Development of irradiation field for neutron capture therapy using direct neutrons from compact proton accelerator
| Project/Area Number |
17300172
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kyoto University |
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Principal Investigator |
KOBAYASHI Tooru Kyoto University, Research Reactor Institute, Associate Professor (90089136)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Masaharu Hiroshima University, Research Institute for Radiation Biology and Medicine, Professor (50099090)
TANAKA Kenichi Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Instructor (70363075)
KAGEJI Teruyoshi University of Tokushirna, Department of Neurosurgery, Lecturer (70294684)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥12,180,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥780,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | Neutron capture therapy / Compact proton accelerator / Direct neutron / Irradiation system / 7Li(p.n)7Be reaction / Backing material / TPD method / BDE method / 7Li (p, n) 7Be反応 / BNCT / 中性子発生ターゲット / リチウムターゲット / バッキング材 / 陽子エネルギー |
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| Research Abstract |
We examined the characteristics of the target assembly for the direct usage of near threshold^7L i(p,n)^7Be neutrons for BNCT. We were able to clarify the following :
1) We performed a parametric survey, via simulation, of the dependence of the characteristics of the BNCT irradiation field on the thickness of the lithium target. Neutron and gamma ray fluxes were determined in order to verify the usability of the irradiation fields for BNCT. We also investigated the influence of incident proton energy on the irradiation field by considering energies between 1.89MeV to 1.92MeV. The evaluation indices applied were the treatable protocol depth (TPD) and boron-dose enhancer (BDE) thickness.
2) Regarding gamma ray production in the target assembly, our experiment at the HIRRAC in Hiroshima University showed that tungsten and molybdenum were better than copper and aluminum as backing materials at the proton energy of 1.9MeV. During the same experiment, solid Li with thickness of 10μm deposited
… More
on a W plate had exfoliated after several hours of irradiation at 150μA. It was therefore judged that solid Li is not suitable for practical use from the viewpoint of target life-time. Based on this result, we performed fundamental experiments on the potential use of thin film liquid Li target simulated by water flow formation. We confirmed that practical liquid film will be possible for a thickness of 1mm at 50mm in width and 50mm in length and a flow rate of 30m/s generated from a linear array of nozzles and flowing against a guide plate.
3) The liquid Li-metal flow experiment (2005) in the IFMIF project and the remarkable achievement of the group of ANL suggested that liquid Li thin film formation is technically possible and the prospect of its practical implementation is high.
As to the neutrons from the near threshold^7Li (p,n) ^7Be reaction, we are going to continue to develop a BNCT irradiation field, and will push for the future implementation of accelerator BNCT irradiation system. Less
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] TPD-based evaluation of near threshold mono-energetic proton energies for the^7Li(p,n)^7Be production of neutrons for BNCT2006
Author(s)
Gerard, Bengua, Tooru, Kobavashi, Kenichi, Tanaka, Yoshinobu, Nakagawa, Hironobu, Unesaki
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Journal Title
Physics in Medicine and Biology 51
Pages: 4095-4109
Description
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[Journal Article] Characterization of moderator assembly dimension for accelerator BNCT of brain tumors using^7Li(p,n)neutrons at proton energy of 2.5MeV2006
Author(s)
Kenichi, Tanaka, Tooru, Kobavashi, Gerard, Bengua, Yoshinobu, Nakagawa, Masaharu, Hoshi
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Journal Title
Medical Physics 33
Pages: 1688-1694
Description
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[Journal Article] An evaluation of near threshold mono-energetic proton energies in the^7Li(p,n)^7Be production of neutrons for BNCT using TPD2006
