| Project/Area Number |
17300141
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Chiba University |
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Principal Investigator |
LIU Hao Chiba University, Graduate School of Engineering, Professor (10342875)
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| Co-Investigator(Kenkyū-buntansha) |
HIMENO Ryutaro RIKEN, Information Center, Director (60342838)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥12,070,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2005: ¥5,700,000 (Direct Cost: ¥5,700,000)
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| Keywords | Bioengineering / Fluid engineering / Lift science / Bioinformatics / Biomedical engineering |
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| Research Abstract |
A new approach on the mufti-scale, multi-physics computational biomechanics in cardiovascular system (CVS) is established to be capable to reasonably predict the cardiovascular functions and the biomechanics of arteries and heart under physiological and pathological conditions. This simulator is composed of four computational models involving an anatomically realistic, three-dimensional arterial tree model, a closed-loop, lumped-parameter compartment model of the global CVS, a systematic control model of the autonomic nervous system (ANS) with consideration of the cerebral auto-regulation (CA), and an image-based three-dimensional CFD model of the local arteries and organs. Combination of the lumped-parameter CVS model and the ANS control model enables the prediction of the hemodynamic parameters of the flow-rate, the blood pressure and the heart rate, etc. in a physiologically realistic way, and the investigation of the nonlinear interactions among multitudinous factors related to hemodynamic regulation. Furthermore, by incorporating the integrated lumped-parameter CVS-and ANS-control-model into the CFD model of an in-house solver of the fully Navier-Stokes equations we can provide a multi-scale, multi-physical prediction of the biomechanics of arteries and heart in health and disease as well as at rest and exercise. The cardiovascular functions of the left ventricle (LV) and the aorta have been studied systematically using the biomechanical simulator. The realistic LV-and aorta-model with consideration of the valves open and closure and the valsalva maneuver is built on a basis of MRI/CT images; and the physiological and the pathological conditions in terms of the boundary conditions are provided by the lumped-parameter CVS-and ANS-control-model. Our results demonstrate that the physiological conditions are of great significance, which points to the importance of the multi-scale and multi-physical modeling of the biomechanics and mechanobiology in the CVS.
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