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Development of a high-throughput molecular delivery method using microbubbles and ultrasound and its application to cancer gene therapy

Research Project

Project/Area Number 17300168
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

KODAMA Tetsuya  Tohoku University, Tohoku University, Biomedical Engineering Research Organization, Professor (40271986)

Co-Investigator(Kenkyū-buntansha) ONO Masao  Tohoku University, Graduate School of Medicine, Professor (20302218)
FUJIKAWA Shigeo  Hokkaido University, Graduate School of Engineering, Professor (70111937)
TOMITA Yukio  Hokkaido University of Education, Faculty of Education, Professor (00006199)
鈴木 麻衣子  東北大学, 先進医工学研究機構, 助手 (70420049)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,400,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2006: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
KeywordsMicrobubble / Gene Therapy / Cancer / Ultrasound / Molecular Delivery / マイクロ気泡
Research Abstract

Non-invasive, tissue-specific molecular delivery is crucial for the efficiency and reduced side effects of a wide range of treatments. A physical method that combines microbubbles (MB) with ultrasound (US) has been regarded as one of the few methods capable of delivering genes into target sites non-invasively. Applied to cancer gene therapy, this method could efficiently target cancer, and may be more efficient than immune gene therapy, as patients are often immunocompromised. However, several essential aspects remain unexplored. First, cavitation bubbles are believed to be a major cause for molecular delivery; however, the relation between wave characteristics and subsequent generation and collapse of cavitation bubbles has not been elucidated, therefore gene transfer has not been optimized. In addition, molecular delivery and subsequent gene expression have not been quantified in vivo. In the present study, these parameters in vitro and in vivo were optimized, and the mechanism of mo … More lecular delivery with theoretical and computer analysis were elucidated. Hypothesizing that free cavitation bubbles were generated from cavitation nuclei created by fragmented MB shells, we estimated the shock wave propagation distance that would induce cell membrane damage from the center of the cavitation bubble. Next, we investigated the structural change of a phospholipid bilayer in water under the action of a shock wave with molecular dynamics simulations. The resulting collapse and rebound of the bilayer followed by the penetration of water molecules into the hydrophobic region of the bilayer induced after the shock wave interaction were demonstrated. Finally, we evaluated the application of this technology to cancer gene therapy using herpes simplex virus thymidine kinase-mediated suicide gene therapy. We observed dramatic reductions of the tumor size by US/MB-mediated transfer. These data demonstrate the potential of US/MB as a new physical gene delivery method for cancer gene therapy. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (80 results)

All 2008 2007 2006 2005

All Journal Article (69 results) (of which Peer Reviewed: 2 results) Presentation (9 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound2008

    • Author(s)
      Aoi A
    • Journal Title

      Ultrasound in Medicine and Biology 34(3)

      Pages: 425-434

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular dynamics simulation of structural changes of lipid bilayers induced by shock waves: effects of incident angles2008

    • Author(s)
      Koshiyama K
    • Journal Title

      Biochimica et Biophysica Acta (BBA) Biomembranes (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound2007

    • Author(s)
      Aoi A
    • Journal Title

      Ultrasound in medicine and Biology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interaction of shock waves generated by cavitation bubbles with cell Membranes during sonoporation.2007

    • Author(s)
      Kodama T
    • Journal Title

      ICBB2007

      Pages: 7-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Molecular mechanisms of cavitation-induced cell membrane permeabilization.2007

    • Author(s)
      Koshiyama K
    • Journal Title

      ICBB2007

      Pages: 8-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Molecular-scale lipid bilayer response to shock wave: molecular dynamics simulations.2007

    • Author(s)
      Koshiyama K
    • Journal Title

      ABSTRACTS of APCOM'07 in conjunction with EPMESC XI

      Pages: 437-437

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ソノポレーションによるシスプラチンの導入2007

    • Author(s)
      小玉 哲也
    • Journal Title

      第46回日本生体医工学会大会特別号プログラム・抄録集 45

      Pages: 180-180

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] ソノポレーションによる遺伝子導入効率:気泡特性に対する検討2007

