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Brain Mechanism of Aggression

Research Project

Project/Area Number 17330151
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research InstitutionUNIVERSITY of TSUKUBA

Principal Investigator

OGAWA Sonoko  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Professor, 大学院人間総合科学研究科, 教授 (50396610)

Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2006: ¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 2005: ¥8,000,000 (Direct Cost: ¥8,000,000)
KeywordsAggressive Behavior / Estrogen Receptors / Activity / Emotionality / Social Investigation / Anxiety-Related Behavior / Serotonin
Research Abstract

During the funding period, we have worked to determine the role of estrogen receptor β (ER-β) in the regulation of aggressive behavior in mice in relation to the levels of anxiety levels, social recognition and stress responsiveness.
(1) In the first set of the studies, we tested the effects of estrogen replacement on the levels of anxiety in gonadectomized male mice of ER-b knockout (βERKO) as well as wild-type (WT). The levels of anxiety measured during the light-dark transition tests significantly decreased by estrogen treatment in WT, but not in βERKO, male mice. We also measured the mRNA levels of serotonin transporter (SERT) in ER-β rich midbrain dorsal raphe nuclei. Again, estrogen increased SERT mRNA levels in WT mice but it failed to do so in βERKO mice.
(2) Aggressive behavior of male mice is known to first appear around the time of puberty onset at 5-6weeks of age. In our previous studies, we found an increase of aggression in PERKO mice at the pubertal age suggesting disruption of inhibitory brain system. In the second set of studies, we studied the effects of stress loading on the onset of aggressive behavior around the puberty age. Aggressive behavior measured at 5weeks of age was greatly decreased in mice those separated from their mothers during neonatal period. Decreased levels and a delayed onset of aggression at pubertal age were particularly pronounced in βERKO male mice compared to WT mice. Therefore, we concluded that ER-β might be involved in the development of stress responsiveness around the time of pubertal onset of aggression.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (37 results)

All 2007 2006 2005 Other

All Journal Article (28 results) Book (9 results)

  • [Journal Article] Silencing of estrogen receptor in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.2007

    • Author(s)
      Musatov, S., Chen, W., Pfaff, D.W., Mobbs, C.V., Yang, X.-J., Clegg, D.J., Kaplitt, M.G., Ogawa, S.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 104

      Pages: 2501-2507

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Silencing of estrogen receptor in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.2007

    • Author(s)
      Musatov, S., Chen, W, Pfaff, D.W., Mobbs, C.V., Yang, X.-J., Clegg, D.J., Kaplitt, M.G, Ogawa, S.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 104

      Pages: 2501-2507

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Silencing of estrogen receptor in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.2007

    • Author(s)
      Musatov, S., Chen, W., Pfaff, D.W., Mobbs, C.V., Yang, X.-J., Clegg, D.J., Kaplitt, M.G., Ogawa, S
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 104

      Pages: 2501-2507

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inadvertent social information and the avoidance of parasitized male mice : A role for oxytocin.2006

    • Author(s)
      Kavaliers, M., Choleris, E., Agmo, A., Braun, W.J., Colwell, D.D., Muglia, L.J., Ogawa, S., Pfaff, D.W.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 103

      Pages: 4293-4298

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Estrogen receptor β gene disruption potentiates estrogen-inducible aggression but not sexual behavior in male mice.2006

    • Author(s)
      Nomura, M., Andersson, S., Korach, K.S., Gustafsson, J-A., Pfaff, D.W., Ogawa, S.
    • Journal Title

      European Journal of Neuroscience 23

      Pages: 1860-1868

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Knockdown of estrogen receptor α using viral-mediated RNA interference abolishes female sexual behavior.2006

    • Author(s)
      Musatov, S.A., Chen, W., Pfaff, D.W., Kaplitt, M., Ogawa, S.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 103

      Pages: 10456-10460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Involvement of estrogen receptor α, β, and oxytocin in social discrimination : a detailed behavioral analysis with knockout female mice.2006

