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SYNTHKI'IC AND FUNCTIONAL STUDIES OF BACTERIAL IMMUNOSTIMULATING GLYCOCONJUGATES

Research Project

Project/Area Number 17310128
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionOsaka University

Principal Investigator

FUKASE Koichi  Osaka University, GARDUATE SCHOOL OF SCJENCE, DEPARTMENT OF CHEMISTRY, PROFESSOR (80192722)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Yukari  OSAKA UNIVERSITY, GARDUATE SCHOOL OF SCIENCE, DEPARTMENT OF CHEMISTRY, ASSOCIATE PROFESSOR (00362616)
TANAKA Katsunori  OSAKA UNIVERSITY, GARDUATE SCHOOL OF SCIENCE, DEPARTMENT OF CHEMISTRY, ASSISTANT PROFESSOR (00403098)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,980,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2006: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2005: ¥6,600,000 (Direct Cost: ¥6,600,000)
KeywordsINNATE IMMUNITY / IMMUNOSTIMULATION / GLYCOCONJUGATE / LIPOPOLYSACCHARIDE / PEPTIDOGLYCAN / RECEPTOR
Research Abstract

Innate immunity is a phylogenetically ancient defense mechanism against pathogens such as bacteria and viruses. Lipopolysaccharide (LPS) of Gram-negative bacteria shows very strong immunostimulating activity and the active entity of LPS is lipid A. In order to investigate the structural basis for expression of the immunostimulating activity, we have synthesized various lipid A and the analogues such as carboxymethyl analogues at 1 position, acidic amino acid containing monosaccharides, conformationally-restricted analogues, and so on. Ru. gelatinosus lipid A having 6 acyl groups with symmetrical acylation distribution and 1- and 4'-phosphate groups showed potent antagonistic activity whereas its 1-O-carboxymethyl analogue showed cytokine inducing activity. The difference of theses two compounds is only 1-O-acidic functional groups. Similar biological results were obtained from the studies of monosaccharide analogues having acidic amino acids. The aspartic acid analogue having two carbo … More xyl groups showed weak but definite immunostimulating activity whereas phosphorerine analogue having one phosphate and one carboxyl group showed antagonistic activity. In both cases the small difference in anionic charge controls the biological activities and this is the new finding by the present study. Helicobacter pylori is a Gram-negative bacteria considered to be an etiological agent of gastroduodental diseases such as the chronic gastritis, gastroduodental ulcer and gastric cancer. H pylori LPS shows very low endotoxic activity and has the characteristic lipid Apart; (1) the presence of less number but of longer fatty acid residues; (2) the absence of the 4'-phosphate group; and (3) the presence of an ethanolamine group linked to the glycosyl phosphate functionality. We previously indicated that H pylori lipid A, which has tri-acyl groups and ethanolamine at the anomeric phosphate, shows weak immunostimulating activity。 In the present study, we synthesized the H pylori LPS partial structures, Kdo-lipid A and the lipid A having no ethanolamine at the anomeric phosphate and found that the compounds are antagonist.
Peptidoglycan partial structures have been synthesized in order to investigate the biofunctional mechanism including the interaction with peptidoglycan receptors, Nod1 and Nod2, and peptidoglycan recognition proteins. We concluded that another peptidoglycan receptor candidate TLR2 does not recognize fundamental structure of peptidoglycan. Potent Nod1 agonists having N-fatty acyl groups (acylated-iE-DAP) have been developed. These Nod1 agonists were used for the investigation of the Nod1 function in living body and we revealed that Nod1 functions at the early stage of bacterial infection. Structures composed of disaccharide and tripeptide or tetrapeptide having diaminopimelic acid (DAP) residue were synthesized. Tracheal cytotoxin (TCT) consisting in disaccharide having anhydrosugar structure and DAP containing tetrapeptide has been also synthesized for the first time. New peptidoglycan partial structures in which two glycan chains is cross-linked with a peptide chain were synthesized. Biological studies of these peptidoglycan partial structures indicated that both Nod1 and Nod2 recognized peptidoglycan partial structures but not intact peptidoglycan. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (251 results)

All 2008 2007 2006 2005

All Journal Article (89 results) (of which Peer Reviewed: 38 results) Presentation (152 results) Book (10 results)

  • [Journal Article] Glycoscience 2007 "Combinatorial methods on oligosaccharide synthesis2008

    • Author(s)
      Tanaka, K
    • Journal Title

      Springer-Verlag (Berlin) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glycoscience "Polymer-supported and tag-assisted methods in oligosaccharide synthesis"2008

    • Author(s)
      Tanaka, K
    • Journal Title

      Springer-Verlag (Berlin) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of various Toll-like receptors, NOD1,and NOD2,in human oral epithelial cells, and their function2007

    • Author(s)
      Sugawara, Y.
    • Journal Title

      Interface Oral Health Science

      Pages: 225-230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Meso-diaminopimelic acid and meso-lanthionine, amino acids peculiar to bacterial cell-wall peptidoglycans, activate human epithelial cells in culture via NOD12007

    • Author(s)
      Uehara, A.
    • Journal Title

      Interface Oral Health Science

      Pages: 275-276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Highly efficient α-salylation by virtue of fixed dipole effects of N-phthalyl group: application to continuous flow synthesis of α(2-3)-and α(2-6)-Neu5Ac-Gal motifs by microreactor.2007

    • Author(s)
      Tanaka, S.
    • Journal Title

      J. Carbohydr. Chem. 26

      Pages: 369-394

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines2007

    • Author(s)
      Uehara, A.
    • Journal Title

      Mol. Immunol. 44

      Pages: 3100-3111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures2007

    • Author(s)
      Fujimoto, Y.
    • Journal Title

      Tetrahadron Lett. 48

      Pages: 6577-6581

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Acceleration of Cu(I)-mediated huisgen 1,3-dipolar cycloaddition by histidine derivatives2007

    • Author(s)
      Tanaka, K.
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 6475-6479

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells2007

    • Author(s)
      Park, J.-H.
    • Journal Title

      J. Immunol. 179

      Pages: 514-521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.2007

    • Author(s)
      Ohto, U.
    • Journal Title

      Science 316

      Pages: 1632-1634

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses2007

    • Author(s)
      Hasegawa, M.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 11757-11764

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells2007

    • Author(s)
      Zhao, L.
    • Journal Title

      J Biol Chem. 282

      Pages: 11618-11628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evidence of immunostimulating lipoprotein existing in nutural lipoteichoic acidfraction2007

    • Author(s)
      Hashimoto, M.
    • Journal Title

      Infect. Immun. 75

      Pages: 1926-1932

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein(BPI)2007

    • Author(s)
      Azuma, M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 354

      Pages: 574-578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step2007

    • Author(s)
      Tanaka, K.
    • Journal Title

      Org. Lett. 9・2

      Pages: 299-302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of various Toll-like receptors, NOD1, and NOD2, in human oral epithelial cells, and their function2007

    • Author(s)
      Sugawara, Y
    • Journal Title

      Interface Oral Health Science

      Pages: 225-230

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Meso-diaminopimelic acid and meso-lanthionine, amino acids peculiar to bacterial cell-wall peptidoglycans, activate human epithelial cells in culture via NOD12007

    • Author(s)
      Uehara, Y
    • Journal Title

      Interface Oral Health Science

      Pages: 275-276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Highly efficient a-salylation by virtue of fixed dipole effects of N-phthalyl group : application to continuous flow synthesis of α(2-3)- and α(2-6)-Neu5Ac-Gal motifs by microreactor2007

