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Molecular mechanism of the synaptic targeting and activity regulation of glutamate receptors

Research Project

Project/Area Number 17300099
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNiigata University

Principal Investigator

SAKIMURA Kenji  Niigata University, Department of Cellular Neurobiology, Professor (40162325)

Co-Investigator(Kenkyū-buntansha) ABE Manabu  Niigata University, Department of Cellular Neurobiology Brain Research Institute, Assistant Professor (10334674)
YAMAZAKI Maya  Brain Research Institute, Niigata University, Department of Cellular Neurobiology Brain Research Institute, Assistant Professor (70401768)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,200,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2005: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsConditional targeting / Glutamate receptor / TARP / C57BL / 6 / AD / HD / NMDA receptor / AMPA receptor / Synaptic targeting
Research Abstract

The aim of this project is to elucidate the molecular mechanism underlying the synaptic targeting and activity regulation of glutamate receptors, which are responsible for excitatory synapse transmission. For this purpose, we generated a series of foxed mouse strains for conditional knockout (KO) mice using the Cre/loxP recombination system. The targeted molecules were four AMPA-receptor subunits and their possibly auxiliary subunits, [○C]2, [○C]3, [○C]4, [○C]5, [○C]7 and[○C]8, which belong to the TARP[○C] molecules and are highly expressed in the brain. GluRε1 and GluRε2 subunits were also targeted in NMDA receptors. To generate flexed mice, we used our original ES-cell line RENKA, derived from C57BL/6 strain. Analysis of the TARP[○C]null KO mice showed that these molecules were crucial for the transfer of AMPA receptor to synapses and its stability, and that they were functioning as auxiliary subunits of AMPA receptors. When TARP[○C]8, which is distributed in telencephalon and highly expressed in hippocampal excitatory neurons, was lost, the KO mice showed impulsive and hyperactive phenomena, which improved with administration of antipsychotic drugs. Therefore, this KO mouse is thought to be an animal model for attention deficit hyperactivity disorder. The GluRε2 hippocampal CA3 selective-conditional KO mice indicated that GluRε2 was an essential subunit for NMDA receptor activity in this region.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (91 results)

All 2008 2007 2006 2005 Other

All Journal Article (47 results) (of which Peer Reviewed: 22 results) Presentation (42 results) Remarks (2 results)

  • [Journal Article] Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells2008

    • Author(s)
      Watanabe, F., et. al.
    • Journal Title

      European Journal of Neuroscience 27

      Pages: 836-854

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions2008

    • Author(s)
      Yasumura, M., et. al.
    • Journal Title

      Neuroscience Letters 433

      Pages: 146-151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of the internal Shank-binding segment of glutamate receptorδ2 in synaptic localization and cerebellar functions2008

    • Author(s)
      Yasumura, M.., et. al.
    • Journal Title

      Neuroscience Letters 433

      Pages: 146-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of FAK ablation on cerebellar foliation, Bergmann gliapositioning and climbing fiber territory on Purkinje cells2008

    • Author(s)
      Watanabe, F., et. al.
    • Journal Title

      European Journal of Neuroscience 27

      Pages: 836-854

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells2007

    • Author(s)
      Uemura, T., et. al.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 12096-12108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex2007

    • Author(s)
      Kitaura, H., et. al.
    • Journal Title

      Neuroscience Research 59

      Pages: 160-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nitric oxide(NO)serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors2007

    • Author(s)
      Xu, L.., et. al.
    • Journal Title

      Nitric Oxide 17

      Pages: 18-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mutation of α1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction2007

    • Author(s)
      Petrenko, A. B., et. al.
    • Journal Title

      Anesthesiology 106

      Pages: 1177-1185

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions.2007

    • Author(s)
      Tanaka, K., et. al.
    • Journal Title

      Multiple sclerosis 13

      Pages: 850-855

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mouse liaison for integrative brain research2007

    • Author(s)
      Aiba, A., et. al.
    • Journal Title

      Neuroscience Research 58

      Pages: 103-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ2007

    • Author(s)
      Xu, L., et. al.
    • Journal Title

      Neuropharmacology 52

      Pages: 1318-1325

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Conditional gene targeting on the pure C57BL/6 genetic background2007

