patients (2006)
  • Author(s): Nakahara Y, Shintani S, Mihara M, Hino S, Hamakawa H
  • Journal Title: Int J Oral Maxillofac Surg 35・4 Pages: 362-365
• [Journal Article] CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma. (2006)
  • Author(s): E Sugimori, S Shintani, K Ishikawa, H Hamakawa
  • Journal Title: Int J Oncol 28・1 Pages: 61-66
• [Journal Article] Inactivation of AR.activates HGF/c-Met system in human prostatic carcinoma cells. (2006)
  • Author(s): Maeda A, Nakashiro K, Hara S, Sasaki T, Miwa Y, Tanji N, Yokoyama M, Hamakawa H, Oyasu R
  • Journal Title: Biochem Biophys Res Commun 347・4 Pages: 1158-1165
• [Journal Article] Surface osteosarcoma : 2 case reports. (2006)
  • Author(s): Isokane M, Sumida T, Okuhira T, Shintani S, Hamakawa H
  • Journal Title: Am J Otolaryngol 27・5 Pages: 349-352
• [Journal Article] The importance of molecular analysis in detecting cervical lymph node metastasis in head and neck squamous cell carcinoma (2006)
  • Author(s): MN Elsheikh, A Rinaldo, H Hamakawa, ME Mahfouz, JP Rodrigo, J Brennan, KO Devaney, JR. Grandis, A Ferlito
  • Journal Title: Head ＆ Neck 28・9 Pages: 842-849
• [Journal Article] P53-dependentradiosensitizingeffectsofHsp9Oinhibitor17-Allylamino-17-demethoxygeldanam ycin on human oral squamous cell carcinoma cell lines (2006)
  • Author(s): Shintani S, Zhang T, Aslam A, Sebastian K, Yoshimura T, Hamakawa H
  • Journal Title: Int J Oncol 29・5 Pages: 1111-1117
• [Journal Article] 唾液腺癌に対する合成PPARγリガンドの血管新生阻害効果 (2006)
  • Author(s): 原 慎吾, Klosek SK, 中城 公一, 新谷 悟, 浜川 裕之
  • Journal Title: 日本口腔組織培養学会雑誌 15・1 Pages: 25-26
• [Journal Article] ヒト唾液腺腺様嚢胞癌におけるプロゲステロンレセプターの役割に関する検討 (2006)
  • Author(s): 住田 知樹, 吉村 友秀, 浜川 裕之
  • Journal Title: 日本口腔組織培養学会雑誌 15・1 Pages: 41-42
• [Journal Article] 外科的矯正手術により症状が再燃した微小変化型ネフロ一ゼ症候群患者の1例 (2006)
  • Author(s): 礒兼 真由美, 住田 知樹, 浜川 裕之
  • Journal Title: 有病者歯科医療学会雑誌 15・2 Pages: 91-95
• [Journal Article] 習慣性顎関節脱臼に対する下顎頭前方運動抑制の1例 -慢性腎不全患者への応用例- (2006)
  • Author(s): 住田 知樹, 浜川 裕之
  • Journal Title: 有病者歯科医療学会雑誌 15・2 Pages: 97-101
• [Journal Article] 口腔癌遺伝子診断の現況と将来 (2006)
  • Author(s): 浜川 裕之, 中城 公一
  • Journal Title: 日本口腔組織培養学会 (印刷中)
• [Journal Article] CD151 forms a functional complex with c-Met in human salivary gland cancer cells (2005)
  • Author(s): Klosek SK, Nakashiro K, Hara S, Shintani S, Hasegawa H, Hamakawa H
  • Journal Title: Biochem Biophys Res Commun 336 Pages: 408-416
  • Peer Reviewed
• [Journal Article] Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas (2005)
  • Author(s): Li C, Shintani S, Terakado N, Klosek SK, Ishikawa T, Nakashiro K, Hamakawa H
  • Journal Title: Int J Oral Maxillofac Surg 34 Pages: 559-565
  • Peer Reviewed
• [Journal Article] 口腔癌 -新しい診断と治療- (2005)
  • Author(s): 浜川 裕之