    • Author(s)
      Tanaka, S
    • Journal Title

      J. Carbohydr. Chem

      Pages: 369-394

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines2007

    • Author(s)
      Uehara, A
    • Journal Title

      Mol. Immunol 44

      Pages: 3100-3111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures2007

    • Author(s)
      Fujimoto, Y
    • Journal Title

      Tetrahedron Lett 48

      Pages: 6577-6581

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Acceleration of Cu(I)-mediated huisgen 1,3-dipolar cycloaddition by histidine derivatives2007

    • Author(s)
      Tanaka, K
    • Journal Title

      Tetrahedron Lett 48

      Pages: 6475-6479

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells Nodl/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells2007

    • Author(s)
      Park, J.H
    • Journal Title

      J. Immunol 179

      Pages: 514-521

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa2007

    • Author(s)
      Ohto, U
    • Journal Title

      Science 316

      Pages: 1632-1634

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nodl-mediated immune responses2007

    • Author(s)
      Hasegawa, M
    • Journal Title

      J. Biol. Chem 282

      Pages: 11757-11764

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HC,T116 cells2007

    • Author(s)
      Zhao, L
    • Journal Title

      J Biol Chem 282

      Pages: 11618-11628

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evidence of immunostimulating lipoprotein existing in natural lipoteichoic acid fraction2007

    • Author(s)
      Hashimoto, M
    • Journal Title

      Infect. Immun 75

      Pages: 1926-1932

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI)2007

    • Author(s)
      Azuma, M
    • Journal Title

      Biochem. Biophys. Res. Commun 354

      Pages: 574-578

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step2007

    • Author(s)
      Tanaka, K
    • Journal Title

      Org. Lett 9 (2)

      Pages: 299-302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comprehensive Glycoscience Vol.1 "Synthesis of lipopolysaccharide, peptidoglycan, and lipoteichoic acid fragments"2007

    • Author(s)
      Kusumoto, S
    • Journal Title

      Elsevier (London) 26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of various Toll-like receptors, NOD1, and NOD2, in human oral epithelial cells, and their function2007

    • Author(s)
      Sugawara, Y.
    • Journal Title

      Interface Oral Health Science

      Pages: 225-230

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines2007

    • Author(s)
      Uehara, A.
    • Journal Title

      Molecular Immunol. 44

      Pages: 3100-3111

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures2007

    • Author(s)
      Fujimoto, Y.
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 6577-6581

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells^12007

    • Author(s)
      Park, J.-H.
    • Journal Title

      J. Immunol. 179

      Pages: 514-521

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses2007

    • Author(s)
      Hasegawa, M.
    • Journal Title

      J Biol Chem. 282

      Pages: 11757-11764

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential modulation of nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells2007

    • Author(s)
      Zhao, L.
    • Journal Title

      J Biol Chem. 282

      Pages: 11618-11628

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence of immunostimulating lipoprotein existing in natural lipoteichoic acid fraction2007

    • Author(s)
      Hashimoto, M.
    • Journal Title

      Infect. Immun. 75

      Pages: 1926-1932

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of lipid A-mediated type I interferon induction by bactericida1/permeability-increasing protein(BPI)2007

    • Author(s)
      Azuma, M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 354

      Pages: 574-578

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step.2007

    • Author(s)
      Tanaka, K., Motomatsu, S., Koyama, K., Tanaka, S., Fukase, K.
    • Journal Title

      Org. Lett. 9・2

      Pages: 299-302

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice2006

    • Author(s)
      Misuzawa, H.
    • Journal Title

      J. Immunol. 177・11

      Pages: 8133-8139

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis and biologicl activities of biscarboxymethyl lipid a analogues2006

    • Author(s)
      Kataoka, M.
    • Journal Title

      Heterocycles 69

      Pages: 395-415

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mannose-binding lectin Augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coliby kupffer cells through increased cell surface expression of scavenger receptor A^1.2006

    • Author(s)
      Ono, K.
    • Journal Title

      J. Immunol. 177・8

      Pages: 5517-5523

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments2006

    • Author(s)
      Hasegawa, M.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 29054-29063

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Meso-diaminopimelic acid and Meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD12006

    • Author(s)
      Uehara, A.
    • Journal Title

      J. Immunol. 177・3

      Pages: 1796-1804

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of lipid A monosaccharide analogues containing acidic aminoacid: Exploring the structural basis for the endotoxic and antagonistic activities2006

    • Author(s)
      Akamatsu, M.
    • Journal Title

      Bioorg. Med. Chem. 14

      Pages: 6759-6777

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering2006

    • Author(s)
      Fujimoto, Y.
    • Journal Title

      J. Immunol. 176・10

      Pages: 6211-6218

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Toll-like receptors, NOD1 and NOD2, in oral epithelial cells2006

    • Author(s)
      Sugawara, S.
    • Journal Title

      J. Dent. Res. 85・6

      Pages: 524-529

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade2006

    • Author(s)
      Palk, J. W.
    • Journal Title

      J. Biol. Chem. 281・12

      Pages: 7747-7755

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture2006

    • Author(s)
      S. C. Gangloff
    • Journal Title

      Biomaterials 27

      Pages: 1771-1777

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis and bioactivity of fluorescence-and biotin-labeled lipid A analogues forinvestigation of recognition mechanism in innateimmunity2006

    • Author(s)
      Fujimoto, Y.
    • Journal Title

      Tetrahedron Lett. 47・4

      Pages: 539-543

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of peptidoglycan fragments and evaluation of their biological activity.2006

    • Author(s)
      Inamura, S.
    • Journal Title

      Org. Biomol. Chem. 4・2

      Pages: 232-242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice2006

    • Author(s)
      Misuzawa, H
    • Journal Title

      J. Immunol 177 (11)

      Pages: 8133-8139

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis and biologicl activities of biscarboxymethyl lipid a analogues2006

    • Author(s)
      Kataoka, M
    • Journal Title

      Heterocycles 69

      Pages: 395-415

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mannose-binding lectin Augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by kupffer cells through increased cell surface expression of scavenger receptor Al2006

    • Author(s)
      Ono, K
    • Journal Title

      J. Immunol 177 (8)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential release and distribution of Nodl and Nod2 immunostimulatory molecules among bacterial species and environments2006

    • Author(s)
      Hasegawa, M
    • Journal Title

      J. Biol. Chem 281

      Pages: 29054-29063

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Meso-diaminopimelic acid and Meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD12006

    • Author(s)
      Uehara, A
    • Journal Title

      J. Immunol 177 (3)

      Pages: 1796-1804

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of lipid A monosaccharide analogues containing acidic amino acid : Exploring the structural basis for the endotoxic and antagonistic activities2006

    • Author(s)
      Akamatsu, M
    • Journal Title

      Bioorg. Med. Chem 14

      Pages: 6759-6777

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering2006

    • Author(s)
      Fujimoto, Y
    • Journal Title

      J. Immunol 176 (10)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Toll-like receptors, NOD1 and NOD2, in oral epithelial cells2006

    • Author(s)
      Sugawara, S
    • Journal Title

      J. Dent. Res 85 (6)

      Pages: 524-529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade2006

    • Author(s)
      Park, J.W
    • Journal Title

      J. Biol. Chem 281 (12)

      Pages: 7747-7755

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture2006

    • Author(s)
      S.C, Gangloff
    • Journal Title

      Biomaterials 27

      Pages: 1771-1777

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis and bioactivity of fluorescence-and biotin-labeled lipid A analogues for investigation of recognition mechanism in innate immunity2006

    • Author(s)
      Fujimoto, Y
    • Journal Title

      Tetrahedron Lett 47 (4)