    • Author(s)
      Mishina, M., Sakimura, K.
    • Journal Title

      Neuroscience Research 58

      Pages: 105-112

    • NAID

      10024414768

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of arylsulfonamide as Aquaporin 4 inhibitors.2007

    • Author(s)
      Huber, V. J., et. al.
    • Journal Title

      Bioorganic & Medical Chemistry Letters 17

      Pages: 1270-1273

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of Long-Term Depression and Climbing Fiber Territory by Glutamate Receptor δ2 at Parallel Fiber Synapses through its C-Terminal Domain Cerebellar Purkinje Cells2007

    • Author(s)
      Uemura, T., et. al.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 12096-12108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nitric oxide(NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors2007

    • Author(s)
      Xu, L., et. al.
    • Journal Title

      Nitric Oxide 17

      Pages: 18-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mutation of alG T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction2007

    • Author(s)
      Petrenko, A.B., et. al.
    • Journal Title

      Anesthesiology 106

      Pages: 1177-1185

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions2007

    • Author(s)
      Tanaka, K., et. al.
    • Journal Title

      Multiple Sclerosis 13

      Pages: 850-855

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mouse liaison for integrative brain research2007

    • Author(s)
      Aiba, A. et. al.
    • Journal Title

      Neuroscience Research 58

      Pages: 103-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Conditional gene targeting on the pure C57BL/6 genetic background2007

    • Author(s)
      Mishina, M., Sakimura, K
    • Journal Title

      Neuroscience Research 58

      Pages: 105-112

    • NAID

      10024414768

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of arylsulfonamide as Aquaporin 4 inhibitors2007

    • Author(s)
      Huber, V.J., et. al.
    • Journal Title

      Bioorganic & Medical Chemistry Letters 17

      Pages: 1270-1273

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nitric oxide(NO)serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors2007

    • Author(s)
      Xu, L., et. al.
    • Journal Title

      Nitric Oxide 17

      Pages: 18-24

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation of αlG T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction2007

    • Author(s)
      Petrenko, A.B., et. al.
    • Journal Title

      Anesthesiology 106

      Pages: 1177-1185

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional gene targeting on the pure C57BL/6 genetic background.2007

    • Author(s)
      Mishima M.
    • Journal Title

      Neuroscience Research (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of arylsulfonamides as Aquaporin 4 inhibitors.2007

    • Author(s)
      Huber VJ.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 17

      Pages: 1270-3

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on shines and dendrites.2006

    • Author(s)
      Fukaya, M., et. al.
    • Journal Title

      European Journal of Neuroscience 24

      Pages: 2177-2190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment.2006

    • Author(s)
      Takahashi, M., et. al.
    • Journal Title

      Journal of Neurochemistry 99

      Pages: 770-780

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate(NMDA)receptor ε1 subunit knockout mice.2006

    • Author(s)
      Petrenko, A. B., et. al.
    • Journal Title

      Neuropharmacology 50

      Pages: 741-747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites2006

    • Author(s)
      Fukaya, M., et. al.
    • Journal Title

      European Journal of Neuroscience 24

      Pages: 2177-2190

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment2006

    • Author(s)
      Takahashi, M., et. al.
    • Journal Title

      Journal of Neurochemistry 99

      Pages: 770-780

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate(NMDA) receptor El subunit knockout mice2006

    • Author(s)
      Petrenko, A.B., et. al.
    • Journal Title

      Neuropharmacology 50

      Pages: 741-747

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites.2006

    • Author(s)
      Fukaya M.
    • Journal Title

      European Journal of Neuroscience 24

      Pages: 2177-90

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine : comparison with adult treatment.2006

    • Author(s)
      Takahashi M.
    • Journal Title

      Journal of Neurochemistry 99

      Pages: 770-80

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.2006

    • Author(s)
      Petrenko AB.
    • Journal Title

      Neuropharmacology 50

      Pages: 741-47

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor ε1 subunit knockout mice2006

