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Ultrasound imaging for tissue characterization to assess cardiovascular involvement in diabetes

Research Project

Project/Area Number 17300177
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionHyogo Medical University

Principal Investigator

MASUYAMA Tohru  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (70273670)

Co-Investigator(Kenkyū-buntansha) TSUJINO Takeshi  Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助手 (90283887)
NAKAO Shinji  Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (80309450)
YUBA Masao  Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (60351821)
MANO Tosiaki  Osaka University, Graduate School of Medicine, Assistant Professor, 医学部附属病院, 講師 (90379165)
SAKATA Yasusi  Osaka University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (90379206)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,500,000 (Direct Cost: ¥14,500,000)
Fiscal Year 2006: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2005: ¥9,500,000 (Direct Cost: ¥9,500,000)
KeywordsCardiac Hypertrophy / Myocardial Fibrosis / Remodeling / Ultrasound / Diabetes Mellitus
Research Abstract

We have developed a system that analyzes ultrasound radiofrequency signals on the basis of chaos theory. This system was used to analyze the ultrasound signals derived from the human myocardium to show (1) that ultrasound signals show quasiperiodic rather than chaotic nature if the myocardium is fibrotic, and that (2) ultrasound signals show chaotic rather than quasiperiodic nature if the myocardium is hypertrophic. Both of fibrosis and hypertrophy are observed in the myocardium in patients with hypertension and/or diabetes mellitus; thus, our data may be interpreted that the analysis of ultrasound radiofrequency signals on the basis of chaos study provides a useful index of myocardial structure in such patients.
The above-mentioned hypotheses were confirmed in the present research by using animal experiments as well as in clinical experiments. Specifically, we established a model in which combination of myocardial fibrosis and myocardial fibrosis causes in left ventricular systolic and diastolic dysfunction. In this model, myocardial fibrosis was associated with a quasiperiodic nature of the myocardial ultrasound signals. On the other hand, chaotic nature of the ultrasound signals was evident in the hypertrophic myocardium. In patients, administration of anti-hypertensive drugs caused non-uniform changes in the chaotic nature of the ultrasound signals. Regression of hypertrophy was associated with a decrease in the value of correlation dimension (a parameter of chaotic nature), while possible reduction of myocardial fibrosis was associated with an increase in the value of correlation dimension.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (21 results)

All 2007 2006 2005

All Journal Article (21 results)

  • [Journal Article] Elevated cardiac tissue level of aldosterone and mineralocorticoid receptor in diastolic heart failure : Beneficial effects of mineralocorticoid receptor blocker.2007

    • Author(s)
      Ohtani T, Masuyama T et al.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 292・2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Therapeutic effects of angiotensin II type 1 receptor blocker at an advanced stage of hypertensive diastolic heart failure.2007

    • Author(s)
      Nishio M, Masuyama T, et al.
    • Journal Title

      J Hypertens 25・2

      Pages: 455-461

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Role of activated renin-angiotensin system in myocardial fibrosis and left ventricular diastolic dysfunction in diabetic patients-reversal by chronic angiotensin II type 1A receptor blockade.2007

    • Author(s)
      Kawasaki D, Masuyama T, et al.
    • Journal Title

      Circ J 71・4

      Pages: 524-529

    • NAID

      110006272141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Elevated cardiac tissue level of aldosterone and mineralocorticoid receptor in diastolic heart failure : Beneficial effects of mineralocorticoid receptor blocker.2007

    • Author(s)
      Ohtani T, Masuyama T et al.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 292(2)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Therapeutic effects of angiotensin II type 1 receptor blocker at an advanced stage of hypertensive diastolic heart failure.2007

    • Author(s)
      Nishio M, Masuyama T, et al.
    • Journal Title

      J Hypertens 25(2)

      Pages: 455-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of activated renin-angiotensin system in myocardial fibrosis and left ventricular diastolic dysfunction in diabetic patients-reversal by chronic angiotensin II type 1A receptor blockade.2007

    • Author(s)
      Kawasaki D, Masuyama T, et al.
    • Journal Title

      Circ J 71(4)

