Study of mechanism of radiation effects for low energy protons by the irradiation of neutrons
| Project/Area Number |
17310034
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
HOSHI Masaharu Hiroshima University, Research Institute for Radiation Biology and Medicine, Professor (50099090)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Satoru Hiroshima University, Research Institute for Radiation Biology and Medicine, Associate Professor (90243609)
TANAKA Kenichi Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor (70363075)
ONIZUKA Yoshihiko Kyushu University, Faculty of Medicine, Professor (30160899)
HIEDA Kotaro Rikkyo University, College of Science, Professor (20062656)
UEHARA Shuzo Kyushu University, Faculty of Medicine, Professor (90038927)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,850,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | proton / neutron / biological effect / dosimetry / track end of proton / DNA strand break / ion chamber / silicon detector / 影響のメカニズム |
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| Research Abstract |
The study of relative biological effectiveness (RBE) of low-energy protons and neutrons attracts considerable interest for many scientific fields. The reason of expected increasing the RBE of protons in the energy range of the Bragg peak is still the matter of scientific discussion. In this institution we have been studied using the neutron generator and the Cf-252 fission neutron irradiator. The effects of neutrons were experienced in the cases of Hiroshima and Nagasaki atomic bomb and Tokai mura (JCO) accident. However effects of neutrons for people are not known well. We studied using the 2MV tandem accelerator at Tsukuba University. By using a parallel plate ion chamber and a silicon surface barrier detector we measured proton beam and studied the dosimetry in the small size like cell level to use for the study of DNA strand breaks. The other purpose was to present theoretical results on quantitative modeling of irradiation of V79 cells using track structure of slowing down protons and simulation of initial DNA breaks for investigation a variation of RBE values as a function of initial proton energy. We simulated yields of DNA breaks: SSB and DSB classified on complexity as a function of energy of proton affected straightforwardly on a DNA segment. The results are the clear illustration of the following statements: (i) sensitive sites for cell lethality (transformation) are located in the cell nucleus and (ii) the complex DSB are the most relevant initial lesions leading to cell killing or transformation. The most efficient for delivering absorbed energy in whole V79 cell nucleus are the protons with incident energy of 550 keV. At that the protons with 200 keV were found to be the most efficient in order to induce a complex double strand breaks of DNA affecting DNA straightforwardly. Those calculated numbers are in the range of experimental RBEMAX values.
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Report
(4 results)
Research Products
(153 results)
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[Journal Article] Radiation in our life2005
Author(s)
Endo, S
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Journal Title
HICARE study. Report of FY2004 Lecture Meeting- "Understanding Present Conditions Regarding Radiation and Radiation Exposure"
Pages: 8-19
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Research standard in Japan2007
Author(s)
Hoshi, M.
Organizer
The Republican seminar-Master Class "The International research standards".
Place of Presentation
Semipalatinsk, Kazakhstan
Year and Date
2007-09-27
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] System of research grants in Japan2007
Author(s)
Hoshi, M.
Organizer
The Republican seminar-Master Class "The International research standards".
Place of Presentation
Semipalatinsk, Kazakhstan
Year and Date
2007-09-27
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] Research standard in Japan2007
Author(s)
Hoshi, M
Organizer
The Republican seminar - Master Class "The International research standards"
Place of Presentation
Semipalatinsk, Kazakhstan
Year and Date
2007-09-27
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] System of research grants in Japan2007
Author(s)
Hoshi, M
Organizer
The Republican seminar - Master Class "The International research standards"
Place of Presentation
Semipalatinsk, Kazakhstan
Year and Date
2007-09-27
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] 放射線と被曝についての解説2006
Author(s)
星 正治
Organizer
第3回広島大学技術センター研修会
Place of Presentation
広島
Year and Date
2006-11-27
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 中性子捕捉療法の物理工学2006
Author(s)
田中憲一
Organizer
日本原子力学会中国・四国支部第8回通常総会講演会
Place of Presentation
岡山
Year and Date
2006-05-20
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 非密封,放射線発生装置2006
Author(s)
遠藤 暁
Organizer
電子科学研究所放射線取扱主任者定期講習会講師
Place of Presentation
広島
Year and Date
2006-03-09
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 広島原爆被ばく資料の紹介2005
Author(s)
田中憲一
Organizer
広島原爆被ばく資料の紹介
Place of Presentation
広島
Year and Date
2005-11-17
Description
「研究成果報告書概要(和文)」より
Related Report
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