    • Author(s)
      Petrenko, A.B.
    • Journal Title

      Neuropharmacology (in press)(Epub ahead of print, Jan 18)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in schaffer collateral synapses in ε1/NR2A knock-out mice.2005

    • Author(s)
      Wu, Y., et. al.
    • Journal Title

      The Journal of Neuroscience 25

      Pages: 9213-9226

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Spatial diversity in gene expression for VDCC_γ subunit family in developing and adult mouse brains.2005

    • Author(s)
      Fukaya, M., et. al.
    • Journal Title

      Neuroscience Research 53

      Pages: 376-383

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of agmatine on heteromeric N-methyl-D-aspartate receptor channels.2005

    • Author(s)
      Askalany, A. R., et. al.
    • Journal Title

      Neuroscience Research 52

      Pages: 387-392

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-D-aspartate receptors.2005

    • Author(s)
      Yamakura, T., et. al.
    • Journal Title

      Anesthesia & Analgesia 100

      Pages: 1687-1692

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Control of synaptic connection by glutamate receptor δ2 in the adult cerebellum.2005

    • Author(s)
      Takeuchi, T., et. al.
    • Journal Title

      The Journal of Neuroscience 25

      Pages: 2146-2156

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in schaffer collateral synapses in cl/NR2A knock-out mice2005

    • Author(s)
      Wu, Y., et. al.
    • Journal Title

      The Journal of Neuroscience 25

      Pages: 9213-9226

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains2005

    • Author(s)
      Fukaya, M., et. al.
    • Journal Title

      Neuroscience Research 53

      Pages: 376-383

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of agmatine on heteromeric N-methyl-D-aspartate receptor channels2005

    • Author(s)
      Askalany, A.R., et. al.
    • Journal Title

      Neuroscience Research 52

      Pages: 387-392

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-D-aspartate receptors2005

    • Author(s)
      Yamakura, T., et. al.
    • Journal Title

      Anesthesia & Analgesia 100

      Pages: 1687-1692

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε 1/NR2A knock-out mice2005

    • Author(s)
      Wu, Y.
    • Journal Title

      Journal of Neuroscience 25(40)

      Pages: 9213-9226

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains2005

    • Author(s)
      Fukaya, M.
    • Journal Title

      Neuroscience Research 53(4)

      Pages: 376-383

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of agmatine on heteromeric N-methyl-D-aspartate receptor channels2005

    • Author(s)
      Askalany, A.R.
    • Journal Title

      Neuroscience Research 52(4)

      Pages: 387-392

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-D-aspartate receptors2005

    • Author(s)
      Yamakura, T.
    • Journal Title

      Anesthesia and Analgesia 100(6)

      Pages: 1687-1692

    • Related Report
      2005 Annual Research Report
  • [Presentation] 線条体は弱い恐怖条件付け学習に関与する2008

    • Author(s)
      岸岡 歩
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 小脳プルキンエ細胞においてグルタミン酸受容体δ2のC末端細胞質内ドメインは小脳LTDと登上線維の支配領域の調節に必要不可欠である2008

    • Author(s)
      植村 健
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] FAK欠損による小脳小葉形成異常、バーグマングリア細胞体の異所配置、及びプルキンエ細胞上での登上線維の支配領域の異常2008

    • Author(s)
      渡辺 文寛
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] グルタミン酸受容体δ2のシナプス局在と小脳機能におけるC末端細胞質内領域の中間に存在するPDZドメイン結合領域の役割2008

    • Author(s)
      安村 美里
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] C57BL/6マウス胚性幹細胞における相同組換えの効率化;UPATrapシステムの応用2007

    • Author(s)
      阿部学
    • Organizer
      BMB2007(第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] リゾホスファチジン酸受容体LPA4とLPA5の生体機能2007

    • Author(s)
      石井 聡
    • Organizer
      BMB2007(第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CysLT2を介したアレルギー性気道炎症の制御2007

    • Author(s)
      斎藤雅倫
    • Organizer
      BMB2007(第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] リゾホスファチジン酸受容体LPA4とLPA5の生体機能2007

