Neural mechanisms of information processing based on the multimodal representation and its interaction on prefrontal cortical neurons

• Project/Area Number: 17300103
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Kyoto University
• Principal Investigator: FUNAHASHI Shintaro Kyoto University, こころの未来研究センター, 教授 (00145830)
• Co-Investigator(Kenkyū-buntansha): KUSHIRO Keisuke 京都大学, 大学院・人間環境学研究科, 助手 (60361599)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥16,670,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000); Fiscal Year 2005: ¥6,200,000 (Direct Cost: ¥6,200,000)
• Keywords: 前頭連合野 / 情報表現 / ワーキングメモリ / 眼球運動 / 単一ニューロン活動 / 記憶表象 / 遅延反応課題 / 空間情報 / 非空間情報 / 多重表現 / 運動方向の決定 / 遅延期間活動 / 方向選択性 / 競合 / 機能的相互作 / 情報処理 / 課題関連活動 / マカクザル / 単一ニューロン記録

Research Abstract

本研究では、マルチモーダルな情報処理に関わる前頭連合野背外側部ニューロンの活動を指標に、同一神経回路網上でモダリティーの異なる情報がどのように表現され、処理されているのかを解析した。その結果、ある情報に関わる細胞集団の空間的な分布の違いにより様々な情報が表現されていること、異なる情報間でこの分布に大きな重なりのあることにより、多様な情報の迅速で柔軟な処理が可能になっていることが示唆された。

Research Products

• [Journal Article] 前頭前野におけるワーキングメモリの神経生理学的研究-その40年の歩みー (2009)
  • Author(s): 船橋新太郎
  • Journal Title: 霊長類研究 24 Pages: 273-287
  • NAID: 130000264052
  • Peer Reviewed
• [Journal Article] Activity of primate orbitofrontal and dorsolateral prefrontal neurons: effect of reward schedule on task-related activity (2008)
  • Author(s): Ichihara-Takeda, S., and Funahashi, S.
  • Journal Title: Journal of Cognitive Neuroscience 20 Pages: 563-574
  • Peer Reviewed
• [Journal Article] 統合失調症のワーキングメモリ-霊長類を用いた研究を通してー (2008)
  • Author(s): 船橋新太郎
  • Journal Title: Schizophrenia Research 51 Pages: 219-225
• [Journal Article] 意思決定のしくみ (2008)
  • Author(s): 船橋新太郎
  • Journal Title: Brain and Nerve(神経研究の進歩) 60 Pages: 1017-1027
• [Journal Article] 前頭前野におけるDynamic Modulation機構 (2008)
  • Author(s): 船橋新太郎
  • Journal Title: 分子精神医学 8 Pages: 91-101
• [Journal Article] Activity of primate orbitofrontal and dorsolateral prefrontal neurons : effect of reward schedule on task-related activity. (2008)
  • Author(s): Ichihara-Takeda, S., Funahashi, S.
  • Journal Title: Journal of Cognitive Neuroscience 20 Pages: 563-574
  • Peer Reviewed
• [Journal Article] 意思決定のしくみ (2008)
  • Author(s): 船橋新太郎
  • Journal Title: Brain and Nerve 60 Pages: 1017-1027
• [Journal Article] Prefrontal delay-period activity reflects the decision process of a saccade direction during a free-choice ODR task (2007)
  • Author(s): Watanabe, K., Funahashi, S.
  • Journal Title: Cerebral Cortex 17
  • Peer Reviewed
• [Journal Article] Activity of primate orbitofrontal and dorsolateral prefrontal neurons: Task-related activity during an oculomotor delayed-response task (2007)
  • Author(s): Ichihara-Takeda, S., Funahashi, S.
  • Journal Title: Experimental Brain Research 181 Pages: 409-425
  • Peer Reviewed
• [Journal Article] Relationship between prefrontal task-related activity and information flow during spatial working memory performances (2007)
  • Author(s): Takeda, K., Funahashi, S.
