| Project/Area Number |
17300148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Niigata University |
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Principal Investigator |
MIYAKAWA Michio Niigata University, Institute of Science and Technology, Professor (50239357)
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| Co-Investigator(Kenkyū-buntansha) |
KIRYU Tohru Niigata University, Institute of Science and Technology, Professor (80115021)
NAKAMURA Yasuo Niigata University, Institute of Science and Technology, Assistant Professor (00323957)
YAMADA Yukio University of Electro-Communications, Faculty of Electro-Communications, Professor (10334583)
TANIKAWA Yukari National Institute ofAdvanced Industrial Science and Tbchnology, Institute for Human Science and Biomedical Engineering, Senior Researcher (20344202)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,560,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2005: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | Exercise / Fatigue of muscle / Image-based measurement / Microwave imaging / Optical diffusion imaging / Functional imaging / Oxidization level / Ox hemoglobin / 筋電図 / 酸素飽和度 / 動脈血酸素分圧 / 機能イメージング / マイクロ波CT / 機能の可視化 / リハビリテーション効果 / 筋活動 / 疲労 / 生理的変化 |
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| Research Abstract |
The objective of this study is to demonstrate the possibility of motor function imaging by use of the microwave imaging modality called CP-MCT that was developed by our groups. The imaging modality basically visualizes the cross-sectional distribution of the attenuation and/or phase shift of microwaves in the biological tissues. Since the reconstructed image of CP-MCT reflects the physical- or chemical-change in the tissues, it is expected that rehabilitation effects are visualized through those physical- or chemical changes mainly in the muscles In order to visualize the effects of exercise, gripping loads were applied to the forearm muscles for 5 minutes. To observe slight changes in the physical- or chemical parameters of the muscle, images obtained before and after having exercises were compared by means of image subtraction between those two images. The physiological condition of muscles under gripping load was monitored by means of electromyography and the optical diffusion imagi
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ng of the corresponding forearm portions was also attempted to gain access information of oxidization in the muscles.
The image subtraction between two CP-MCT images revealed the bone regions clearly, because the gray level did not change in the bone regions. Conversely, the gray level in the other regions showed an uneven distribution probably due to the difference in the muscle activities. In fact, fatigue of muscles was confirmed by the electromyography in some experiments. The optical diffusion tomography showed oxidization processes in various muscles and vessels. Some of those images showed a reasonable distribution of oxi- and deoxi-hemoglobin. Although the strong relationships between the optical diffusion image and subtracted CP-MCT image were not found in this study, the areas of gray level change showed close resemblance. Therefore, it will be concluded that new modality using chirp pulse microwaves will be used for evaluating the rehabilitation effects by improving the measurement techniques. Less
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