| Project/Area Number |
17350113
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | National Institute of Advanced Industrial Science and Technolog |
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Principal Investigator |
IWATSUBO Takashi National Institute of Advanced Industrial Science and Technolog, Nanotechnology Research Institute, Senior Researcher, ナノテクノロジー研究部門, 主任研究員 (30356539)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Kensaku Shizuoka University, Dept. of Materials Sci. & Chem. Eng., Professor, 工学部物質工学科, 教授 (60293601)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2005: ¥6,100,000 (Direct Cost: ¥6,100,000)
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| Keywords | biomineralization / cartilage / skeleton / hyper complex gel / organic / inorganic solid solution / hydrogen bond / phase transition / hydroxyapatite |
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| Research Abstract |
Hydroxyapatite was formed within the cross linked Polyvinyl Alcohol(PVA)/Poly acrylic Acid(PAA) gel that was immersed in salt solution containing PAA. In this method, the space within the gel was fulfilled with HAP and HAP was not formed outside the gel. Deposition experiment using seed HAP crystal revealed that the salt solution was not saturated with respect to HAP> At the intermediate stage on the way to the equilibrium state at which the whole space within the gel was fulfilled with HAP, solid phase where the space was fulfilled with HAP and gel phase where HAP was not formed coexisted. The equilibrium sate was attained with the increase of the solid phase at the cost of gel phase. Equilibrium states were examined with various salt concentrations. Equilibrium state was gel state for salt concentrations below the transition concentration while it was solid state for salt concentrations above the transition concentration.
Experimental results described above, powder X-ray diffraction analysis and ICP (Inductively Coupled Plasma atomic emission spectroscopy), EDAX (Energy Dispersive Analysis of X-ray) experiments can explain the process of HAP formation within the PVA/PAA gel as follows. The gel phase corresponds to the hyper complex gel consisted of PVA/PAA, calcium and hydrogen phosphate ions that are connected by electrostatic and hydrogen bonding forces while solid phase corresponds to the solid solution of PVA/PAA and HAP. And both the former phase changes to the later by the phase transition of open system. Furthermore, The hyper complex gel give the fundamental structure of cartilage while the solid solution gives the fundamental structure of skeletal material.
This mechanism can be applicable to the formation of calcium carbonate or silica skeletal material. Any skeletal material is formed by the phase transition of cartilage-like precursor.
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