    • Author(s)
      小玉 哲也
    • Journal Title

      日本超音波医学会第80回学術集会プログラム・講演抄録集

      Pages: 295-295

    • NAID

      10019999428

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] ナノバブルと超音波を用いたがん治療法の開発2007

    • Author(s)
      小玉 哲也
    • Journal Title

      日本学術会議第26回混相流シンポジウム講演資料集

      Pages: 10-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] ナノバブルと超音波を用いたDDS:骨格筋への応用2007

    • Author(s)
      小玉 哲也
    • Journal Title

      日本機械学会2007年度年次大会講演論文集 2

      Pages: 151-152

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 超音波による分子の細胞膜通過機構:分子動力学シュミレーション2007

    • Author(s)
      越山 顕一郎
    • Journal Title

      日本機械学会2007年度年次大会講演論文集 2

      Pages: 153-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] シスプラチンを使った抗腫瘍効果:高周波超音波による定量化2007

    • Author(s)
      冨田 典子
    • Journal Title

      日本機械学会2007年度年次大会講演論文集 2

      Pages: 155-156

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Evaluation of antitumor effects using high frequency ultrasound Biomicroscopy.2007

    • Author(s)
      堀江 佐知子
    • Journal Title

      第66回日本癌学会学術総会

      Pages: 352-352

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Construction of three-dimentional image of intratumoral vessel using high-fr equency contrast-enhanced micro-ultrasound.2007

    • Author(s)
      冨田 典子
    • Journal Title

      第66回日本癌学会学術総会

      Pages: 353-353

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Spinal gene transfer using ultrasound and microbubbles2007

    • Author(s)
      Takahashi M
    • Journal Title

      Journal of Controlled Release 117

      Pages: 267-272

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound2007

    • Author(s)
      Aoi A
    • Journal Title

      Ultrasound in Medicine and Biology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular-scale lipid bilayer response to shock wave: molecular dynamics simulations.2007

    • Author(s)
      Koshiyama K
    • Journal Title

      ABSTRACTS of APCOM' 07 in conjunction with EPMESC XI

      Pages: 437-437

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Miraculous microbubbles keep getting better.2007

    • Author(s)
      Kodama T
    • Journal Title

      ACCJ Journal (March)

      Pages: 80-80

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interaction of impulsive pressures of cavitation bubbles with cell membrane during sonoporation2006

    • Author(s)
      Kodama T
    • Journal Title

      AIP Conference Proceedings 829

      Pages: 34-38

    • NAID

      120001857968

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular dynamics simulation of water pore formation in lipid bilayer induced by shock waves2006

    • Author(s)
      Koshiyama K
    • Journal Title

      AIP Conference Proceedings 829

      Pages: 583-587

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transfection effect of microbubbles on cells in superposed ultrasound wzves and behavior of cavitation bubble2006

    • Author(s)
      Kodama T
    • Journal Title

      ultrasound in Medicine and Biology 32(6)

      Pages: 905-914

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structural change of lipid bilayer and water penetration induced by shock wave molecular dynamics simulations2006

    • Author(s)
      Koshiyama K
    • Journal Title

      Biophysical Journal 91(6)

      Pages: 2198-2205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A non-invasive tissue -specific molecular delivery method of cancer gene therapy2006

    • Author(s)
      Kodama T
    • Journal Title

      Minimally Invasive Therasive Therapy and Allied Technologies 15(4)

      Pages: 226-229

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interaction of impulsive oressures of cavitation bubbles with cell membrane during sonoporation.2006

    • Author(s)
      Kodama T
    • Journal Title

      AIP Conference Proceedings 829

      Pages: 34-38

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular dynamics simulation of water pore formation in lipid bilayer induced by shock waves.2006

    • Author(s)
      Kodama T
    • Journal Title

      AIP Conference Proceedings 829

      Pages: 583-587

    • NAID

      120001857970

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transfection effect of microbubbles on cells in superposed ultrasound waves and behavior of cavitation bubble.2006

    • Author(s)
      Kodama T
    • Journal Title

      Ultrasound in Medicine and Biology. 32(6)

      Pages: 905-914

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structural change of lipid bilayer and water penetration induced by shock wave : molecular dynamics simulations.2006

    • Author(s)
      Kodama T
    • Journal Title

      Biophysical Journal 91(6)

      Pages: 2198-2205

    • NAID

      120000960715

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A non-invasive tissue-specific molecular delivery method of cancer gene therapy2006