      Pages: 524-9

    • NAID

      110006272141

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Left ventricular diastolic dysfunction in diabetic patients : pathophysiology and therapeutic implications.2006

    • Author(s)
      Tsujino T, Masuyama T, et al.
    • Journal Title

      Am J Cardiovasc Drugs 6. 4

      Pages: 219-230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Left ventricular diastolic dysfunction in diabetic patients : pathophysiology and therapeutic implications.2006

    • Author(s)
      Tsujino T, Masuyama T, et al.
    • Journal Title

      Am J Cardiovasc Drugs 6(4)

      Pages: 219-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Left ventricular diastolic dysfunction in diabetic patients : pathophysiology and therapeutic implications.2006

    • Author(s)
      Tsujino T, Masuyama T, et al.
    • Journal Title

      Am J Cardiovasc Drugs 6・4

      Pages: 219-30

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Different effects of long-and short-actingloop diuretics on survivalrate in Dahi-salt heart failure model rats.2005

    • Author(s)
      YoshidaJ, Masuyama T, et al.
    • Journal Title

      Cardiovasc Res 68. 1

      Pages: 118-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differentiation of myocardial infarction and angina pectoris by processing ultrasonic color kinesis images.2005

    • Author(s)
      Shiozaki A, Masuyama T, et al.
    • Journal Title

      J Med Ultrasonics 32. 2

      Pages: 49-56

    • NAID

      10016473168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Value of the measurements of left atrial geometry in patients eith pseudonormalized or restrictive miral flow velocity patterns.2005

    • Author(s)
      Naito M, Masuyama T, et al.
    • Journal Title

      J Echocardiogr 3. 3

      Pages: 109-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Long - term effect of spironolactone on cardiac structure as assessed by analysis of ultrasonic radio-frequency signals in patients with ventricular hypertrophy.2005

    • Author(s)
      Nishikawa N, Masuyama T, et al.
    • Journal Title

      Circ J 69. 11

      Pages: 1394-1400

    • NAID

      110002703901

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Different effects of long-and short-actingloop diuretics on survivalrate in Dahi-salt heart failure model rats.2005

    • Author(s)
      YoshidaJ, Masuyama T, et al.
    • Journal Title

      Cardiovasc Res 68(1)

      Pages: 118-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differentiation of myocardial infarction and angina pectoris by processing ultrasonic color kinesis images.2005

    • Author(s)
      Shiozaki A, Masuyama T, et al.
    • Journal Title

      J Med Ultrasonics 32(2)

      Pages: 49-56

    • NAID

      10016473168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Value of the measurements of left atrial geometry in patients eith pseudonormalized or restrictive miral flow velocity patterns.2005

    • Author(s)
      Naito M, Masuyama T, et al.
    • Journal Title

      J Echocardiogr 3(3)

      Pages: 109-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Long -term effect of spironolactone on cardiac structure as assessed by analysis of ultrasonic radio-frequency signals in patients with ventricular hypertrophy.2005

    • Author(s)
      Nishikawa N, Masuyama T, et al.
    • Journal Title

      Circ J 69(11)

      Pages: 1394-1400

    • NAID

      110002703901

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats.2005

    • Author(s)
      Yoshida J, Masuyama T, et al.
    • Journal Title

      Cardiovasc Res 68・1

      Pages: 118-127

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differentiation of myocardial infarction and angina pectoris by processing ultrasonic color kinesis images.2005

    • Author(s)
      Shiozaki A, Masuyama T et al.
    • Journal Title

      J Med Ultrasonics 32・2

      Pages: 49-56

    • NAID

      10016473168

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Value of the measurements of left atrial geometry in patients with pseudonormalized or restrictive mitral flow velocity patterns.2005

    • Author(s)
      Naito M, Masuyama T, et al.
    • Journal Title

      J Echocardiogr 3・3

      Pages: 109-117

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Long-term effect of spironolactone on cardiac structure as assessed by analysis of ultrasonic radio-frequency signals in patients with ventricular hypertrophy.2005

    • Author(s)
      Nishikawa N, Masuyama T, et al.
    • Journal Title

      Circ J 69・11

      Pages: 1394-1400

    • NAID

      110002703901

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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