Grant-in-Aid for Scientific Research (A)
|Allocation Type||Single-year Grants |
|Research Institution||OKAYAMA UNIVERSITY |
WATANABE Tatsuo Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (20034176)
TAKEHARA Tadamichi Kyushu Dental College, School of Dentistry, Professor, 歯学部, 教授 (00038879)
NAKAGAKI Haruo Aichi-Gakuin University, School of Dentistry, Professor, 歯学部, 教授 (10097595)
SHIZUKUISHI Satoshi Osaka University, Graduate School of Dentistry, Professor, 大学院歯学研究科, 教授 (00028789)
YAMASHITA Yoshihisa Kyushu University, Graduate School of Dentistry, Professor, 大学院歯学研究院, 教授 (20192403)
SAITO Toshiyuki Nagasaki University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (10170515)
宮崎 秀夫 新潟大学, 医歯学系, 教授 (00157629)
|Project Period (FY)
2005 – 2006
Completed (Fiscal Year 2006)
|Budget Amount *help
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2006: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2005: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
|Keywords||Periodontal disease / Periodontal medicine / Biochemical test / Diabetes / Stress / Hepatic steatosis / Aspiration pneumonia / Hypercholesterolemia|
The purpose of this research project was to examine the casual and epidemiological relationships between periodontal diseases and systemic health. We obtained conclusions described below from seven different experimental groups.
1.(Miyazaki H) We analyzed the relationship between periodontal disease progression and serum vitamin C, calcium and albumin concentrations obtained from community-dwelling elderly Japanese aged 78 years. The results suggest that lower vitamin C, calcium and albumin levels independently influence to progress periodontal destruction in elderly people.
2.(Takehara T and Ansai T) We analyzed an association between the rate of eating and adipocyte-derived hormones, adiponectin and leptin. It was suggested that chewing well and eating slow may lead to a preventive strategy for metabolic syndrome.
3.(Nakagaki H) This study was undertaken the relation between smoking habits and blood test values of persons with periodontitis. The results of this study helped clarify the
relationship between the CRP value and periodontal disease, suggesting the possibility that this can be used as a screening test for periodontal disease.
4.(Yamashita Y and Saito T) Periodontal disease was closely associated with metabolic syndrome in Japanese women. Within several kinds of adipocytokines, resistin was suggested to be elevated in the subjects with periodontal disease.
5.(Nishimura F) Infection by P. gingivalis was associated with elevated LDL-cholesterol. This appeared to be accompanied by increased cholesterol synthesis, which was induced by up-regulation of HMG-CoA mRNA level by TNF-a and IL-6 produced by periodontal infection.
6.(Watanabe T, Yamamoto T and Tomofuji T) We established experimental rat periodontitis model by topical application of lipopolysaccharide and proteases. In rat periodontitis model, oxidative damage of brain, heart, liver and kidney were found.
7.(Shizukuishi S) FomA, F. nucleatum outer membrane protein (OMP) bound to salivary statherin-peptide and induced mucosal and systemic immune responses in mice given with cholera toxin as mucosal adjuvant. Less