      Pages: 539-543

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of peptidoglycan fragments and evaluation of their biological activity2006

    • Author(s)
      Inamura, S
    • Journal Title

      Org. Biomol. Chem 4 (2)

      Pages: 232-242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice.2006

    • Author(s)
      Misuzawa, H., Nishitani, C., Hyakushima, N., Shimizu, T., Sano, H., Matsushima, N., Fukase, K., Kuroki, Y.
    • Journal Title

      J. Immunol. 177・11

      Pages: 8133-8139

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthesis and biologicl activities of biscarboxymethyl lipid a analogues.2006

    • Author(s)
      Kataoka, M., Hashimoto, M., Suda, Y., Kusumoto, S., Fukase, K.
    • Journal Title

      Heterocycles 69

      Pages: 395-415

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mannose-binding lectin Augments the uptake of lipid A, Staphylococcus a ureus, and Escherichia coli by kupffer cells through increased cell surface expression of scavenger receptor A^1.2006

    • Author(s)
      Ono, K., Nishitani, C., Mitsuzawa, H., Shimizu, T., Sano, H., Suzuki, H., Kodama, T., Fujii, N., Fukase, K., Hirata, K., Kuroki, Y.
    • Journal Title

      J. Immunol 177・8

      Pages: 5517-5523

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.2006

    • Author(s)
      Easegawa, M., Yang, K., Hashimoto, M., ark, J.-H., Kim, Y.-G., Fujimoto, Y., miez, G., Fukase, K., Inohara.N.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 29054-29063

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Meso-diaminopimelic acid and Meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.2006

    • Author(s)
      Uehara, A., Fujimoto, Y., Kawasaki, Kusumoto, S., Fukase, K., Takada, H.
    • Journal Title

      J. Immunol. 177・3

      Pages: 1796-1804

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthesis of lipid A monosaccharide analogues containing acidic amino acid : Exploring the structural basis for the endotoxic and antagonistic activities2006

    • Author(s)
      Akamatsu, M., Fujimoto, Y., Kataoka, M., Suda, Y., Kusumoto, S., Fukase, K.
    • Journal Title

      Bioorg. Med. Chem. 14

      Pages: 6759-6777

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.2006

    • Author(s)
      Fujimoto, Y., Fukase, K., Akashi-Takamura, S., Miyake, K.
    • Journal Title

      J. Immunol. 176・10

      Pages: 6211-6218

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Toll-like receptors, NOD1 and NOD2, in oral epithelial cells.2006

    • Author(s)
      Sugawara, S., Sasano, T., Takada.H.
    • Journal Title

      J. Dent. Res. 85・6

      Pages: 524-529

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade.2006

    • Author(s)
      Park, J.W., Je, B-R., Piao, S., Inamura, S., Fujimoto, Y., Fukase, K, Kusumoto, S., Soderhall, K., Ha, N.-C., Lee, B.L.
    • Journal Title

      J. Biol. Chem. 281・12

      Pages: 7747-7755

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture.2006

    • Author(s)
      S.C.Gangloff
    • Journal Title

      Biomaterials 27

      Pages: 1771-1777

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Synthesis and bioactivity of fluorescence- and biotin-labeled lipid A analogues for investigation of recognition mechanism in innate immunity.2006

    • Author(s)
      Y.Fujimoto
    • Journal Title

      Tetrahedron Lett. 47・4

      Pages: 539-543

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Synthesis of peptidoglycan frgments and eveluation of their biological activity.2006

    • Author(s)
      S.Inamura
    • Journal Title

      Org.Biomol.Chem. 4・2

      Pages: 232-242

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Synthesis of lipid A and its analogues for investigation of the structural basis for their bioaetivity2005

    • Author(s)
      Fujimoto, Y.
    • Journal Title

      J. Endotoxin Res. 11・6

      Pages: 341-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Upregulation of PGRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NOD1 and NOD2 in oral epithelial cells2005

    • Author(s)
      Uehara, A.
    • Journal Title

      International Congress Series 1284

      Pages: 163-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] New deprotection method of the 2,2,2-trichloroethoxycarbonyl(Troc)group with(Bu_3Sn)_2.2005

    • Author(s)
      Tokimoto, H.
    • Journal Title

      Tetrahedron Lett. 46・40

      Pages: 6831-6832

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dendritic cell maturation induced by muramyl dipeptide(MDP)derivatives: monoacylated MDP confers TLR2/TLR4 activation.2005

    • Author(s)
      Uehori, J.
    • Journal Title

      J. Immunol 174・11

      Pages: 7096-7103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells2005

    • Author(s)
      Uehara, A.
    • Journal Title

      Cell. Microbiol. 7・5

      Pages: 675-686

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity2005

    • Author(s)
      Fujimoto, Y
    • Journal Title

      J. Endotoxin Res 11 (6)

      Pages: 341-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Upregulation of PGRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NOD1 and NOD2 in oral epithelial cells2005

    • Author(s)
      Uehara, A
    • Journal Title

      International Congress Series 1284

      Pages: 163-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] New deprotection method of the 2,2,2-trichloroethoxycarbonyl (Troc) group with (Bu3Sn)2005

    • Author(s)
      Tokimoto, H
    • Journal Title

      Tetrahedron Lett 46 (40)

      Pages: 6831-6832

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives : monoacylated MDP confers TLR2/TLR4 activation2005

    • Author(s)
      Uehori, J
    • Journal Title

      J. Immunol 174 (11)

      Pages: 7096-7103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells2005

    • Author(s)
      Uehara, A
    • Journal Title

      Cell. Microbiol 7 (5)

      Pages: 675-686

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity.2005

    • Author(s)
      Y.Fujimoto
    • Journal Title

      J.Endotoxin Res. 11・6

      Pages: 341-347

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Upregulation of PFRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NOD1 and NOD2 in oral epithelial cells.2005

    • Author(s)
      A.Uehara
    • Journal Title

      International Congress Series 1284

      Pages: 163-168

    • Related Report
      2005 Annual Research Report
  • [Journal Article] New deprotection method of the 2,2,2-trichloroethoxycarbonyl (Troc) group with (Bu_3Sn)_2.2005

    • Author(s)
      H.Tokimoto
    • Journal Title

      Tetrahedron Lett. 46・40

      Pages: 6831-6832

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives : monoacylated MDP confers TLR2/TLR4 activation.2005

    • Author(s)
      J.Uehori
    • Journal Title

      J.Immunol 174・11

      Pages: 7096-7103

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.2005

    • Author(s)
      A.Uehara
    • Journal Title

      Cell.Micorbiol. 7・5

      Pages: 675-686

    • Related Report
      2005 Annual Research Report
  • [Presentation] 架橋構造を持つLys型細菌細胞壁ペプチドグリカン部分構造の合成と生物活性2008

    • Author(s)
      小西康子
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ランチオニン含有細菌細胞壁ペプチドグリカン部分構造の合成と生物活性2008

    • Author(s)
      烏谷幸枝
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Lys-type linked structures of bacterial cell wall peptidoglycan partial structures and biological evaluation2008

    • Author(s)
      Y., Konishi
    • Organizer
      The 88th Chemical Society of Japan Annual Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of immunostimulating bacterial cell wall peptidoglycan partial structures containing lanthionine2008

    • Author(s)
      Y., Karasudani
    • Organizer
      The 88th Chemical Society of Japan Annual Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヘリコバクターピロリ細胞表層成分リポ多糖部分構造の合成2008

    • Author(s)
      下山敦史
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ライブラリー構築を志向した複合型N-結合型糖蛋白質糖鎖の固相合成2008