    • Author(s)
      Kodama T
    • Journal Title

      Minimally Invasive Therapy an Allied Technologies 15(4)

      Pages: 226-229

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Spinal gene transfer using ultrasound and microbubbles2006

    • Author(s)
      Kodama T
    • Journal Title

      Journal of Controlled Release 117

      Pages: 267-272

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HSV-tk/GCV Cytotoxic Gene Therapy using ultrasound and nanobubbles2006

    • Author(s)
      Kodama T
    • Journal Title

      Ultrasound in Medicine and Biology 32

      Pages: 280-280

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of anti-cancer drug of cisplatin using nanobubbles and ultrasound2006

    • Author(s)
      Kodama T
    • Journal Title

      Ultrasound in Medicine and Biology 32

      Pages: 280-280

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Formation of water pore in a bilayer induced by shock wave : molecular dynamics simulation2006

    • Author(s)
      Kodama T
    • Journal Title

      The Journal of the Acoustical Society of America 120

      Pages: 3231-3231

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antitumor effectiveness of cisplatin with ultrasound and nanobubbles.2006

    • Author(s)
      Kodama T
    • Journal Title

      The Journal of the Acoustical Society of America 120

      Pages: 3231-3231

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 微小気泡超音波破砕による脊髄への遺伝子導入2006

    • Author(s)
      小玉哲也
    • Journal Title

      第44巻特別号第45回日本生体医工学会大会プログラム論文集

      Pages: 167-167

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 超音波場でのナノキャビテーション気泡の挙動2006

    • Author(s)
      小玉哲也
    • Journal Title

      第45回日本生体医工学会大会プログラム論文集 第44巻特別号

      Pages: 170-170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 5FUの拡散に関する分子動力学シミュレーション2006

    • Author(s)
      小玉哲也
    • Journal Title

      第45回日本生体医工学会大会プログラム論文集 第44巻特別号

      Pages: 171-171

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波による抗がん剤感受性の増強2006

    • Author(s)
      小玉哲也
    • Journal Title

      第3回東北大学バイオサイエンスシンポジウム講演要旨集

      Pages: 205-205

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ソノポレーションを用いたHSVtk/GCV自殺遺伝子治療法2006

    • Author(s)
      小玉哲也
    • Journal Title

      第3回東北大学バイオサイエンスシンポジウム講演要旨集

      Pages: 206-206

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波を用いた細胞への分子導入に関する研究2006

    • Author(s)
      小玉哲也
    • Journal Title

      第13回キャビテーションに関するシンポジウム

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脂質膜に形成する水孔のMD予測2006

    • Author(s)
      小玉哲也
    • Journal Title

      日本膜学会第28年会講演要旨集

      Pages: 89-89

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脂質膜近傍での抗がん剤の運動に関するMDシミュレーション2006

    • Author(s)
      小玉哲也
    • Journal Title

      日本機械学会2006年度年次大会講演論文集 Vol. 5

      Pages: 233-233

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波を用いた自殺遺伝子導入法の開発2006

    • Author(s)
      小玉哲也
    • Journal Title

      日本機械学会2006年度年次大会講演論文集 Vol. 5

      Pages: 291-291

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 超音波ナノバブルを利用した抗がん剤および遺伝子デリバリ2006

    • Author(s)
      小玉哲也
    • Journal Title

      第65回日本癌学会学術総会記事

      Pages: 221-221

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 卵巣がん遺伝子・核酸治療法の開発2006

    • Author(s)
      小玉哲也
    • Journal Title

      第65回日本癌学会学術総会記事

      Pages: 428-428

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波を用いた自殺遺伝子導入法の開発2006

    • Author(s)
      小玉哲也
    • Journal Title

      第10回オーガナイズド混相流フォーラム 06-仙台(OMF2006)講演論文集

      Pages: 38-43

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波を利用したがん治療法の開発2006

    • Author(s)
      小玉哲也
    • Journal Title

      東北大学イノベーションフェア2006 in 仙台. 展示概要

      Pages: 8-8

    • Related Report
      2006 Annual Research Report
  • [Journal Article] がん遺伝子治療を目指した非侵襲組織標的性分子導入法の開発2006