    • Author(s)
      Choleris, E., Ogawa, S., Kavaliers, M., Gustafsson, J-A., Korach, K.S., Muglia, L.J., Pfaff, D.W.
    • Journal Title

      Genes, Brain and Behavior 5

      Pages: 528-539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor α knockout mice.2006

    • Author(s)
      Tomihara, K., Kaitsuka, T., Soga, T., Korach, K.S., Pfaff, D.W., Takahama, K., Ogawa, S.
    • Journal Title

      Neuroreport 17

      Pages: 1169-1173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] From gene networks underlying sex determination and gonadal differentiation to the development of neural networks regulating sociosexual behavior.2006

    • Author(s)
      Crews, D., Lou, W., Fleming, A., Ogawa, S.
    • Journal Title

      Brain Research 1126

      Pages: 109-121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Estrogen receptor β gene disruption potentiates estrogen-inducible aggression but not sexual behavior in male mice.2006

    • Author(s)
      Nomura, M., Andersson, S., Korach, KS., Gustafsson, J-A., Pfaff, D.W., Ogawa, S.
    • Journal Title

      European Journal of Neuroscience 23

      Pages: 1860-1868

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Knockdown of estrogen receptor a using viral-mediated RNA interference abolishes female sexual behavior.2006

    • Author(s)
      Musatov, S.A., Chen, W, Pfaff, D.W., Kaplitt, M., Ogawa, S.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 103

      Pages: 10456-10460

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of estrogen receptor a, b, and oxytocin in social discrimination : a detailed behavioral analysis with knockout female mice.2006

    • Author(s)
      Choleris, E., Ogawa, S., Kavaliers, M., Gustafsson, J-A., Korach, K.S., Muglia, L.J., Pfaff, D.W.
    • Journal Title

      Genes, Brain and Behavior 5

      Pages: 528-539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor a knockout mice.2006

    • Author(s)
      Tomihara, K., Kaitsuka, T, Soga, T., Korach, K.S., Pfaff, D.W., Takahama, K, Ogawa, S.
    • Journal Title

      Neuroreport 17

      Pages: 1169-1173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inadvertent social information and the avoidance of parasitized male mice : A role for oxytocin.2006

    • Author(s)
      Kavaliers, M.Cholenris, E.Agmo, A., Braun, W.J.Colwell, D.D., Muglia, L.J., Ogawa, S., Pfaff, D.W.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 103

      Pages: 4293-4298

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of estrogen receptor receptor α,β, and oxytocin in social discrimination : a detailed behavioral analysis with knockout female mice.2006

    • Author(s)
      Choleris, E., Ogawa, S., Kavaliers, M., Gustafsson, J-A., Korach, K.S., Muglia, L.J., Pfaff, D.W.
    • Journal Title

      Genes, Brain and Behavior 5

      Pages: 528-539

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor a knockout mice.2006

    • Author(s)
      Tomihare, K., Kaitseka, T., Soga, T., Karachi, K.S., Pfaff, D.W., Taka hama, K., Ogawa, S.
    • Journal Title

      Neuroreport 17

      Pages: 1169-1173

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inadvertent social information and the avoidance of parasitized male mice : A role for oxytocin.2006

    • Author(s)
      Kavaliers, M.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 103

      Pages: 4293-4298

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nonmammalian gonadotropin-releasing hormone molecules in the brain of promoter transgenic rats.2005

    • Author(s)
      Parhar, I.S., Soga, T., Ogawa, Satoshi, Ogawa, Sonoko, Pfaff, D.W., Sakuma, Y.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 102

      Pages: 5880-5885

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats : Effects of adult ovariectomy and estradiol replacement.2005

    • Author(s)
      Cataldo, G., Bernal, S., Markowitz, A., Ogawa, S., Ragnauth, A., Pfaff, D.W., Bodnar, R.J.
    • Journal Title

      Brain Research 1059

      Pages: 13-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of the oxytocin gene in the recognition and avoidance of parasitized males by female mice.2005