    • Author(s)
      藤井遥平
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 免疫刺激活性を持つグラム陽性菌由来リポペプチドの合成研究2008

    • Author(s)
      勝本麻美
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures2008

    • Author(s)
      A., Shimoyama
    • Organizer
      The 88th Chemical Society of Japan Annual Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Library-directed Solid-phase Synthesis of Complex-type N-glycans2008

    • Author(s)
      Y., Fujii
    • Organizer
      The 88th Chemical Society of Japan Annual Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic studies of lipopeptides from Gram-positive bacteria having immunostimulating activity2008

    • Author(s)
      M., Katsumoto
    • Organizer
      The 88th Chemical Society of Japan Annual Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヘリコバクターピロリ細胞表層成分リボ多糖部分構造の合成2008

    • Author(s)
      下山敦史
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生物機能解明のための複合糖質合成2008

    • Author(s)
      深瀬浩一
    • Organizer
      有機合成のニュートレンド2008
    • Place of Presentation
      京都
    • Year and Date
      2008-02-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis and Biological Functions of Oligosaccharides2008

    • Author(s)
      K., Fukase
    • Organizer
      New Trends in Organic Synthesis
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-02-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マイクロリアクターを用いた生理活性物質の合成2008

    • Author(s)
      森 康貴
    • Organizer
      第8回グリーン・サステイナブルブルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-02-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Biofunctional Molecules Using Microfluidic Systems2008

    • Author(s)
      Y., Mori
    • Organizer
      The 8'h Symposium for Green Sustainable Chemistry
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of meso-DAP containing peptidoglycan fragments for investigation of molecular basis for the innate immunostimulation2008

    • Author(s)
      A. Kawasaki
    • Organizer
      The 1st International Global COE Symposium on Bio-Environmental Chemistry
    • Place of Presentation
      Osaka
    • Year and Date
      2008-01-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures2008

    • Author(s)
      A. Shimoyama
    • Organizer
      The 1st International Global COE Symposium on Bio-Environmental Chemistry
    • Place of Presentation
      Osaka
    • Year and Date
      2008-01-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacterpylori Lipopolysaccharide Partial Structures2008

    • Author(s)
      A., Shimoyama
    • Organizer
      The 1st International Global COE Symposium on Bio-Environmental Chemistry
    • Place of Presentation
      Osaka
    • Year and Date
      2008-01-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic Study of Bacterial Glycoconjugates for Elucidation of Immunoregulating Functions2007

    • Author(s)
      K. Fukase
    • Organizer
      International Symposium on Catalysis and Fine Chemicals 2007
    • Place of Presentation
      Singapore
    • Year and Date
      2007-12-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] SOLID-PHASE SYNTHESIS OF N-LINKED GLYCANS AND FIRST PET IMAGING OF GLYCOPROTEINS2007

    • Author(s)
      K. Tanaka
    • Organizer
      International Symposium on Catalysis and Fine Chemicals 2007
    • Place of Presentation
      Singapore
    • Year and Date
      2007-12-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ライブラリー構築を志向した複合型N-結合型糖蛋白質糖鎖の固相合成2007

    • Author(s)
      藤井遥平
    • Organizer
      第27回有機合成若手セミナー
    • Place of Presentation
      京都
    • Year and Date
      2007-11-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Library-directed Solid-phase Synthesis of Complex-type N-glycans2007

    • Author(s)
      Y., Fujii
    • Organizer
      The 27th Organic Chemistry Symposium for Young Scientist
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-11-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] meso-ジアミノピメリン酸の新規合成法の開発とグラム陰性菌ペプチドグリカン部分構造の合成2007

    • Author(s)
      川崎彰子
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of meso-Diaminopimelic Acid for Construction of Gram-negative Bacterial Peptidoglycan Partial Structures2007

    • Author(s)
      A., Kawasaki
    • Organizer
      44th Japanese Peptide Symposium
    • Place of Presentation
      Toyama
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] meso-ジアミノピメリン酸の新規合成法の開発とグラム陰性菌ペプチドグリカン部分構造の合成2007

    • Author(s)
      川崎彰子
    • Organizer
      第44回ぺプチド討論会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis of Phosphoglycolipid from Thermus thermophilus HB8 with-Selective Glycosylation2007

    • Author(s)
      Y. Fujimoto
    • Organizer
      The Fourth International Symposium on Integrated Synthesis(ISIS-4)
    • Place of Presentation
      Hikone
    • Year and Date
      2007-09-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Phosphoglycolipid from Thermus thermophilus HB8 with-Selective Glycosylation.2007

    • Author(s)
      Y. Fujimoto
    • Organizer
      The Fourth International Symposium on Integrated Synthesis (ISIS-4)
    • Place of Presentation
      Hikone
    • Year and Date
      2007-09-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高度好熱菌Thermus thermophilus糖脂質の全合成と免疫刺激活性2007

    • Author(s)
      藤本ゆかり
    • Organizer
      第49回 天然有機化合物討論会
    • Place of Presentation
      札幌
    • Year and Date
      2007-09-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Total Synthesis and Immunostimulatory Activity of Glycolipid from Thermus thermophilus2007

    • Author(s)
      Y., Fujimoto
    • Organizer
      The 49th Symposium on the Chemistry of Natural Products
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-09-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Efficient Microfluidic α-sialylation for the Synthesis of Sialic Acid Containing Oligosaccharides2007

    • Author(s)
      S. Tanaka
    • Organizer
      5th HGPI meeting/2nd Japanese/German Joint Meeting
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori lipopolysaccharide(LPS)partial structures, which regulate the host's innate immune activation2007

    • Author(s)
      A. Shimoyama
    • Organizer
      5th HGPI meeting/2nd Japanese/German Joint Meeting
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Efficient Microfluidic a-sialylation for the Synthesis of Sialic Acid Containing Oligosaccharides2007

    • Author(s)
      S., Tanaka
    • Organizer
      5th HGPI meeting/2nd Japanese/German Joint Meeting
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori lipopolysaccharide (LPS) partial structures, which regulate the host's innate immune activation2007

    • Author(s)
      A., Shimoyama
    • Organizer
      5th HGPI meeting/2nd Japanese/German Joint Meeting
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structure for the Elucidation of the Innate Immune Activation2007

    • Author(s)
      A. Shimoyama
    • Organizer
      14th European Carbohydrate Symposium
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Efficient Microfluidic a-sialylation for the Synthesis of Sialic Acid Containing Oligosaccharides2007

    • Author(s)
      S. Tanaka
    • Organizer
      14th European Carbohydrate Symposium
    • Place of Presentation
      Lubeck, Germany
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of immunostimulating peptidoglycan fragments recognized by intracellular receptor2007

    • Author(s)
      Y. Fujimoto
    • Organizer
      American Chemical Society 234th National Meeting & Exposition
    • Place of Presentation
      Boston, USA
    • Year and Date
      2007-08-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 実用的なシアル酸含有糖鎖の合成を目的としたα選択的シアリル化反応の開発2007

    • Author(s)
      田中伸一
    • Organizer
      FCCAグライコサイエンス若手フォーラム2007
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Development of Efficient a-Sialylation and its Application to Oligosaccharides Synthesis2007

    • Author(s)
      S., Tanaka
    • Organizer
      FCCA Glycoscience Forum for Young Scientists
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-08-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫活性化機構解明を目指した細菌細胞壁ペプチドクリカン部分構造の合成2007

    • Author(s)
      川崎彰子
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      博多
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of peptidoglycan partial structures for investigation of immunostimulating mechanism2007