    • Author(s)
      小玉哲也
    • Journal Title

      第84期 日本機械学会流体工学部門講演会講演概要集

      Pages: 91-91

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 衝撃波による細胞膜の透過性変化に関する分子動力学シミュレーション2006

    • Author(s)
      小玉哲也
    • Journal Title

      日本機械学会バイオエンジニアリング部門第17回バイオフロンティア講演会論文集

      Pages: 33-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波を利用した抗がん剤とsiRNAの導入に関する研究2006

    • Author(s)
      小玉哲也
    • Journal Title

      第3回日本生体医工学会専門別研究会分子デリバリーのME研究会

    • Related Report
      2006 Annual Research Report
  • [Journal Article] キャビテーション気泡から発生する衝撃波による細胞膜の透過性変化に関するMDシミュレーション2006

    • Author(s)
      小玉哲也
    • Journal Title

      第20回数値流体力学シンポジウム講演要旨集

      Pages: 334-334

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular mechanisms of cell membrane permeabilization induced by shock waves : water pore formation2006

    • Author(s)
      小玉哲也
    • Journal Title

      第9回北海道大学+ソウル大学ジョイントシンポジウム

    • Related Report
      2006 Annual Research Report
  • [Journal Article] がん局所療法を目指したナノバブルと超音波を用いたドラッグおよび核酸送達システムの開発2006

    • Author(s)
      小玉哲也
    • Journal Title

      東北大学イノベーションフェア2007年展示概要

      Pages: 11-11

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 衝撃波による細胞膜の透過性変化機構に関する分子動力学シミュレーション2006

    • Author(s)
      小玉哲也
    • Journal Title

      第56回理論応用力学講演会講演論文集

      Pages: 599-600

    • NAID

      130004603807

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波を用いたシスプラチン導入による抗腫瘍効果の検討2006

    • Author(s)
      小玉哲也
    • Journal Title

      日本超音波医学会第33回東北地方会学術集会プログラム・抄録集

      Pages: 5-5

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 超音波DDSにおける分子導入機構2006

    • Author(s)
      小玉哲也
    • Journal Title

      日本超音波医学会第33回東北地方会学術集会プログラム・抄録集

      Pages: 5-5

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノバブルと超音波を用いた分子導入システムの開発と癌治療への応用2006

    • Author(s)
      小玉哲也
    • Journal Title

      日本機械学会関西支部の第82期定時総会講演会講演論文集

      Pages: 2-14

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Microbubble-mediated gene expression using ultrasound.2006

    • Author(s)
      Kodama T
    • Journal Title

      Ultrasound in Medicine and Biology. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mechanisms of action of acoustic energy on biologicalsystems : physical processes, sites of action.2006

    • Author(s)
      Kodama T
    • Journal Title

      5^<th> International Symposium on Therapeutic Ultrasound,27-29 October 2005, Boston, Massachusetts, USA. Program & Abstract.

      Pages: 98-98

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interaction of impulsive pressures of cavitation bubbles with cell membranes during sonoporation.2006

    • Author(s)
      Kodama T
    • Journal Title

      5^<th> International Symposium on Therapeutic Ultrasound, 27-29 October 2005, Boston, Massachusetts, USA. Program & Abstract.

      Pages: 41-41

    • NAID

      120001857968

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Delivery of oligodeoxynucleotides into human sphenous veins and the adjunct effect of ultrasound and microbubbles2005

    • Author(s)
      Kodama T
    • Journal Title

      Ultrasound in Medicine and Biology 31(12)

      Pages: 1683-1691

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular delivery into a lipid bilayer with a single shock wave using molecular dynamics simulation2005

    • Author(s)
      Koshiyama K
    • Journal Title

      AIP Conference Proceedings 754

      Pages: 104-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular delivery into a lipid bilayer with a single shock wave using molecular dynamics simulation.2005

    • Author(s)
      Kodama T
    • Journal Title

      AIP (American Institute of Physics) Conference Proceedings 754

      Pages: 104-106

    • NAID

      120001857969

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Application of nanobubbles for HSV-tk/GCV cytotoxic gene therapy using ultrasound.2005

    • Author(s)
      Kodama T
    • Journal Title

      ECCO 13-the European Cancer Conference, 30 October-3 November 2005, Paris, France. European Journal of Cancer Supplements, The European Cancer Conference, Abstract Book. 32