  • Journal Title: Cortex 43(1) Pages: 38-52
  • Peer Reviewed
• [Journal Article] ワーキングメモリと意識 (2007)
  • Author(s): 船橋新太郎
  • Journal Title: 生体の科学 58(1) Pages: 53-64
• [Journal Article] サルを用いたメタ記憶の神経生理学的研究に向けて (2007)
  • Author(s): 田中暁生、船橋新太郎
  • Journal Title: 霊長類研究 23 Pages: 91-104
  • NAID: 10020018442
  • Peer Reviewed
• [Journal Article] Prefrontal delay-period activity reflects the decision process of a saccade direction during a free-choice ODR (2007)
  • Author(s): K. Watanabe & S. Funahashi
  • Journal Title: Cerebral Cortex 17
  • Peer Reviewed
• [Journal Article] Activity of primate orbitofrontal and dorsolateral prefrontal neurons: task-related activity during an (2007)
  • Author(s): S. Ichihara-Takeda & S. Funahashi
  • Journal Title: Experimental Brain Research 181 Pages: 409-425
  • Peer Reviewed
• [Journal Article] Relationship between prefrontal task-related activity and information flow during spatial working memory (2007)
  • Author(s): K. Takeda & S. Funahashi
  • Journal Title: Cortex 43 Pages: 38-52
  • Peer Reviewed
• [Journal Article] ワーキングメモリと意識 (2007)
  • Author(s): 船橋新太郎
  • Journal Title: 生体の科学 58 Pages: 53-64
• [Journal Article] Contributions of prefrontal cue-, delay-, and response-period activity to thedecision process of saccade direction in afree-choice ODR task (2006)
  • Author(s): Watanabe, K., Igaki, S., and Funahashi, S.
  • Journal Title: Neural Networks 19 Pages: 1203-1222
  • Peer Reviewed
• [Journal Article] Prefrontal cortex and working memory processes (2006)
  • Author(s): Funahashi, S.
  • Journal Title: Neuroscience 139 Pages: 251-261
  • Peer Reviewed
• [Journal Article] Reward-period activity in primate dorsolateral prefrontal and orbitofrontal neurons is affected by reward schedules (2006)
  • Author(s): Ichihara-Takeda, S. and Funahashi, S.
  • Journal Title: Journal of Cognitive Neuroscience 18 Pages: 212-226
  • Peer Reviewed
• [Journal Article] 前頭葉・視床背内側核系と情動行動 (2006)
  • Author(s): 船橋新太郎、竹田里江
  • Journal Title: 神経研究の進歩 50 Pages: 89-97
• [Journal Article] Reward-period activity in primate dorsolateral prefrontal and orbitofrontal neurons is affected by reward schedules (2006)
  • Author(s): Ichihara-Takeda, S., Funahashi, S.
  • Journal Title: Journal of Cognitive Neuroscience 18 Pages: 212-226
• [Journal Article] Contributions of prefrontal cue-, delay-, and response-period activity to the decision process of saccade (2006)
  • Author(s): Watanabe, K., Igaki, S., Funahashi, S.
  • Journal Title: Neural Networks 19 Pages: 1203-1222
• [Journal Article] 注意欠陥/多動性障害と動物モデル (2006)
  • Author(s): 船橋新太郎
  • Journal Title: 霊長類研究 22 Pages: 85-96
  • NAID: 10018823073
• [Journal Article] Relationship between prefrontal task-related activity and information flow during spatial working memory (2006)
  • Author(s): Takeda, K., Funahashi, S.
  • Journal Title: Cortex 43 Pages: 38-52
• [Journal Article] 前頭葉・視床背内側核系と情動行動 (2006)
  • Author(s): 船橋新太郎, 竹田里江
  • Journal Title: 神経研究の進歩 50 Pages: 89-97
• [Journal Article] 行動の制御と前頭葉 (2005)
  • Author(s): 新田統昭、船橋新太郎
  • Journal Title: 神経研究の進歩 49 Pages: 555-564
• [Journal Article] 前頭前野とワーキングメモリ (2005)
  • Author(s): 船橋新太郎
  • Journal Title: Clinical Neuroscience 23 Pages: 619-622
• [Journal Article] 前頭前野トワーキングメモリ (2005)
  • Author(s): 船橋新太郎
  • Journal Title: Clinical Neuroscience 23 Pages: 619-622
• [Journal Article] ワーキングメモリとその神経機構 (2005)
  • Author(s): 竹田里江, 竹田和良, 船橋新太郎
  • Journal Title: 前頭葉:その機能とネットワーク(板倉徹編) Pages: 1-9
• [Journal Article] 行動の制御と前頭葉 (2005)
  • Author(s): 新田統昭, 船橋新太郎
  • Journal Title: 神経研究の進歩 49 Pages: 555-564
• [Journal Article] Prefrontal cortex and working memory processes
  • Author(s): Funahashi, S.