    • Author(s)
      A., Kawasaki
    • Organizer
      The 27'h Annual Meeting of Japanese Society of Carbohydrate Research
    • Place of Presentation
      Hakata
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫活性化機構解明を目指した細菌細胞壁ペプチドグリカン部分構造の合成2007

    • Author(s)
      川崎彰子
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      博多
    • Year and Date
      2007-08-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 自然免疫活性化機構解明を目指したリポ多糖部分構造と標識体の合成2007

    • Author(s)
      下山敦史
    • Organizer
      第34回有機反応懇談会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高度好熱菌Thermus thermophilus糖脂質の合成と免疫刺激活性2007

    • Author(s)
      光延邦浩
    • Organizer
      第34回有機反応懇談会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Lipopolysaccharide Partial Structures and the Laveled analogues for the Elucidation of the Receptor Recognition2007

    • Author(s)
      A., Shimoyama
    • Organizer
      The 34th Organic Reactions Seminar
    • Place of Presentation
      Osaka
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and Immunostimulatory Activity of Glycolipid from Thermus thermophilus2007

    • Author(s)
      K., Mitsunobe
    • Organizer
      The 34th Organic Reactions Seminar
    • Place of Presentation
      Osaka
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然免療活性化機構解明を目指したリポ多糖部分構造と標識体の合成2007

    • Author(s)
      下山敦史
    • Organizer
      第34回有機反応懇談会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Syuthesis and Immunoregulatory Activity of Lipopolysaccharide Partial Structures for the Elucidation of the Receptor Recognition2007

    • Author(s)
      A. Shimoyama
    • Organizer
      The 27th Sapporo Cancer Seminar International Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高度好熱菌Thermus thermophilus糖脂質の合成と免疫刺激活性2007

    • Author(s)
      光延邦浩
    • Organizer
      第42回天然化学談話会
    • Place of Presentation
      仙台
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis and Immunoregulatory Activity of Lipopolysaccharide Partial Structures for the Elucidation of the Receptor Recognition2007

    • Author(s)
      A., Shimoyama
    • Organizer
      The 27th Sapporo Cancer Seminar International Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis and Immunostimulatory Activity of Glycolipid from Thermus thermophilus2007

    • Author(s)
      K., Mitsunobe
    • Organizer
      The 42th Seminar of Natural Product Chemistry
    • Place of Presentation
      Sendai
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 実用的なシアル酸含有糖鎖の合成を目的としたα選択的シアリル化反応の開発2007

    • Author(s)
      田中伸一
    • Organizer
      第8回関西グライコサイエンス
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Development of Efficient a-Sialylation and its Application to Oligosaccharides Synthesis2007

    • Author(s)
      S., Tanaka
    • Organizer
      The 8th Kansai Glycoscience
    • Place of Presentation
      Osaka
    • Year and Date
      2007-05-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然免疫活性化機構解明を目指したリポ多糖部分構造及びその標識体の合成2007

    • Author(s)
      下山敦史
    • Organizer
      日本ケミカルバイオロジー研究会 第2回年会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Lipopolysaccharide Partial Structure for the Elucidation of the Receptor Recognition2007

    • Author(s)
      A., Shimoyma
    • Organizer
      The 2nd annual meeting of Japanese Society for Chemical Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-05-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ペプチドグリカン受容体Nod1の機能解明を目指したリガンドの活性増強と蛍光標識体の合成2007

    • Author(s)
      川崎彰子
    • Organizer
      日本ケミカルバイオロジー研究会 第2回年会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Synthesis of Nodl ligands possessing enhanced immunostimulating activity and fluorescence-labeled derivatives for investigation ofNodl function2007

    • Author(s)
      A., Kawasaki
    • Organizer
      The 2nd annual meeting of Japanese Society for Chemical Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-05-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 光学活性ジアミノピメリン酸の合成とグラム陰性菌ペプチドグリカン部分構造への展開2007

    • Author(s)
      川崎彰子
    • Organizer
      日本化学会第87春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞内自然免疫受容体Nod1リガンドの蛍光標識体の合成と機能2007

    • Author(s)
      下山敦史
    • Organizer
      日本化学会第87春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ペプチドグリカンの免疫増強活性機構の解明と応用を目指したペプチドグリカン誘導体の合成2007

    • Author(s)
      塩川善右
    • Organizer
      日本化学会第87春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of meso-diaminopimelic acid for construction of Gram-negative bacterial peptidoglycan partial structures2007

    • Author(s)
      A., Kawasaki
    • Organizer
      The 87th Chemical Society of Japa Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and Function of Fluorescence-labeled Ligands of Intracellular Innate Immune Receptor Nodl2007

    • Author(s)
      A., Shimoyama
    • Organizer
      The 87th Chemical Society ofJapar Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of peptidoglycan derivatives for elucidation of the action mechanism of peptidoglycan2007

    • Author(s)
      Z., Shiokawa
    • Organizer
      The 87th Chemical Society ofJapar Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫増強活性複合糖質リピドA配座固定類縁体の合成と生物活性制御2007

    • Author(s)
      赤松雅夫
    • Organizer
      日本化学会第87春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigation for the bioactive conformation of immunostimulating glycoconjugate lipid A ; the synthesis of conformationally constrained analogues2007

    • Author(s)
      M., Akamatsu
    • Organizer
      The 87th Chemical Society of Japa Annual Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Nodl Ligands Studies toward Solid Phase Synthesis of N-Linked Glycans Having Enhanced Immunostimulating Activity2007

    • Author(s)
      A. Kawasaki
    • Organizer
      The 9th International 21st Century COE Symposium on Integrated EcoChemistry
    • Place of Presentation
      Hyogo
    • Year and Date
      2007-01-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic and Biological Study of Bacterial Glycoconjugates, Key Substances in Innate Immnunity2006

    • Author(s)
      K. Fukase
    • Organizer
      International Symposium on Chemical Biology and Combinatorial Chemistry
    • Place of Presentation
      Shandong, China
    • Year and Date
      2006-12-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic and Biological Study of Bacterial Glycoconjugates, KeySubstances in Innate Immnunity2006

    • Author(s)
      K., Fukase
    • Organizer
      International Symposium on Chemical Biology and Combinatorial Chemistry
    • Place of Presentation
      Shandong, China
    • Year and Date
      2006-12-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細菌細胞壁ペプチドグリカン部分構造の合成と免疫増強活性2006

    • Author(s)
      塩川善右
    • Organizer
      第26回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of bacteria cell wall peptidoglycan fragments for investigation of the immunositmulatory activity2006

    • Author(s)
      Z., Shiokawa
    • Organizer
      The 26th Seminar for Younger Orga Chemists
    • Place of Presentation
      Osaka
    • Year and Date
      2006-12-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Peptidoglycan Fragments for Elucidation of Structural Requirements Allowing Detection by Pattern Recognition Receptors2006

    • Author(s)
      K., Fukase
    • Organizer
      Innate Immunity : Receptors, Regulation, and Response
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2006-11-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori and Yersinia pestis Lipopolysaccharide(LPS)Partial Structures, Which Regulate the Host's Innate Immune Activation2006

    • Author(s)
      Y. Fujimoto
    • Organizer
      The 10th International Kyoto Conference on New Aspects of Organic Chemistry(IKCOC10)
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-11-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacterpylori and Yersinia pestis Lipopolysaccharide (LPS) Partial Structures, Which Regulate the Host's Innate Immune Activation2006

    • Author(s)
      Y., Fujimoto
    • Organizer
      The 10th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC10)
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-11-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Peptidoglycan Fragments for Elucidation of Structural Requirements Allowing Detection by Pattern Recognition Receptors2006

