Basic study on optical coherence tomography to analyze neuro-activity
| Project/Area Number |
17300140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yamagata University |
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Principal Investigator |
SATO Manabu Yamagata University, Graduate School of Science and Engineering, Professor (50226007)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUTI Takashi Yamagata University, Graduate School of Science and Engineering, Professor (80110493)
WATANABE Yuuki Yamagata University, Graduate School of Science and Engineering, Associate professor (00333328)
市村 勉 山形大学, 工学部, 助教授 (30250947)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,420,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2005: ¥11,500,000 (Direct Cost: ¥11,500,000)
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| Keywords | Low Coherence / Full Feild-OCT / Quadrature Phase / Optical Hilbert Transform / Video-Rate / Rat Brain |
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| Research Abstract |
The objective of this research is confirmations that quadrature fringes full field optical coherence tomography (QF IF OCT) proposed by us is valuable to study on neuro-activities in cortexes. It was impossible to obtain the en-face OCT images to show the neuro-activity in rat cortex. However we could notice the difference in depth intensity profiles through the comparisons between in vivo and in situ.
The measured three-dimensional (3D) area was 4 x 4 x 2.9 mm^3 (160x160x400pixels, XxYxdepth). In signal variations of OCT image on time, the mean of signal intensity in situ was 1.4 times larger than that of in vivo. The ratio of standard deviation to mean of signal intensity in vivo was 2 times larger than that of in situ. In vivo 3D imaging, the cross-section of thinned skull with thickness of 170 μm and the vein with of 150 μm were recognized without averaging. The vein with diameter of 70 μm was also recognized by averaging 300 en face images. In situ 3D imaging, cross-sections of the thinned skull and the vein with a diameter of 200 μm were measured. Compared the depth intensity profile in situ with in vivo, in case of in situ the maximum was observed below the surface at the depth of 1500 μm. This difference in intensity profiles between in vivo and in situ might be useful to measure and monitor the viability of cortexes non-invasively with time and spatial resolution.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Quadrature fringes wide-field optical coherence tomography and its applic ations to biological tissues2006
Author(s)
Manabu, Sato, Tetsuo, Nagata, Takuya, Niizuma, Liviu, Neagu, Razvan, Dabu, Yuuki, Watanabe
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Journal Title
Optics Communications 271
Pages: 573-580
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Presentation] 生体組織の光波イメージング2006
Author(s)
佐藤学
Organizer
理化学研究所シンポジウム
Place of Presentation
和光市
Year and Date
2006-03-13
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 直交位相干渉フルフィールドOCT2006
Author(s)
佐藤学・渡部裕輝
Organizer
レーザー学会学術講演会第26回年次大会
Place of Presentation
大宮市
Year and Date
2006-02-09
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] Basic Study of Rat Brain Imaging2006
Author(s)
Koudai Yoshida, Yuuki Watanabe and Manabu Sato
Organizer
Abstracts(The 61th Annual Meeting, 2006) ; Tohoku Chapter of The Japan Society of Applied Physics, 8p-A3
Place of Presentation
Sendai
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] In Situ Rat Brain Imaging using Full field OCT2005
Author(s)
Nagata Tetsuhiro, Yasuhisa Gojou, Yuuki Watanabe, Takashi Yamaguchi, Tsutomu Ichimura and Manabu Sato
Organizer
Extended Abstracts(The 66th Autumn Meeting, 2005) ; The Japan Society of Applied Physics
Place of Presentation
10a-ZE-4, Tokushima
Description
「研究成果報告書概要(欧文)」より
Related Report
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