| Project/Area Number |
17350059
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Polymer chemistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
UYAMA Hiroshi Osaka University, Graduate School of Engineering, Professor, 大学院工学研究科, 教授 (70203594)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAGEYAMA Hiroshi Osaka University, Graduate School of Engineering, Lecturer, 大学院工学研究科, 講師 (50294038)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2006: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2005: ¥10,000,000 (Direct Cost: ¥10,000,000)
|
|---|
| Keywords | Oxidative Coupling / Enzyme / Enzyme Model Complex / Lignophenol / γ-Poly(glutamic acid) / Phenol / Poly(amino acid) / Hydrogel / 酸化重合 / ポリフェノール |
|---|
| Research Abstract |
Oxidative coupling of lignophenol was carried out using Fe-salen (an enzyme model complex) as catalyst. Under the selected reaction conditions, soluble lignophenols polymers with molecular weight of several hundred thousands were obtained quantitatively. Structure of the lignophenols affected the polymerization behaviors. Light scattering analysis showed the formation of the ultrahigh molecular weight polymers (molecular weight higher than one million). The cross-coupling of lignophenol with phenol-containing poly(amino acid) was examined. The appropriate coupling conditions enabled the quantitative production of the soluble hybrids of both polymers.
Poly(amino acid) hydrogels were synthesized by utilizing the enzyme catalysis. Peroxidase catalyzed the oxidative coupling of phenol-containing γ-poly(glutamic acid) (PGA) to produce the PGA hydrogel. The gel properties (crosslinking density, swelling ratio, etc) could be controlled by the reaction conditions such as the PGA and enzyme concentration. The elastic modulus (G') increased with increasing the enzyme concentration. The G' value of resulting hydrogels was not dependent on the measurement frequency, suggesting the formation of uniform hydrogels. The swelling ratio of the PGA hydrogel depended on pH; the hydrogel enormously swelled in high pH due to the neutralization of carboxylic acid group in the side chain of PGA.
|