    • Author(s)
      K. Fukase
    • Organizer
      Innate Immunity: Receptors, Regulation, and Response
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic study of Glycoconjugates for Elucidation of Their Biological Functions2006

    • Author(s)
      K. Fukase
    • Organizer
      International Symposium on Biotechnology, Metal Complexes and Catalysis
    • Place of Presentation
      Haikou, China
    • Year and Date
      2006-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic study of Glycoconjugates for Elucidation of Their Biological Functions2006

    • Author(s)
      K., Fukase
    • Organizer
      International Symposium on Biotechnology, Metal Complexe : and Catalysis
    • Place of Presentation
      Haiko China
    • Year and Date
      2006-11-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of potent immunostimulating Nod1 ligands; Acylated diaminopimelic acid containing peptides2006

    • Author(s)
      A. Kawasaki
    • Organizer
      43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-11-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Fluorescent Probe for Intracellular Innate Immune Receptor Nod12006

    • Author(s)
      A. Shimoyama
    • Organizer
      43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-11-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of potent immunostimulating Nodl ligands ; Acylated diaminopimelic acid containing peptides2006

    • Author(s)
      A., Kawasaki
    • Organizer
      43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-11-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Fluorescent Probe for Intracellular Innate Immune Receptor Nodl2006

    • Author(s)
      A., Shimoyama
    • Organizer
      43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-11-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Immunostimulating Bacterial Components and Investigation of the Innate Immune Receptors2006

    • Author(s)
      Y. Fujimoto
    • Organizer
      1st International Conference of Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      Okinawa
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Immunostimulating Bacterial Components and Investigation of the Innate Immune receptors2006

    • Author(s)
      Y., Fujimoto
    • Organizer
      1st International Conference of Cutting-EdgeOrganic Chemistry a Asia
    • Place of Presentation
      Okinawa
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然免疫受容体TLR4/MD-2による認識配座解明を目指したリピドA配座固定類縁2006

    • Author(s)
      赤松雅夫
    • Organizer
      第48回天然有機化合物討論会
    • Place of Presentation
      仙台
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigation for the bioactive conformation of immunostimulating glycoconjugate Lipid A ; The synthesis of conformationally constrained analogues2006

    • Author(s)
      M., Akamatsu
    • Organizer
      The 48th Symposium on the Chemist ofNaturalProducts
    • Place of Presentation
      Senai
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然免疫活性化機構の解明を目指した細菌細胞壁ペプチドグリカンの合成と生物活性2006

    • Author(s)
      藤本やかり
    • Organizer
      生体機能関連化学部会・バイオテクノロジー部会・生命化学研究会合同シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The synthesis and immunostimulating activity of bacterial cell wall component peptidoglycan ; Investigation for receptor recognition and the function in innate immune system2006

    • Author(s)
      Y., Fujimoto
    • Organizer
      The Joint-symposium of Division of Biofunctional Chemistry, Biotechnology, and Forum on Biomolecular Chemistry in the Chemical Society of Japan
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sythesis and enhanced immunostimulating activity of Nod1 ligand2006

    • Author(s)
      A. Kawasaki
    • Organizer
      The 8th International 21st Century COE Symposium on Integrated Eco Chemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-08-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sythesis and enhanced immunostimulating activity of Nodl ligand2006

    • Author(s)
      A., Kawasaki
    • Organizer
      The 8th International 21st Century COE Symposium on Integrated EcoChemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-08-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ピロリ菌およびペスト菌リポ多糖部分構造の合成と自然免疫活性化の制御2006

    • Author(s)
      藤本ゆかり
    • Organizer
      第26回に本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori and Yersinia pestis Lipopolysaccharide (LPS) Partial Structures, Which Regulate the Host's Innate Immune Activation2006

    • Author(s)
      Y., Fujimoto
    • Organizer
      The 26th Annual Meeting of Japanese Society of Carbohydrate Research
    • Place of Presentation
      Sendai
    • Year and Date
      2006-08-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic and Biological Studies of Lipopolysaccharide a Major Stimulator of Innate Immunity2006

    • Author(s)
      K. Fukase
    • Organizer
      The Second International Symposium on Biomoleclar Chemistry
    • Place of Presentation
      Kobe
    • Year and Date
      2006-08-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunostimulating peptidoglycan fragments recognized by Cellular receptors2006

    • Author(s)
      Y. Fujimoto
    • Organizer
      The Second International Symposium on Biomoleclar Chemistry
    • Place of Presentation
      Kobe
    • Year and Date
      2006-08-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然免疫活性化機構の解明を目指した細胞内受容体Nod1リガンドの蛍光標識体合成2006

    • Author(s)
      下山敦史
    • Organizer
      第33回有機反応懇談会
    • Place of Presentation
      京都
    • Year and Date
      2006-08-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Fluorescent Probe for Intracellular Innate Immune Receptor Nodl2006

    • Author(s)
      A., Shimoyama
    • Organizer
      The 33rd Organic reactions seminar
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-08-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and enhanced immunostimulating activity of Nod1 ligand2006

    • Author(s)
      A. Kawasaki
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products Scientific Program
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of peptidoglycan fragments for elucidation of immunostimulating mechanism2006

    • Author(s)
      Y. Fujimoto
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products Scientific Program
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigation for the bioactive conformation of immunostimulating glycoconjugate lipid A; the synthesis of conforma tionally constrained analogues2006

    • Author(s)
      M. Akamatsu
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products Scientific Program
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and enhanced immunostimulating activity of Nodl ligand2006

    • Author(s)
      A., Kawasaki
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products Scientific Program
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of peptidoglycan fragments for elucidation of immunostimulating mechanism2006

    • Author(s)
      Y., Fujimoto
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products Scientific Program
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigation for the bioactive conformation of immunostimulating glycoconjugate lipid A ; the synthesis of conformationally constrained analogues2006

    • Author(s)
      M., Akamatsu
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products Scientific Program
    • Year and Date
      2006-07-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori and Yersinia pestis Lipopolys accharide(LPS)Partial Structures, Which Regulate the Host's Innate Immune Activation2006

    • Author(s)
      Y. Fujimoto
    • Organizer
      XXIIIrd International Carbohydrate Symposium
    • Place of Presentation
      Whistler, Canada
    • Year and Date
      2006-07-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Helicobacter pylori and Yersinia pestis Lipopolysaccharide (LPS) Partial Structures, Which Regulate the Host's Innate Immune Activation2006

    • Author(s)
      Y., Fujimoto
    • Organizer
      XXIIIrd International Carbohydrate Symposium
    • Place of Presentation
      Whistler, Canada
    • Year and Date
      2006-07-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細菌細胞壁ペプチドグリカ著部分構造の合成と免疫増強活性2006

    • Author(s)
      塩川善右
    • Organizer
      第41回天然物化学談話会
    • Place of Presentation
      北海道日高
    • Year and Date
      2006-07-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of bacteria cell wall peptidoglycan fragments for investigation of the immunositmulatory activity2006

    • Author(s)
      Z., Shiokawa
    • Organizer
      The 42th Seminar of Natural Product Chemistry
    • Place of Presentation
      Hidaka
    • Year and Date
      2006-07-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫増強活性複合糖質リピドAの活性配座解明を目指した合成研究-配座固定 類縁体によるアプローチ-2006

    • Author(s)
      赤松雅夫
    • Organizer
      第7回関西グライコサイエンスフォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2006-05-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigation for the bioactive conformation of immunostimulating glycoconjugate lipid A ; the synthesis of conformationally constrained analogues2006