  • Journal Title: 臨床と研究 82・7 Pages: 133-137
• [Journal Article] Growth inhibition of human salivary gland tumor cells by introduction of pogesterone receptor and progesterone treatment
  • Author(s): T Yoshimura, T Sumida, S Liu, A Onishi, S Shintani, P-Y Desprez, H Hamakawa
  • Journal Title: Endocrine-Related Cancer (印刷中)
• [Journal Article] Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
  • Author(s): K Nakaya, HD Yamagata, N Arita, K-i, Nakashiro, M Nose, T Miki, H Hamakawa
  • Journal Title: Oncogene (印刷中)
• [Presentation] Sentinel node navigation surgery (2008)
  • Author(s): Hamakawa H
  • Organizer: 12th International Congress on Oral Cancer
  • Place of Presentation: Shanghai, China
  • Year and Date: 2008-05-24
• [Presentation] Mole cular targeted therapy using RNAi for or alcacer (2008)
  • Author(s): K Nakashiro、G、Shingo H、Hiroyuki H
  • Organizer: 12th
  • Place of Presentation: Shsnghai, China
• [Presentation] Sentinel node navigation surgery (2008)
  • Author(s): Hiroyuki H
  • Organizer: 12th ICOOC
  • Place of Presentation: Shsnghai, China
• [Presentation] Adverse effect on pro lifertionof human salivary gland tomo r cells by estorgen and progesterone after introduction of their receptor (2008)
  • Author(s): T Sumida、T Yoshimura、A Onishi、K Nashiro、H Hamakawa
  • Organizer: 12th ICOOC
  • Place of Presentation: Shsnghai, China
• [Presentation] awa : Akt1 is a potent molecular target for treatment of oral cancer (2007)
  • Author(s): K Nakashiro, S Hara, H Gohda, H Hamakawa
  • Organizer: American Association of Oral and Maxillofacial Surgeons in conjunction with the Japanese Society of Oral and Maxillofacial Surgeons an dthe Korean Association of Oral and Ma xillofacial Surgeons
  • Place of Presentation: Honolulu
• [Presentation] A comparative study of sentinel node biosy and positron emission tomography to identify neck metastases of oral cancer (2007)
  • Author(s): T Sumida, H Goda, T Yoshimura, K Naka shiro, H Hamakawa
  • Organizer: 1st world congress of IAOO
  • Place of Presentation: Amsterdam
• [Presentation] 愛媛県における地域開業医に向けた大学主導インプラント講習会の実施について (2007)
  • Author(s): 住田知樹、飛野一弘、篠原こずえ、中城公一、浜川裕之
  • Organizer: 第55回日本口腔科学会中国・四国地方部会
  • Place of Presentation: 徳島
• [Presentation] 口腔扁平上皮癌における治療標的分子の探索 (2007)
  • Author(s): 中城公一、合田啓之、浜川裕之
  • Organizer: 第45回日本癌治療学会
  • Place of Presentation: 京都
• [Presentation] Suppression of Akt2 inhibits the growth of human oral squamous cell carcinoma cells (2007)
  • Author(s): K Nakashiro, S Hara, H Gohda, K Honma, H Hamakawa
  • Organizer: JCA 2007
  • Place of Presentation: Yokohama
• [Presentation] 癌遺伝子Akt1を分子標的とした口腔癌治療 (2007)
  • Author(s): 中城公一、原慎吾、合田啓之、浜川裕之
  • Organizer: 第52回日本口腔外科学会学術集会総会
