Design of hybrid hydrogels by nanogel engineering for biomaterials
| Project/Area Number |
17300147
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKIYOSHI Kazunari Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor, 生体材料工学研究所, 教授 (90201285)
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Yasuhiko Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor, 生体材料工学研究所, 助教授 (90280990)
WATANABE Akihiko Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor, 生体材料工学研究所, 助手 (30126263)
MORIMOTO Nobuyuki Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor, 生体材料工学研究所, 助手 (00313263)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2006: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2005: ¥10,700,000 (Direct Cost: ¥10,700,000)
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| Keywords | nanogels / hydrogel / hydrophobized polysacchardes / quantum dot / apatite / molecular chaperone / 生分解性 / リポソーム |
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| Research Abstract |
Tailor-made functional nanogels and hydrogels were could created by self-assembly of functional associating polysaccharides. In particular, hydrophobized polysaccharides such as cholesterol-bearing pullulans formed physically cross-linked nanogels by their self-assembly in water. The nanogels can form complexes with proteins and nucleic acids. Macrogels with well-defined nanostructures can be obtained by self-assembly using these nanogels as building blocks. The self-assembling method using associating polymers is an efficient and versatile technique for preparing functional nanogels and hydrogels for application to bionanotechnology such as drug delivery system and artificial molecular chaperone. Nanogel-inorganic hybrid nanomaterials about nanogel-calcium phosphate and nanogel-Quantum dots were also described.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan2006
Author(s)
Kitano S, Kageyama S, Nagata Y, Miyahara Y, Hiasa A, Naota H, Okumura S, Imai H, Shiraishi T, Masuya M, Nishikawa M, Sunamoto J, Akiyoshi K, Kanematsu T, Scott AM, Murphy R, Hoffman EW, Old LJ, Shiku H
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Journal Title
Clin Cancer Res. 12
Pages: 7397-7405
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan2006
Author(s)
S.Kitano, S.Kageyama, Y Nagata, Y.Miyahara, A.Hiasa, H.Naota, S.Okumura, H.Imai, T.Shiraishi, M.Masuya, M.Nishikawa, J.Sunamoto, K.Akiyoshi, T.Kanematsu, AM.Scott, R.Murphy, EW.Hoffman, LJ.Old, H.Shiku
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Journal Title
Clin Cancer Res. 12
Pages: 7397-7405
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan2006
Author(s)
Kitano S, Kageyama S, Nagata Y, Miyahara Y, Hiasa A, Naota H, Okumura S, Imai H, Shiraishi T, Masuya M, Nishikawa M, Sunamoto J, Akiyoshi K, Kanematsu T, Scott AM, Murphy R, Hoffman EW, Old LJ, Shiku H.
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Journal Title
Clin Cancer Res. 12
Pages: 7397-7405
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[Book] ナノバイオ大辞典2007
Author(s)
森本展行, 秋吉一成
Total Pages
3
Publisher
テクノシステム
Description
「研究成果報告書概要(和文)」より
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[Book] 糖鎖化学の最先端技術2005
Author(s)
森本展行, 秋吉一成
Total Pages
10
Publisher
シーエムシー出版
Description
「研究成果報告書概要(和文)」より
Related Report
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