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Development of Radiography Using Proton-Induced X-Rays to Reduce the Dosages of Contrast-Medium and Radiation

Research Project

Project/Area Number 17300170
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTokyo Institute of Technology

Principal Investigator

OGURI Yoshiyuki  Tokyo Institute of Technology, Research Laboratory for Nuclear Reactors, Associate Professor (90160829)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Jun  Tokyo Institute of Technology, Research Laboratory for Nuclear Reactors, Assistant Professor (90302984)
OGAWA Masao  Komazawa University, Faculty of Health Sciences, Professor (60016863)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,760,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2005: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsAngiography / Iodinated contrast medium / Exposure dose / K-absorption edge / Proton-induced X-ray emission / Characteristic X-ray / Micro ion beam / Glass micro capillary / 医療・福祉 / X線診断 / 静電加速器 / 画像分解能 / マイクロビーム / ガラスキャピラリー / 画像コントラスト / Energy subtraction法 / 医療用X線撮影 / 単色X線 / 吸収係数 / 陽子線 / コントラスト
Research Abstract

Characteristic-line radiation from heavy metal targets bombarded by MeV proton beams has been tested as an X-ray source for angiography based on iodinated contrast media. To utilize the strong absorption by iodine (Z=53) at its K-absorption edge (33.2 keV), we used K-alpha line of La (lanthanum, Z=57) at 33.4 keV. As a reference, also K-alpha emission of Sn (tin, Z =50) at 25.2 keV was employed. Metallic plates of La and Sn were irradiated by 7-MeV protons to produce these X-rays. Dual-energy K-edge subtraction method was tested using Lucite phantoms which contain aqueous solutions of potassium iodide. Also Calcium compound was stuffed in these phantoms to simulate bones. The transmission images of the phantoms were recorded on imaging plates. We found that the contrast of images of iodide solutions taken with La X-rays was higher than that with Sn X-rays. Also the energy subtraction procedure was successfully applied to reduce the graphical noise due to the bones and inhomogeneity of the soft tissue. However, for actual clinical use, the X-ray intensity must be increased by several orders of magnitude.
To increase spatial resolution of images, we constructed a compact proton micro-beam system using a tapered glass capillary tube with a tip diameter on the order of 10 microns. The transport efficiency of 2-3-MeV protons through the capillary was examined as a function of the capillary tilt angle and the tip diameter. We obtained transport efficiencies of approximately three times larger than would be expected from the geometrical shape of the capillary. A metallic thin foil was irradiated with the micro beam and quasi-monochromatic X-rays were produced. We demonstrated magnification radiography of a small object to show that a spatial resolution on the order of 10 microns was achievable in our system.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (37 results)

All 2008 2007 2006 Other

All Journal Article (17 results) (of which Peer Reviewed: 4 results) Presentation (19 results) Remarks (1 results)

  • [Journal Article] マイクロビームを用いた高分解能X線イメージング装置の開発2008

    • Author(s)
      長谷川 純
    • Journal Title

      第20回「タンデム加速器及びその周辺技術の研究会」報告集, JAEA-Conf 2008-005

      Pages: 78-81

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Compact Micro-Beam System Using a Tapered Glass Capillary for Proton-Induced X-ray Radiography2008

    • Author(s)
      Jun Hasegawa
    • Journal Title

      Nucl. Instr. and Meth. B 266

      Pages: 2125-2129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development of a High-Resolution X-ray Imaging System Using Proton Micro-Beams2008

    • Author(s)
      Jun, Hasegawa, Shigeki, Shiba, Hitoshi, Fukuda, Yoshiyuki, Oguri
    • Journal Title

      Proc. the 20th Workshop on Tandem Accelerators and Related Technologies JAEA-Conf 2008-005

      Pages: 78-81

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Compact Micro-Beam System Using a Tapered Glass Capillary for Proton-Induced X-ray Radiography2008

    • Author(s)
      Jun, Hasegawa, Sigeki, Shiba, Hitoshi, Fukuda, Yoshiyuki, Oguri
    • Journal Title

      Nucl. Instr. and Meth B 266

      Pages: 2125-2129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A compact Micro-Beam System Using a Tapered Glass Capillary for Proton-Induced X-ray Radiography2008

    • Author(s)
      Jun Hasegawa
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Phantom Test of Proton-Induced Dual-Energy X-Ray Angiography Using Iodinated Contrast Media2007

    • Author(s)
      Yoshiyuki Oguri
    • Journal Title

      International J. of PIXE 17

      Pages: 11-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Phantom Test of Proton-Induced Dual-Energy X-Ray Angiography Using Iodinated Contrast Media2007