    • Author(s)
      Kavaliers, M., Agmo, A., Choleris, E., Muglia, L.J., Ogawa, S., Pfaff, D.W.
    • Journal Title

      Animal Behaviour 70

      Pages: 693-702

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats : Effects of adult ovariectomy and estradiol replacement.2005

    • Author(s)
      Cataldo, G, Bernal, S., Markowitz, A., Ogawa, S., Ragnauth, A., Pfaff, D.W., Bodnar, RJ.
    • Journal Title

      Brain Research 1059

      Pages: 13-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of the oxytocin gene in the recognition and avoidance of parasitized males by female mice.2005

    • Author(s)
      Kavaliers, M., Agmo, A., Choleris, E., Muglia, L.J., Ogawa, S., Pfaff, D.W.
    • Journal Title

      Animal Behavior 70

      Pages: 693-702

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inadvertent social information and the avoidance of parasitized male mice : A role for oxytocin.2005

    • Author(s)
      Kavaliers, M., Choleris, E., Agmo, A., Braun, W.J.Colwell, D.D., Muglia, L.J., Ogawa, S., Pfaff, D.W.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 103

      Pages: 4293-4298

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nonmammalian gonadotropin-releasing hormone molecules in the brain of promoter transgenic rats.2005

    • Author(s)
      Parhar, I.S.
    • Journal Title

      Proceedings of the National Academy of Sciences, U.S.A. 102

      Pages: 5880-5885

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats : Effects of adult ovariectomy and estradiol replacement.2005

    • Author(s)
      Cataldo, G.
    • Journal Title

      Brain Research 1059

      Pages: 13-19

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of the oxytocin gene in the recognition and avoidance of parasitized males by female mice.2005

    • Author(s)
      Kavaliers, M.
    • Journal Title

      Animal Behaviour 70

      Pages: 693-702

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differential involvement of estrogen receptor α, β, and oxytocin in social discrimination : a detailed behavioral analysis with knockout female mice.

    • Author(s)
      Choleris, E.
    • Journal Title

      Genes, Brain and Behavior in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Estrogen receptor β gene disruption potentiates estrogen-inducible aggression but not sexual behavior in male mice.

    • Author(s)
      Nomura, M.
    • Journal Title

      European Journal of Neuroscience in press

    • Related Report
      2005 Annual Research Report
  • [Book] Biology of Aggression2006

    • Author(s)
      Ogawa, S., Nomura, M., Choleris, E., Pfaff, D.W.
    • Total Pages
      512
    • Publisher
      Oxford University Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 脳神経科学イラストレイテッド2006

    • Author(s)
      小川園子
    • Total Pages
      372
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] Brain Sciences, Illustrated (In Japanese)2006

    • Author(s)
      Ogawa, S.
    • Publisher
      Yodosha
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 神経科学イラストレイテッド(2^<nd>Ed.)2006

    • Author(s)
      小川園子
    • Total Pages
      372
    • Publisher
      羊土社
    • Related Report
      2006 Annual Research Report
  • [Book] Biology of Aggression2006

    • Author(s)
      Ogawa, S.
    • Total Pages
      512
    • Publisher
      Oxford University Press
    • Related Report
      2005 Annual Research Report
  • [Book] Gene Therapy of the Central Nervous System : From Bench to Bedside.2005

    • Author(s)
      Musatov, S.A., Pfaff, D.W., Kaplitt, M., Ogawa, S.
    • Total Pages
      370
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 生体統御システムと内分泌撹乱2005

    • Author(s)
      小川園子
    • Total Pages
      321
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] Endocrine Disrupters and Biological Regulatory System (In Japanese)2005

    • Author(s)
      Ogawa, S.
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Gene Therapy of the Central Nervous System : From Bench to Bedside.2005

    • Author(s)
      Musatov, S.A.
    • Total Pages
      370
    • Publisher
      Elsevier
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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