Author(s)
Gerard, Bengua, Tooru, Kobavashi, Kenichi, Tanaka, Yoshinobu, Nakagawa, Hironobu, Unesaki
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Journal Title
Advances in Neutron Capture Therapy 2006 : Proc. of the 12th International. Conference on Neutron Capture Therapy
Pages: 288-291
Description
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[Journal Article] Study on the practical conditions for Li-target thickness and Gaussian proton energies in the production of neutrons for BNCT using the near-threshold^7Li(p,n)^7Be reaction2006
Author(s)
Tooru, Kobavashi, Gerard, Bengua, Kenichi, Tanaka, Yoshinobu, Nakagawa, Masaharu, Hoshi
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Journal Title
Advances in Neutron Capture Therapy 2006 : Proc. of the 12th International Conference on Neutron Capture Therapy
Pages: 300-303
Description
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[Journal Article] Characterization indexes of moderator assembly for accelerator-based BNCT using^7Li(p,n)neutrons at proton energy of 2.5MeV2006
Author(s)
Kenichi, Tanaka, Tooru, Kobavashi, Gerard, Beneua, Yoshinobu, Nakagawa, Satan, Endo, Masaharu, Hoshi
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Journal Title
Advances in Neutron Capture Therapy 2006 : Proc. of the 12th International Conference an Neutron Capture Therapy
Pages: 323-326
Description
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[Journal Article] TPD based Evaluation of Moderator Characteristics for BNCT using^7Li(p,n)Neutrons at Proton Energy of 2.5 MeV2005
Author(s)
K., Tanaka, T., Kobavashi, G., Bengua Y., Nakagawa, S., Endo, M., Hoshi
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Journal Title
Jpn. Jour. Med. Phys 3-1
Pages: 355-358
Description
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[Presentation] An evaluation of near threshold mono-energetic proton energies in the^7Li(p,n)^7Be production of neutrons for BNCT using TPD2006
Author(s)
Gerard, Bengua, Tooru, Kobavashi, Kenichi, Tanaka, Yoshinobu, Nakagawa, Hironobu, Unesaki
Organizer
12th International Conference on Neutron Capture Therapy
Place of Presentation
Takamatsu
Description
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[Presentation] Study on the practical conditions for Li-target thickness and Gaussian proton energies in the production of neutrons for BNCT using the near-threshold^7iLi(p,n)^7Be reaction2006
Author(s)
Tooru, Kobavashi, Gerard, Bengua, Kenichi, Tanaka, Yoshinobu, Nakagawa, Masaharu, Hoshi
Organizer
12th International. Conference on Neutron Capture Therapy
Place of Presentation
Takamatsu
Description
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[Presentation] Characterization indexes of moderator assembly for accelerator-based BNCT using^7Li(p,n)neutrons at proton energy of 2.5MeV2006
Author(s)
Kenichi, Tanaka, Tooru, Kobavashi, Gerard, Bengua, Yoshinobu, Nakagawa, Satoru, Endo, Masaharu, Hoshi
Organizer
12th International Conference on Neutron Capture Therapy
Place of Presentation
Takamatsu
Description
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[Presentation] TPD-based Optimization of Proton Energies for the Near-Threshold^7Li(p,n)Neutron Production2006
Author(s)
G., Bengua, T., Kobavashi, K., Tanaka, H., Unesaki, Y., Nakagawa
Organizer
2006 Annual Meeting of the Atomic Energy Society of Japan
Place of Presentation
Oarai
Description
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[Presentation] Influence of BDE Shane and Size on the Dose Components for BNCT using the Near Threshold^7Li(p,n)^7Be Direct Neutrons2005
Author(s)
M., Teraishi, T., Kobavashi, G., Bengua, K., Tanaka, Y., Nakagawa, N., Sakamotol
Organizer
P-B-062 48th Japan Radiation Research Society
Place of Presentation
Hiroshima
Description
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[Presentation] TPD Based Evaluation of Moderator Characteristics for BNCT using^7Li(p,n)Neutrons at Proton Energy of 2.5 MeV2005
Author(s)
K,. Tanaka, T., Kobavashi, G., Bengua Y., Nakagawa, S., Endo, M., Hoshi
Organizer
4th Japan-Korea Joint Meeting on Medical Physics
Place of Presentation
Kyoto
Description
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