      Pages: 57-57

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ナノバブルによる衝撃波発生と分子導入のメカニズム2005

    • Author(s)
      小玉哲也
    • Journal Title

      日本超音波医学会第78回学術集会プログラム・講演抄録集 32

      Pages: 213-213

    • NAID

      10020456045

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 衝撃波による脂質膜構造変化のMD予測2005

    • Author(s)
      小玉哲也
    • Journal Title

      日本膜学会第27年会講演要旨集

      Pages: 105-105

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ナノバブルを用いたHSV-TK-GCV自殺遺伝子治療法の開発2005

    • Author(s)
      小玉哲也
    • Journal Title

      日本バイオレオロジー学会誌(B&R)第19巻増刊号 19

      Pages: 22-22

    • NAID

      10014344838

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ナノバブルを利用したsonoporationのメカニズム2005

    • Author(s)
      小玉哲也
    • Journal Title

      第21回日本DDS学会プログラム予稿集

      Pages: 343-343

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 衝撃波による脂質膜の水孔形成に関するMDシミュレーション2005

    • Author(s)
      小玉哲也
    • Journal Title

      日本流体力学会年会講演論文集

      Pages: 315-315

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 超音波場におけるナノサイズの超音波造影剤の挙動と分子導入機構のメカニズム2005

    • Author(s)
      小玉哲也
    • Journal Title

      日本機械学会2005年度年次大会講演論文集 05-1

    • Related Report
      2005 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いた高周波超音波三次元画像診断・分子導入システムの開発2007

    • Author(s)
      小玉 哲也
    • Organizer
      ナノバイオテクノロジー連携群成果報告会
    • Place of Presentation
      日本科学未来館
    • Year and Date
      2007-12-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ナノバブルと高周波超音波による腫瘍内血管の三次元画の構築2007

    • Author(s)
      冨田 典子
    • Organizer
      東北大学イノベーションフェア2007 in仙台
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高周波超音波画像診断によるシスプラチン(CDDP)の抗腫瘍効果の評価2007

    • Author(s)
      堀江 佐知子
    • Organizer
      東北大学イノベーションフェア2007 in仙台
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ナノバブルと高周波超音波による腫瘍内血管の三次元画像の構築2007

    • Author(s)
      富田 典子
    • Organizer
      東北大学イノベーションフェア2007 in仙台
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular-scale lipid bilayer response to shock wave: molecular dynamics and the Eleventhsimulations2007

    • Author(s)
      Koshiyama K
    • Organizer
      Third Asian-Pacific Congress on Computational Mechanics (APCOM''07) International Conference on the Enhancement and Promotion of Computational Methods in Engineering and Science (EPMESC XI)
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antitumor effectiveness of cisplatin with ultrasound and nanobubbles2006

    • Author(s)
      Kodama T
    • Organizer
      152nd Meeting (4th joint meeting of the Acoustical Society of America and the Acoustical Scociety of Japan)
    • Place of Presentation
      Honolulu, Hawaii
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Delivery of sodium/iodide symportter therapy using nanobubbles with ultrasound2006

    • Author(s)
      Kodama T
    • Organizer
      The 11th Congress of the World Federation for Ultrasound in Medicine and Bioloy
    • Place of Presentation
      Seoul
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Delivery of oligodeoxynucleotides into human saphenous veins and the adjunct effect of ultrasound and microbubbles2006

    • Author(s)
      Kodama T
    • Organizer
      American Society of Gene Therapy. The 9th Annual Meeting
    • Place of Presentation
      Baltimore, Maryland
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nanobubble enhanced drug susceptibility of cancer cells using ultrasound2005

    • Author(s)
      Suzuki M.
    • Organizer
      International Congress Series
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 超音波発生プローブ2006

    • Inventor(s)
      小玉哲也, 森士朗
    • Industrial Property Rights Holder
      日本素材(株)
    • Industrial Property Number
      2006-109894
    • Filing Date
      2006-04-12
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] がん治療用組成物2006

    • Inventor(s)
      小玉哲也, 小濱泰昭
    • Industrial Property Rights Holder
      小玉哲也, 小濱泰昭
    • Industrial Property Number
      2006-285961
    • Filing Date
      2006-10-20
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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