  • Journal Title: Neuroscience (印刷中)
• [Presentation] Neuralactivity in the primate prefrontal cortexduring pair-association performances (2008)
  • Author(s): Andreau, J.M., Funahashi, S.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2008-11-15
• [Presentation] A behavioral study of metamemory in monkeys using an oculomotor working memory task (2008)
  • Author(s): Tanaka, A., Funahashi, S.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2008-11-15
• [Presentation] Task-related activity of primate prefrontal neurons during pair-association performances (2008)
  • Author(s): Andreasu, J.M., Funahashi, S
  • Organizer: 14th Biennial Meeting of the International Society for Comparative Psychology, Buenos Aires
  • Place of Presentation: Argentina
  • Year and Date: 2008-10-09
• [Presentation] Neural mechanisms of working memory in the prefrontal cortex. Workshop on "Working Memory" (2008)
  • Author(s): Funahashi, S.
  • Organizer: 5th European Conference on Complex Systems Jerusalem
  • Place of Presentation: Israel
  • Year and Date: 2008-09-18
• [Presentation] Prefrontal cortex and decision making (2008)
  • Author(s): Funahashi, S.
  • Organizer: 5th European Conference on Complex Systems, Jerusalem
  • Place of Presentation: Israel
  • Year and Date: 2008-09-16
• [Presentation] Prefrontal cortex and decision making. (2008)
  • Author(s): Funahashi, S.
  • Organizer: 5th European Conference on Complex Systems
  • Place of Presentation: Jerusalem, Israel
  • Year and Date: 2008-09-16
• [Presentation] Task-related activity of prefrontal neurons during pair-association performances (2008)
  • Author(s): Andreau, J.M., 船橋新太郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11
• [Presentation] ヒト前頭葉における眼球運動関連領域 : fMRI 研究 (2008)
  • Author(s): 松井正太、田内真惟人、山本洋紀、澤本伸克、福山秀直、船橋新太郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] ヒト前頭眼野におけるトポグラフィック・マップ : fMRI 研究 (2008)
  • Author(s): 田内真惟人、松井正太、山本洋紀、澤本伸克、福山秀直、船橋新太郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] 空間性ワーキングメモリ課題遂行中のサルによる戦略的なFization Breakはメタ記憶の使用を示唆する (2008)
  • Author(s): 田中暁生、船橋新太郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] アフリカツメガエルの定位行動にみられた短期記憶の影響 (2008)
  • Author(s): 岡澤剛起、船橋新太郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 注意欠陥/多動性障害(ADHD)の霊長類モデル (2007)
  • Author(s): 船橋新太郎、清水慶子
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-09-11
• [Presentation] サルを用いたメタ記憶の神経生理学的研究のための行動課題 (2007)
  • Author(s): 田中暁生、船橋新太郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-09-10
• [Presentation] 空間性、非空間性視覚刺激に応答する神経活動のサル前頭連合野背外側部における空間分布パターン (2007)
  • Author(s): 新田統昭、船橋新太郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-09-10
• [Presentation] 遅延自由選択課題における前頭連合野ニューロン活動 (2007)
  • Author(s): 渡邉慶、船橋新太郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-09-10
• [Presentation] Primate model of attention-deficit/hyperactivity - disorders(ADHD) (2007)
  • Author(s): Funahashi, S., Shimizu, K
  • Organizer: Dopamine 50 Years'Congress, Goeteborg
  • Place of Presentation: Sweden
  • Year and Date: 2007-05-30
• [Presentation] Populationvector analysis of primate mediodorsalthalamic activity during oculomotor delayedresponse performances (2006)
  • Author(s): Watanabe, Y., Funahashi, S.