  • Place of Presentation: 名古屋
• [Presentation] 口腔癌の遺伝子診断と個別化治療 (2007)
  • Author(s): 中城公一、原慎吾、合田啓之、浜川裕之
  • Organizer: 第61回日本口腔科学会総会
  • Place of Presentation: 神戸
• [Presentation] 原発および肺・肝転移巣の網羅的遺伝子発現を解析した口蓋腺salivary dute carcinomaの1例 (2007)
  • Author(s): 中城公一、合田啓之、岡野勝、浜川裕之
  • Organizer: 第25回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 名古屋
• [Presentation] 骨組織再生における骨梁型アパタイトフォームと多血小板血漿(PRP)の併用に関する検討 (2006)
  • Author(s): 新谷悟、杉森英一郎、石川邦夫、矢野淳也、浜川裕之
  • Organizer: 第34回(社)日本口腔外科学会中国・四国地方会
  • Place of Presentation: 米子
  • Year and Date: 2006-05-21
• [Presentation] Comparison of sentinel node biopsy and positron emission tomography in the detection of neck lymph node metastases of oral cancer (2006)
  • Author(s): Tomoki Sumida、Tomohide Yoshimura、Hiroyuki Goda、Akiko Onishi、Koh-ichi Nak ashiro、Hiroyuki Hamakawa
  • Organizer: 5th Biennial Inter national Sentinel Node Society Meeting
  • Place of Presentation: Rome
• [Presentation] Signaring key molecules of oral squamous cell carcinoma (2006)
  • Author(s): Koh-ichi Nakashiro、Shingo Hara、Sebas tian K Klosek、Hiroyuki Gohda、Satoru Shintani、Hiroyuki Hamakawa
  • Organizer: 11th International Congress on Oral Cancer
  • Place of Presentation: Grado
• [Presentation] 口腔癌遠隔転移症例に対するマイクロアレイを用いた治療標的分子の同定と個別化治療 (2006)
  • Author(s): 中城公一、合田啓之、原慎吾、荒本孝良、住田知樹、新谷悟、浜川裕之
  • Organizer: 第44回日本癌治療学会
  • Place of Presentation: 東京
• [Presentation] 口腔扁平上皮癌原発組織を用いた頸部リンパ節転移遺伝子診断 (2006)
  • Author(s): 中城公一、合田啓之、原慎吾、荒本孝良、住田知樹、新谷悟、浜川裕之
  • Organizer: 第51回日本口腔外科学会総会
  • Place of Presentation: 小倉
• [Presentation] 口腔扁平上皮癌における治療標的分子Akt1の同定 (2006)
  • Author(s): 中城公一、原慎吾、新谷悟、浜川裕之
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] ヒト全遺伝子型マイクロアレイを用いた口腔癌の個別遺伝子診断 (2006)
  • Author(s): 中城公一、合田啓之、原慎吾、新谷悟、浜川裕之
  • Organizer: 第30回日本頭頸部癌学会
  • Place of Presentation: 大阪
• [Presentation] 口腔扁平上皮癌N0症例におけるセンチネルリンパ節微小転移診断の有用性と問題点 (2006)
  • Author(s): 中城公一、合田啓之、原慎吾、新谷悟、浜川裕之
  • Organizer: 第24回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 小倉
• [Presentation] ヒト全遺伝子型マイクロアレイを用いた口腔癌のオーダーメイド医療 (2006)
  • Author(s): 新谷悟、Aslam Almedhi、吉村友秀、中城公一、合田啓之、原慎吾、新谷悟、浜川裕之
  • Organizer: 第24回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 小倉
• [Presentation] 口腔癌切除不能再発症例に対する抗癌剤感受性試験に基づく癌化学療法 (2006)
  • Author(s): 新谷悟、日野聡史、中城公一、浜川裕之
  • Organizer: 第29回頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] マイクロアレイ解析による抗癌剤感受性関連遺伝子の同定 (2006)
  • Author(s): 新谷悟、原慎吾、中城公一、浜川裕之
  • Organizer: 第29回頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] 口腔癌における腫瘍マーカーの個別化とその有用性 (2006)
  • Author(s): 中城公一、礒兼真由美、原慎吾、合田啓之、新谷悟、浜川裕之
  • Organizer: 第29回頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] ヒト全遺伝子型マイクロアレイを用いた口腔癌個別診断の試み (2006)
  • Author(s): 中城公一、原慎吾、礒兼真由美、Klosek SK、新谷悟、浜川裕之