    • Author(s)
      石井 聡
    • Organizer
      BMB2007 (第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロトカドヘリン-α遺伝子クラスターにおける進化的に保存された非コード領域2007

    • Author(s)
      金子涼輔
    • Organizer
      BMB2007(第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bclllb/Ritlヘテロ欠損はAPCmin/+マウスの消化管発がんを促進する2007

    • Author(s)
      葛城美徳
    • Organizer
      BMB2007(第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自己リン酸化型CaMKII結合能を阻害する変異を導入したSyntaxin-1Aknock-inマウスの作成と解析2007

    • Author(s)
      渡邊 裕美
    • Organizer
      BMB2007(第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自己リン酸化型CaMKII結合能を阻害する変異を導入したSyntaxin-1A knock-inマウスの作成と解析2007

    • Author(s)
      渡邊 裕美
    • Organizer
      BMB2007 (第30回 日本分子生物学会年会第80回 日本生化学会大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of climbing fiber territory by the carboxyl terminal of GluRδ2 at parallel fiber synapses in cerebellar Purkinje cells2007

    • Author(s)
      T, Uemura, et. al.
    • Organizer
      NEUROSCIENCE 2007(Society for Neuroscience)
    • Place of Presentation
      San Diego,,California, USA
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of climbing fiber territory by the carboxyl terminal of GluRδ2 at paraller fiber synapses in cerebellar Purkinje cells2007

    • Author(s)
      T. Uemura
    • Organizer
      NEUROSCIENCE2007(Society for Neuroscience)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ2007

    • Author(s)
      E. Okuda-Ashitaka
    • Organizer
      NEUROSCIENCE2007(Society for Neuroscience)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Nitric oxide is involved in activation of neuronal nitric oxide synthase as a retrograde messenger in the spinal card2007

    • Author(s)
      S. Ito
    • Organizer
      NEUROSCIENCE2007(Society for Neuroscience)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ2007

    • Author(s)
      E, Okuda-Ashitaka, et. al.
    • Organizer
      NEUROSCIENCE 2007(Society for Neuroscience)
    • Place of Presentation
      San Diego,California, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nitric oxide is involved in activation of neuronal nitric oxide synthase as a retrograde messenger in the spinal card2007

    • Author(s)
      S, Ito, et. al.
    • Organizer
      NEUROSCIENCE 2007(Society for Neuroscience)
    • Place of Presentation
      San Diego,California, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C57BL/6ES細胞RENKAを用いたコンディショナルノックアウトマウスの系統的作成2007

    • Author(s)
      崎村 建司
    • Organizer
      Neuro 2007(第30回 日本神経科学会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CaMK IIとの相互作用が不能な変異Syntaxin-1Aマウスの作成と解析2007

    • Author(s)
      渡邊 裕美
    • Organizer
      Neuro 2007(第30回 日本神経科学会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-09-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] セリンラセマーゼノックアウトマウスを用いた脳内D-セリンの機能解析2007

    • Author(s)
      趙 英らん
    • Organizer
      Neuro 2007(第30回 日本神経科学会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-09-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Calcium channel γ-7 subunit is an essential cofactor of AMPA receptor2007

    • Author(s)
      Yamazaki, M.
    • Organizer
      7th IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2007-07-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Regulation of climbing fiber territory by the carboxyl terminal of GluRδ2 at parallel fiber synapses in cerebellar Purkinje cells2007

    • Author(s)
      T. Uemura
    • Organizer
      NEUROSCIENCE2007(Society for Neuroscience)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C57BL/6N由来ES細胞RENKA株の核型解析について2007

    • Author(s)
      藤田 恒久
    • Organizer
      第54回 日本実験動物学会総会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2007-05-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 高効率コンディショナルノックアウトマウス作成法の開発:C57BL/6系統ES細胞株RENKAを用いて2007

    • Author(s)
      崎村建司
    • Organizer
      臨床研セミナー
    • Place of Presentation
      東京都文京区
    • Year and Date
      2007-03-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 情動行動に影響を及ぼす新規ポリコーム群遺伝子Sfmbtの解析2006