    • Author(s)
      Yoshiyuki, Oguri, Jun, Hasegawa, Masao, Ogawa, Jun-ichi, Kaneko, Kimikazu, Sasa
    • Journal Title

      International J. of PIXE 17

      Pages: 11-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Phantom Test of Proton-Induced Duai-Energy X-Ray Angiography Using Iodinated Contrast Media2007

    • Author(s)
      Yoshiyuki Oguri
    • Journal Title

      International Journal of PIXE 17

      Pages: 11-21

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance Evaluation of a High-Resolution X-ray Imaging System Using Glass-Capillary-Generated Micro Proton Beams2007

    • Author(s)
      Jun Hasegawa
    • Journal Title

      Bulletin of the Research Laboratory for Nuclear Reactors 31

      Pages: 110-112

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ガラスキャピラリーを用いたマイクロ陽子ビームの発生とX線イメージングへの応用2007

    • Author(s)
      長谷川 純, 柴 茂樹, 福田一志, 小栗慶之, 小川雅生
    • Journal Title

      日本原子力学会2007年春の年会要旨集

      Pages: 14-14

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Imaging of Iodinated Contrast Medium Using Proton-lnduced Quasi-Monochromatic X-ray Emission2006

    • Author(s)
      Jun Hasegawa
    • Journal Title

      UTTAC Annual Report 2005 UTTAC-75

      Pages: 47-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Imaging of Iodinated Contrast Agent Using Proton-lnduced Quasi-Monochromatic X-rays2006

    • Author(s)
      Jun Hasegawa
    • Journal Title

      Bull. Res. Lab. Nucl. Reactor. 30

      Pages: 275-276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Imaging of Iodinated Contrast Medium Using Proton-Induced Quasi-Monochromatic X-ray Emission2006

    • Author(s)
      Jun, Hasegawa, Jun-ichi, Kaneko, Yoshiyuki, Oguri, Kimikazu, Sasa
    • Journal Title

      UTTAC Annual Report 2005, UTTAC-75, ISSN1880-4748

      Pages: 47-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Imaging of Iodinated Contrast Agent Using Proton-Induced Quasi-Monochromatic X-rays2006

    • Author(s)
      Jun, Hasegawa, Yoshiyuki, Oguri, Masao, Ogawa
    • Journal Title

      Bull. Res. Lab. Nucl. Reactor 30

      Pages: 275-276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PIXEによる環境・医療関連研究2006

    • Author(s)
      小栗慶之
    • Journal Title

      第19回タンデム加速器及びその周辺技術の研究会報告集

      Pages: 95-98

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Imaging of Iodinated Contrast Agent Using Proton-Induced Quasi-Monochromatic X-rays2006

    • Author(s)
      J.Hasegawa, Y.Oguri, M.Ogawa
    • Journal Title

      Bull. Res. Lab. Nucl. Reactor 30

      Pages: 275-276

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Imaging of Iodinated Contrast Medium Using Proton-Induced Quasi-Monochromatic X-ray Emission2006

    • Author(s)
      J.Hasegawa, J.Kaneko, Y.Oguri, H.Fukuda, M.Ogawa, K.Sasa
    • Journal Title

      UTTAC Annual Report 2006 (掲載決定)

    • Related Report
      2005 Annual Research Report
  • [Presentation] 絶縁体キャピラリー内におけるMeVイオンの輸送過程2008

    • Author(s)
      長谷川 純
    • Organizer
      日本物理学会第63回年次大会
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      2008-03-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transportation of MeV Ions in Glass Capillaries2008

    • Author(s)
      Jun Hasegawa, Shigeki Shiba, Hitoshi Fukuda, Yoshiyuki Oguri
    • Organizer
      The 63rd Annual Meeting of the Physical Society of Japan
    • Place of Presentation
      Headquarters Campus, Kinki University, Osaka Japan
    • Year and Date
      2008-03-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 絶縁体キャプラリー内におけるMeVイオンの輸送過程2008

    • Author(s)
      長谷川 純
    • Organizer
      日本物理学会第63回年次大会
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      2008-03-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 小型マイクロイオンビーム源の可能性2008

    • Author(s)
      小栗慶之
    • Organizer
      第9回化学放射線治療科学研究会-先進加速器開発と医学物理
    • Place of Presentation
      東京大学医学部付属病院
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Possibilities of a Compact Micro Ion Beam Source2008