    • Author(s)
      M., Akamatsu
    • Organizer
      The 7the Kansai Glycoscience forum
    • Place of Presentation
      Osaka
    • Year and Date
      2006-05-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 糖鎖合成と糖鎖のケミカルバイオロジー:免疫増強活性糖質の機能研究を中心に2006

    • Author(s)
      深瀬浩一
    • Organizer
      日本農芸化学会2006年度大会
    • Place of Presentation
      京都
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic studies and chemical biology of bioactive sugar chains2006

    • Author(s)
      K., Fukase
    • Organizer
      Annual Meeting of the Japan Societ for Bioscience Biotechnology, and Agrochemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫増強活性複合糖質リピドAの活性配座解明を目指した合成研究-配座固定類縁体によるアプローチ2006

    • Author(s)
      赤松雅夫
    • Organizer
      日本化学会第86春季年会
    • Place of Presentation
      千葉県
    • Year and Date
      2006-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ペプチドグリカン受容体Nod1リガンドのアシル類縁体合成と免 疫増強活性2006

    • Author(s)
      川崎彰子
    • Organizer
      日本化学会第86春季年会
    • Place of Presentation
      千葉県
    • Year and Date
      2006-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Investigation for the bioactive conformation of immunostimulating glycoconjugate lipid A ; the synthesis of conformationally constrained analogues2006

    • Author(s)
      M., Akamatsu
    • Organizer
      The 86th Chemical Society of Japan Annual Meeting
    • Place of Presentation
      Chiba
    • Year and Date
      2006-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and biological activity of acyl derivatives recognized bypeptidoglycan intracellular receptor Nodl2006

    • Author(s)
      A., Kawasaki
    • Organizer
      The 86th Chemical Society ofJapan Annual Meeting
    • Place of Presentation
      Chiba
    • Year and Date
      2006-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Immunostimulating Peptidoglycan Fragments and Investigation of the Receptors-TLR2, Nod1 and Nod2.2006

    • Author(s)
      Y. Fujimoto
    • Organizer
      Toll2006-Recent Advances in Pattern Recognition-
    • Place of Presentation
      Salvador, Brazil
    • Year and Date
      2006-03-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of lmmunostimulating Peptidoglycan Fragments and Investigation of the Receptors-TLR2, Nodl and Nod22006

    • Author(s)
      Y., Fujimoto
    • Organizer
      To112006 -Recent Advances in Patten Recognition
    • Place of Presentation
      Salvador, Bra
    • Year and Date
      2006-03-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Host recognition of bacterial peptidoglycan by intracellular receptor Nod1, investigation with synthetic partial structures2005

    • Author(s)
      A. Kawasaki
    • Organizer
      The 7th International 21st Century COE Symposium on Integrated Eco Chemistry
    • Place of Presentation
      東京
    • Year and Date
      2005-12-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Host recognition of bacterial peptidoglycan by intracellular receptor Nodl, investigation with synthetic partial structures2005

    • Author(s)
      A., Kawasaki
    • Organizer
      The 7th International 21st Century CO Symposium on Integrated EcoChemistry
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-12-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and biological activity of Helicobacter pylori lipopolysaccharide pcrtial structures containing 2-keto-3-deoxy-D-mannno-octonic acid(Kdo)2005

    • Author(s)
      Y. Fujimoto.
    • Organizer
      Pacifichem 2005
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunostimulation by bacterial Peptidoglycan: Synthetic partial structures for the study of receptor recognition2005

    • Author(s)
      Y. Fujimoto.
    • Organizer
      Pacifichem 2005
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and biological activity of Helicobacter pylori lipopolysaccharide partial structures containing 2-keto -3-deoxy-D-mannno-octonic acid (Kdo)2005

    • Author(s)
      Y., Fujimoto
    • Organizer
      Pacifichem
    • Place of Presentation
      Honolu Hawaii
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Immunostimulation by bacterial Peptidoglycan : Synthetic partial structures for the study of receptor recognition2005

    • Author(s)
      Y., Fujimoto
    • Organizer
      Pacifichem
    • Place of Presentation
      Honolu Hawaii
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Host recognition of bacterial peptidoglycan by intracellular receptor Nodl, investigation with synthetic partial structures2005

    • Author(s)
      A., Kawasaki
    • Organizer
      Pacifichem
    • Place of Presentation
      Honolu Hawaii
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of fluorescence labeled lipid A for investigation of the recognition2005

    • Author(s)
      S., Murata
    • Organizer
      Pacifichem
    • Place of Presentation
      Honolul Hawaii
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Host recognition of bacterial peptidoglycan by intracellular receptor Nod1, investigation with synthetic partial structures2005

    • Author(s)
      A. Kawasaki
    • Organizer
      Pacifichem 2005
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2005-12-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of fluorescence labeled lipid A for investigation of the recognition mechanism in innate immune system2005

    • Author(s)
      S. Murata
    • Organizer
      Pacifichem 2005
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2005-12-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 生物機能解明を目指した複合糖質の合成研究2005

    • Author(s)
      深瀬浩一
    • Organizer
      第3回糖質科学コンソーシアムシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2005-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic studies of glycoconjugates for elucidation of their biological functions2005

    • Author(s)
      K., Fukase
    • Organizer
      The 3rd Symposium of Japanese Consortium for Glycobiology and Glycotechnology
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-12-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 受容体機能の制御を指向したlipid A類縁体の合成2005

    • Author(s)
      藤本ゆかり
    • Organizer
      第11回 日本エンドトキシン研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-11-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of lipid A analogues for the regulation of innate immune receptors2005

    • Author(s)
      Y., Fujimoto
    • Organizer
      The 11th Jampanese Endotoxin Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-11-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Separation of S-form lipopolysaccharide with resins having branchedtri-lysine, aputative phosphate recognition sequence2005

    • Author(s)
      T. Goi
    • Organizer
      第42回ペプチド討論会
    • Place of Presentation
      大阪
    • Year and Date
      2005-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Separation of S-form lipopolysaccharide with resins having branched tri-lysine, aputative phosphate recognition sequence2005

    • Author(s)
      T., Goi
    • Organizer
      The 42nd Japanese Peptide Synposium
    • Place of Presentation
      Osaka
    • Year and Date
      2005-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヘリコバクター・ピロリ菌リポ多糖部分構造の合成と生物活性2005

    • Author(s)
      藤本ゆかり
    • Organizer
      第47回天然有機化合物討論会
    • Place of Presentation
      徳島
    • Year and Date
      2005-10-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis and Biological Activity of Helicobacter pylori Lipopolysaccharide Partial Structures2005

    • Author(s)
      Y., Fujimoto
    • Organizer
      The 48th Symposium on the Chemistry of NaturalProducts
    • Place of Presentation
      Tokushima
    • Year and Date
      2005-10-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Chemistry and chemical biology of bacterial glycoconjugates, key molecules in innate immunity2005

    • Author(s)
      K. Fukase
    • Organizer
      3rd Japan-Korea Young Scientists Meeting on Bioorganic and Natural Products Chemistry
    • Place of Presentation
      Hyogo
    • Year and Date
      2005-09-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of peptidoglycan partial structures for investigation of intracellular receptor Nod1 and Nod2 recognition2005

    • Author(s)
      A. Kawasaki
    • Organizer
      New Developments in Synthetic Organic Chemistry of Natural Products and Medicines
    • Place of Presentation
      Kyoto
    • Year and Date
      2005-09-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of peptidoglycan partial structures for investigation of intracellular receptor Nodl and Nod2 recognition2005