  • Organizer: 第59回日本口腔科学会総会
  • Place of Presentation: 徳島
• [Presentation] Human genome survey array system (AB1700)を用いた口腔癌個別遺伝子診断の試み (2005)
  • Author(s): 中城公一、浜川裕之
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2005-12-10
• [Presentation] Identification of predictor gene of lymph node metastases from primary oral squamous cell carcinomas Sympsium in Kochi (2005)
  • Author(s): Nakashiro K
  • Year and Date: 2005-08-20
• [Presentation] Genetic diagno sis of lymph node metastases from primary oral souamous cell carcinomas The HealthWorlds Asia 2005 Internationa l Health Congress (2005)
  • Author(s): Nakashiro K、Hara S、I Mayumi、Goda H、Shintani S、Hamakawa H
  • Place of Presentation: Singapore
• [Presentation] Sentinel node navigation surgery based on intraoperative genetic diagnosis (2005)
  • Author(s): Hamakawa H、Shintani S、Nakashiro K、Sumida S、Aramoto T
  • Organizer: The Health Worlds Asia 2005 International Health Congress
  • Place of Presentation: Singapore
• [Presentation] Thing Zhang、Almedihi Aslam、Klosek Sebastian、吉村友秀、浜川裕之 : 口腔扁平上皮癌におけるHPS90の発現と分子標的としての可能性 (2005)
  • Author(s): 新谷悟、中城公一
  • Organizer: 第43回日本口腔癌治療学会総会
  • Place of Presentation: 名古屋
• [Presentation] Genetic diagnosis of oralcancer-from diganosis to therapy-In ternational Symposium of Maxillofacial & Oral regenerative Biology in OKAY AMAOkayama (2005)
  • Author(s): Hamakawa H
• [Presentation] 唾液腺癌のHGF依存性浸潤増殖における癌遺伝子Akt isoformの役割 (2005)
  • Author(s): 中城公一、原慎吾、Klosek SK、新谷悟、浜川裕之
  • Organizer: 第64回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Book] 口腔内科学(頭頭部の画像の読み方、前癌病変、異形成性病変、色素沈着とメラノーマ) (2008)
  • Author(s): 浜川 裕之
  • Publisher: 飛鳥出版室
• [Remarks]
  • URL: http://www.m.ehime-u.ac.jp/school/dentistry/index.html
• [Patent(Industrial Property Rights)] 頭頸部癌の腫瘍マーカー (2007)
  • Inventor(s): 中城公一、浜川裕之
  • Industrial Property Rights Holder: 愛媛大学
  • Filing Date: 2007-08-03
• [Patent(Industrial Property Rights)] ADAT1遺伝子に特異的なsiRNA (2007)
  • Inventor(s): 中城公一、浜川裕之
  • Industrial Property Rights Holder: 愛媛大学
  • Filing Date: 2007-03-20
• [Patent(Industrial Property Rights)] 頭頸部癌の腫瘍マーカー (2007)
  • Inventor(s): 中城 公一、浜川 裕之
  • Industrial Property Rights Holder: 愛媛大学
  • Industrial Property Number: 2007-203371
  • Filing Date: 2007-08-03
• [Patent(Industrial Property Rights)] Akt遺伝子に特異的なsiRNA (2006)
  • Inventor(s): 中城公一、浜川裕之
  • Industrial Property Rights Holder: 愛媛大学
  • Filing Date: 2006-11-09
• [Patent(Industrial Property Rights)] アンドロゲン受容体遺伝子に特異的なsiRNA (2006)
  • Inventor(s): 中城公一、浜川裕之
  • Industrial Property Rights Holder: 愛媛大学
  • Filing Date: 2006-02-16
• [Patent(Industrial Property Rights)] 頭頸部癌の腫瘍マーカー (2005)
  • Inventor(s): 中城公一、浜川裕之
  • Industrial Property Rights Holder: 愛媛大学
  • Filing Date: 2005-06-22