    • Author(s)
      Yoshiyuki, Oguri
    • Organizer
      The 9th Workshop on Chemical and Radiation Therapy Sciences-Advanced Accelerator Development and Medical Physics
    • Place of Presentation
      University of Tokyo Hospital, Tokyo, Japan
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マイクロガラスキャピラリーを用いたMeV陽子の輸送とビーム品質評価2007

    • Author(s)
      長谷川 純
    • Organizer
      日本原子力学会2007年秋の大会
    • Place of Presentation
      北九州国際会議場他
    • Year and Date
      2007-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Beam Quality Evaluation of MeV-Protons Passing Through a Micro Glass Capillary2007

    • Author(s)
      Jun, Hasegawa, Shigeki, Shiba, Hitoshi, Fukuda, Yoshiyuki, Oguri
    • Organizer
      2007 Fall Meeting of the Atomic Energy Society of Japan
    • Place of Presentation
      Kitakyushu International Conference Center, Fukuoka, Japan
    • Year and Date
      2007-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マイクロガラスキャピラリーを用いたMeV陽子の輸送とビーム品質評価2007

    • Author(s)
      長谷川 純
    • Organizer
      日本原子力学会2007年秋の大会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2007-09-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] ガラスキャピラリーで集束されたMeV陽子線の特性評価2007

    • Author(s)
      柴 茂樹
    • Organizer
      日本物理学会第62回年次大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-09-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Quality Evaluation of MeV-Proton Beam Focused with a Glass Capillary2007

    • Author(s)
      Shigeki, Shiba, Jun, Hasegawa, Hitoshi, Fukuda, Yoshiyuki, Oguri
    • Organizer
      The 62th Meeting of the Physical Society of Japan
    • Place of Presentation
      Sapporo campus, Hokkaido University, Hokkaido, Japan
    • Year and Date
      2007-09-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 微小準単色X線源としてのMeVマイクロイオンビーム2007

    • Author(s)
      小栗慶之
    • Organizer
      第1回大学原子力実験施設シンポジウム
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      2007-07-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MeV Micro Ion Beams as a Monochromatic Micro X-ray source2007

    • Author(s)
      Yoshiyuki, Oguri
    • Organizer
      The 1st Symposium on Experimental Facilities for Atomic Energy Researches in Universities
    • Place of Presentation
      Headquarters Campus, Kinki University, Osaka Japan
    • Year and Date
      2007-07-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 第1回大学原子力施設シンポジウム2007

    • Author(s)
      小栗慶之
    • Organizer
      微小準単色X線源としてのMeVマイクロイオンビーム
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      2007-07-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] マイクロビームを用いた高分解能X線イメージング装置の開発2007

    • Author(s)
      長谷川 純
    • Organizer
      第20回タンデム加速器およびその周辺技術の研究会
    • Place of Presentation
      日本原子力研究開発機構東海研究開発センター
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] ガラスキャピラリーを用いたマイクロ陽子ビーム発生とX線イメージングへの応用2007

    • Author(s)
      長谷川 純
    • Organizer
      日本原子力学会2007年春の年会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Generation of Micro Proton Beam Using a Glass Capillary and Its Application to X-ray Imaging2007

    • Author(s)
      Jun, Hasegawa, Shigeki, Shiba, Hitoshi, Fukuda, Yoshiyuki, Oguri, Masao, Ogawa
    • Organizer
      2007 Annual Meeting of the Atomic Energy Society of Japan
    • Place of Presentation
      Nagoya University, Nagoya, Japan
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Observation of Fluid Motion in a Micro-Channel Based Chemical Chip Using Quasi-Monochromatic X-rays Induced by MeV-Protons2006

    • Author(s)
      Jun Hasegawa
    • Organizer
      The 2nd COE-INES International Symposium, INES-2
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2006-11-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヨウ素造影剤と陽子線励起特性X線を用いた二波長差分法による血管造影のファントム試験2006

    • Author(s)
      小栗慶之
    • Organizer
      第23回PIXEシンポジウム
    • Place of Presentation
      ホテル松島大観荘(宮城県宮城郡松島町)
    • Year and Date
      2006-11-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A Phantom Test on Dual-Energy Angiography Using Iodinated Contrast Agent and Proton-Induced Characteristic X-rays2006

    • Author(s)
      Yoshiyuki, Oguri, Jun, Hasegawa, Masao, Ogawa, Jun-ichi, Kaneko, Kimikazu, Sasa
    • Organizer
      The 23th PIXE Symposium
    • Place of Presentation
      Hotel Matsushima-Taikanso, Miyagi, Japan
    • Year and Date
      2006-11-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.nr.titech.ac.jp/~yoguri/

    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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