    • Author(s)
      A., Kawasaki
    • Organizer
      New Developments in Synthetic Organic Chemistry of Natural Products and Medicines
    • Place of Presentation
      Kyoto
    • Year and Date
      2005-09-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Chemistry of Key Molecules in Innate Immunity2005

    • Author(s)
      K. Fukase
    • Organizer
      The 2nd Yamada Symposium
    • Place of Presentation
      Awaji
    • Year and Date
      2005-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of immunostimulating peptidoglycan fragments for investigation of intracellular receptors Nodl and Nod2 recognition2005

    • Author(s)
      Y., Fujimoto
    • Organizer
      The 2nd Yamada Symposium
    • Place of Presentation
      Awaji
    • Year and Date
      2005-09-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of immunostimulating peptidoglycan fragments for investigation of intracellular receptors Nod1 and Nod2 recognition2005

    • Author(s)
      Y. Fujimoto
    • Organizer
      The 2nd Yamada Symposium
    • Place of Presentation
      Awaji
    • Year and Date
      2005-09-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 糖鎖合成と糖鎖のケミカルバイオロジー:免疫増強複合糖質における展開2005

    • Author(s)
      深瀬浩一
    • Organizer
      第17回生体機能関連化学若手の会サマースクール
    • Place of Presentation
      広島
    • Year and Date
      2005-08-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic studies of bioactive sugar chains2005

    • Author(s)
      K., Fukase
    • Organizer
      Synthetic studies of bioactive sugar chains, 17th Summer School of Division ofBiofunctional Chemistry
    • Place of Presentation
      Hiroshima
    • Year and Date
      2005-08-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞内受容体Nod1, Nod2によるペプチドグリカンの認識2005

    • Author(s)
      川崎彰子
    • Organizer
      第38回若手ペプチド夏の勉強会
    • Place of Presentation
      長野
    • Year and Date
      2005-08-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Peptidoglycan recognition with intercellular receptors Nodl, Nod22005

    • Author(s)
      A., Kawasaki
    • Organizer
      The 3Sth Summer school for younger peptide chemists
    • Place of Presentation
      Nagano
    • Year and Date
      2005-08-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Oligosaccharide Synthesis by Using Solid-Phase Method and Affinity Separation Method2005

    • Author(s)
      K. Fukase
    • Organizer
      Parallel Synthesis Approaches for Drug Discovery and Catalysis
    • Place of Presentation
      Southampton, UK
    • Year and Date
      2005-07-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic Library Approach in Innate Immunity; Elucidation of I. mmunostimulating Mechanism of Bacterial Glycoconjugates2005

    • Author(s)
      Y. Fujimoto
    • Organizer
      Parallel Synthesis Approaches for Drug Discovery and Catalysis
    • Place of Presentation
      Southampton, UK
    • Year and Date
      2005-07-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic Library Approach in Innate Immunity ; Elucidation of Immunostimulating Mechanism of Bacterial Glycoconjugates2005

    • Author(s)
      Y., Fujimoto
    • Organizer
      Parallel Synthesis Approaches for Drug Discovery and Catalysis
    • Place of Presentation
      Southampton, UK
    • Year and Date
      2005-07-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Library of Peptidoglycan Fragments for Elucidation of Their Action Mechanism in Immunostimulation2005

    • Author(s)
      Y. Fujimoto
    • Organizer
      The Third European Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials
    • Place of Presentation
      Winchester, U. K.
    • Year and Date
      2005-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Microwave-assisted Radical Reactions for Solid-phase Synthesis2005

    • Author(s)
      K. Fukase
    • Organizer
      The Third European Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials
    • Place of Presentation
      Winchester, U. K.
    • Year and Date
      2005-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of Library of Peptidoglycan Fragments for Elucidation of Their Action Mechanism in Immunostimulation2005

    • Author(s)
      Y., Fujimoto
    • Organizer
      The Third European Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials
    • Place of Presentation
      Winchester, U. K
    • Year and Date
      2005-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Microwave-assisted Radical Reactions for Solid-phase Synthesis2005

    • Author(s)
      K., Fukase
    • Organizer
      The Third European Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials
    • Place of Presentation
      Winchester, U. K
    • Year and Date
      2005-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 糖鎖の化学合成と化学生物学、免疫増強複合糖質の機能研究を中心に2005

    • Author(s)
      深瀬浩一
    • Organizer
      疾患グライコプロテオミクスセミナー
    • Place of Presentation
      大阪
    • Year and Date
      2005-05-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional studies of immunostimulating glycoconjugates2005

    • Author(s)
      K., Fukase
    • Organizer
      Disease-related glycoproteomics seminar
    • Place of Presentation
      Osaka
    • Year and Date
      2005-05-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The 2nd Workshop of Netherlands-Japan on Recent Advances in Glycobiology2005

    • Author(s)
      K. Fukase
    • Organizer
      The 2nd Workshop of Netherlands-Japan on Recent Advances in Glycobiology
    • Place of Presentation
      Utrecht, The Netherlands
    • Year and Date
      2005-04-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The 2nd Workshop of Netherlands - Japan on Recent Advances in Glycobiology2005

    • Author(s)
      K., Fukase
    • Organizer
      The 2nd Workshop of Netherlands - Japan on Recent Advances in Glycobiology
    • Place of Presentation
      Utrecht, The Netherlands
    • Year and Date
      2005-04-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Glycoscience 2007 "Combinatorial methods on oligosaccharide synthesis"2008

    • Author(s)
      Tanaka, K.
    • Publisher
      Springer-Verlag(Berlin)(in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Glycoscience "Polymer-supported and tag-assisted methods in oligosaccharide synthesis"2008

    • Author(s)
      Tanaka, K.
    • Publisher
      Springer-Verlag(Berlin)(in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Glycoscience "Polymersupported and tag-assisted methods in oligosaccharide synthesis"2008

    • Author(s)
      Tanaka, K.
    • Publisher
      Springer-Verlag(Berlin)(in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Glycoscience 2007 "Combinatorial methods on oligosaccharide synthesis2008

    • Author(s)
      Tanaka, K
    • Publisher
      Springer-Verlag (Berlin)(in press)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Glycoscience "Polymer-supported and tag-assisted methods in oligosaccharide synthesis"2008

    • Author(s)
      Tanaka, K
    • Publisher
      Springer-Verlag (Berlin)(in press)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Comprehensive Glycoscience Vol.1 "Synthesis of lipopolysaccharide, peptidoglycan, and lipoteichoic acid fragments"2007

    • Author(s)
      Kusumoto, S.
    • Total Pages
      26
    • Publisher
      Elsevier(London)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Comprehensive Glycoscience Vol.1 "Synthesis of lipopolysaccharide, peptidoglycan, and lipoteichoic acid fragments"2007

    • Author(s)
      Kusumoto, S
    • Total Pages
      26
    • Publisher
      Elsevier (London)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Comprehensive Glycoscience Vol.1 "Synthesis of lipopolysaccharide, peptidoglycan, and lipoteichoic acid fragments"2007

    • Author(s)
      Kusumoto, S.
    • Total Pages
      26
    • Publisher
      Elsevier (London)
    • Related Report
      2007 Annual Research Report
  • [Book] Glycoscience 2007 "Combinatorial methods on oligosaccharide synthesis"2007

    • Author(s)
      Tanaka, K.
    • Publisher
      Springer-Verlag (Berlin)(In press)
    • Related Report
      2007 Annual Research Report
  • [Book] Glycoscience "Polymer-supported and tag-assisted methods in oligosaccharide synthesis"2007

    • Author(s)
      Tanaka, K.
    • Publisher
      Springer-Verlag (Berlin)(In press)
    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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