  • Organizer: Society for Neuroscience Meeting
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2006-10-17
• [Presentation] Prefrontal neuronal activity representing decision process of saccade direction in free-choice ODR tasks with variable delay length (2006)
  • Author(s): Watanabe, K., Funahashi, S.
  • Organizer: Society for Neuroscience Meeting, Atlanta
  • Place of Presentation: GA, USA
  • Year and Date: 2006-10-16
• [Presentation] Neural activity related to spatial and nonspatial visual processing in primate prefrontal cortex (2006)
  • Author(s): Nitta, M., Funahashi, S.
  • Organizer: Society for Neuroscience Meeting
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2006-10-16
• [Presentation] 注意欠陥/多動性障害(ADHD)のサル・モデル (2006)
  • Author(s): 船橋新太郎、清水慶子
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都市
  • Year and Date: 2006-07-20
• [Presentation] Prefrontal delay-period activity contributes to the decision of saccade directions in the free-choice task (2005)
  • Author(s): Watanabe, K., Funahashi, S.
  • Organizer: Society for Neuroscience Meeting,
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2005-11-14
• [Presentation] ワーキングメモリに関わる前頭連合野の神経機構 (2005)
  • Author(s): 船橋新太郎
  • Organizer: 日本認知科学会第22回大会
  • Place of Presentation: 京都市
  • Year and Date: 2005-07-30
• [Presentation] 眼球運動方向の決定に関わる前頭連合野の神経機構 (2005)
  • Author(s): 渡辺慶、船橋新太郎
  • Organizer: 第28回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2005-07-27
• [Presentation] 前頭連合野背外側部及び前頭眼窩野の神経活動に対する報酬スケジュールの影響 (2005)
  • Author(s): 竹田里江、船橋新太郎
  • Organizer: 第28回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2005-07-27
• [Presentation] 前頭連合野ドーパミン機能不全による注意欠陥/多動性障害(ADHD)のサル・モデル (2005)
  • Author(s): 船橋新太郎
  • Organizer: 第28回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2005-07-27
• [Presentation] サルを使った注意欠陥/多動性障害(ADHD)のモデル化 (2005)
  • Author(s): 船橋新太郎
  • Organizer: 第82回日本生理学会大会
  • Place of Presentation: 仙台市
  • Year and Date: 2005-05-19
• [Book] The prefrontal cortex as a model system to understand representation and processing of information (2007)
  • Author(s): Funahashi, S.
  • Publisher: The prefrontal cortex as a model system to understand representation and processing of information
• [Book] "Representation and Brain" Springer Verlag (2007)
  • Author(s): Funahashi, S.
• [Book] 「感情の神経科学」藤田和生編『感情科学』 (2007)
  • Author(s): 船橋新太郎
  • Publisher: 京都大学学術出版会
• [Book] General-purpose working memory system and functions of the dorsolateral prefrontal cortex (2007)
  • Author(s): Funahashi, S.
  • Publisher: In : "TheCognitive Neuroscience of Working Memory : Behavioural and Neural Correlates," N.Osaka, R.H. Logie, & M. D'Esposito (eds.), Oxford University Press
• [Book] Representation and Brain (2007)
  • Author(s): S. Funahashi(ed.)
  • Total Pages: 350
  • Publisher: Springer Verlag
• [Book] 前頭葉の謎を解く (2005)
  • Author(s): 船橋新太郎
  • Publisher: 京都大学学術出版会
• [Book] ワーキングメモリとその神経機構 (2005)
  • Author(s): 竹田里江、竹田和良、船橋新太郎
  • Publisher: 板倉徹編著『前頭葉 : その機能とネットワーク』ブレーン出版
• [Remarks]
  • URL: http://www.users.iimc.kvoto-u.ac.jp/~z59035
• [Remarks]
  • URL: http://www.users.kudpc.kyoto-u.ac.jp/~h50400
• [Patent(Industrial Property Rights)] 前頭連合野リハビリテーションプログラムおよび前頭連合野リハビリテーションシステム (2007)
  • Inventor(s): 特願, 竹田里江、竹田和良、船橋新太郎
  • Industrial Property Rights Holder: 竹田里江、竹田和良、船橋新太郎
  • Filing Date: 2007-10-03