    • Author(s)
      薄井宏
    • Organizer
      日本生化学会関東支部例会
    • Place of Presentation
      新潟市
    • Year and Date
      2006-10-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小脳LTDの閾値制御は運動学習の学習効率に重要である2006

    • Author(s)
      竹内倫徳
    • Organizer
      Neuroscience 2006(第29回日本神経科学大会)
    • Place of Presentation
      京都府京都市
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Stargazinファミリーγ4ノックアウトマウスにおけるAMPA型受容体発現量の解析2006

    • Author(s)
      駒井太陽
    • Organizer
      Neuroscience 2006(第29回日本神経科学大会)
    • Place of Presentation
      京都府京都市
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新生仔期フェンサイクリジン投与による持続的なBDNF増加と感覚運動情報処理障害2006

    • Author(s)
      高橋誠
    • Organizer
      Neuroscience 2006(第29回日本神経科学大会)
    • Place of Presentation
      京都府京都市
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GluRα2ノックアウトマウスの作製と生化学的解析2006

    • Author(s)
      畦地裕統
    • Organizer
      Neuroscience 2006(第29回日本神経科学大会)
    • Place of Presentation
      京都府京都市
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GluRβ2/GluR6サブユニット欠損によるカイニン酸受容体サブユニットの動態への影響2006

    • Author(s)
      明石馨
    • Organizer
      Neuroscience 2006(第29回日本神経科学大会)
    • Place of Presentation
      京都府京都市
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TARPγ-8の海馬ニューロンでの局在とそのAMPA受容体発現調節における役割2006

    • Author(s)
      深谷昌弘
    • Organizer
      Neuroscience 2006(第29回日本神経科学大会)
    • Place of Presentation
      京都府京都市
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of GluRβ2/GluR6 disruption on dynamics of other kainate receptor subunits2006

    • Author(s)
      K. Akashi
    • Organizer
      Neuroscience 2006(ヨーロッパ神経科学会)
    • Place of Presentation
      ウィーン・オーストリア
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of GluR(32/GluR6 disruption on dynamics of other kainate receptor subunits2006

    • Author(s)
      K, Sakimura, et. al.
    • Organizer
      FENS(5th Forum of European Neuroscience 2006)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2006-06-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C57BL/6由来ES細胞株RENKAを用いた標的組換えマウス作成効率化の検討(III)2006

    • Author(s)
      夏目里恵
    • Organizer
      第53回 日本実験動物学会総会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2006-05-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C57BL/6由来ES細胞株RENKAを用いた遺伝子破壊マウス作製について2006

    • Author(s)
      中務胞
    • Organizer
      第53回 日本実験動物学会総会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2006-05-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characterization of cysteinyl leukotriene2 receptor(CysLT2)2005

    • Author(s)
      Satoshi Ishii
    • Organizer
      第78回 日本生化学会大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2005-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characterization of cysteinyl leukotriene2 receptor(CysLT2)2005

    • Author(s)
      S, Ishii, et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Kobe, Hyogo, Japan
    • Year and Date
      2005-10-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] カルシウムチャネルγサブユニットはAMPA型受容体機能に必須な補助因子である2005

    • Author(s)
      山崎真弥
    • Organizer
      Neuroscience 2005(第28回日本神経科学大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2005-07-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脳発達時期に発現するNMDA受容体チャネルGluRε2、GluRε4サブユニットの機能的差異2005

    • Author(s)
      柿崎利和
    • Organizer
      Neuroscience 2005(第28回日本神経科学大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2005-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 神経系特異的FAK欠損マウスにおける小脳小葉構造異常2005

    • Author(s)
      渡辺文寛
    • Organizer
      Neuroscience 2005(第28回日本神経科学大会)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2005-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C57BL/6由来ES細胞株RENKAを用いた標的組換えマウス作成効率化の検討(II)2005

    • Author(s)
      夏目里恵
    • Organizer
      第52回 日本実験動物学会総会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2005-05-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.bri.niigata-u.ac.jp/~cellular/

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~cellular/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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